PIO injection timing

jbasore1123 · July 2014

Ladies, I need help.
My husband and I can't decide when it would be best to give me the injection. The two options are either 5:30am every morning (I would go back to bed until 7:20 during the work week, or later on the weekends) or 8:00pm at night (my husband works late). I would dislike waking up early every single day, but I would also dislike having to pretty much cancel evening plans and worry that I wouldn't be very active after 8:00, which I hear helps. If the transfer works, then I will be doing this until the 10 week mark.

What would you do, or what have you done? Evening injectors, did you regret not doing it in the morning when you may have been more active for the rest of the day?

jencity9 · July 2014

I haven't done PIO yet, but I would think the evening would be better for me... for one, I would hate to wake up that early! I set my alarm to get up for my Lupron injection on days when I am not already up at that time, and sometimes it's hard for me to get back to sleep. I've also found that sometimes when I get up and go straight for the injections, I am not fully awake and it confuses me sometimes whereas in the evening I feel more confident about what I'm doing.

Would PIO injections at night really cause cancellation of plans? Of course not having done them yet I'm not sure how I would feel but I would look at it like just taking a short time out from whatever the plans were instead of having to cancel all together.

CMH25 · July 2014

I did late evening and it worked best for me. I also just brought my PIO shots with me, if needed, and my husband gave me the shot wherever we were. Depends on if you are comfortable with that. GL!

Annabellef · July 2014

Same for us. We do the PIO before bedtime, around 10. If it's a weekend and we happen to be out that late I pack a meds bag and we sneak off to the bathroom together.

Once my hubby gave me the ovidrel shot in the car 5 minutes before going into a restaurant to celebrate a friend's birthday!

Pintobean39 · July 2014

I only did mine for a few days but I did it in the morning so I could have to day to move around so I wouldn't be as sore, per my nurses instruction. One thing that I found useful when doing it in the morning is I got the syringe filled and ready at night. I laid it all on my night stand and when my husband got up for work I just rolled over in bed and he injected it in me.

pblge · July 2014

My nurses recommend morning injections bc it's less painful. Are you up for doing them yourself? Lots of ladies do, but I'll be honest that it was difficult for me. I've only done morning shots, so I don't know how much night shots hurt.

jbasore1123 · July 2014

@pblge- I don't know if I'm brave enough to do them myself. I hate needles and it freaks me out watching it go into my skin. DH has done all but one of my injections and that has worked best for me.

jbasore1123 · July 2014

@snegde- I wish my RE gave me more direction. The only thing I was told about the PIO was to take them the same time everyday.

Lillovebug79 · July 2014

My nurse told me to do them between 8 and 10 pm. She said it didn't matter if it was at the same exact time everyday just so long as it was within a couple of hours. We aimed for 9pm but if we were out, we have done it as late as 10:30. Doing it that way sure hasn't effected my level because on 0.5ml my 7dpo progesterone level was >60 which is fantastic. I am pretty sore now that it's been almost 3 weeks but I think that's mostly because I'm on Aspirin so I'm all bruised up! I ice it before and use a heating pad after which helps a lot!

shelbeans82 · July 2014

I did mine in the AM, but immediately went to take a shower and started my day after. I had zero issues with soreness or pain. It sounds like either way you won't be very active post injection. Maybe do in the am with a warm washcloth on the area while you sleep in the morning? Or take a walk every evening after the PIO?

jencity9 · July 2014

@pblge‌ Why is it less painful in the mornings?

Sunny B · July 2014

My RE requires they be done between 7-9pm. I'm not sure why, but we did them at 8pm after our IVF. I walked around the house a little bit and typically went to bed about 1.5 hours later.

pblge · July 2014

@jencity9 said:

@pblge‌ Why is it less painful in the mornings?

Movement/activity is supposed to help the meds disperse and avoid sore spots.

I have a new theory, which is that the most important part is a super relaxed muscle during the injection.

jencity9 · July 2014

Oh ok, hehe.

For me, I guess I am not so worried about the soreness which I will deal with, but I am just afraid of feeling the needle!

Lillovebug79 · July 2014

@jencity9‌ just put a nice pack on the area for 5 minutes beforehand. I barely feel it at all. That is until the next day!! I'm so sore and bruised, the aspirin doesn't help. Trust me, no matter what you do after so long it gets really sore. Tomorrow will make 3 weeks for me, ouch!!

jszy10 · July 2014

My clinic recommended nighttime injections. We do mine before we go to bed (around 10pm) each night. I like the timing because (1) I don't have to wake up early to a shot! and (2) I don't have to worry about my plans throughout the morning/day/night because we are always home or getting ready for bed at 10pm.

jbasore1123 · July 2014

Thanks for the input ladies!

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