Secondary IF

Elective freeze-all: thoughts?

So I'm currently scheduled for a fresh embryo transfer on Sunday, but my husband and I are more and more tempted to freeze the embryos that make it to blasts and do an FET next month.  My thinking is this:
  • I don't think my lining/uterus are in optimal condition at the moment.  My progesterone almost got too high for a fresh transfer.  It didn't technically cross the threshold, but it came close.  Also, my lining kind of plateaued around the time of trigger, and had actually gotten thinner by the day of egg retrieval.  It was still OK-ish (8), but the DR put me on estrace to make sure it didn't get worse. It just seems like my lining and everything else is out of sync with the proposed transfer.
  • We're moving the weekend after next.  It would be nice not to be restricted from lifting stuff.
  • We just have a lot of stress/stuff going on (the move, DD is having a mysterious allergy issue that doesn't seem to be effecting her health--thankfully--but has her in and out of daycare, in and out of the ER, etc, etc).  I feel like going through with the transfer and the meds, etc, that accompany it might just be one thing too many.

What do you all think?  Am I being ridiculous?  Is this even something clinics DO?  I did talk to mine, and they'll be getting back to me with the Dr's recommendation.  I just thought I'd ask for your feedback in the meantime.  Thanks!

 


*****Signature/Ticker Warning******

Me: 41, DH: 45
DD, 6/15/2013
TTC #2 beginning January 2014
AMH 1.05; FSH range 7-11

July 2014: IUI #1.  Follistim + Pregnyl.  2 follicles--BFN
September 2014: IUI #2.  Follistim + Pregnyl + Ganirelix + Crinone.  4(?) follicles--BFN
October 2014: IUI #3.  More Follistim + More Ganirelix + Pregnyl + Crinone.  4 follicles--BFP!  Beta #1=10 Beta #2=33 Beta #3=97 Beta #4=158.  M/C 11/1/14
December 2014: IVF #1.  Microdose Lupron protocol.  9R, 9M, 9F.  3 5-day blasts transferred 12/15. BFFN.
April 2015: IVF #2.  Microdose Lupron protocol.  16R, 15M, 12F. Transferred 2 5-day blasts 4/12 and froze 4--BFP!  M/C 5/25/15
August 2015: IVF #3.  14R, 13M, 11F.  Froze 5 blasts for CCS testing.  3 normals.  FET planned for 10/2015.



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Re: Elective freeze-all: thoughts?

  • You are not being ridiculous. Each and every blast is precious, and you just went through A LOT to create them. If you don't feel your body or mind is in optimal condition then you may want to wait until you feel you are giving the transfer its 100% best chance.

    With that said, you should wait to see what your doctor says BUT definitely listen to your gut in the end. 

    Also, your office should easily be able to freeze the embies and do a FET later, but of course talk with them.

    GL!

    Me: 35 DOR - AMH 1.1 FSH 5.6

    DH: 39

    09/01/10 - First pregnancy - my sweet son was born 

    04/25/14 - Miscarriage at 9 weeks - Turner Syndrome 

    08/01/14 - Miscarriage at 8 weeks - Trisomy 9 

    October 2014 - Unsuccessful IUI 

    November 2014 - IUI month skipped due to cyst 

    December 2014 - Unsuccessful IUI 

    January/February 2015 - Failed IVF (standard long protocol) - 7 eggs, 6 mature, 4 fertilized (ICSI), 0 made it to blast, 0 for testing 

    March/April 2015 - Microflare IVF protocol with HGH - 6 eggs, 6 mature, 5 fertilized (ICSI), 2 blasts for biopsy! 

    May/June 2015 - Microflare IVF protocol with HGH - 9 eggs, 6 mature, 5 fertilized (ICSI), 3 blasts for biopsy!

    06/18/15 -  Two healthy embies based on PGS testing by Natera!

    June/July 2015 - FET cycle with estradiol & PIO shots, a Neupogen treatment, and accupuncture

    07/08/2015 - Transferred one lovely embie 

    07/17/2015 - Beta #1 136

    07/20/2015 - Beta #2 529 -- BFP!!!

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  • If your lining isn't perfect and you do a fresh transfer and it fails, you will always wonder 'what if'.  I would freeze all just because of the lining issue.  Endometrial receptivity is a huge deal, and raised prog levels can make it impossible for implantation.  

    My doctor, after my m/c fresh transfer last cycle, will only do a FET after a freeze now in case the failure was in part due to receptivity issues caused by superovulation stimulation. 

    image

    June 19, 2010 - Miracle Baby Girl

    Round 2
    Since March 2013
    BFP April 2013 - Missed M/C July 2013 @ 12w6d
    BFP December 2013 - CP @ 4w3d
    Eight medicated cycles, three IUIs: FAIL
    IVF #1 Antagonist - January 2015: CP/FAIL

    IVF #2 April 2015: Microdose lupron Flare
    ICSI, CCS Freeze all
    6 blasts biopsied/5 normal

    FET #1 June 25, 2015 6AA and 5AA blast transfer
    BFP 3dp5dt!
    Beta 8dp5dt 195.2, 10dp5dt 474.8, 12dp5dt 977, 22dp5dt 25,580
    <3 Twins! Our boy and girl coming end of February!  <3

  • If your lining isn't perfect and you do a fresh transfer and it fails, you will always wonder 'what if'.  I would freeze all just because of the lining issue.  Endometrial receptivity is a huge deal, and raised prog levels can make it impossible for implantation.  

    This.  I think with the borderline lining I would go for a freeze all as well.  You just went through a lot of work to get those precious blasts.  I hope your doctor has some advice soon too.
    Me: 31     DH: 33
    Dx: Me: Recurrent Pregnancy Loss; DH: Low Morphology (2%)
    BFP#1: MC 3/1/11 at 6w1d - EDD 10/21/11
    BFP#2: 5/3/11 - EDD 1/9/12 - DD Born 1/6/12
    image
    TTC #2 since 12/13
    BFP#3: MC 2/8/14 at 4w5d - EDD 10/13/14
    BFP#4: MC 5/6/14 at 4w4d - EDD 1/9/15
    BFP#5: MMC discovered 8/4/14 at 9w1d - D&C 8/5/14 - Baby Boy with Trisomy 16 (maternal origin) - EDD 3/8/15
    BFP#6: CP 11/6/14 at 4w2d - EDD 7/14/15
    IVF #1 with ICSI & PGS: May/June 2015, ER 6/3/15, 17R/17M/15F
    IVF #2 with ICSI & PGS: July 2015, ER 7/16/15, 16R/11M/9F
    PGS results = 6 normal embryos (4 boys, 2 girls)
    FET 9/23/15 = BFFN
    Natural FET 11/4/15 = BFP!
    Beta 9dp5dt = 92

  • I just wanted to wish you good luck with whatever you choose. :)
    ~~ All Welcome~~
    ME: 32, SER aggregates on eggs, anovulatory
    DH:  33, 2% morphology
    TTC #1 
    2 clomid cycles, 3 hybrid clomid/bravelle IUI's = 4 BFN/1 CP@ 5.5 weeks
    IUI #6 -Follitism IUI cycle converted to IVF and back to IUI-4 mature, 3 maybe mature = BFP!!   DS Born 9/2014
    TTC#2 
    IVF #1 9/15 Antagonist- 19 R 1F (Frozen day 1 @ 2PN stage) Diagnosed with SER aggregates in 13/19 eggs after failed fertilization
    IVF #2 11/15 Antagonist w/ICSI  (Higher stims & Letrosole added last minute on stim day 7)- 39R, 24M (20/24 SER free), 15F (14/15 SER free & all frozen @ 2PN stage) 
    FET#1 Cultured all 16- 2pn embryos to day 5- transferred 1 good hatching blast and 1 early blast on 1/28- None to freeze - beta 2/5

  • I just wanted to wish you good luck with whatever you choose. :)

    Thanks!
    *****Signature/Ticker Warning******

    Me: 41, DH: 45
    DD, 6/15/2013
    TTC #2 beginning January 2014
    AMH 1.05; FSH range 7-11

    July 2014: IUI #1.  Follistim + Pregnyl.  2 follicles--BFN
    September 2014: IUI #2.  Follistim + Pregnyl + Ganirelix + Crinone.  4(?) follicles--BFN
    October 2014: IUI #3.  More Follistim + More Ganirelix + Pregnyl + Crinone.  4 follicles--BFP!  Beta #1=10 Beta #2=33 Beta #3=97 Beta #4=158.  M/C 11/1/14
    December 2014: IVF #1.  Microdose Lupron protocol.  9R, 9M, 9F.  3 5-day blasts transferred 12/15. BFFN.
    April 2015: IVF #2.  Microdose Lupron protocol.  16R, 15M, 12F. Transferred 2 5-day blasts 4/12 and froze 4--BFP!  M/C 5/25/15
    August 2015: IVF #3.  14R, 13M, 11F.  Froze 5 blasts for CCS testing.  3 normals.  FET planned for 10/2015.



    Baby Birthday Ticker Ticker

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    My Ovulation Chart


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  • GL @davie813!!! let us know how it goes!
    Me: 36, DH: 36
    DH's SA = normal
    1 tube only wonder
    AFC 3-5, AMH 0.30

    BFP #1 3/29/11.  EDD 12/4/11... Missed m/c 5/9/11. Cytotec fail. D&C 5/17/11.
    BFP #2   7/5/11.  EDD 3/14/12... Our rainbow Kellen born 3/14/12 via c/s.
    BFP #3 5/30/13.  EDD 2/8/14...  6wk u/s HB 126. 8wk u/s lost HB. D&C 7/12/13.
    BFP #4 2/18/14.  EDD 10/30/14... Ruptured ectopic with L tube removed & D&C 3/7/14.
    BFP #5 7/27/14.  EDD 4/9/15...  m/c @ 5w4d.

    IVF #1    Oct 2014 - antagonist protocol: 9R, 7M, 5F. 3dt of 3 Grade 2 embies. BFN. 
    IVF #2    Jan 2015 cancelled due to dominant follicle.  Converted to IUI #1. BFFN
    IVF #2.1 March 2015 cancelled due to dominant follicle.

    BFP #6  (SUPRISE!) 3/19/15.  EDD 11/30/15...  CP at 4w2d.
    IUI #2:    Clomid + Follistim = 3 follies. BFN.
    IVF #2.2 May 2015 - horrible response to micro lupron flare protocol: 3R, 3M, 3F. 3dt of 2 Grade 3 embies. BFFN. 

    BFP #7 (beyond surprised again!) 4/26/16. EDD 1/5/17. beautiful betas!!!! and then near-fatal hemorrhagic corpus luteum. turns out baby was ectopic after all; another lap 5/6 (@24dpo).

    the universe can fuck off.


     "You are overly paranoid and delusional that every one is out to get you." -lastsliverofhope

    Baby Birthday Ticker Ticker
    all AL welcome. TTC #2 for 43 44 months.
    follow my infertility journey here at timestandsstillblog.com

  • Good luck tomorrow with whatever you choose!!
    DS: Born November 2011
    TTC #2 since April '13
    DH 35, Me: 34
    DX: Unexplained Secondary Infertility, Slight DOR
    Sept 14 - IUI (Clomid + Ovidrel) = BFN
    Oct 14 - IUI (Clomid + Ovidrel + Progesterone) = BFN
    Nov 14- Benched due to cysts Looking for New Doc
    Feb - IUI #3 (Letrozole + Ovridrel)
    March/April - IVF #1 - Antagonist Protocol - Follistim+HGH+Low Dose HCG - 11R/9M/5F - 2 8 cell 3dtransfer - BFN on April 23, 2014


  • Good luck @Davie813 :)

    image

    June 19, 2010 - Miracle Baby Girl

    Round 2
    Since March 2013
    BFP April 2013 - Missed M/C July 2013 @ 12w6d
    BFP December 2013 - CP @ 4w3d
    Eight medicated cycles, three IUIs: FAIL
    IVF #1 Antagonist - January 2015: CP/FAIL

    IVF #2 April 2015: Microdose lupron Flare
    ICSI, CCS Freeze all
    6 blasts biopsied/5 normal

    FET #1 June 25, 2015 6AA and 5AA blast transfer
    BFP 3dp5dt!
    Beta 8dp5dt 195.2, 10dp5dt 474.8, 12dp5dt 977, 22dp5dt 25,580
    <3 Twins! Our boy and girl coming end of February!  <3

  • Great news @Davie813!



    imageimageimage
    image
    My FF Chart:
    http://www.fertilityfriend.com/home/490dd7
    TTC #3 since June 2013
    BFP #1 7/21/2013--EDD 3/30/14--D&C 9/24/13
    BFP #2 1/28/14--MC 2/7/14

    IUI #1 5mg Femara + trigger = BFN
    IUI #2 5mg Femara + trigger = BFN
    IUI #3 5mg Femara + trigger = BFN
    IVF #1, Stimmed for 12 days, ER 8/22/14, 9 retrieved, 7M, 7F!!  Freeze all due to fluid in uterus.
    FET end of October 2014 cancelled due to fluid in uterus due to possible c-scar defect
    Surgery scheduled 12/12/14 to fix possible isthmocele
    3/26/15 transferred one 8 cell grade 4 embryo and one 6 cell grade 3 embryo = slow rising betas for 2+ weeks = ectopic MTX shot 4/29/15
    Repeat c-scar surgery June 2015
    2nd and last IVF cycle August 2015, stimmed for 12 days, 2 egg retrieved, both mature and both fertilized.  Transferred both 8-cell embryos on Day 3, beta 9/5/15 = BFFN
    MOVING TO ADOPTION!  


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