Community› The Bump Message Boards› Pregnant after IF
Pregnant after IF
New Discussion

*lurker* If you were given cabergoline...

tweetyknickstweetyknicks member
edited October 2014 in Pregnant after IF
My RE is concerned that I may develop OHSS since I had 41 eggs retrieved yesterday and my E2 level the morning of trigger day was nearly 4300. He's giving me cabergoline to reduce the likelihood of OHSS. As I understand it, cabergoline suppresses ovarian function.

My question is, what progesterone and estrogen supplements did your doc give you?

I have PIO 2cc, oral estrace, and crinone 8% in my Rx order. PIO and crinone seem like they're doing the same thing, especially since the dose of PIO seems to be pretty high.

ETA: Too many meds start with E.


***siggy warning***

Me: 29; DH: 53
TTC since February 2013 --- mild thin PCOS (or not, depending on which RE you ask), MFI

TI#1: BFN (April 2014; Clomid 50mg x5 days, Estrace x5 days, Clomid 50 mg x4 days)
IUI#1: c/p (May 2014; Letrozole 2.5 mg x5 days, Estrace x5 days, Bravelle 75 IU x10 days)
IUI#2: abandoned... O'd early & DH hormone issues (June 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x2 days)
IUI#2.1: BFN (July 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x4 days)

Moving on to IVF. (Why we're moving on to IVF)

IVF#1 (w/ICSI): BCP 9/9-9/23. Gonal-F, Ganirelix, Low-dose HCG (antagonist protocol). 41R/35M/32F... 2 transferred on 10/14, 14 frosties! On cabergoline to help avoid OHSS. BFN, possibly because of 90% drop in estrogen and progesterone a few days after ET.
FET#1: Transferring 2 on January 8. BFP! beta#1 (1/17): 408, beta#2 (1/20): 1310, first u/s scheduled 2/5

 image 
 image    image
Report Reply to Post

Re: *lurker* If you were given cabergoline...

  • yvonne0001yvonne0001 member
    I was given cabergoline as well because of a risk of OHSS. I had a mild case. My levels were super high too. I was/am on crinone 8% and estrace 2mg. Both vaginally. I ended up ok. Some bloating and ovaries are still a bit large but I am almost 8 weeks now and all is going well.

    If you are concerned, ask them. I asked a lot because of my concerns and I also trusted that they knew qhat they are doing - that took a while though haha.

    Good luck! And congrats on a good reterival. Hope your recovery is fast and easy.
    Report Reply
  • Loading the player...
  • southernyankeegirlsouthernyankeegirl member
    I know lots of IVF patients that do both crinone and PIO, so it's not atypical to do both. The PIO will show up in blood work but the crinone will not, I believe.

    My SIL took that drug due to severe OHSS after they retrieved >40 eggs - she ended up hospitalized with over 10 lbs of fluid in her belly so they pulled out all the stops to calm it, but was able to maintain her pregnancy and carry to term. That's about all I know!
    ************************SIGGY WARNING***********************

    Me: 29      DH:  32
    Off birth control March 2012 - Actively trying Sept 2012-April 2014
    Unexplained Infertility
    BFP on May 5th after Follistim & IUI #3
    Ryan Henry - born 1/10/15, 7 lb 5 oz, 20 1/4 inches

    NTNP for a sibling starting March 2015
    Waiting on cycle to resume while EBF


    imageimage

    Report Reply
  • Milagros315Milagros315 member
    I was on cabergoline because my estrogen was over 6000 the day after trigger. I didn't get any symptoms of OHSS other than prolonged cysts.

    As far as I know, I just took the clinic's standard amount of estrogen and progesterone which was estrogen (2 my, oral) twice a day and progesterone (8% Crinone) once a day until ~9 weeks.
    ******************************************** siggy warning ******************************************

    image image

    image

    Married July 2011 * TTC #1 since 8/12 * Me: 29 DH: 29
    21 Cycles TI: BFNs
    DX: Stage 2 Endo, uterine polyps and paratubal cysts removed
    2/14: IVF #1 Lupron Protocol = 12R/10M/9F, no frosties; transferred one 3BB blast = BFN
    4/14: IVF #2 Antagonist Protocol = 18R/16M/15F/6 frosties; transferred one 4BB blast = BFP!!
    Beta #1 (5/12) = 232 Beta #2 (5/16) = 886 Beta #3 (5/20) = 3168
    EDD 1/18/15 It's a BOY 

    ~~~~~~ All Are Welcome ~~~~~~

    Report Reply
  • pblgepblge member
    Congrats on an awesome retrieval! I never took cabergoline, even though I had pretty high e2 and lots retrieved. Never had any OHSS symptoms, either. Apparently some women just aren't prone to getting it. Hope you're one of them!
    **********************siggy/ticker warning**********************

    ***Losses mentioned.*** TTC #1 since May 2012. Me: 37, OH: 41. Ectopic August 2012 => tubal damage. :'(  Stage 1 endo removed June 2013. IVF #1 Oct/Nov 2013: Long Lupron with Gonal-F. 7R, 7M, 7F. 2 txfer@3d. Nothing frozen.  => M/C @ 8 wks. :'( Selected RPL panel all normal. Very hyper and brittle response to stims. IVF #2 (antagonist protocol) Feb 2014 => Converted to IUI (Perfect conditions). BFN. IVF #2.1 w/ new RE June 2014: Antagonist protocol. 33R, 31M, 30F, 19 blasts to test!!! I made it through without crashing!! :) Hats off to Dr. Fancypants!! ET of one 5AB blast. BFN. 13 10 CCS'ed snowflakes! FET #1 PUPO as of 7/29 Betas: 8/7@24, 8/9@97, 8/11@334 (etc.) Two sacs on 8/15, one seen on 8/18 after a bleed. U/s 8/25 (6+3) "perfect": 5.9 mm + HB@120bpm! U/s 9/4 (7+6): 15.9 mm + HB@172 bpm! Please, PLEASE stick this time!!!!
    http://i955.photobucket.com/albums/ae39/catfreeburg/866da40f5178fed79efe23fc8a4e8a_zps4498a9cc.jpgimageimageimageimage
    image
    Report Reply
  • tweetyknickstweetyknicks member
    Thank you all for your feedback. That makes me feel better that this is all manageable (well, except that mention of hospitalization @southernyankeegirl ;-) ). I've been concerned about late-onset OHSS if any embies take.


    ***siggy warning***

    Me: 29; DH: 53
    TTC since February 2013 --- mild thin PCOS (or not, depending on which RE you ask), MFI

    TI#1: BFN (April 2014; Clomid 50mg x5 days, Estrace x5 days, Clomid 50 mg x4 days)
    IUI#1: c/p (May 2014; Letrozole 2.5 mg x5 days, Estrace x5 days, Bravelle 75 IU x10 days)
    IUI#2: abandoned... O'd early & DH hormone issues (June 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x2 days)
    IUI#2.1: BFN (July 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x4 days)

    Moving on to IVF. (Why we're moving on to IVF)

    IVF#1 (w/ICSI): BCP 9/9-9/23. Gonal-F, Ganirelix, Low-dose HCG (antagonist protocol). 41R/35M/32F... 2 transferred on 10/14, 14 frosties! On cabergoline to help avoid OHSS. BFN, possibly because of 90% drop in estrogen and progesterone a few days after ET.
    FET#1: Transferring 2 on January 8. BFP! beta#1 (1/17): 408, beta#2 (1/20): 1310, first u/s scheduled 2/5

     image 
     image    image
    Report Reply
  • southernyankeegirlsouthernyankeegirl member
    @tweetyknicks‌ - Sorry, didn't mean to scare!!! I think she was an extreme and rare case. Her doctor had said he had never seen such a severe response. And even then, it was a night in the hospital, a week of bed rest, another week of slight discomfort, and then a perfectly normal pregnancy.
    ************************SIGGY WARNING***********************

    Me: 29      DH:  32
    Off birth control March 2012 - Actively trying Sept 2012-April 2014
    Unexplained Infertility
    BFP on May 5th after Follistim & IUI #3
    Ryan Henry - born 1/10/15, 7 lb 5 oz, 20 1/4 inches

    NTNP for a sibling starting March 2015
    Waiting on cycle to resume while EBF


    imageimage

    Report Reply
  • tweetyknickstweetyknicks member
    @southernyankeegirl Okay, that sounds better. :-P


    ***siggy warning***

    Me: 29; DH: 53
    TTC since February 2013 --- mild thin PCOS (or not, depending on which RE you ask), MFI

    TI#1: BFN (April 2014; Clomid 50mg x5 days, Estrace x5 days, Clomid 50 mg x4 days)
    IUI#1: c/p (May 2014; Letrozole 2.5 mg x5 days, Estrace x5 days, Bravelle 75 IU x10 days)
    IUI#2: abandoned... O'd early & DH hormone issues (June 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x2 days)
    IUI#2.1: BFN (July 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x4 days)

    Moving on to IVF. (Why we're moving on to IVF)

    IVF#1 (w/ICSI): BCP 9/9-9/23. Gonal-F, Ganirelix, Low-dose HCG (antagonist protocol). 41R/35M/32F... 2 transferred on 10/14, 14 frosties! On cabergoline to help avoid OHSS. BFN, possibly because of 90% drop in estrogen and progesterone a few days after ET.
    FET#1: Transferring 2 on January 8. BFP! beta#1 (1/17): 408, beta#2 (1/20): 1310, first u/s scheduled 2/5

     image 
     image    image
    Report Reply
  • Mrs.EssMrs.Ess member
    I also took cabergoline, I believe my e2 was around 4500 before trigger ( I can't believe I don't remember exactly). I still was able to do a fresh transfer and so far so good. I've been on 1ml (50mg) of PIO and 4mg of estrace daily (the extra estrace is bc I triggered with Lupron). I'm still thinking about late onset OHSS but hoping maybe I've passed that point. I guess I'm not really sure how late it can set in!

    GL to you!
    TTC #2 since 2011 (took 1.5 years to conceive spontaneously after multiple failed clomid cycles and 1 failed clomid +IUI)
    Me- PCOS, borderline hypothyroid
    Him- low concentration/count

    Feb 2014- started acupuncture
    Feb 2014- BFP
    March 2014- m/c @ 5 weeks
    May 2014- HSG, all clear, started Synthroid, Femara 5mg CD 3-7 + trigger + TI= BFN
    Waiting for new RE appointment end of July 2014

    Report Reply
  • SKLHSKLH member
    I was on cabergoline b/c of my E2 also... However, I was doing a freeze all so I could test my embryos so I'm not sure my experience relates to yours but I know it's common to use cabergoline to protect against OHSS developing. I still had fluid built up but not enough to drain! Thank God for the cabergoline!
    Me (28) DH (32)  Endometriosis                                                                                   IVF  #1 (1/2013) - 17 Retrieved, 16 Mature, 14 Fertilized- 2 transferred- BFN
    FET #1 (7/2013) - 2 embryos - BFN
    FET #2 (9/2013) - 2 emrbyos - BFN
    New RE. Fresh Start
    IVF  #2 (2/2014) - 25 Retrieved, 19 Mature, 16 Fertilized, 9 blasts.
                                 CGH Testing: 6 Normal
    FET #3 (4/2014) -1 embryo -  BFP! Beta#1: 35 Beta #2: 16 :(
    FET #4 (5/2014) -1 embryo -  BFP! Beta#1: 321!!! Beta #2: 727.9!     6/5/2014 Heartbeat! 144bpm It's a girl!     Due January!
           

    Report Reply
  • tweetyknickstweetyknicks member
    @Mrs.Ess It sounds like I'm where you are, except the doc took me off of all progesterone and estrogen supplements because my levels were really high at ET (>80 and >2000, respectively).

    @SLKH From what I've read recently, it sounds like cabergoline reduced the chance of early-onset OHSS but has no effect on late-onset OHSS.


    ***siggy warning***

    Me: 29; DH: 53
    TTC since February 2013 --- mild thin PCOS (or not, depending on which RE you ask), MFI

    TI#1: BFN (April 2014; Clomid 50mg x5 days, Estrace x5 days, Clomid 50 mg x4 days)
    IUI#1: c/p (May 2014; Letrozole 2.5 mg x5 days, Estrace x5 days, Bravelle 75 IU x10 days)
    IUI#2: abandoned... O'd early & DH hormone issues (June 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x2 days)
    IUI#2.1: BFN (July 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x4 days)

    Moving on to IVF. (Why we're moving on to IVF)

    IVF#1 (w/ICSI): BCP 9/9-9/23. Gonal-F, Ganirelix, Low-dose HCG (antagonist protocol). 41R/35M/32F... 2 transferred on 10/14, 14 frosties! On cabergoline to help avoid OHSS. BFN, possibly because of 90% drop in estrogen and progesterone a few days after ET.
    FET#1: Transferring 2 on January 8. BFP! beta#1 (1/17): 408, beta#2 (1/20): 1310, first u/s scheduled 2/5

     image 
     image    image
    Report Reply
This discussion has been closed.
Choose Another Board
Search Boards
"
"