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Estradiol- Delayed Period

WiscoJaneWiscoJane member
in Infertility
We have been TTC for about 19 months now, I am 32 and my partner is 35. We have done two rounds of IUI, but three cycles of taking Letrizole (7.5mg) (we did timed intercourse first cycle as we had to be out of town for a wedding), triggering with Ovidrel. This last round of IUI I also used estradiol (2mg) twice daily to increase my uterine lining.  We did the IUI on cycle day 14 (3 viable eggs this time around), and I tested on DPO13, 15,18 & 21. We also did a blood serum test which was negative.

 I am now cd38 and 24dpo, no AF (9 days overdue) and no symptoms other then the occasional cramping flare (best way to describe) over the last few days.

I am assuming I am not pregnant with all the negative tests, however since my cycle is usually 28-32 days long I'm getting tired of this and want to move on to the next cycle attempt (It has been exactly 27 days with both previous rounds of Letrizole). Does anyone have any experience as to how long estradiol can delay the period and extend the cycle?
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Re: Estradiol- Delayed Period

  • riveridgionalriveridgional member
    Mine started 3 or 4 days after stopping progesterone and estradiol. I've heard of as late of a week after. I would call your doctor and advise of the delay. You may have a cyst preventing AF, which I believe happened to someone on here a month or two ago.
    Married to DH 10/6/12
    TTC since 5/14
    Unexplained with (controlled) hypothyroidism and suspected ovulatory dysfunction (but, I do ovulate on my own)
    Clomid 50 mg 3/15 (unmonitored) - BFN
    Clomid 50 mg + metformin 4/15 (unmonitored) - BFN 
    First RE appt. 5/15; Natural cycle 5/15 monitored with 2 mature follicles and Pregnyl Trigger (full dose) + prometrium - BFN
    6/15 HSG - clear tubes & normal uterus; great PCT test results
    TI - 100 mg Clomid + prometrium (AM & PM) + vaginal estrace (AM & PM) 6-7/15 (monitored) --> no additional response and thinned lining - BFN
    TI - Injectables (follistim + Gonal-F, Ganirelix, & 1/2 dose Pregnyl) + prometrium (AM & PM) 9/15 --> 3-7 mature follicles (3 definites and 4+ that could have matured due to trigger) @ O -->BFN + 5 large cysts
    BC for 2 weeks due to cysts
    TI - Injectables (Gonal-F, Ganirelix & full dose Pregnyl) + prometrium (AM & PM) 10/15 --> 1 mature follicle --> BFN 
    TI - Last attempt at injectables (Gonal-F, Ganirelix & 1/2 dose Pregnyl) + crinone (AM only) + vaginal estrace (AM & PM) 11/15 --> 3-4 mature follicles --> BFP!! 11/27/15 @ 13dpo (shockingly, actually waited until then to test)

    Beta #1 @ 16dpo (11/30/15) = 1,075
    Beta #2 @ 19dpo (12/3/15) = 3,150
    One baby: Saw heartbeat @ 5w5d (114 bpm; baby measuring 2.3mm)

    "Great Things are Happening"
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  • rachlee2010rachlee2010 member
    I have been on progesterone and estradiol for the past two cycles.  The first one it took a full week for AF to show up after stopping the meds..this month it took 5 days.  I think the normal range is 2-5 days but they say it can take upwards of a week. I know both times if it didn't show I was going to go in to be checked so they could check my levels and check for cysts which can give off estrogen and delay af
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