Since DS has started going to bed regularly at 7:30 pm (about 2 months) I pump before I go to bed, around 9:30 pm. In the last 2 weeks, I have not been able to pump at this time because I don't have a let down. I have tried a bunch of different things that have not helped: breast compressions, massage, heat, watching videos of him nursing, looking at pictures, smelling his clothes. Nothing. I pump at work during the day and don't have a problem, so I don't think it's anything wrong with my pump either. It's just that one time of day. I don't know if it's a coincidence - I'm assuming it's not - but I also went back to work 2 weeks ago which is when the problem started. Maybe I should add that I've always struggled with low supply too, so I can't even tell if I'm just empty and have nothing to pump because I never feel "full" so I wouldn't notice if I felt "empty." This is just ruining my self esteem and self worth - I've never really gotten over the fact that we've had to supplement with formula from the start, and since I can't pump even close to what he eats during the day my stash is dwindling fast and I'm going to be out by the end of next week, which just adds to my shitty feelings of being a shitty mom because I can't adequately feed my kid. Sorry for the sob story... Anyone have advice on how to encourage let down?

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Re: No let down during pumping?
I pump the most first thing in the morning and it slowly decreases throughout the day as pp mentioned.
You sound like you are working really hard and you are not a bad mom!
Try not to put so much pressure on yourself. I think stress can affect let down. Continue to pump but don't worry so much about production.
I don't have any advice - you're trying so much - except that when I'm stressedc if I can't relax, I won't get a let down (since I've been back to work, I can't let down my first pump on Mondays... So weird...)
You are going above and beyond for your baby!! If you start supplementing with formula, you're still doing what's best for you and baby! Hang in there, mama!!
During the day she had started taking more in her bottles while I am at work and I am pumping less so I have been dipping into my freezer stash too. Yesterday and the day before I drank tons of water and had oatmeal for breakfast and that seemed to help - I pumped a couple more oz yesterday. Oh and I have started drinking a beer at night after LO goes to bed.
With DS it did not take long for the amount he was taking at DC to be a lot more than I could pump so I started mixing BM and formula in his bottles. I held onto BFing as long as I could but we both got frustrated after a while and I had to stop before I wanted to.
But he is a happy and healthy 9-yr-old now so it all worked out ok. So with this LO I am just doing the best I can and if I have to stop BFing before I wanted to I know it will be ok. I was so stressed about it with DS and I am not doing that to myself again.
You are doing great - don't be so hard on yourself!
The PP's have offered great advice so the only thing I can add is that even without a letdown, it's all about the stimulation to get your body thinking it needs to produce more milk. That's why they say to let babies use you as a pacifier when nursing, the sucking increases supply. So maybe pumping even though hardly anything is coming out will help boost supply.
Also, I don't have supply issues (doc just informed me at our 4 month checkup that my son gained too much weight) and I only pump 10-12oz all day in 4 sessions at work. I send my so to daycare with 9oz since he's gone 9hrs (following the 1oz per hour rule). He may be drinking less during the day, but he makes up for it in the morning and at night nursing. I beat myself up about not pumping enough, but the reverse cycling also can help supply and "power" sessions on the weekend may help to build back up your supply and stash. Just some things to try. Hugs.
BFP #1 11/19/12 EDD: 7/25/13 Natural MC on 12/31/12 at 10w4d
BFP#2 3/1/13 EDD: 11/5/13 Missed MC 4/9/13 at 10w D&C 4/11/13
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I had a similar problem when I returned to work. Prior to working I could pump and get enough for the occasional bottle here or there and to freeze a few bags. When I went to work I had trouble pumping enough during the day and by the evenings it was practically dry. The only thing that helped me has been drinking Gatorade. On the days that I go to work I drink a big G2 Gatorade and by the time I pump I feel full and I'm able to get enough for two of her three bottles for the next day. Then in the evenings I'm able to get a couple more ounces right after she's gone to bed.
At first I thought it was just a fluke and that I was just more comfortable pumping at work which was why I was having some supply issues in the first place. Then yesterday I didn't have my Gatorade and I only pumped enough for one and a half bottles. So today I made sure to get the Gatorade and I have enough to freeze for next week.
If you haven't tried the Gatorade thing before it might be worth it. Good luck and keep your head up! You're doing a great job!