letrozole rage?

Re: letrozole rage?

• BunnyBerry member

  June 2014

  I just took it this cycle, and I read the side effects can include depression and irritability. I didn't really experience that though - I was on the lookout but ended up feeling pretty good this cycle compared to most. But it definitely messes with hormones.

  January 3T Siggy Challenge - New Year's Resolutions

  
  

  

  
  

  Me (29), DH (30) TTC actively 54 55+ cycles | All BFNs

  MFI (low everything) | Endo Stage 1 & Stenotic Cervix (treated) | PCO

  Married - July 2008 | Started TTC - Jan 2009 | RE Visit #1 - Mar 2014 

  IUI #1 ICI #1 - June | IUI #1.1 Laparoscopy - Aug

  IUIs #1.2, 2, 3 - Sept, Oct, Nov (Letrozole) - BFNs 

  IUI #4 - Dec (Bravelle) | IUI #5 - Dec/Jan (Bravelle) - 5 follies + TI - BFNs

  IUI #5.1 - Jan (Bravelle) Cancelled 

  Planning to start IVF in March!

  ***All Welcome***

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• AngM123 member

  June 2014

  I did one round...before I knew how important it was to be monitored...and I was a sobbing mess throughout. No rage, just sensitive and sad.

  Me:30 DH:30 

  TTC since January 2013 

  Him: Excellent SA

  Me: 2 clear HSG's, perfect 28 day cycle with ovulation, all testing/blood work good

  1/23/14- **Surgery**

  Diagnosis: severe pelvic adhesions from stage 3/4 endo and old ruptured appendix

  RE Recommends IVF due to likely tubal damage

  IVF #1- November 2014 

                   Started stims 11/7. Antagonist Protocol

                   Trigger 11/17, HCG/Lupron

                   ER 11/19   27R/24m/14F

                   ET 11/24   1 little embie 

                   5 frosties!!! 

                   First ever BFP-  12/4 Beta #1: 35  12/8 Beta #2: 9  CP 

  
  

  FET #1- February 2015 

  
  

  
  

  
  

   

  
  

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• jencity9 member

  June 2014

  I don't know about rage but definitely moodiness and irritability.

  
  

  Me: 32  DH: 33  Married: March 2004
  

  
  

  July 2006: started TTC
  2008: HSG (normal), couple rounds of clomid through gyno
  2008 - 2010: dragging my feet out of fear and procrastination
  October 2010: first consultation with RE, dx PCOS and fibroids (DH slightly low count/motility)
  Oct. 2010 - Dec. 2012:  In DENIAL! avoided the issue because I was scared of surgery
  January 2013: returned to RE, fibroids grew significantly
  February 2013: second HSG, fibroids pushed on tubes which blocked them somewhat
  March 2013: MRI to determine what type of surgery may be necessary
  July 29, 2013: fibroids (5) removed via robotic laparascopy
  August 2013 - Nov 2013 : benched due to recent surgery
  

  
  

  IUI #1, Dec. 24, 2013, BFN 
  

  IUI #2, Jan. 25, 2014, BFN
  IUI #3, Feb. 25, 2014  BFN
  IUI #4 canceled due to lack of response to letrozole
  IUI #4.1 April 28, 2014, BFN
  May 16, 2014: wtf consult, start prepping for IVF in June and add injects for one last IUI in the meantime
  IUI #5 started letrozole and bravelle but canceled after HSG led to new diagnosis
  May 21, 2014: third HSG, tubes blocked, one at the beginning, one hydrosalpinx??
  

  June 11, 2014: consult, approved to move on to IVF because the hydro is not completely blocked therefore allowing fluid to move through slowly rather than backwards
  IVF #1 August 8, 2014 - 3dt of 2 embryos, BFN
  September 17, 2014 - 4th HSG, the right tube is very patent (open!!) dye went straight through this time. Weird!
  October 2, 2014 - started metformin treatment
  November 14, 2014 - blood work, brought A1C down from 5.8 to 5.5
  November 26, 2014 - RE finally back from vaca and reviewed my chart, no more IVFs for rest of calendar year
  December 1, 2014 - Right after Thanksgiving, I called a new clinic and got in right away! Plan for IVF
  December 17, 2014 - ER! 29 retrieved (!!), 16 mature, all 16 fertilized (ICSI)
  IVF #2 December 20, 2014 - 3dt of 3 embryos, BFN
  

  
  We are done with treatment unsuccessfully.
  
  

  
  

  PAIF/SAIF/All Welcome!
  
     
  

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• StacyLH24 member

  June 2014

  I had one little incident of rage during my third cycle on it. It came out of nowhere and was brief.

  Me: 30  DW (aka C): 29

  Together since 2/15/11 ~ Legally married in NY on 9/29/12

  ***CP mentioned***

  We've been working on baby #1 since July 2013 using Open ID donor sperm.  8 IUI attempts with 5 actual IUIs and one chemical pregnancy.  We have one fresh IVF cycle under our belts as well as a FET.  I have endometriosis and a uterine septum that was corrected via surgery in November 2013. 

  11/14/14 -  Second HSG shows that tubes are still clear and ute is looking good. 

  12/6/14 - Started BCPs in prep for IVF #2

  12/22/14 - Saline u/s and endometrial scratch (All was clear and OUCH!)

  1/2/15 - Began stimming for IVF #2

   ****All Welcome!****

  We are Mommas to four fur babies - 3 dogs and 1 cat.

     
  

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• tweetyknicks member

  June 2014

  I actually wasn't too moody on letrozole. Clomid was much worse.

  Click here for a great blog that explains things that many of you are confused and wondering about. Just check it out.

  
  

  
  

  ***siggy warning***
  

  
  

  Me: 29; DH: 53

  TTC since February 2013 --- mild thin PCOS (or not, depending on which RE you ask), MFI

  
  

  TI#1: BFN (April 2014; Clomid 50mg x5 days, Estrace x5 days, Clomid 50 mg x4 days)

  IUI#1: c/p (May 2014; Letrozole 2.5 mg x5 days, Estrace x5 days, Bravelle 75 IU x10 days)

  IUI#2: abandoned... O'd early & DH hormone issues (June 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x2 days)

  IUI#2.1: BFN (July 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x4 days)

  
  

  Moving on to IVF. (Why we're moving on to IVF)

  
  

  IVF#1 (w/ICSI): BCP 9/9-9/23. Gonal-F, Ganirelix, Low-dose HCG (antagonist protocol). 41R/35M/32F... 2 transferred on 10/14, 14 frosties! On cabergoline to help avoid OHSS. BFN, possibly because of 90% drop in estrogen and progesterone a few days after ET.
  

  FET#1: Transferring 2 on January 8. BFP! beta#1 (1/17): 408, beta#2 (1/20): 1310, first u/s scheduled 2/5

  
  

    

       

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• horeill member

  June 2014

  I just finished a second cycle of Clomid and it was horrible. Moving into letrozole after I start with the RE. Been dealing with gyn so far. She told me letrozole has less side effects but I need to be monitored closely which is why only the RE will prescribe it. I'm sorry to hear it's effecting you so. Hopefully it works for you though!

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• juneroses member

  June 2014

  Thanks everyone for sharing... It seems to be getting better. I did not have moodiness & irritability listed as side affects, so I was wondering if it was just me.

  Me (33), PCOS. Bloodwork normal, AMH slightly high, HSG clear 

  DH (40) SA good 

  Trying since 1/2012, RE 6/2014 

  Letrozole & TI June 2014-September 2014 -BFN

  October 2014 - IUI #1, lertozole - BFN

  November 2014 - IUI cancelled due to holiday, TI & Lertozole - BFN

  December 2014 - TI 

  January 2015 - IUI #2 - ?

  
  

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• xlittlerosebudx member

  June 2014

  I didn't have any side effects on Clomid or Femara....it's the progesterone that kills me every time.  That stuff makes me cry constantly.  I hate it!

  Me: 30 yrs (PCOS), DH: 28 yrs (SA normal)
  June 19, 2008: Started dating
  August 12, 2012: Got married
  September 2012: Came off BC pills after 12 yrs
  September 2012-May 2013: Irregular periods (every 45-55 days), no positives on OPKs, used fertility friend
  May 2013: Started actively TTC, talked to OB about irregular periods and possible anovulation
  October 2013: HSG all clear, hormone levels normal, U/S showed polycystic ovaries, PCOS diagnosis
  February 2014: Clomid 50mg days 4-8, many follicles on CD14 but none bigger than 8mm
  March 2014: Switched to RE, saline u/s all clear
  April 2014: 3hr glucose showed IR, started on Metformin 1000mg/day, put on low-carb low-sugar diet
  June 2014: Femara 2.5mg x10 on CD3, 19mm follicle on CD17, Ovidrel, TI, Endometrin suppositories = BFP!!!

  Our little one due March 11, 2015

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