Trouble TTC

Double vs Single insemination for IUI

I'm sure this has been discussed here before but I haven't seen it - curious if your RE's have double insemination as part of their protocol or if they just do a single?  Last cycle I did a double insemination (on 2 consecutive days).  My RE said "There's some research that shows it could increase your chances by ensuring we nail the timing but many specialists don't advocate it because studies haven't shown a huge difference.  It's a personal decision on whether you'd like to try it."  Obviously that cycle didn't work.  But I'm just thinking ahead and wondering if I should continue to go for the double insemination or if that's overkill and I should just do single.  This cycle we will only be able to do single because DH is leaving to go out of town early tomorrow AM.  
**Formerly EastBayBride508**

Me 34   Him 33

Me - Left salpingo-oophorectomy at 19 due to large cyst/torsion  and 2 large uterine fibroids found at age 30
Him - Borderline low sperm count (correcting through Fertility Blend supplement)

Married 8/20/2011
TTC #1 since Jan 2013
First appointment with RE 10/2013.  
April 2014 - Clomid 100mg CD3-7.  HCG shot CD10 IUI #1 done on 4/12/14 (CD12) ....BFN
May 2014 - Break cycle to repeat saline sonogram and re-group.  Travel to Kauai 5/7-5/12 (Yay!!)
June 2014 - Clomid 150mg CD4-8.  HCG shot CD14.  IUI#2 done on 6/9 and 6/10 (CD15-16) w/ Prometrium suppositories during TWW .... BFN
July 2014 - Clomid 150mg CD3-7.  Ultrasound CD12 - 4 mature follies! HCG trigger shot CD12 AM.  IUI#3 on CD13 w/ Prometrium suppositories during TWW ....BFN
July 2014 - Repeat ultrasound done to measure size of fibroid - 8x9cm (the size of a grapefruit!) Surgery referral made.
August 2014 - MRI done which revealed 2 fibroids: a 13x15cm fibroid as well as an 8x7cm one.  Super freak out mode over surgery plan.  OB-GYN/surgeon said surgery would most likely have to be a laparotomy (open abdominal surgery)
August 2014 - After a 2nd opinion, plan to take Lupron x 2 months to shrink fibroids then laparoscopic/robotic myomectomy.  Surgery date is set for Nov 21st!  
November 2014 - Robotic myomectomy done (2 large fibroids removed, mild endo found).  Benched x 3 months

PAIF/SAIF welcome

Re: Double vs Single insemination for IUI

  • Single, but we were using donor sperm, so double would get expensive.

    Official diagnosis: Unexplained IF. I am 32. I have low ovarian reserve (low AMH), and poor egg quality. I've also been diagnosed with mild glandular developmental arrest (lining problems, detected with EFT).

    We are using open ID donor sperm. IUIs #1-7=BFN. IVF September 2014 antagonist protocol, 8R,5M,3F, 5 day transfer of 1 morula = BFN. IVF#2 planned for January 2015 (antagonist protocol + HGH).

    Image and video hosting by TinyPic image

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  • I have done 2 IUI's with B2B insems, BFN's!! This time I only did one insem, just because of the timing and office hours. At first the office wanted me to trigger, do TI, then come in for an insem, but I said no, I prefer to just come in for the one insem then do TI the next night. (Reason being DH's numbers always seem to tank from one collection to the next)...I am hoping this new routine is successful!  I really don't think one or two statistically makes a difference. If you can afford it and like peace of mind, go for the B2B! If not, no worries, the best and the brightest are going in, and it only takes one!

    ME:      36, on BC since 1996,  irregular periods.   HUBS:      37, healthy

    2001—meet.  2005—marry.  2006—Furbaby is born. 

    On BC till end of 2009.  2010 NTNP.   

    New Year’s Eve 2010—BFP?! January 13, 2011—early loss, HCG peaked at 324, no D&C needed.

    +++++

    Feb 2011-Nov 2012—NTNP 

    Dec 2012 --present (TTC 20 months) Not even a hint of a BFP

    Me:  BW, U/S, HSG, HSN normal.  AMH 2.33.  Hubs: SA normal 

    +++++

    April 2014--IUI #1 Clomid 100 4-8 Follistim 150 9-14, 5 mature follies at trigger, Peak E2 5/5 1100, BFN 

    May 2014 ---IUI#2 Clomid 100 3-7 Follistim 150 8-13, 3 mature follies at trigger, Peak E2 6/6 547, BFN

    June 2014--IUI#3 Follistim 150/225 3-15, 3-5 mature follies at trigger, Peak E2 7/11 1450, BFN

    July 2014--IUI#4 Follistim 225 2-12, 3 mature follies at trigger, Peak E2 8/12 841, BFN

    Breaking till after Christmas, then IVF...taking 4000 mgs daily Inositol and Melatonin 3mg


  • We only do single, but we are MFI, so the 2nd sample would probably be awful!

    image

    Me: (30) HSG/Bloodwork/Ultrasound: All looks good

    DH: (30): MFI

     IUIs #1-4 = BFN


    IVF #1 December January


    **********************All Welcome**********************

    January 3T Siggy

    image


  • My clinic does two B2B IUI's normally.  They said they believe it gives you a slightly better chance.  I only did one on our first medicated cycle due to timing issues. 

    Me (29): Hashimoto's, CD3/7DPO bloodwork & ultrasound normal, HSG & SHG(x2) all clear
    DH (29): SA Perfect
    TTC Since Jan '13, First RE Appt Jan '14
    DX: Unspecified Ovarian Dysfunction, Long Cycles
    May '13 BFP, C/P 4w3d
    Apr '14:  50mg clomid + ovidrel + B2B IUI #1=BFP,  Natural M/C 6.5wks
    Aug '14: 50mg clomid + ovidrel + B2B IUI #2=BFN
    Oct '14: 100mg clomid + ovidrel + IUI#3 =BFN
    Nov 14: 100mg clomid + ovidrel + B2B IUI#4=slow response, bad lining, cancelled
    FU with RE, more bloodwork: Anticardiolipin +
    Dec 14: 5mg Letrozole+baby aspirin +ovidrel + B2B IUI#4.1=BFFN
    Jan '15: 5mg Letrozole +baby aspirin + ovidrel +B2B IUI #5= BFP!! 
    Beta #1 210  Beta #2 546


  • My RE does 1. Would be curious to ask about 2 though.

    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    January & February: 2 IUIs, BFN
    March:  IUI, ectopic, 2 surgeries with 1 tube removed
    May - July: 3 more IUIs, all BFN, on to IVF
    August: IVF#1, BFN
    September:  FET#1, BFP!!!
    It's a girl!!!
    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    Lilypie Pregnancy tickers
  • Our RE does one the morning after my first OPK. They said I could go with a trigger instead but so far the timing worked fine for me (as confirmed by ultrasound).

    I, too, had heard that back to back IUI has a slightly higher chance (like a percentage point I think), but since we have male factor infertility, and our insurance pays for one each month, I wouldn't really consider back to back.
    January 3T Siggy Challenge - New Year's Resolutions
    image
    imageimage

    Me (29), DH (30) TTC actively 54 55+ cycles | All BFNs
    MFI (low everything) | Endo Stage 1 & Stenotic Cervix (treated) | PCO
    Married - July 2008 | Started TTC - Jan 2009RE Visit #1 - Mar 2014 
    IUI #1 ICI #1 - June | IUI #1.1 Laparoscopy - Aug
    IUIs #1.2, 2, 3 - Sept, Oct, Nov (Letrozole) - BFNs 
    IUI #4 - Dec (Bravelle) | IUI #5 - Dec/Jan (Bravelle) - 5 follies + TI - BFNs
    IUI #5.1 - Jan (Bravelle) Cancelled 
    Planning to start IVF in March!
    ***All Welcome***
  • Our RE did one, but she told us to intercourse after 12 hours to have a little bt of higher chances... we had to wake up at 3am for that! urgh
  • Only one for us (RE never mentioned option of two) then we BD that night and the following day/night.
    ________
    ME: 34, Atypical PCOS (lean, no O without meds) + unexplained; DH: 33, mildly low motility
    09/2012: Start TTC after stopping NuvaRing.  No cycles seemed to occur.
    01/2013 - 05/2013: Tried Provera to "jumpstart" cycles. No luck.
    12/2013-
    01/2014: Clomid 50mg - no big follies, stepped to 100mg; One mature follie, Ovidrel (HCG trigger), IUI #1 completed - BFN
    02/2014: Clomid 100mg;
    One mature follie, Ovidrel trigger, IUI #2 completed, Crinone - BFN
    03/2014: Clomid 100mg -
    no big follies on 1st round, 2nd round prescribed; One mature follie, Ovidrel, IUI #3 completed, Crinone - BFN
    04/2014-05/2014: Letrozole 5mg + Ovidrel HG to prep for IUI #4 switched to TI, Crinone - BFN
    05/2014-06/2014: Letrozole 5mg; one mature follie,
    Ovidrel, IUI #4.1 completed, Crinone - BFN
    07/2014-08/2014: Letrozole 5mg; one mature follie,
    Ovidrel, IUI #5 completed, Crinone - BFN
    09/2014-10/2014: IVF Prep - Insurance requires IUI #6;
    Letrozole 5mg - no big follies 1st round, 2nd round prescribed; IUI #6, Crinone - BFN
    11/2014: "Break" - Letrozole 5mg to cycle before prepping for IVF - successfully O'ed, but BFN
    12/2014: Extending 'break' one more Letrozole-only TI cycle for mental health break - BFN
    01/2015-
    02/2015: Prep for IVF - BCP then Gonal-F, Ganirelex, Novarel trigger;  ER scheduled 2/11!
    http://www.fertilityfriend.com/home/4cf919
    PAIF/SAIF Welcome.
    December 3T Siggy Challenge: Favorite Holiday Movie
    image
  • My RE did one but told us to have sex that night as well. In all our discussions he has never mentioned B2B IUI's.
    Married 07/15/2006 DS # 1&2 born 07/06/2007 TTC# 3 since 10/2013
  • Tiko99Tiko99 member
    My RE does B2B IUI's and so far I have had two cycle with BFN. This cycle I'm going to try TI because I want to get the sperm right before the 36 hour after the trigger. My doctor doesn't due the 36 hours IUI because he restricts IUI's to the morning hours as well. 

    Me: 33, DH: 32

    TTC: 2 years
    Fertility blood tests all normal
    Tilted uterus
    3 day ultrasound 17 follicles
    HSG: 11/13/13- tubes open
    DH SA: SUPER sperm (145 million, 84% motility, 22% morphology)
    All infection disease and immunity blood tests NORMAL

    FIRST IUI May 2014: 100 mg Clomid days 5-9, third ultrasound CD 13 revealed four follicles 27, 24 and 20 and 13mm. Trigger shot May 28 with IUI May 29 and 30 (fingers crossed) - BFN started spotting 11DPO :(

    IUI #2 B2B 6/23 and 6/24, three mature eggs and 130 million sperm! FX this is the month!  BFN 7/8

    3rd cycle benched due to cysts - TI with OPK tests -  BFN

    3rd mediated cycle: Clomid+Trigger+TI  (three follies left side, one on right as usual....what the hell right ovary get it together and produce some damn follicles!) 7DPO progesterone level 43 with NO suppositories YAY for a natural strong ovulation. Beta canceled started spotting 13DPO - Third time is not a CHARM! 14 day cycle WTF! Everything looks normal - RE wants to start injectables next cycle so this cycle I'm benched

    Officially benched until March....but still plan on trying the baking soda douche due to my excessive and thick CM

    JANUARY SIGGY CHALLENGE...This is so me!

    image


    Love this man....he was so before his time in his thoughts and ideas about the world....been obsessed about him lately bringing it back to the early 90s.

    image

    Never thought I would like long hair....

    image

  • Thanks for the feedback ladies.  I did B2B IUI's last month but I'm not convinced it really has any value.  This month we did 1 (and then BD'd that night).  I was just curious how common it was to do B2B.  
    **Formerly EastBayBride508**

    Me 34   Him 33

    Me - Left salpingo-oophorectomy at 19 due to large cyst/torsion  and 2 large uterine fibroids found at age 30
    Him - Borderline low sperm count (correcting through Fertility Blend supplement)

    Married 8/20/2011
    TTC #1 since Jan 2013
    First appointment with RE 10/2013.  
    April 2014 - Clomid 100mg CD3-7.  HCG shot CD10 IUI #1 done on 4/12/14 (CD12) ....BFN
    May 2014 - Break cycle to repeat saline sonogram and re-group.  Travel to Kauai 5/7-5/12 (Yay!!)
    June 2014 - Clomid 150mg CD4-8.  HCG shot CD14.  IUI#2 done on 6/9 and 6/10 (CD15-16) w/ Prometrium suppositories during TWW .... BFN
    July 2014 - Clomid 150mg CD3-7.  Ultrasound CD12 - 4 mature follies! HCG trigger shot CD12 AM.  IUI#3 on CD13 w/ Prometrium suppositories during TWW ....BFN
    July 2014 - Repeat ultrasound done to measure size of fibroid - 8x9cm (the size of a grapefruit!) Surgery referral made.
    August 2014 - MRI done which revealed 2 fibroids: a 13x15cm fibroid as well as an 8x7cm one.  Super freak out mode over surgery plan.  OB-GYN/surgeon said surgery would most likely have to be a laparotomy (open abdominal surgery)
    August 2014 - After a 2nd opinion, plan to take Lupron x 2 months to shrink fibroids then laparoscopic/robotic myomectomy.  Surgery date is set for Nov 21st!  
    November 2014 - Robotic myomectomy done (2 large fibroids removed, mild endo found).  Benched x 3 months

    PAIF/SAIF welcome
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