Success after IF

Question for PCOS mamas

My sister was diagnosed with PCOS a few months ago. She has a 5 yr old but had been having trouble getting pregnant so OB did some testing and diagnosed her. They started her on metformin and then after monitoring her a while started clomid. She's been closely monitored but no luck. This month she had four really good follicles and they said they wouldn't do the shot to make her ovulate bc they didn't want her to have four babies. They told her to do OPKs and she did, but never turned positive. So she didn't ovulate. She's at the point of being ready to give up which breaks my heart.

What advice to you all have? They can't really afford IVF and going to an RE freaks her out (although I'm gently pushing her to go). What did you do that finally resulted in success? Thanks ladies!
MF (low motility) - Began stims for IVF#1 7/21/12
ER 8/2/12 - 14 eggs retrieved, 12 mature and ICSI'd, 6 fertilized. ET 8/7 - 2 embies. Beta#1 8/17: 143! Beta#2 8/20: 590! Beta#3 8/22: 1,162! 1st US 9/4: one beautiful little bean with the best sounding HB I've ever heard!
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Re: Question for PCOS mamas

  • I would keep trying to push her to to the RE. They are the ones who are there to get you pregnant, not your OB. The RE can likely tweek her meds for less follies, but healthier follies. Maybe she would respond better to letrozole (and not risk the side effects of Clomid).

    I'm so sorry she is struggling :(
    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    TTC# 1 since 5/10
    Me:34 Type 1 Diabetes, Ankylosing Spondylitis, Hypothyroid DH:35 Perfect
    DX: Unexplained IF
    Many IUI's with various meds all BFFN
    IVF #1 11/11 canceled due to OHSS
    IVF #2 Feb/March 2012 ET of 2 on day 3 4/7 BFP! 5/1 u/s blighted ovum
    IVF #3 July 2012 ET of 3 on day 3 7/24 BFP!
    Healthy baby girl born at 36w4d on 3/9/13

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    TTC #2
    IVF #4 May/June 2014 ER 6/4 18R 8M 8F ET 6/9 1 blast, 2 frosties
    Beta 6/18 BFFN

    FET of 2 blasts 7/24...BFP!
    Healthy baby girl born at 36w3d on 3/17/15

    TTC#3
    IVF #5 June 2018- PGS planned, no surviving embryos
    IVF #6 August 2018- ET of 2 on day 3 - Chemical pregnancy
    IVF #7 August 2019-....?
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  • I have PCOS as well and I have never ovulated on my own. I went to the RE for a year and a half, went through testing and two rounds of iui's both with no results (last one resulted in a miscarriage. I found Pregnitude on amazon and was amazed by all of the positive reviews. I gave pregnitude a try for a month and and half and I had my first real period ever, first ever positive OPK ever and first positive pregnancy test ever from the good ol natural way. And I'm current 9 weeks along. I can't say enough good things about this product. Have her give it a shot, it's it's a much cheaper route that has no effect on the baby.
    Hannah

    Nov'12- Started TTC
    Sept-Dec'13- HSG, 2 IUI's, DX PCOS
    Jan '14- IUI#2=BFP!!
    Mar '14- M/C @ 8w2d when I should've been 9 weeks. D & C 3/7/14
    May'14- Started Pregnitude
    June'14- BFP! (Naturally!!) Beta #1 (4w2d)=78, Beta #2 (4w4d)=219, Beta #3 (5w0d)=785

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  • Ditto on the go see an RE. There are several things to try before IVF.


    TTC#1 for 19 months with PCOS and MFI IUI#3 + injectables = BFP!!!!  Beta#1-134(13dpiui) Beta #2-392(15dpiui) 
    #1 born December 2011
    TTC#2 - Beta #1 -51@10dpo Beta#2 -1353 @16dpo
    #2 born May 2013
    TTC # 3 June 2014 BFP 12-1-14
    #3 born August 2015 
    #4!!!!!!! due June 2017 
  • She really needs to see an RE. She could get lucky with just clomid, trigger, and TI. Or have better luck with femara (I did.) IUI is also much simpler and cheaper than Ivf so that's an option too. REs make babies, OBs deliver them.
    TTC with PCOS since November 2009
    IUI#1 Femara/Ovidrel (cd 3-7) = BFP, m/c
    IUI#2 Femara/Ovidrel (cd 5-9) = BFN
    IUI#3 Femara/Ovidrel (cd 3-7) = BFP!
    beta #1 11/23 = 270, P4 = 75
    beta #2 11/28 = 2055
    Our daughter E was born 7/29/2012!
    Surprise, our 2nd daughter P was born 5/22/14!
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  • She really needs to see an RE. She could get lucky with just clomid, trigger, and TI. Or have better luck with femara (I did.) IUI is also much simpler and cheaper than Ivf so that's an option too. REs make babies, OBs deliver them.
    TTC with PCOS since November 2009
    IUI#1 Femara/Ovidrel (cd 3-7) = BFP, m/c
    IUI#2 Femara/Ovidrel (cd 5-9) = BFN
    IUI#3 Femara/Ovidrel (cd 3-7) = BFP!
    beta #1 11/23 = 270, P4 = 75
    beta #2 11/28 = 2055
    Our daughter E was born 7/29/2012!
    Surprise, our 2nd daughter P was born 5/22/14!
     image
    imageImage and video hosting by TinyPicimage
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  • Thank you ladies! I'll keep pushing her to go to the RE. I appreciate your help!!
    MF (low motility) - Began stims for IVF#1 7/21/12
    ER 8/2/12 - 14 eggs retrieved, 12 mature and ICSI'd, 6 fertilized. ET 8/7 - 2 embies. Beta#1 8/17: 143! Beta#2 8/20: 590! Beta#3 8/22: 1,162! 1st US 9/4: one beautiful little bean with the best sounding HB I've ever heard!
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  • Ditto what other said go to RE. Without proper monitoring it's hard to know what to change. Clomid never made me ovulate and I would have never known that without going to an RE.

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

  • I agree with PPs. She really needs to be monitored and do further testing. My BFF tried for a year with an OB after being diagnosed with PCOS. I gently pushed her toward an RE because I could see the OB seemed to just be shooting in the dark w/o doing proper testing. She got pregnant on her first cycle with an RE. It's definitely possible to get pregnant with an OB, but it's definitely second best. 

    GL to her!  
    DH and I are Americans living an adventure in Kenya since 2011
    DX: PCOS (annovulatory)
    Feb 2012: IUI #1 w/ only 1M sperm and a single follie = BFP! 
    Nov 2012: Little buddy born in Kenya
    Nov 2013: Trying for a second, still w PCOS
    Dec 2013: IUI cycle canceled for non-response
    Jan 2014: Break cycle BFP!

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  • FYI - OPKs don't always work for women with a PCOS diagnosis.
  • FYI - OPKs don't always work for women with a PCOS diagnosis.
    This exactly. I was told not to use them by my re because you get false positives

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

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