Talk to me about PIO?

Re: Talk to me about PIO?

• MsAmandaPants member

  July 2014

  I'm sorry. I'm sure that is nerve wracking. I hope that it does the trick quickly.
  
  I don't have any experience myself, but have heard that they can hurt a bit, but that massage and heat can help afterwards to prevent knots from forming and that warming it a bit before injection can lessen the pain. On the upside, with PIO you get to skip the vag irritation and possible spotting that can come with supps.
  
  If you end up getting a prescription to do them at home, there are some recent threads that might help (you may have already seen them). 
  
  https://forums.thebump.com/discussion/comment/82811163
  
  
  

  Me: 36 yo, TTC #1 since Feb. 2012
  BFP #1, 3/12, EDD 11/9/12, MMC 3/27/12, D&C 4/10/12
  
  BFP #2: 11/16/12, EDD 7/25/13, MMC 12/5/12, D&C 12/6/12, Complete molar pregnancy confirmed 2/9/13, benched for 6 months until  August 2013
  
  IUI #1, 8/16/13 Femara + Menopur, 3 mature follicles, BFN

  IUI #2 (back-to-back, 9/12/13 and 9/13/13) Femara + Menopur, four mature follicles, BFFN
  IUI #3, 10/8/13 Femara + Menopur, six mature follicles, BFN
  
  BFP #3, 12/9/2013, while on treatment break, EDD: 8/22/2014  Please stick and grow, LO!
  
  Additional Dx: hypothyroidism, TgAb positive & anti-TPO positive, POR/DOR (2/2013), and suspected endometriosis
  
  ******All AL always welcome******
  

  
  My Ovulation Chart   Fruit

  
  
  

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• uneek1323 member

  July 2014

  Thanks MAP! That link was very helpful. I hadn't seen it before. 

  }Sweet Pea{  }Bug{  }Turkey{  }Anni{  Little
  

     

  ~*~Everyone is welcome~*~
  

   

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• CallaLily30 member

  July 2014

  ***lurking***

  I hope you don't mind me responding even though I'm not PgAL.  I've been on PIO shots for two FET cycles and they did seem scary at first but they aren't too bad.  I usually ice first and then DH runs warm water over the PIO in the syringe.  This helps thin the PIO out so it's not as thick going in.  I usually stand on the opposite leg from the shot side to take all the weight off the muscle the shot is going into.   Afterwards, DH massages the area so the PIO doesn't cause a lump in the muscle.  I usually sit on a heating pad after that for about 10 mins.  We alternate sides to give each side a rest for a day.  I do find my left side is always more sore than my right for some reason.

  I hope this helps!

   

  BFP #1: 1/4/13, EDD 9/8/13, Missed M/C confirmed 2/8/13, Misoprostol

  2013: Three CPs w/ EDDs: EDD 2/10/14, EDD 3/24/14, EDD 6/24/14

  IVF/ICSI #1 (Antagonist) - Jan 2014- 19R, 14M, 11F, 3 penguins (6BB, 4BB, 6BC)  PGD tested- All Normal!

  IVF/ICSI #2 (Antagonist) - Feb 2014 - 23R, 11M, 10F, 1 penguin (3BB) - Another Normal!

  FET #1 - March 26, BFN

  FET #2- Beta #1 (9dp5dt) -332, Beta #2 (11dp5dt) -1027, EDD 1/30/2015, Missed M/C, D&C 6/19/14

  IVF/ICSI #3 (Lupron Down Reg) - Oct 2014 - 38R, 28M, 27F, 20 frozen on day 5, 16 normal penguins!!

  FET#3 - February 1, 2015, Prep begins 1/13

  All Welcome!

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• LifeofCat member

  July 2014

  No advice, just a big ol' (((hug)))

  
  

  
  

  ~All are welcome~

  MC 23/01/2013 natural @ 7 Weeks

  
  

  

  
  

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• footprint member

  July 2014

  I have no advice. But sending big ((hugs)) and all the good vibes I have!

  
  Married August 2003

  
  

  BFP: January 8, 2012

  Due: September 5, 2012

  DS: August 14, 2012

  
  

  BFP: November 5, 2013

  Due: July 11, 2014

  MMC Detected d&c: December 29, 2013 12w5d

  
  

  BFP: June 10, 2014

  Due: February 16, 2015

  
  
  

  

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• Unknown

  July 2014

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• LiaMadi1 member

  July 2014

  Lots of love, lady!!! ((Hugs))

  "Once you are real, you can't become unreal again.  It lasts for always." ~ The Velveteen Rabbit
  
  

  *8.3.13*  mc @ 6-7 weeks {natural mc at 12 weeks}

  *3.14.14*  mc @ 5-6 weeks DnC {blood clotting disorder discovered}

  *8.7.14* mc @ 6 weeks DnC {uterine septum removed March '14)

  *3.17.15* mc @ 7 weeks DnC {genetic testing & meeting with a new RE in Jan '15}
  *8.31.16* mc @ 8 weeks DnC {genetic testing, new medications upon next pregnancy}
  *7.17.16* praying everyday for my rainbow baby {progesterone supplements, blood thinning injections}
  
  

  
  

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• uneek1323 member

  July 2014

  CallaLily30 said:

  ***lurking***

  I hope you don't mind me responding even though I'm not PgAL.  I've been on PIO shots for two FET cycles and they did seem scary at first but they aren't too bad.  I usually ice first and then DH runs warm water over the PIO in the syringe.  This helps thin the PIO out so it's not as thick going in.  I usually stand on the opposite leg from the shot side to take all the weight off the muscle the shot is going into.   Afterwards, DH massages the area so the PIO doesn't cause a lump in the muscle.  I usually sit on a heating pad after that for about 10 mins.  We alternate sides to give each side a rest for a day.  I do find my left side is always more sore than my right for some reason.

  I hope this helps!

  I don't mind one bit if you respond. I appreciate your help and support. Thanks for sharing your experience and tips. It really helps.

  }Sweet Pea{  }Bug{  }Turkey{  }Anni{  Little
  

     

  ~*~Everyone is welcome~*~
  

   

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• MsAmandaPants member

  July 2014

  Good luck with your injection today. I hope it isn't too bad for you. 
  

  Me: 36 yo, TTC #1 since Feb. 2012
  BFP #1, 3/12, EDD 11/9/12, MMC 3/27/12, D&C 4/10/12
  
  BFP #2: 11/16/12, EDD 7/25/13, MMC 12/5/12, D&C 12/6/12, Complete molar pregnancy confirmed 2/9/13, benched for 6 months until  August 2013
  
  IUI #1, 8/16/13 Femara + Menopur, 3 mature follicles, BFN

  IUI #2 (back-to-back, 9/12/13 and 9/13/13) Femara + Menopur, four mature follicles, BFFN
  IUI #3, 10/8/13 Femara + Menopur, six mature follicles, BFN
  
  BFP #3, 12/9/2013, while on treatment break, EDD: 8/22/2014  Please stick and grow, LO!
  
  Additional Dx: hypothyroidism, TgAb positive & anti-TPO positive, POR/DOR (2/2013), and suspected endometriosis
  
  ******All AL always welcome******
  

  
  My Ovulation Chart   Fruit

  
  
  

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• Mom2anAngel2 member

  July 2014

  I have had decreasing progesterone in all 4 of my pregnancies. They were usually between 35-50 at 17dpo and would continue to fall for 3-4 weeks. I usually bottomed out around 13-16. I did injections with my first pregnancy, but ended up having an injection site reaction to one of the preservatives. Since then I have stuck with the suppositories (sometimes twice daily depending on the value). After the 3-4 weeks my progesterone would slowly climb.
  
  I know it is do stressful, but I'm sure that the injections will help boost you numbers for you. Try to hang in there. ((HUGS))

  

   

  
   TTC since 11/2009; Lap/HSG/Hysteroscopy: 5/2011 (endometriosis - removed; endocervical polyp - removed; high pressure in bilateral tubes - cleared)
  
  BFP #1: 8/4/11; DS1 born sleeping on 11/16/11 at 19w1d

  BFP # 2: 5/7/12, EDD 1/10/13, DS2 born 1/4/13

  BFP # 3: 11/8/13, EDD 7/17/14, mmc 10wks

  BFP # 4: 5/16/14, EDD 1/15/15, praying for our 2nd rainbow baby 
  

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• labgrand2012 member

  July 2014

  No advice, just wanted to send you ((hugs))

  BFP #1 1/4/14  |  Diagnosed with Trisomy 13 at 12 weeks 3/6/14  |  MMC 3/21/14  |   D&C 3/24/14

  BFP #2 7/1/14  |  DS born March 2015
  BFP#3 5/22/17 | MC 6/17/17 at 7w3d

  
  

   My Chart

  
  

  
  

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• carlsonbaby2014 member

  July 2014

  Thinking of you today and sending lots of good vibes your way!

  Began trying for a baby January 2012
  BFP 4.25.2013  EDD 1.3.2014  MMC 6.3.2013  D&C 6.19.2013
  BFP 11.3.2013  CP 11.6.2013
  BFP 3.31.2014 EDD 12.10.2014 Baby boy Carlson born 12.19.2014 

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• MrsG80inTN member

  July 2014

  Lurking. no experience, but tons of hugs and love headed your way.

  
  

  Me 35 / DH 36

  TTC since 09/2009

  Hashimoto's diagnosis 11/2011 / Endometriosis removal surgery 04/2013

  Other diagnosis: 1 mutation - PAI-1 gene

  BFP#1 9/27/2013  /  EDD 6/4/14  /  MC 10/17/2013

  BFP#2 3/4/14  /  EDD 11/13/14  /  CP

  BFP#3 6/7/14  / EDD 2/16/15  /  CP

  BFP #4 11/7/2014 / EDD 7/17/15  /  CP

  Current  Plan: Waiting to change RE... Appt on 1/16
  

  RXs: Metformin, Levothyroxin, Baby Aspirin, CoQ10, Vitamin D, Folic Acid, Pre-natal. Progesterone post O.

  My FF Chart

  
  

  
  

  ***Jeremiah 29:11 For I know the plans I have for you, says the Lord, plans to prosper you and not to harm you, plans to give you hope and a future.

  
  

  All Welcome

  
  

  
  

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• chicagojackie member

  July 2014

  I'm on the scary progesterone journey this time too but I'm on oral progesterone. OB says as long as level >15 things should be cool.
  
  With DD my levels fluctuated between 15 to 17 and 18 to 22 depending on the week and the dose and the time of day I had the labs.
  
  It is scary to have the levels fall! Be good to yourself. Hugs.

  BFP #1: It's a GIRL! DD born October, 2012
  BFP #2: m/c at 7w, February, 2014
  BFP #3: It's a BOY! Please be our rainbow! Due February, 2015
  *everyone always welcome*
   
  

        

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• TVLily member

  July 2014

  Sending you lots of love and ((hugs)) as you start PIO today.

  EDD 5/2/14, NMC 9/11/13
  EDD 10/15/14, CP 2/8/14
  IF Diagnosis: PCOS, MFI 

  Current Cycle: 5 mg Femara/1000mg Metformin + TI = BFP, EDD 4/23/15 Please be our RAINBOW

  

  **ALL AL/IF Welcome**
  My Chart
  

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• LilNugget19 member

  July 2014

  ::Lurking::

  
  

  Sending you positive vibes!  ((hugs)), I hope the PIO isn't too bad.

  BFP #1 2/26/14 EDD 11/4/14 MMC 4/1/14 D&C 4/2/14

   BFP #2 5/24/14 EDD 2/3/15 MC 6/12/2014

  
  

  

  
  

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• Amores0121 member

  July 2014

  Don't have any experience with this, but wanted to wish you luck. 

  
  

  BFP #1 ended in MMC. Discovered Oct 2005 @10w5d, baby stopped growing around 6w. D&C.
  BFP#2 Nov 2005. Baby's heart stopped @ 8w3d. D&C Jan 2006. Trisomy 18
  BFP#3 Nov 2006. My "miracle baby" DD born 7/25/07
  BFP #4 11/6/12. EDD 7/16/13~my birthday! No sac found @ 5w1d, betas not increasing. Natural m/c started 11/20/12.

  BFP#5 11/9/13.  EDD 7/21/14  Our beautiful rainbow born on his due date!!

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• luciddreamer106 member

  July 2014

  I don't have any advice, just want to send good vibes. Good luck today!

  

  

   TTC #1 since March 2011 
  

  BFP #1: EDD 4/16/13~~blighted ovum w/ 2 gestational sacs~~Loss on 9/18/12
  BFP #2: EDD 9/3/13~~Slow HB at 1st U/S~~MMC -Loss on 2/13/13

  9/13, 10/13, 1/14: letrozole + trigger + TI = All BFNs

  3/14: IUI#1 letrozole/Bravelle/Menopur + trigger = BFN

  BFP #3: EDD 1/27/15 Please be our rainbow! ...Team Green

  
  

  
  

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• uneek1323 member

  July 2014

  jcar2 said:

  No personal advice.  However a friend of mine had the suppositories until 13 weeks or 16 weeks or something like that and switched to injections.

  
  

  This may not be helpful (sorry if it's not).  She has a nurse that comes once a week to inject, which occurs on her behind.  They switch cheeks each week.  She prefers to have it done on Friday while working from home as it takes up to a minute to actually inject since it's oil based.  She also said she's very sore afterwards for the next day.  She tries massage and a hot pad on the area to help afterwards.

  
  

  Good luck!

  Oh how I would love to have a nurse come to my house. That would be extremely helpful. But since I have to do the inject once a day that's not really an appropriate expectation. Thanks for the tips!

  }Sweet Pea{  }Bug{  }Turkey{  }Anni{  Little
  

     

  ~*~Everyone is welcome~*~
  

   

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• uneek1323 member

  July 2014

  Thank you everyone for your support and advice. I did the first inject in the doctor's office today. I'll be doing them at home once a day from now on - or I should say my husband will be doing them. It's hard to reach around your own ass with a syringe. Next appt and blood draw is Wednesday. Nothing to do but stay on mother humping expensive meds and hang on. (((hugs)))) back to all. 

  }Sweet Pea{  }Bug{  }Turkey{  }Anni{  Little
  

     

  ~*~Everyone is welcome~*~
  

   

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• Eliz77 member

  July 2014

  Just saw this. No advise on the PIO.With my last loss, I was put on HCG IM injections and I just could not stand to let my H do them. I was able to do them myself, but felt I had to contort and I didn't like having to do injections with my left hand when I did the left side. 

  
  

  My progesterone levels never took off-started low (13), climbed up (highest was 27), then back down. Before being released to o/b, level was 16.9 at 7 weeks, then was 23.7 at 9 weeks. I always had blood draws around 7:30-8am and did not eat before, so at least that stayed consistent. I haven't had a draw for p4 since 9 weeks. My RE had said they look for the number to be above 12. 

  
  

  Good luck to you!

  
  

  ~ES~

  
  

  ~*~EVERYONE always welcome!!~*~

  TTC #1 since October 2012

  BFP #1 11/22/12 EDD 7/29/13 MMC 1/14/13, D&C 1/16/13
  BFP #2 5/7/13 EDD 1/14/2014 Ectopic discovered 5/21/13, lost left tube
  Referred to RE, blood work done August 2013, AMH 0.27, all else normal, HSG clear
  

  BFP #3 12/1/13 EDD 8/8/14, MC 12/24/13

  January 2014: RE #2, blood work repeated, homozygous MTHFR c677t, SHG clear

  BFP #4 4/7/14 EDD 12/15/14 Our rainbow was born 12/6/14 at 4:26pm!  

  
  

  
  

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