How Do You Feel About PGS?

KateBee · December 2014

Talk to me about the pros/cons of PGS. Our first son was born via gestational carrier in May. We did not do any genetic screening. This will be our last child, and the doctor mentioned doing PGS only because of the fear something could go wrong during the pregnancy that we could have prevented. How do you feel about PGS? Is it necessary? I'm 31 and my husband is 34.

lincoln79 · December 2014

I think it could depend on if you are using frozen or fresh embryos and how many you get.

RunCC37 · December 2014

We did CCS screening with our embryo that we transferred back in April, mostly because we were asked to be in a study. It was very reassuring to know that we were transferring a chromosomally normal blastocyst, though the outcome of the cycle was negative.

vibeee · December 2014

I had 7 losses so I may have different view on things than other people here. I just did my first donor egg cycle. She was only 24. We ended up with only 2 day 5 blastocysts and tested them overnight for day 6 transfer. They both came back euploid - chromosomally normal. The risk of early MC is lowered I believe by 15%. The piece of mind that I had a fair chance with every transfer is priceless. I am also 37 and been in a position when I wasted 3-6 months after MC's for recovery time. If you can afford it I would totally do it. If you are in the sated and on the east coast ask you clinic if they could use IVIGEN. They are fairly inexpensive and you don't have to do a frozen cycle with them.

jbasore1123 · January 2015

I agree with @vibeee. I have a chromosomal issue that affects egg quality. During my first IVF cycle, we had 2 embryos that were graded perfectly, however after PGS testing it showed that they were chromosomally abnormal. Had I transferred them, I would have either ended up with m/c's, stillbirths, or children that would have died shortly after birth. The grading of embryos isn't always a great indicator of how healthy they actually are.

AmCheri · January 2015

I think it depends on the circumstances. For our situation, we saw no reason to use it. We had a young donor and no known sperm issues. Once I got pregnant, we also declined all genetic screening. On the other hand, my dear friend had a long history of losses. She could not stay pregnant and ultimately found out that her husband has a rare chromosomal translocation. So for them, it made sense. If they continued to transfer embryos without testing first their chances of repeat losses were so high as to almost be a certainty.

AmCheri · January 2015

And just to add what I would think is super obvious, gender selection is never a reason for embryo testing. That is profoundly unethical and my clinic refuses to do it.

mm29 · January 2015

We did PGD when we cycled with DE and my DH's sperm, because he carries a balanced translocation. 4 were tested, we only had 1 normal. Had we transferred the that were chromosomally abnormal it would have likely ended in m/c, or like jbasore1123 mentioned, stillbirths, or children that would have died shortly after birth.

I personally would not do it solely for gender selection.

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