Question for DOR ladies/poor responders... — The Bump
Success after IF

Question for DOR ladies/poor responders...

What do you think made the difference between your successful/unsuccessful (if you had any) IVF cycles?  I had my consult last week to starting thinking about jumping back on the IVF train for a sibling and I want to make sure we do everything possible to make this work the first time.  Any supplements, etc. that you think made a difference?  Protocol?  RE/Lab that made the difference?  Any experiences are greatly appreciated! 
~TTC#1 since 05/10~
Me (38), DH (43)
DX: MFI & DOR (FSH=9.9, 7.2, 11.6, 12.3; AMH=.19, .27, .007)
06/11 IUI#1 (clomid unmonitored)=BFN
09/11 IVF#1 (long lurpon) converted to IUI#2 due to poor response=BFN
11/11 IVF#1.2 (MDLF) 5R/5M/4F w/ICSI 3dt of 3=BFN
1/12 hysteroscopy to remove polyps
3/12 IVF #2 (MDLF) 7R/5M/5F w/ICSI 3dt of 3=BFP!!! Beta #1 (14dpo)=113, Beta #2 (16 dpo)=385, Beta #3 (23 dpo)=3267, Beta #4 (30 dpo)=15,494 
first u/s (6 wks, 3 days) reveals possible cervical pregnancy
confirmed cervical pregnancy with fetal HB (7 wks, 2 days)
5 days in the hospital to end pregnancy (8 wks, 3 days) and monitor bleeding + MTX injects
6/1/12 hCG finally at zero!!
6/21/12 hysteroscopy #2=all clear!
8/12 IVF#3 (EPP/MDLF) 4R/4F w/ICSI, 3dt of 4=chem pg
10/12 IVF#4 (MDLF) 10R/9M/7F w/ICSI, 5dt of 2, Beta#1 (14dpo)=193, Beta #2 (16dpo)=741, Beta #3 (19dpo)=3949, Beta #4 (5w5d)=35,000+, Beta #5 (6w5d)=91,000+
04/13 Hospital bed rest at 24wks due to severe cervical shortening and dilation
05/13 Home bed rest for remainder of pregnancy
06/26/13 Baby Boy "O" born via unplanned c-section (failure to progress ironically!) after my water broke 
ON HIS DUE DATE!!!!
Lilypie Breastfeeding tickers

Re: Question for DOR ladies/poor responders...

  • Oh, also, this is kind of a post and run, because I'm just between classes right now, but I'd really appreciate any experiences any one has to share and I'll try to check back later tonight!  Thanks ladies!!
    ~TTC#1 since 05/10~
    Me (38), DH (43)
    DX: MFI & DOR (FSH=9.9, 7.2, 11.6, 12.3; AMH=.19, .27, .007)
    06/11 IUI#1 (clomid unmonitored)=BFN
    09/11 IVF#1 (long lurpon) converted to IUI#2 due to poor response=BFN
    11/11 IVF#1.2 (MDLF) 5R/5M/4F w/ICSI 3dt of 3=BFN
    1/12 hysteroscopy to remove polyps
    3/12 IVF #2 (MDLF) 7R/5M/5F w/ICSI 3dt of 3=BFP!!! Beta #1 (14dpo)=113, Beta #2 (16 dpo)=385, Beta #3 (23 dpo)=3267, Beta #4 (30 dpo)=15,494 
    first u/s (6 wks, 3 days) reveals possible cervical pregnancy
    confirmed cervical pregnancy with fetal HB (7 wks, 2 days)
    5 days in the hospital to end pregnancy (8 wks, 3 days) and monitor bleeding + MTX injects
    6/1/12 hCG finally at zero!!
    6/21/12 hysteroscopy #2=all clear!
    8/12 IVF#3 (EPP/MDLF) 4R/4F w/ICSI, 3dt of 4=chem pg
    10/12 IVF#4 (MDLF) 10R/9M/7F w/ICSI, 5dt of 2, Beta#1 (14dpo)=193, Beta #2 (16dpo)=741, Beta #3 (19dpo)=3949, Beta #4 (5w5d)=35,000+, Beta #5 (6w5d)=91,000+
    04/13 Hospital bed rest at 24wks due to severe cervical shortening and dilation
    05/13 Home bed rest for remainder of pregnancy
    06/26/13 Baby Boy "O" born via unplanned c-section (failure to progress ironically!) after my water broke 
    ON HIS DUE DATE!!!!
    Lilypie Breastfeeding tickers
  • I had success with estrogen priming, CoQ10 for three months beforehand, and a high stim antagonist protocol with a mix of menopur and follistim, plus HCG on days 7,8,9. This was with a new RE with a better lab. Best of luck!

    Age: 35 TTC since 2005, MFI & DOR 

    IVF #1 Sep '11 - canceled poor response

     IVF #2 Nov '11  8R/8M/4F 3dt x2 - chemical

    IVF #3 April '12  11R/6M/4F 3dt x2 - m/c

    FET #1 Aug 2012  3dt x2 - BFN

    **new RE**

     IVF #4 Jan '13 BFN 11R/6M/6F 5dt x2 - BFN

     IVF #5 July '13 16R/10M/10F 5dt x2 + 1 frostie

    9dp5dt Beta 1 = 344!! 16dp5dt. Beta 2 = 4822 7wk u/s= 2 heartbeats!

    Twin girls! 3/6/14

     

    Jenfilly
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  • Have you had your FSH retested recently? Looking at your old numbers,it wasn't bad at all IMO. My info is in my siggy and I never responded well. But my FSH was mid 20s at age 38. Eventually I switched to DE after 4 OE IVF where we only got a total of 7 eggs from 4 ERs and bad quality for all of them. I did "best" on estrogen priming and low stim but never "good" enough. I'd get your labs retested and go from there.

    TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
    DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
    5 IUI's: 2/11 to 6/11 and 1/12= BFN
    OE IVF#1-4 8/11-6/12= all BFN
    DE IVF#1 11/12 bad embryos= BFN
    DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
    CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
    DE IVF #3 1/14  ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d

    DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
    First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!

    K & K born 11/21/14 at 38wks 4 days

    imageimage

    SAIF/PAIF Welcome


    http://waitingforraintostop.wordpress.com

  • Well in our case the difference that led to the bfp was DH having sperm. I have yet to have a successful Ivf cycle but I definitely responded a bit better with having taken DHEA and coq10 on round 2. I will be on a different protocol this round (not an antagonist one) and they are adding in growth hormone. Results are TBD. GL
  • Looks like CoQ10 is definitely something to try! Thanks ladies!!
    ~TTC#1 since 05/10~
    Me (38), DH (43)
    DX: MFI & DOR (FSH=9.9, 7.2, 11.6, 12.3; AMH=.19, .27, .007)
    06/11 IUI#1 (clomid unmonitored)=BFN
    09/11 IVF#1 (long lurpon) converted to IUI#2 due to poor response=BFN
    11/11 IVF#1.2 (MDLF) 5R/5M/4F w/ICSI 3dt of 3=BFN
    1/12 hysteroscopy to remove polyps
    3/12 IVF #2 (MDLF) 7R/5M/5F w/ICSI 3dt of 3=BFP!!! Beta #1 (14dpo)=113, Beta #2 (16 dpo)=385, Beta #3 (23 dpo)=3267, Beta #4 (30 dpo)=15,494 
    first u/s (6 wks, 3 days) reveals possible cervical pregnancy
    confirmed cervical pregnancy with fetal HB (7 wks, 2 days)
    5 days in the hospital to end pregnancy (8 wks, 3 days) and monitor bleeding + MTX injects
    6/1/12 hCG finally at zero!!
    6/21/12 hysteroscopy #2=all clear!
    8/12 IVF#3 (EPP/MDLF) 4R/4F w/ICSI, 3dt of 4=chem pg
    10/12 IVF#4 (MDLF) 10R/9M/7F w/ICSI, 5dt of 2, Beta#1 (14dpo)=193, Beta #2 (16dpo)=741, Beta #3 (19dpo)=3949, Beta #4 (5w5d)=35,000+, Beta #5 (6w5d)=91,000+
    04/13 Hospital bed rest at 24wks due to severe cervical shortening and dilation
    05/13 Home bed rest for remainder of pregnancy
    06/26/13 Baby Boy "O" born via unplanned c-section (failure to progress ironically!) after my water broke 
    ON HIS DUE DATE!!!!
    Lilypie Breastfeeding tickers
  • I had success with long lupron which is not commonly used for DOR. I tried several other protocols with poor results and begged to try something out of the box. It took some tweaking but it eventually worked. I used only lupron for suppression, no bcps. I did high amounts of gonal (550) and tapered it down throughout the cycle. I added in menopur after day 3 (1/2 vial). I also was on CoQ10 (300 mg twice daily) for a long time (a year +) before I cycled. BOL to you!

    Me & DH (33), 3 Furbabies, TTC since October 2011
    Day 3 #’s (Dec 2012) FSH 9, AMH .77, LH 2.4, E2 31, AFC 9 

    DX: Me-DOR + No Tubes, DH-Fine

    Ectopic 2007; lost tube/2nd tube removed Dec 2011 (hydro)

    April 2012=IVF#1- EPP Antag+ICSI, 2R,0F (BFN), Now dx’d with DOR.

    June-July 2012=IVF#2- MDL+ICSI&AH, 8R,4M,3F (BFP 9dp3dt) Beta#1 at 11dp3dt=36, Beta#2 at 15dp3dt=156, Beta#3 at 19dp3dt=671, dx'd with SCH, no growth-m/c at 7wks/Lap Dec 2012 to remove small fibroid.

    Feb 2013=IVF#3-MDL, 2/1=baseline, started 10 units mdl, AFC-7, 2/3 start gonal f, self cxld cycle b/c of low e2.

    April 2013=IVF#3.5-(with new RE)AG/ANT Conv + ICSI. 4/10-4/23 bcp's, 4/20-4/27 lupron, 4/28-ganirelix until end of stimming, 5/2-600 gonal f, 5/4-add 1/2 vial menopur, 5/13-ER (9R,1M,1F), 5/17-ET, 1 beautiful 8 cell (please be my sticky baby!!!!) 5/28-BFFN.

    Oct 2013=IVF#4-LLP+ICSI &AH, 10/14 (6R, 2M, 2F), 10/17-ET, 1 seven cell & a six cell, BFP at 9dp3dt, 1st beta=56, 2nd beta=52, CP.

    Jan 2014=IVF #5-LLP, Cxld after 6 days of stims due to fast response and lead follicle. 

    March 2014=IVF 5.5-LLP, Lupron 3/10, BL 3/18, 11 days of stims, Trigger 3/29, ER 3/31. 7R, 2M, 2F. ET 4/3. Txfd one 5 cell & one 9 cell. BFP on hpt from 7dp3dt & on. Praise be to God. Beta #1 at 11dp3dt=106, #2 at 13dp3dt=239. First u/s 4/28, measuring on track & heartbeat seen. 5/5-2nd u/s, measuring on track with strong heartbeat. 5/12- 3rd u/s & released from RE. Grow baby grow, we love you! Baby G&T is a BOY! Born 12/2014 via c/s! 8lbs, 8oz & 21 inches.


     *******Ticker Warning**********

     


    Lilypie First Birthday tickers

     


    "God's Delay is not God's Denial"
  • Thanks again girls!  

    @chiwifey, do you know what the dosage on the Acai supplement was?  I've not heard of that until now, but seems worth adding to my repertoire of supplements if it might help...

    @Mrs.McIrish, the last lab numbers in my siggy are from October 2014, so the FSH has gone up, but not appreciably for someone who's 38.  We think the AMH is a lab/nurse error, since most labs can't/don't report numbers that low for AMH...
    ~TTC#1 since 05/10~
    Me (38), DH (43)
    DX: MFI & DOR (FSH=9.9, 7.2, 11.6, 12.3; AMH=.19, .27, .007)
    06/11 IUI#1 (clomid unmonitored)=BFN
    09/11 IVF#1 (long lurpon) converted to IUI#2 due to poor response=BFN
    11/11 IVF#1.2 (MDLF) 5R/5M/4F w/ICSI 3dt of 3=BFN
    1/12 hysteroscopy to remove polyps
    3/12 IVF #2 (MDLF) 7R/5M/5F w/ICSI 3dt of 3=BFP!!! Beta #1 (14dpo)=113, Beta #2 (16 dpo)=385, Beta #3 (23 dpo)=3267, Beta #4 (30 dpo)=15,494 
    first u/s (6 wks, 3 days) reveals possible cervical pregnancy
    confirmed cervical pregnancy with fetal HB (7 wks, 2 days)
    5 days in the hospital to end pregnancy (8 wks, 3 days) and monitor bleeding + MTX injects
    6/1/12 hCG finally at zero!!
    6/21/12 hysteroscopy #2=all clear!
    8/12 IVF#3 (EPP/MDLF) 4R/4F w/ICSI, 3dt of 4=chem pg
    10/12 IVF#4 (MDLF) 10R/9M/7F w/ICSI, 5dt of 2, Beta#1 (14dpo)=193, Beta #2 (16dpo)=741, Beta #3 (19dpo)=3949, Beta #4 (5w5d)=35,000+, Beta #5 (6w5d)=91,000+
    04/13 Hospital bed rest at 24wks due to severe cervical shortening and dilation
    05/13 Home bed rest for remainder of pregnancy
    06/26/13 Baby Boy "O" born via unplanned c-section (failure to progress ironically!) after my water broke 
    ON HIS DUE DATE!!!!
    Lilypie Breastfeeding tickers
  • My only successful cycle was a long lupron cycle with HGH and immune protocol.  My worst cycles were antagonist with EPP and MDLF.

    As far as numbers, my best cycle would be my last cycle (IVF #6).  We did a luteal phase ganirelix protocol.  I started half doses of ganirelix a few days after I ovulated in one cycle and had a basline to check lining and ovaries before starting stims several weeks later (and at least a week or two after my last bleed).  I then started on high dose stims for two days and then lowered after that.  I added half doses of menopur starting a few days into stims.  I also did HGH and immune protocol.  I had 10 mature eggs retrieved and 8 fertilized.  I transferred to perfect day 3 embryos and got a BFP.  I had one blast make it to their freezing criteria (although all 6 of the remaining embryos made it to day 5).  I hope to transfer the frozen blast as soon as possible but I have problems with my clinics batching requirement as I tend to get cysts (and apparently ovulate) through BCPs and Lupron.

    Good luck!  I did ubiquinol and PQQ before my last cycle.  I intended to do DHEA but it caused my testosterone levels to sky rocket!

    image image


    ~SAIF/PAIF/Everyone Welcome~ 

    Me= 37 and DH = 41 

    Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)

    IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN

    IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.

    IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132.  Lil is here!

    TTC#2:  Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.

    IVF #4:  BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN

    IVF #5:  MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN

    IVF #6:  (New RE):  Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN

    FET#1:  BFN

  • My 2 successful cycles were two different protocols, but both we added in ICSI.  With DD I was on an EPP protocol and this cycle I was on the MDLF.  In previous cycles, I responded best with the EPP.  Dr. wanted to try the MDLF again with ICSI and it worked.  I also took CoQ10(300mg 2x a day) for 3 months before cycling.

    Good luck!
    Me 35, DH 36
    TTC summer 2008
    Diagnose me. DOR, DH perfect
    IUI # 1 6/2010, BFN
    IUI # 2 8/2010, BFN
    IVF # 1 10/2010 Canceled poor response
    IVF 1.2 12/2010 BFP! mc 6 weeks 2 days
    Mental health break for 10 months
    IVF # 2 10/2011 BFN
    IVF # 3 5/2012 BFP! 10 eggs retrieved (best ever)
    7 fertilized transferred 3
    Beta #1 14dpo - 72, Beta #2 17dpo 145 Beta 3 20dpo 521
    First u/s June 15 saw HB 126 bpm missed m/c 7/5/12 10 weeks D&C 7/6/12
    IVF#4 ER 9/30 ET 10/3 Beta 10/16 BFFN. IVF #5 final with o/e. ER 1/21 only 1 retrieved, hoping my lonestar is the one. Beta #1 2/6/13 = 209.... please let this be it! Keep growing lonestar! Beta #2 2/8/13 - 586! , Beta #3 2/10/13 = 1898. First u/s perfect little heart beat at 116 bpm. Measure 6 weeks 1 day. EDD 10/14/13
    3/4/13 measuring right on track beautiful heartbeat 171 bpm, graduated from RE to OB... bittersweet.
    PAIF/SAIF always welcome! Its a girl! 

    Maggie Grace is here!  10/5/13... 8lbs 6 ounces of pure joy!

    TTC#2  No birth control since DD was born.  Getting ready to jump back in the saddle.  Weaning this month. RE
    appt scheduled 5/8.   Here we go again!

    IFV# 6.  10/27  6 retrieved 4 mature 3 fertilized.  2 made it to 3dt 10/30. 1"very pretty 8 cell" and 1 6 cell.  Beta
    11/13.   Please stick embies!!!!  We love you so much already! 11/12/14  POAS, BFP... beta tomorrow!
    11/13 beta #1  924!!!  2nd bet 11/15 1906, one more on 11/17 3rd & final beta 3430.  First u/s 12/5, 7w4d, 2 heartbeats,
    both measuring right on track....2nd u/s... all is well... both beans measuring right on track... released from RE... first
    appointment with MFM 1/5.  Looks like this is really happening!





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