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Fifth Cycle of Femara (loss mentioned)

cln125cln125 member
edited December 2014 in Trouble TTC

Hello,

I just turned 37 and have been TTC for 3 years.  I am diagnosed with PCOS and did not respond to clomid.  I've had great response to femara minus this cycle.  The first cycle on femara I think I may have had an early miscarriage.  And I ovulated the next three cycles but ended in BFNs.  This cycle (#5) I did not ovulate.  Anyone else have this experience?  I'm asking because we were thinking of doing a final round of femara and then we are going to move to IVF.  Now I'm wondering if we should even bother with the 6th round.  Thanks for any help!



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Re: Fifth Cycle of Femara (loss mentioned)

  • blsav23blsav23 member
    Hi there!! Sorry you find yourself here. I am currently on my fourth IUI, third on femara. The first round ended in a chemical pregnancy. I didn't respond great the second time. This time (with a new RE), I didn't respond great at my first follicle check so he put me on the "stair step" protocol. So...I took femara 5mg CD 3-7 then femara 7.5mg CD 9-13. I go tomorrow to see if I have nature follicles. Perhaps this protocol could be beneficial for you? My RE said PCOSers can develop resistance to meds like femara & stair stepping gives the follies a little nudge. He even said it produces better pregnancies. I will let you know tomorrow how I responded!
    DH & I married 12/17/2012
    Me (31)-dx w/PCOS 2007, when married to ex-husband after MC
    DH (41)-no MFI
    07/2014-Femara 5mg + trigger + IUI= chem preg ;(
    08/2014-Femara 5mg + trigger + IUI + 2nd trigger= BFN
    09/2014-Clomid 100mg + trigger + IUI + 2nd trigger= BFN
    10/2014-benched due to RE out of town, tying naturally!
    11/2014-benched due to cyst
    12/2014-Femara 5mg + stair step with additional 5 days Femara 5mg + trigger + IUI=BFN
    01/2015-Femara 5mg + Gonal F 25 units + trigger (plus additional Gonal F 100 units on trigger night) + IUI= BFP!!! Twins due 10/2015
    09/28/2015- Surprise!  Conrad and Hudson born at 35w6d!  
    Report Reply
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  • cln125cln125 member
    Thanks for your response.  After 3 years I feel as if I should be an expert in all things dealing with infertility, but I feel just as clueless sometime.  We were so happy to have such a great response on femara after such a long journey with clomid and it not really working.  So it was a huge let down this month when I didn't respond.  We have done 5 rounds of femara with IUI on the 3rd and 4th.  I'm hoping you have good news tomorrow!  I'll keep my fingers crossed!
    Report Reply
  • blsav23blsav23 member
    Well...I went in for my monitoring u/s this AM after my stair step protocol. I have 2 lead follicles on my R ovary, currently measuring 14mm each. I have to go back Monday to ensure they've matured more & will likely be ready to trigger around then. So---the protocol did work but damn, it seems like my body is taking forever!
    Also--I'm not trying to hijack your board but just wanted you to know it seems like the stair step protocol was effective (albeit, slow) for me. It sounds as if our situations are similar so perhaps it's worth looking into??
    DH & I married 12/17/2012
    Me (31)-dx w/PCOS 2007, when married to ex-husband after MC
    DH (41)-no MFI
    07/2014-Femara 5mg + trigger + IUI= chem preg ;(
    08/2014-Femara 5mg + trigger + IUI + 2nd trigger= BFN
    09/2014-Clomid 100mg + trigger + IUI + 2nd trigger= BFN
    10/2014-benched due to RE out of town, tying naturally!
    11/2014-benched due to cyst
    12/2014-Femara 5mg + stair step with additional 5 days Femara 5mg + trigger + IUI=BFN
    01/2015-Femara 5mg + Gonal F 25 units + trigger (plus additional Gonal F 100 units on trigger night) + IUI= BFP!!! Twins due 10/2015
    09/28/2015- Surprise!  Conrad and Hudson born at 35w6d!  
    Report Reply
  • blsav23blsav23 member
    cln125 said:

    Thanks for your response.  After 3 years I feel as if I should be an expert in all things dealing with infertility, but I feel just as clueless sometime.  We were so happy to have such a great response on femara after such a long journey with clomid and it not really working.  So it was a huge let down this month when I didn't respond.  We have done 5 rounds of femara with IUI on the 3rd and 4th.  I'm hoping you have good news tomorrow!  I'll keep my fingers crossed!

    Sorry-I should've quoted you on my response. Please see my post below
    DH & I married 12/17/2012
    Me (31)-dx w/PCOS 2007, when married to ex-husband after MC
    DH (41)-no MFI
    07/2014-Femara 5mg + trigger + IUI= chem preg ;(
    08/2014-Femara 5mg + trigger + IUI + 2nd trigger= BFN
    09/2014-Clomid 100mg + trigger + IUI + 2nd trigger= BFN
    10/2014-benched due to RE out of town, tying naturally!
    11/2014-benched due to cyst
    12/2014-Femara 5mg + stair step with additional 5 days Femara 5mg + trigger + IUI=BFN
    01/2015-Femara 5mg + Gonal F 25 units + trigger (plus additional Gonal F 100 units on trigger night) + IUI= BFP!!! Twins due 10/2015
    09/28/2015- Surprise!  Conrad and Hudson born at 35w6d!  
    Report Reply
  • blsav23blsav23 member
    blsav23 said:

    cln125 said:

    Thanks for your response.  After 3 years I feel as if I should be an expert in all things dealing with infertility, but I feel just as clueless sometime.  We were so happy to have such a great response on femara after such a long journey with clomid and it not really working.  So it was a huge let down this month when I didn't respond.  We have done 5 rounds of femara with IUI on the 3rd and 4th.  I'm hoping you have good news tomorrow!  I'll keep my fingers crossed!

    Sorry-I should've quoted you on my response. Please see my post below
    Damn it!! Sorry---see my post above
    DH & I married 12/17/2012
    Me (31)-dx w/PCOS 2007, when married to ex-husband after MC
    DH (41)-no MFI
    07/2014-Femara 5mg + trigger + IUI= chem preg ;(
    08/2014-Femara 5mg + trigger + IUI + 2nd trigger= BFN
    09/2014-Clomid 100mg + trigger + IUI + 2nd trigger= BFN
    10/2014-benched due to RE out of town, tying naturally!
    11/2014-benched due to cyst
    12/2014-Femara 5mg + stair step with additional 5 days Femara 5mg + trigger + IUI=BFN
    01/2015-Femara 5mg + Gonal F 25 units + trigger (plus additional Gonal F 100 units on trigger night) + IUI= BFP!!! Twins due 10/2015
    09/28/2015- Surprise!  Conrad and Hudson born at 35w6d!  
    Report Reply
  • cln125cln125 member
    blsav23 said:
    Well...I went in for my monitoring u/s this AM after my stair step protocol. I have 2 lead follicles on my R ovary, currently measuring 14mm each. I have to go back Monday to ensure they've matured more & will likely be ready to trigger around then. So---the protocol did work but damn, it seems like my body is taking forever! Also--I'm not trying to hijack your board but just wanted you to know it seems like the stair step protocol was effective (albeit, slow) for me. It sounds as if our situations are similar so perhaps it's worth looking into??
    Awesome news! Fingers crossed for you this month!
    Report Reply
  • blsav23blsav23 member
    cln125 said:


    blsav23 said:

    Well...I went in for my monitoring u/s this AM after my stair step protocol. I have 2 lead follicles on my R ovary, currently measuring 14mm each. I have to go back Monday to ensure they've matured more & will likely be ready to trigger around then. So---the protocol did work but damn, it seems like my body is taking forever!
    Also--I'm not trying to hijack your board but just wanted you to know it seems like the stair step protocol was effective (albeit, slow) for me. It sounds as if our situations are similar so perhaps it's worth looking into??

    Awesome news! Fingers crossed for you this month!
    Aw! Thanks so much!!

    DH & I married 12/17/2012
    Me (31)-dx w/PCOS 2007, when married to ex-husband after MC
    DH (41)-no MFI
    07/2014-Femara 5mg + trigger + IUI= chem preg ;(
    08/2014-Femara 5mg + trigger + IUI + 2nd trigger= BFN
    09/2014-Clomid 100mg + trigger + IUI + 2nd trigger= BFN
    10/2014-benched due to RE out of town, tying naturally!
    11/2014-benched due to cyst
    12/2014-Femara 5mg + stair step with additional 5 days Femara 5mg + trigger + IUI=BFN
    01/2015-Femara 5mg + Gonal F 25 units + trigger (plus additional Gonal F 100 units on trigger night) + IUI= BFP!!! Twins due 10/2015
    09/28/2015- Surprise!  Conrad and Hudson born at 35w6d!  
    Report Reply
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