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multiple trigger shots?

xraymommy2007xraymommy2007 member
in Secondary IF
Had a follicle scan yesterday and scheduled the IUI for Wednesday morning. They had me trigger w 10,000 yesterday afternoon, and I am to trigger four more times 2,500mg every other day starting Wednesday after the IUI. They are hoping that the shots will help lengthen my LP since the clomid and progesterone aren't doing it on their own.
Have any of you ever heard of doing multiple shots?

Sorry Im still kinda new to all the different RE methods

Me(27)+ DH(30) Married since Sept.2007
BFP #1 DD born 6/1/2009 (no complications)
TTC #2 March 2011
BFP# 2 after 4 rounds of clomid (blighted ovum)12/11
BFP# 3 w help of clomid 2/12 DS born 10/24/2012

TTC#3

 Stopped preventing when DS was 6 months old (4/13), really started TTC 10/13
Started clomid July 2014, 3 failed rounds of clomid w OB (low pro on CD 21) sent to RE

HSG and blood work all good
round 1: clomid and trigger shot~BFN
round 2: clomid, trigger and IUI~BFN
round 3: clomid, trigger and IUI +4 booster HCG~NOPE

On a break!!! Til April/May 

round 4:clomid, trigger (missed IUI window) NO fricking way BFP


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Re: multiple trigger shots?

  • Davie813Davie813 member
    I have heard of protocols that include additional HCG after the trigger, but I don't know much about them.  Very helpful, I know. :)
    *****Signature/Ticker Warning******

    Me: 41, DH: 45
    DD, 6/15/2013
    TTC #2 beginning January 2014
    AMH 1.05; FSH range 7-11

    July 2014: IUI #1.  Follistim + Pregnyl.  2 follicles--BFN
    September 2014: IUI #2.  Follistim + Pregnyl + Ganirelix + Crinone.  4(?) follicles--BFN
    October 2014: IUI #3.  More Follistim + More Ganirelix + Pregnyl + Crinone.  4 follicles--BFP!  Beta #1=10 Beta #2=33 Beta #3=97 Beta #4=158.  M/C 11/1/14
    December 2014: IVF #1.  Microdose Lupron protocol.  9R, 9M, 9F.  3 5-day blasts transferred 12/15. BFFN.
    April 2015: IVF #2.  Microdose Lupron protocol.  16R, 15M, 12F. Transferred 2 5-day blasts 4/12 and froze 4--BFP!  M/C 5/25/15
    August 2015: IVF #3.  14R, 13M, 11F.  Froze 5 blasts for CCS testing.  3 normals.  FET planned for 10/2015.



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  • xraymommy2007xraymommy2007 member
    at least you've heard of it :-)

    Me(27)+ DH(30) Married since Sept.2007
    BFP #1 DD born 6/1/2009 (no complications)
    TTC #2 March 2011
    BFP# 2 after 4 rounds of clomid (blighted ovum)12/11
    BFP# 3 w help of clomid 2/12 DS born 10/24/2012

    TTC#3

     Stopped preventing when DS was 6 months old (4/13), really started TTC 10/13
    Started clomid July 2014, 3 failed rounds of clomid w OB (low pro on CD 21) sent to RE

    HSG and blood work all good
    round 1: clomid and trigger shot~BFN
    round 2: clomid, trigger and IUI~BFN
    round 3: clomid, trigger and IUI +4 booster HCG~NOPE

    On a break!!! Til April/May 

    round 4:clomid, trigger (missed IUI window) NO fricking way BFP


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  • pettycrockerpettycrocker member
    Yea, I thought this was more common with IVF cycles, but I've only ever done 1 trigger per cycle. I don't think there is any harm in it, just a little bit of a boost. Good luck. 


    Spontaneous pregnancy #1
    DD1 July 31, 2011

    Trying for #2 since Oct 11
    732973 Clomid Cycles
    2 IUIs 
    3 Fresh IVFs= 1 Ectopic treated with MTX
    Spontaneous pregnancy #2= Ectopic #2= lost left tube
    Spontaneous pregnancy #3= DD2 January 29, 2016
    Spontaneous pregnancy #4= Ectopic #3
    Spontaneous pregnancy #5= Baby #3 is a BOY!!! 



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  • Jodee37Jodee37 member
    I've never heard of that but glad other people have!
    Me: 36, DH: 36
    DH's SA = normal
    1 tube only wonder
    AFC 3-5, AMH 0.30

    BFP #1 3/29/11.  EDD 12/4/11... Missed m/c 5/9/11. Cytotec fail. D&C 5/17/11.
    BFP #2   7/5/11.  EDD 3/14/12... Our rainbow Kellen born 3/14/12 via c/s.
    BFP #3 5/30/13.  EDD 2/8/14...  6wk u/s HB 126. 8wk u/s lost HB. D&C 7/12/13.
    BFP #4 2/18/14.  EDD 10/30/14... Ruptured ectopic with L tube removed & D&C 3/7/14.
    BFP #5 7/27/14.  EDD 4/9/15...  m/c @ 5w4d.

    IVF #1    Oct 2014 - antagonist protocol: 9R, 7M, 5F. 3dt of 3 Grade 2 embies. BFN. 
    IVF #2    Jan 2015 cancelled due to dominant follicle.  Converted to IUI #1. BFFN
    IVF #2.1 March 2015 cancelled due to dominant follicle.

    BFP #6  (SUPRISE!) 3/19/15.  EDD 11/30/15...  CP at 4w2d.
    IUI #2:    Clomid + Follistim = 3 follies. BFN.
    IVF #2.2 May 2015 - horrible response to micro lupron flare protocol: 3R, 3M, 3F. 3dt of 2 Grade 3 embies. BFFN. 

    BFP #7 (beyond surprised again!) 4/26/16. EDD 1/5/17. beautiful betas!!!! and then near-fatal hemorrhagic corpus luteum. turns out baby was ectopic after all; another lap 5/6 (@24dpo).

    the universe can fuck off.


     "You are overly paranoid and delusional that every one is out to get you." -lastsliverofhope

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  • fuzzbumblefuzzbumble member
    It makes sense, because hCG being produced triggers the corpus luteum to increase progesterone production.  If it detects hCG, it will think you're pregnant and produce higher levels of progesterone to lengthen the LP.  Makes sense on paper, but like any of this infertility shit it might work differently for whatever the hell reason.  

    Good luck!  I have heard of it being done before, and succeeding.  :) 

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    June 19, 2010 - Miracle Baby Girl

    Round 2
    Since March 2013
    BFP April 2013 - Missed M/C July 2013 @ 12w6d
    BFP December 2013 - CP @ 4w3d
    Eight medicated cycles, three IUIs: FAIL
    IVF #1 Antagonist - January 2015: CP/FAIL

    IVF #2 April 2015: Microdose lupron Flare
    ICSI, CCS Freeze all
    6 blasts biopsied/5 normal

    FET #1 June 25, 2015 6AA and 5AA blast transfer
    BFP 3dp5dt!
    Beta 8dp5dt 195.2, 10dp5dt 474.8, 12dp5dt 977, 22dp5dt 25,580
    <3 Twins! Our boy and girl coming end of February!  <3

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  • xraymommy2007xraymommy2007 member
    Thank you all for your input and fuzzbumble that does make perfect sense

    Me(27)+ DH(30) Married since Sept.2007
    BFP #1 DD born 6/1/2009 (no complications)
    TTC #2 March 2011
    BFP# 2 after 4 rounds of clomid (blighted ovum)12/11
    BFP# 3 w help of clomid 2/12 DS born 10/24/2012

    TTC#3

     Stopped preventing when DS was 6 months old (4/13), really started TTC 10/13
    Started clomid July 2014, 3 failed rounds of clomid w OB (low pro on CD 21) sent to RE

    HSG and blood work all good
    round 1: clomid and trigger shot~BFN
    round 2: clomid, trigger and IUI~BFN
    round 3: clomid, trigger and IUI +4 booster HCG~NOPE

    On a break!!! Til April/May 

    round 4:clomid, trigger (missed IUI window) NO fricking way BFP


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  • annibesannibes member
    fuzzbumble said:

    It makes sense, because hCG being produced triggers the corpus luteum to increase progesterone production.  If it detects hCG, it will think you're pregnant and produce higher levels of progesterone to lengthen the LP.  Makes sense on paper, but like any of this infertility shit it might work differently for whatever the hell reason.  


    Good luck!  I have heard of it being done before, and succeeding.  :) 
    So wise. I always learn something from you!
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  • pdxvegpdxveg member
    A remember reading a summary of a study looking at if HCG administered after O increased pregnancy success rates. 
    Me: 34 DH: 36 
    DD#1 04/28/11

    TTC#2 since April 2012 - Unexplained Secondary IF (probably PCOS)
    Dec 13-March 14 Femara and TI - BFN
    April 2014 IUI#1 (Femara + Ovidrel) - BFN
    June 2014 IUI#2 (Femara + Ovidrel) - BFP 7/9/14 - No HB on 8/13/14 @ 8w4d
    Nov 2014 IUI#3 (Femara + Ovidrel) - BFFN
    Jan 2015 IUI#4 (Femara + Ovidrel) - BFN
    Feb 2015 IUI#5 Converted to TI (7.5mg Femara) - BFP 3/17/15!!!
    Beta #1 82, Beta #2 202 Please let this be it.
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  • sailorgalsailorgal member
    I have heard of it but heard it referred to under a different name, maybe booster vs multiple trigger. Maybe try googling that? Good luck!
    Me: 32, DH: 33
    DS #1: April 2010
    DS #2: July 2015 (preemie born at 31 weeks) - our little miracle conceived through ART - unexplained secondary infertility/adenomyosis
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  • STL34STL34 member
    Yes, like sailorgal said, it is typically called HCG boosters since the additional HCG is not to trigger ovulation.  fuzzbumble gave a very good explanation for it.  I will say that it can really play with your head, though.  You cannot test in the same manner you would typically test because you are injecting additional HCG into your blood after the trigger and will consequently show it in blood tests and with HPTs longer.  

    Good luck!  I hope this is the trick you need!

    imageimage


    ~SAIF/PAIF/Everyone Welcome~ 

    Me= 37 and DH = 41 

    Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)

    IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN

    IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.

    IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132.  Lil is here!

    TTC#2:  Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.

    IVF #4:  BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN

    IVF #5:  MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN

    IVF #6:  (New RE):  Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN

    FET#1:  BFN

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