Trouble TTC

Starting letrozole soon

Well it's been awhile since I have made a post, I have been in waiting land. Finally had my first appointment with my RE and he is super funny which made the appoinent less awkward. So he scheduled some test and they confirmed I have PCOS.which is what we have suspected the whole time. Anyways... So he is planning on starting me on Letrozole. Is there any thing I should know before I start taking this? Any side effects ?? I'd rather ask people who have taken this before then looking on web md or some other internet site. Thanks in Advance!

Re: Starting letrozole soon

  • Hello. I had only slight side effects on this med. A headache the first day or so and maybe a day of heat flashes. Much less than Clomid so I liked it better. Good luck and I'm glad you got some answers.

    Me-36
    DH -35
    Married in 2008
    Started TTC in 2011
    Began testing May 2014
    Test Results
    HSG- clear
    Hysteroscopy- clear
    SA- 11 mil count
    45% motility
    Diagnosis: MFI
    July 2014: Femera 5mg CD 4-8, Trigger, IUI = BFN
    August 2015: Femera 5mg CD 4-8, Trigger, IUI = BFN
    September 2015: Femera 5mg CD 4-8, Trigger, IUI = BFN
    May 2018 after long period of not trying, starting adoption process with family friend's newborn
    November 2018 Adoption complete!


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  • Hi! I took letrozole this cycle and I didn't really have much for side effects. I think two nights I had some hot flashes (woke up very warm/sweaty) but nothing I really remember. Will you be doing IUI or TI? Do you have any MFI? Just curious! If you are going to do TI I'd ask about the trigger shot. For us it was really nice to have an exact window when I'd ovulate.Just an idea! Good luck!
    ***********siggy warning **********



    Me: 26 DH: 27
    TTC #1 Since Aug. 2013
    Cycle 1: O CD 25=bfn
    Cycle 2: O CD 48=bfn
    Cycle 3: Anovulatory/Provera =120 days!
    Cycle 4: Anovulatory/Prometrium=127 days! RE consult 6/16
    Me: Anov/poss. pcos?  HSG=normal/SA= Normal 
    July/Aug. 2014= Femara+trigger+TI=BFP!!
    Beta #1@ 16dpo=626!! Beta #2=1510
    Ultrasound @ 5w6d=heartbeat at 110!
    Ultrasound @ 6w6d =heartbeat at 131!


    Pregnancy Ticker

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  • I had just a few side effects. A couple of hot flashes. My RE did recommend if I had any trouble to take meds at in evening so majority of side effects would be while I slept.

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    Me: (30) HSG/Bloodwork/Ultrasound: All looks good

    DH: (30): MFI

     IUIs #1-4 = BFN


    IVF #1 December January


    **********************All Welcome**********************

    January 3T Siggy

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  • Just curious @kkeglar13 - what is the 4000mg P4 you refer to in your signature?


    TTC since 2013 (grad of 3T)
    EDD: May 24, 2015
  • I didn't have much side effects. I did feel as thought I got upset a little easier .. but it also could have been just the ppl that annoy me in general at work lol. GL!!
    *** If you want to know where I (and soo many others) have gone, click here ***
  • I've just taken 3 days so far, but nothing more than a little dizziness and slight headache. Sooo much better than Clomid, I'll take it!
    Me:
    Dx, PCOS
    Began TTC Mar 12 both @ age 33.
    HSG and SA Dec 12: All good.


    9 completed medicated cycles so far (*BFP and loss mentioned*):
    Clomid 50mg, TI, BFN.
    Clomid 50mg, HCG trigger, TI, BFN.
    ~Break~
    Clomid 50mg, HCG trigger, IUI#1, BFP. M/C @ 7 weeks.
    ~Break~
    Clomid 50mg, IUI#2, BFN
    Clomid 100mg, IUI #3, BFN
    Clomid 100mg, HCG trigger, IUI #4, BFN
    Started Metformin
    Clomid 150mg, HCG trigger, IUI #5, BFN
    Clomid 150mg, HCG trigger, IUI #6, BFN

    Letrozole 7.5mg, HCG trigger, IUI #7, TWW...

    ~Break~

    Gathering info for IVF...
  • I took letrozole for 2 cycles, same dose both times.  The first time, I had hot flashes and a dull headache.  The second time, I had hot flashes and bad headaches/migraines that nothing helped for a week.


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    Me: 33, DH: 35
    Married 10/13, TTC since 7/13
    Dx: MFI
    IUI #1 7/14: BFN
    IUI #2 8/14: BFN
    IVF #1 11/14: 20R17M15F
    Transferred 1 three day embryo! 7 frosties!
    BFP!  EDD 7/27/15



                                                                      image

  • I had headaches when I was on Letrozole. Not horrible ones but annoying.

    Me: 32  DH: 33  Married: March 2004

    July 2006: started TTC
    2008: HSG (normal), couple rounds of clomid through gyno
    2008 - 2010: dragging my feet out of fear and procrastination
    October 2010: first consultation with RE, dx PCOS and fibroids (DH slightly low count/motility)
    Oct. 2010 - Dec. 2012:  In DENIAL! avoided the issue because I was scared of surgery
    January 2013: returned to RE, fibroids grew significantly
    February 2013: second HSG, fibroids pushed on tubes which blocked them somewhat
    March 2013: MRI to determine what type of surgery may be necessary

    July 29, 2013: fibroids (5) removed via robotic laparascopy
    August 2013 - Nov 2013 : benched due to recent surgery

    IUI #1, Dec. 24, 2013, BFN 
    IUI #2, Jan. 25, 2014, BFN
    IUI #3, Feb. 25, 2014  BFN
    IUI #4 canceled due to lack of response to letrozole
    IUI #4.1 April 28, 2014, BFN

    May 16, 2014: wtf consult, start prepping for IVF in June and add injects for one last IUI in the meantime
    IUI #5 started letrozole and bravelle but canceled after HSG led to new diagnosis

    May 21, 2014: third HSG, tubes blocked, one at the beginning, one hydrosalpinx??
    June 11, 2014: consult, approved to move on to IVF because the hydro is not completely blocked therefore allowing fluid to move through slowly rather than backwards
    IVF #1 August 8, 2014 - 3dt of 2 embryos, BFN
    September 17, 2014 - 4th HSG, the right tube is very patent (open!!) dye went straight through this time. Weird!
    October 2, 2014 - started metformin treatment
    November 14, 2014 - blood work, brought A1C down from 5.8 to 5.5

    November 26, 2014 - RE finally back from vaca and reviewed my chart, no more IVFs for rest of calendar year
    December 1, 2014 - Right after Thanksgiving, I called a new clinic and got in right away! Plan for IVF
    December 17, 2014 - ER! 29 retrieved (!!), 16 mature, all 16 fertilized (ICSI)

    IVF #2 December 20, 2014 - 3dt of 3 embryos, BFN

    We are done with treatment unsuccessfully. :(


    PAIF/SAIF/All Welcome!

    image    image
  • Congrats, I'm glad you have a funny RE and a plan! Letrozole wasn't bad for me either, a bit headachy, a couple hot flashes. Good luck!
    January 3T Siggy Challenge - New Year's Resolutions
    image
    imageimage

    Me (29), DH (30) TTC actively 54 55+ cycles | All BFNs
    MFI (low everything) | Endo Stage 1 & Stenotic Cervix (treated) | PCO
    Married - July 2008 | Started TTC - Jan 2009RE Visit #1 - Mar 2014 
    IUI #1 ICI #1 - June | IUI #1.1 Laparoscopy - Aug
    IUIs #1.2, 2, 3 - Sept, Oct, Nov (Letrozole) - BFNs 
    IUI #4 - Dec (Bravelle) | IUI #5 - Dec/Jan (Bravelle) - 5 follies + TI - BFNs
    IUI #5.1 - Jan (Bravelle) Cancelled 
    Planning to start IVF in March!
    ***All Welcome***
  • jennym25jennym25 member
    edited August 2014
    I had a headache for about two days with cycle 1 on letrozole. This second cycle I had not side effects. Good luck!

    Me (29), DH (38)

    Oct 2009   - Married
    Aug 2011   - Started TTC
    Jan 2012   - OB Referred to RE
    Feb 2012   - RE Visit #1
    Apr 2012   - HSG (Normal), PCOS - DH SA (low count and low motility)  
    June 2012   - Provera, Clomid, TI - BFN
    July 2012   - IUI #1, Provera, Clomid 50mg, Trigger Injection - BFN
    Aug 12 - Feb 14 - Break
    Feb 2014   - New OB referred to new RE
    Mar 2014   - New RE visit #1
    Apr 2014    - TSH  level elevated, need to retest.
    May 2014   - TSH retested, higher than 1st test. Start on Synthroid. DH SA (Normal)
    June 2014   - Start on DHEA, CO-Q10, New brand of Prenatals
    July 2014   - Cycle came on its own, b/w on CD2, TSH (normal), Femara CD3-CD7, CD14 - u/s + Ovidrel + baby aspirin regimen. IUI #1 B2B on CD15/16 - BFN

    August 2014 - u/s on CD3 normal, Femara CD3-CD7, u/s CD12, Ovidrel on CD13. IUI #2 B2B on CD 14/CD15 - BFN.

    September  2014 - u/s on CD3 normal, Femara CD3-CD7, u/s scheduled for CD12

    *** September 3T Siggy Challenge: Favorite Fall Shows ***

    image
  • I've been on letrozole the last 2 months. No side effects from the med, responded well to it too, just no BFP! Good luck to you on Letrozole!
    Me: 37 DH: 37, married since Sept. 2013. "actively" TTC for a total of 13 months (after 7 months of TTC, took a 1 1/2 year hiatus due to work scheduling and wedding planning. Started up again after our wedding in Sept.) First evaluation by an RE November 2013

    HSG-normal
    OH-tiny polyp found, but RE assured me she doesn't think it's contributing to infertility and doesn't recommend me to remove it because it's so small.
    DH's SA-normal
    Hormones all within normal levels
    Ovarian Reserve-RE says "is great" she's not concerned about my egg quantity (which I was until I saw her and results came back good!) 

    04/2012 50mg Clomid=BFN (prescribed by OBGYN, not monitored)
    06/2012 50mg Clomid=BFN (prescribed by OBGYN, not monitored)
    11/2013 100mg Clomid, with HCG trigger=BFN (prescribed by RE, monitored with US (2 dominant follicles) and baseline bloodwork done)
    01/2014 100mg Clomid, with HCG trigger-(prescribed by RE, monitored with US-1 dominant follicle)=BFN
    06/2014 7.5mg Letrozole, HCG trigger (prescribed by RE, monitored with US-2 dominant follicles), IUI #1 on 7/3/14=BFN
    07/2014 7.5mg Letrozole, benched for IUI#2 this cycle, because I ovulated on my own before my follicular US. Progesterone suppositories=BFN Diagnosed with PCOS this month too. Testosterone levels high at 76. =( 
    08/2014 7.5mg Letrozole, HCG trigger with 19mm follicle. IUI#2 on 8/31 cancelled last minute due to family emergency. 
    09/2014 Taking a 3 month break starting this month. If not pregnant in 3 months, will start up again with medicated cycles and IUIs. Had all my labs and AFC re-evaluated this month also. RE says nothing much has changed since my eval last November, okay for me to take a little break. =) 




  • This is my 4th cycle on it- I take it at bedtime as it makes me tired
    Married July 2 2011
    Not trying Not preventing since 2011
    Me: Ovulate on my own (but poorly) DH: Low count and poor motility
    Oct 2013 Uterine polyp removed
    Feb 2014 First round Ferama, trigger and IUI...BFN
    March 2014 Second round Ferama, trigger and iui
    Waiting....
    Trying to Conceive Ticker
  • @catlover790 they want to see how I respond to the letrozole first, then if I respond well we will try naturally TC for three months then if no luck move on to an IUI. I'm still a little new what is an MFI? they actually started me on Metformin 1500mg and 10 days of provera. once AF start I call  for an ultrasound to check for cyst  because I have PCOS. and then I will start the letrozole on day 3-7. that's all the info I have for now  :)

  • Thank you everyone for the replies, I am  just glad to have an idea of what to expect!  
  • steen9713 said:

    @catlover790 they want to see how I respond to the letrozole first, then if I respond well we will try naturally TC for three months then if no luck move on to an IUI. I'm still a little new what is an MFI? they actually started me on Metformin 1500mg and 10 days of provera. once AF start I call  for an ultrasound to check for cyst  because I have PCOS. and then I will start the letrozole on day 3-7. that's all the info I have for now  :)


    That sounds like a good plan! I'm glad you can get started soon! MFI is male factor infertility. I was just curious about your treatment plan but it sounds good so far! Good luck this cycle!
    ***********siggy warning **********



    Me: 26 DH: 27
    TTC #1 Since Aug. 2013
    Cycle 1: O CD 25=bfn
    Cycle 2: O CD 48=bfn
    Cycle 3: Anovulatory/Provera =120 days!
    Cycle 4: Anovulatory/Prometrium=127 days! RE consult 6/16
    Me: Anov/poss. pcos?  HSG=normal/SA= Normal 
    July/Aug. 2014= Femara+trigger+TI=BFP!!
    Beta #1@ 16dpo=626!! Beta #2=1510
    Ultrasound @ 5w6d=heartbeat at 110!
    Ultrasound @ 6w6d =heartbeat at 131!


    Pregnancy Ticker

    image
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