Success after IF

PIO tips and tricks

Need your help ladies...

With my first IVF that got us L, I used Endometrin suppositories as my progesterone. With my upcoming FET (which could be as soon as the 24th...holy soon-ness! Lol), I am using PIO (apparently they have had more success with FETs this way).

So, I need all your tips and tricks when using this lovely injectable. What worked before, during and after the injection? H will be most likely doing it for me if he can get past his huge fear of needles.

TIA!
Married July 2011; TTC since April 2011; DX: MFI
IVF #1 in August 2012: BFP!
L was born on May 5, 2013, 8lb. 6oz.
PAIF/SAIF welcome!

Our Project Make A Baby

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Re: PIO tips and tricks

  • My RE prescribed a numbing cream that I applied an hour before the shot and I never felt the shot itself. Massage the area after the shot and walk around after- it helps with lumps.
    Good luck!
    Me 36/DH 46 Me: Low AMH (.21) DOR, mild endo; Started seeing RE 11/12
    Jan-March '13 3 IUIs Clomid + Trigger = BFN
    April '13 IVF 1 MDLF converted to 4th IUI due to 3 runaway follicles! BFN
    July/Aug '13 IVF 1.2 Long Lupron = 7R, 6F, 2T= BFP!!!
    Beta 1=512, Beta 2=1,368 Beta 3= 4,128
    It's a boy!!!!
    SUA, GD
    EDD 4/26/14

    He's Here! Arrived 4/15/14!!!!

    September 2015 - FET with remaining embryos
    Twins! EDD: 6/14/15

    PAIF/SAIF Everyone welcome!
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  • DH does mine for me, with the exception of 4 days when he was OOT. I did those myself and it actually wasn't too bad. Tell your husband not to hesitate when doing the injection - commit to it and go :) You will find spots that are less painful - stick to those. I know some people ice before, but I never have. I did find that a heating pad helped afterwards. I also have MH massage the areas every few days to work the knots out. I get itchy at the injection sites but I haven't found anything that helps with that. 

    Good luck!!! 
    Dx: Unexplained Infertility

    TTC #1 
    IUI's #1 - #3 Clomid = BFN's, IUI #4 Follistim = BFP
    Grayson arrived via emergency c-section on 7/28/12!

    TTC #2 
    IUI's #1 - #4 Follistim = BFN's
    IVF #1 w/ ICSI + PGS: Lupron/Follistim/Menopur
    ER 4/13 - 19R, 13F, 4 PGS tested embryos, 1 normal
    5/14 FET: BFP. Beta #1: 123, Beta #2: 327, Beta #3: 854
    Cora arrived 1/23/15 via RCS!
  • ccamccam member

    Numbing cream?!  What the eff.... everyone should be given that!!

    I normally warm up the oil before drawing up the injection (aka shove it in my bra for a little while).  It makes drawing it up and injecting the oil much easier since it's a little thinner when warm.  After DH does the injection, he massages the area until his hand is numb (keeps him involved!) and then I sit on a heating pad for a little while.  Not only do those things help with the actual injection site but they help to distribute the oil.

    ___________________________________________________________________________

    Trying for #1 since May 2010   l   DX ~ Unexplained Infertility June 2011

    IUI #1&2 = BFN; IUI #3 = BFP, m/c @ 6 weeks

    November '11 ~ IVF#1 ~ ER 11/18 (29R, 17F) ~ 5dt of one beautiful blast on 11/23 = BFP!!

    Beta #1 9dp5dt = 116, P4 = 28 ~ Beta #2 13dp5dt = 700 ~ Beta #3 20dp5dt = 9500, P4 = 26

    1st u/s 12/27 - hb of 156!! EDD 8.10.12 :)   **TEAM GREEN!**

    Sweet baby boy born 8.18.12

    Baby Birthday Ticker Ticker

    Trying for #2

    FET #1 - October '13 - c/p   l   FET #2 - December '13 - cancelled :(   l   FET #2.2 - 1.30.14 - BFN

    ~ More testing - hysteroscopy, endometrial biopsy & more b/w - all normal / negative~

    Surprise BFP while waiting on FET #3 ~ beta #1 500; beta #2 1600; first u/s 4/3 - measuring 5w5d, no hb yet!; 2nd u/s 4/10 - hb 132, measuring 6w6d - EDD 11.29.14 :)    **TEAM GREEN!**

    Beautiful baby girl born 11.24.14

      Baby Birthday Ticker Ticker

  • ccam said:


    I normally warm up the oil before drawing up the injection (aka shove it in my bra for a little while).  It makes drawing it up and injecting the oil much easier since it's a little thinner when warm. 

    This!!!!  I also have the nurse draw circles since I inject it myself.  I lean on the bathroom counter with one leg down, there are some great youtube that taught me this!  Always rub rub rub that oil in to disperse it and walk around a bit after.  I never had lumps because of this.  Also I feel for the least sore spot before choosing an injection site, some areas will become more tender.  And I agree, heating pad about 15 min after the shot.  Good Luck :)
    H: 34 dx Azoospermia due to CBAVD from CF  
    ME: 39 IS FINE!!!  DOR and poor AMH/FSH/LH
    IVF/ICSI/PESA #1 Beta 1 373 Beta 2 1783 BOY/GIRL TWINS!! Born April 2010!!
    Natural FET 5/26/12 2 blasts Beta 1 207 Beta 2 513 Beta 3 1377 U/S 6/28 Pregnancy not viable d & c scheduled :( 
    IVF/ICSI/PESA #2 ER 11/15/12 Nothing to transfer :( 
    IVF/ICSI #3 April 2013 MDLF 3dt of 3 embryos, chemical :(  
    IVF #4/ICSI/MESA/CCS/FET EPP April 2015
    ODWU CCRM with Dr. Sch COMPLETE!!!! Put on acai supplement they are studying for DOR and embryo quality.
    DAY 3 Labs Drawn 2/26 put on vitamin D and calcium supplements
    Regroup and Protocol Reveal 3/04 "Bazooka Protocol" EPP with MDLF "Protocol 6 with patches"
    ER/MESA 4/10 ER 9 eggs retrieved MESA success found live swimmers :)
    Fertilization Report 6 eggs mature and ICSI'd 4 eggs fertilized normally
    Day 6 Report to Blast for CCS 4/16: 2 DAY 5 BLASTS BIOPSIED FOR CCS a 4AB and a 3AB!!!!
    CCS Results BOTH BLASTS CCS NORMAL!!!!!!  call on 4/24
    Regroup call to discuss CCS results and FET call on 5/20
    FET prep: CD 1 6/08 CD 3 Start BCP 6/10, HSG 6/12 Lupron Start 10 iu 6/17 End BCP 6/21 CD 1 6/23!!!
    Start vivelle patches 6/25 change e/o/d reduce Lupron to 5iu 6/25 Blood Draw 7/01, 7/08, 7/15, 7/19
    Increase vivelle patches 7/03 2 change e/o/d and 7/05 change e/o/d 3 and 7/07 4 change e/o/d add vaginal estrace 2x a day
    Lining Check/Blood Draw 7/08 and 7/15 End Lupron 7/18  Start PIO 1ml daily 7/18  Blood  Draw 7/19
    Flight to clinic 7/22
    FET 2 CCS BLASTS :):)  7/23 :):) YES YES both thawed and both fully expanded :):)
    7/26 :):) 3dp5dt PM very very faint positive FRER
    7/27: 4dp5dt Neg Digi AM but very very faint positive FRER PM POSITIVE DIGI CLEARBLUE PREGNANT 1-2 :):) 
    7/31:8dp5dt AM POSITIVE DIGI CLEARBLUE PREGNANT 2-3!!!! :):) 
    Beta 1 8/01= 408!!!!!!!!!! at 9dp5dt FET
    Beta 2 8/03 = 1014!!!!!!!!!! at 11dp5dt FET
    8/05/2015 AM POSITIVE DIGI CLEARBLUE PREGNANT 3+!!!! :):) 
    First Ultrasound: 8/20!!!!!! TWINS!!!!!!!!!!!!!!!!!  Genetics says BOTH BOYS!!!!!!!!!
    Second Ultrasound: 9/03!!!!!!!!!!










     










  • ccamccam member
    edited July 2014
    Oh yes, forgot about the circles!  Have the nurse draw those for you.  Also, I would stand on the opposite foot of the side that DH did the shot and sort of lean over the counter.  That way the injection cheek wasn't so "tense".

    ___________________________________________________________________________

    Trying for #1 since May 2010   l   DX ~ Unexplained Infertility June 2011

    IUI #1&2 = BFN; IUI #3 = BFP, m/c @ 6 weeks

    November '11 ~ IVF#1 ~ ER 11/18 (29R, 17F) ~ 5dt of one beautiful blast on 11/23 = BFP!!

    Beta #1 9dp5dt = 116, P4 = 28 ~ Beta #2 13dp5dt = 700 ~ Beta #3 20dp5dt = 9500, P4 = 26

    1st u/s 12/27 - hb of 156!! EDD 8.10.12 :)   **TEAM GREEN!**

    Sweet baby boy born 8.18.12

    Baby Birthday Ticker Ticker

    Trying for #2

    FET #1 - October '13 - c/p   l   FET #2 - December '13 - cancelled :(   l   FET #2.2 - 1.30.14 - BFN

    ~ More testing - hysteroscopy, endometrial biopsy & more b/w - all normal / negative~

    Surprise BFP while waiting on FET #3 ~ beta #1 500; beta #2 1600; first u/s 4/3 - measuring 5w5d, no hb yet!; 2nd u/s 4/10 - hb 132, measuring 6w6d - EDD 11.29.14 :)    **TEAM GREEN!**

    Beautiful baby girl born 11.24.14

      Baby Birthday Ticker Ticker

  • I liked PIO much better than endometrin!! So much easier to just do it 1x/day. PPs had wonderful tips. I iced, had DH do the shot while I was laying on my belly, and used the heating pad while alternating heat and rubbing the injection site. I also had the nurse draw circles and just redid them as needed. I used sesame oil PIO and found it easy to warm the oil in the crook of my elbow- my boobs aren't big enough to warm it in my bra!!

    GL!!
    TTC in 2009, Dx: Unexplained IF
    Three TI cycles (BFP...miscarriage), five IUI attempts and 2.5 IVF cycles later...BFP!!
    12dp5dt: 765; 15dp5dt: 1979; 17dp5dt: 3379...TWINS!!!!!
    Our perfect baby boys were born at 36w1d!! 








  • ccam said:

    Numbing cream?!  What the eff.... everyone should be given that!!


    @ccam no kidding!!!!!! No one offered me that  :((
    Dx: Unexplained Infertility

    TTC #1 
    IUI's #1 - #3 Clomid = BFN's, IUI #4 Follistim = BFP
    Grayson arrived via emergency c-section on 7/28/12!

    TTC #2 
    IUI's #1 - #4 Follistim = BFN's
    IVF #1 w/ ICSI + PGS: Lupron/Follistim/Menopur
    ER 4/13 - 19R, 13F, 4 PGS tested embryos, 1 normal
    5/14 FET: BFP. Beta #1: 123, Beta #2: 327, Beta #3: 854
    Cora arrived 1/23/15 via RCS!
  • Thanks ladies! Am I correct that I am drawing up with the 18 gauge and injecting with the 22? I don't go to meet with my nurse to get the lesson until after my U/S on the 19th.
    Married July 2011; TTC since April 2011; DX: MFI
    IVF #1 in August 2012: BFP!
    L was born on May 5, 2013, 8lb. 6oz.
    PAIF/SAIF welcome!

    Our Project Make A Baby

    Baby Birthday Ticker Ticker
  • There are great tips on here, but what worked for me:
    Again, warm the oil for 15 mins.  
    Instead of numbing with ice pack, I heated with heating pad.  It didn't numb the area, but helped prevent bruising and knots.  
    Give the shots as high in the quadrant as you can go (not too high!) and there's less pain.  
    Lay across the arm of the couch with no weight on your legs
    Quickly rub the area when done to help distribute.
    When we gave the shots high in the quadrants, it really, really cut down on the pain.  Less nerves there.  

    Keep in mind, though, after you do all this - it's gonna be sore anyway.  ;P
    m/c my Angel Baby in 2000
    IUIs with clomid from 2009-2011   Feb 2011 - Tubal surgery (repair)  Jan 2012 - Tubal surgery (remove)  
    8/13 IVF#1.  Lupron/Follistim protocol - b/g twins born April 1 at 34 +1.  Luckiest woman in the world.
    8/15 FET #1 - transferred 1 thawed embryo - Pregnant with Baby C, it's a girl!  Due April 2016. Pregnancy Ticker  

     Baby Birthday Ticker Ticker
    "For I know the plans I have for you, declares the LORD.  Plans to prosper you and not to harm you, plans for hope and a future"   Jer 29:11
    "All things work together for good to them that love God, who are the called according to His purpose"  Rom 8:28
    "I am not ashamed of the gospel of Christ, for it is the power of salvation unto all who believe"  Rom 1:16
  • Oh, yeah, draw with the larger gauge, inject with the smaller.  
    Numbing cream might help the initial stick, but won't help with the soreness you'll feel for 2 months.  Sorry.  
    m/c my Angel Baby in 2000
    IUIs with clomid from 2009-2011   Feb 2011 - Tubal surgery (repair)  Jan 2012 - Tubal surgery (remove)  
    8/13 IVF#1.  Lupron/Follistim protocol - b/g twins born April 1 at 34 +1.  Luckiest woman in the world.
    8/15 FET #1 - transferred 1 thawed embryo - Pregnant with Baby C, it's a girl!  Due April 2016. Pregnancy Ticker  

     Baby Birthday Ticker Ticker
    "For I know the plans I have for you, declares the LORD.  Plans to prosper you and not to harm you, plans for hope and a future"   Jer 29:11
    "All things work together for good to them that love God, who are the called according to His purpose"  Rom 8:28
    "I am not ashamed of the gospel of Christ, for it is the power of salvation unto all who believe"  Rom 1:16
  • jmorta04 said:

    Thanks ladies! Am I correct that I am drawing up with the 18 gauge and injecting with the 22? I don't go to meet with my nurse to get the lesson until after my U/S on the 19th.

    Yes. Do not inject w the smaller needle. It hurts like a bitch.

    IVF, acupuncture, meditation and a miracle. 

    image

     Our sweet Valentine's Day FET.

    image


  • ccam said:

    Numbing cream?!  What the eff.... everyone should be given that!!



    @ccam no kidding!!!!!! No one offered me that  :((

    It worked like a charm for the needle itself. That said, it still hurt after once I was covered in lumps and bruises but I would highly recommend the cream! I don't remember the name of it but it was a prescription. I am sorry you didn't get it!!!

    Me 36/DH 46 Me: Low AMH (.21) DOR, mild endo; Started seeing RE 11/12
    Jan-March '13 3 IUIs Clomid + Trigger = BFN
    April '13 IVF 1 MDLF converted to 4th IUI due to 3 runaway follicles! BFN
    July/Aug '13 IVF 1.2 Long Lupron = 7R, 6F, 2T= BFP!!!
    Beta 1=512, Beta 2=1,368 Beta 3= 4,128
    It's a boy!!!!
    SUA, GD
    EDD 4/26/14

    He's Here! Arrived 4/15/14!!!!

    September 2015 - FET with remaining embryos
    Twins! EDD: 6/14/15

    PAIF/SAIF Everyone welcome!
  • I echo everything @ccam said to a tee!
    Honestly I had no issues with PIO. I really didn't mind it and next time around would choose to stay on it rather than switch to crinone (I haaaaated crinone).

    Good luck. You got this!


    "I won't give up on us, even if the skies get rough, I'm giving you all my love, I"m still looking up."
    TTC #1 since August 2011 MFI Diagnosis - April 2012
    IVF #1 - July 2012 - Stims start 7/2, ER 7/12, 20 retrieved, 16 mature, 13 fertilized!
    ET - 7/17 - 1 blast transferred. Beta - 7/26 273, Beta 2 7/30 - 1143. Beta 3 8/6 - 11,597
    12/25 - Santa tells us "IT'S A GIRL!" EDD - April 4th

    Our Little Easter Bunny has arrived!

    Molly Mildred born 03/31/13


    TTC A Sibling....... FET #1 11/14/14, Transferred one beautiful blast

    Remaining four frosties arrested due to "embryologist error"

    Plllllleasssee stick little icicle.....Beta 11/23...BFN

    Starting ALL over with a fresh IVF cycle

    Stims start 11/28/14, ER December 10th, 13 eggs retrieved, 11 mature, only 4 fertilized 

    1 Blast Transferred on December 15th..... Beta Christmas Eve... Please Santa, bring me a baby!

    Beta #1 345.....Beta #2....750/ First U/S 1/13/15/HB 131....EDD 9/2/2015

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