Trouble TTC

(BFP/loss mentioned) That was quick and slow

I'm back here after a very short stint in 1st tri and a very early chemical pregnancy. I'm not sure if I should even consider it a loss because my beta only reached 22, not even the 25 that is the minimum for a definitively positive blood pregnancy test. And people always say you can't be "just a little pregnant!" I beg to differ.

For anyone looking this up: My beta was 7.4 at 12 dpiui, 22 at 15 dpiui, and back down to 5.4 17 dpiui. Progesterone was 16.7 ng/mL, ~20 ng/mL, and 16.7 ng/mL for the same days. In the mean time, I had spotting start 13 dpiui and heavy bleeding with clots the night of 14dpiui night 15 dpiui. The doc recommended that I double prometrium to 2x200mg daily. I did that for the last two nights and the bleeding slowed to a trickle.

I'm not too broken up about it because this was the most likely outcome with low and slowly rising betas and this is my first IUI (second medicated cycle). Actually, I'm relieved that we got to fertilization and it didn't end up ectopic. I'll take that as a good sign for the next round.

I have a follow-up lab scheduled in two days (19 dpiui/cd ?) to make sure my beta is back below 2. They're also going to check progesterone and estrogen and do an u/s to see if I'm back to baseline and ready for another round of meds. I hope so!

Anyone have a similar experience? How'd your ensuing cycles go?


***siggy warning***

Me: 29; DH: 53
TTC since February 2013 --- mild thin PCOS (or not, depending on which RE you ask), MFI

TI#1: BFN (April 2014; Clomid 50mg x5 days, Estrace x5 days, Clomid 50 mg x4 days)
IUI#1: c/p (May 2014; Letrozole 2.5 mg x5 days, Estrace x5 days, Bravelle 75 IU x10 days)
IUI#2: abandoned... O'd early & DH hormone issues (June 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x2 days)
IUI#2.1: BFN (July 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x4 days)

Moving on to IVF. (Why we're moving on to IVF)

IVF#1 (w/ICSI): BCP 9/9-9/23. Gonal-F, Ganirelix, Low-dose HCG (antagonist protocol). 41R/35M/32F... 2 transferred on 10/14, 14 frosties! On cabergoline to help avoid OHSS. BFN, possibly because of 90% drop in estrogen and progesterone a few days after ET.
FET#1: Transferring 2 on January 8. BFP! beta#1 (1/17): 408, beta#2 (1/20): 1310, first u/s scheduled 2/5

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Re: (BFP/loss mentioned) That was quick and slow

  • I don't have a similar experience but wanted to say I'm sorry for the loss. Fingers crossed for a better next round!
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  • I'm sorry for your loss

    Missed M/C natural cycle 10/2013

    DX PCOS 3/2014

    2 cycles Clomid 50 mg + Ovidrel + TI

    1 cycle Clomid 50 mg + TI - no response stair-stepped to Clomid 75 mg + Ovidrel + TI

    1 cycle Clomid 50 mg + Ovidrel + IUI

    1 cycle Letrozole 7.5 mg + 150 mg Follistim + Ovidrel + TI

    1 cycle Letrozole 7.5 mg + 150 mg Folistim + Ovidrel + IUI

    1 cycle Letrozole 7.5 mg + 150 mg Follistim  - no response, repeated Letrozole 7.5 mg + 150 mg Follistim + Ovidrel + IUI = success! 12/2014

    Beta 1 - 15 dpiui, 324, Beta 2 - 17 dpiui 750. Twins!!

    My Blog: pcosandpizza.blogspot.com


  • I'm sorry for your loss.

    My last mc my beta was 8 and they said over 5 was positive. I had to go back a few days later for a blood test to make sure it was going back below 5, so we could start a new cycle. I wasn't able to cycle right away because I had 2 cyst. I got on bcp for 2 weeks and they went away and I started another cycle. We knew I was miscarrying because it was full on period at that point. My other 3 miscarriages were with my ob and he never checked my beta's down then again 2 I had a D&C's.

    Fucking bump!!!!
  • I don't have any experience, I just wanted to say sorry. 
    **siggy warning**  **everyone welcome**

    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    DS- 11.07.02
    DSS- 6.26.04
    Married- 6.29.13
    TTC Again- Sept. 2013
    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    Test Results/Diagnosis- HSG & SA totally normal
    DX: 3/2014 Prolactinoma/Hyperprolactinemia- Started cabergoline 2/2014
    5/2014 Possible mild PCOS in addition to hyperprolactinemia??
    7/2014 Adding probable tubal factor to the diagnosis list
    9/2014 And now adding hypothyroid to the list- Started synthroid 9/2014
    Cycles 1-4 - Sept.-March- All Anovulatory 
    IUI #1 March/April-  Clomid 50mg + Clomid 100mg +Trigger + IUI #1 = BFN
     IUI #2 April/May-Clomid 100mg + Clomid 150mg + Trigger + IUI #2 + Endometrin=BFN
    IUI #3- June- Follistim 75iu + Trigger + IUI #3  Benched due to a 40 mm cyst. :-(
    IUI #3- July- Follistim 75iu + Trigger + IUI #3 + Endometrin = BFP! on 7/25/14
    Slowly rising betas - Ectopic suspected on 8/8/14 & confirmed on 8/11/14
    Methotrexate on 8/12/14 -HCG negative on 9/2/14
    IVF #1- November- Antagonist protocol: 11/1: start stims, 200iu of Follistim; 11/12 ER 17R/14M/14F; 11/17 5 day transfer of two blasts, 2 blasts and 2 expanding morulas frozen; 11/22 BFP!! (On FRER at 5dp5dt)
    Betas: 9dp5dt 205, 11dp5dt 497, 14dp5dt 1,709
    u/s at 5w0d- 1 sac; u/s at 6w0d 1 baby with heartbeat, another sac without a heartbeat
    image


  • I'm sorry about this tough experience you've had to go through. I'm glad it gives you more hope for next time! :) 
    January 3T Siggy Challenge - New Year's Resolutions
    image
    imageimage

    Me (29), DH (30) TTC actively 54 55+ cycles | All BFNs
    MFI (low everything) | Endo Stage 1 & Stenotic Cervix (treated) | PCO
    Married - July 2008 | Started TTC - Jan 2009RE Visit #1 - Mar 2014 
    IUI #1 ICI #1 - June | IUI #1.1 Laparoscopy - Aug
    IUIs #1.2, 2, 3 - Sept, Oct, Nov (Letrozole) - BFNs 
    IUI #4 - Dec (Bravelle) | IUI #5 - Dec/Jan (Bravelle) - 5 follies + TI - BFNs
    IUI #5.1 - Jan (Bravelle) Cancelled 
    Planning to start IVF in March!
    ***All Welcome***
  • I'm so sorry for your loss. I don't have any advice, but best of luck to you.
    Love 2010 | Marriage 2011 | TTC #1 since 2012
    PCOS | Anovulatory | Metformin + Letrozole
  • I, too, don't have any advice - but wanted to say that I'm so sorry that it didn't work out.  Good luck with your next round!
    ________
    ME: 34, Atypical PCOS (lean, no O without meds) + unexplained; DH: 33, mildly low motility
    09/2012: Start TTC after stopping NuvaRing.  No cycles seemed to occur.
    01/2013 - 05/2013: Tried Provera to "jumpstart" cycles. No luck.
    12/2013-
    01/2014: Clomid 50mg - no big follies, stepped to 100mg; One mature follie, Ovidrel (HCG trigger), IUI #1 completed - BFN
    02/2014: Clomid 100mg;
    One mature follie, Ovidrel trigger, IUI #2 completed, Crinone - BFN
    03/2014: Clomid 100mg -
    no big follies on 1st round, 2nd round prescribed; One mature follie, Ovidrel, IUI #3 completed, Crinone - BFN
    04/2014-05/2014: Letrozole 5mg + Ovidrel HG to prep for IUI #4 switched to TI, Crinone - BFN
    05/2014-06/2014: Letrozole 5mg; one mature follie,
    Ovidrel, IUI #4.1 completed, Crinone - BFN
    07/2014-08/2014: Letrozole 5mg; one mature follie,
    Ovidrel, IUI #5 completed, Crinone - BFN
    09/2014-10/2014: IVF Prep - Insurance requires IUI #6;
    Letrozole 5mg - no big follies 1st round, 2nd round prescribed; IUI #6, Crinone - BFN
    11/2014: "Break" - Letrozole 5mg to cycle before prepping for IVF - successfully O'ed, but BFN
    12/2014: Extending 'break' one more Letrozole-only TI cycle for mental health break - BFN
    01/2015-
    02/2015: Prep for IVF - BCP then Gonal-F, Ganirelex, Novarel trigger;  ER scheduled 2/11!
    http://www.fertilityfriend.com/home/4cf919
    PAIF/SAIF Welcome.
    December 3T Siggy Challenge: Favorite Holiday Movie
    image
  • Thank you for all your positive comments.

    If you or anyone you know has gone through a chemical pregnancy or 1st trimester miscarriage and is scientifically minded, this may be of interest: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712881/

    I would hazard a guess that the assisted reproduction population is the only one in which very early miscarriages/chemical pregnancies are regularly identified, so these results may be more generally applicable. (Note: I am not a medical scientist.)


    ***siggy warning***

    Me: 29; DH: 53
    TTC since February 2013 --- mild thin PCOS (or not, depending on which RE you ask), MFI

    TI#1: BFN (April 2014; Clomid 50mg x5 days, Estrace x5 days, Clomid 50 mg x4 days)
    IUI#1: c/p (May 2014; Letrozole 2.5 mg x5 days, Estrace x5 days, Bravelle 75 IU x10 days)
    IUI#2: abandoned... O'd early & DH hormone issues (June 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x2 days)
    IUI#2.1: BFN (July 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x4 days)

    Moving on to IVF. (Why we're moving on to IVF)

    IVF#1 (w/ICSI): BCP 9/9-9/23. Gonal-F, Ganirelix, Low-dose HCG (antagonist protocol). 41R/35M/32F... 2 transferred on 10/14, 14 frosties! On cabergoline to help avoid OHSS. BFN, possibly because of 90% drop in estrogen and progesterone a few days after ET.
    FET#1: Transferring 2 on January 8. BFP! beta#1 (1/17): 408, beta#2 (1/20): 1310, first u/s scheduled 2/5

     image 
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  • KT416KT416 member

    I'm really sorry for your loss.

    Me: 29, DH: 30

    Married: April, 2011; TTC: July, 2012

    Dx: MFI; June '14 IVF w/ ICSI: 11R, 8M, 5F... 1 5dt, beta #1: 213, beta #2: 621, beta #3: 8545!



    BabyFruit Ticker
  • I am very sorry for you loss. I know that is hard. Yes, it does seem that a lot of women who are going to ART have chemical pregnancies. However, I know lots of women who have not had any help suffer multiple chemical pregnancies. I have suffered a first tri loss, but it was ectopic. I am not much help in a chemical pregnancy sense. I do know that since my loss, my body has gone backwards. I hope that your betas falls quickly, and that you are able to start your meds again. ((Hugs)) hun. 
    Multiple TTCAL 1IF 3
    imageimage
    DX: stage 2 Endo 2012, PCOS 7/2/14,  HSG 6/11/14, Lefty open!!
    BFP#1, EDD: 4/27/14, Missed EP confirmed: 9/23/13, R tube removal: 9/25/13 
    Clomid/TI #1=BFN, 
    Clomid/TI#2=BFN, Clomid/TI #3=CP
    BFP #2 CP, EDD 7/12/15
    On a treatment break: 2 natural cycles. Saving money, sigh*

    Goodbye my sweet babies. We miss you so much
    All Welcome


  • I am very sorry for your loss.  Best of luck in your next cycle.
    image
    Me:36 DH:40
    Married since May, 2012; TTC since September, 2012
    DX: Blocked Fallopian Tube, Hashimoto's
    March 2014 - Clomid, Trigger, TI = BFN, April 2014 - Clomid, Trigger, TI = BFN, May 2014 - Clomid, estrogen, trigger, IUI = BFN, June & July 2014 - Natural cycles = BFN, August 2014 - Femara, estrogen, trigger, IUI = BFN, September 2014 - Femara, estrogen, trigger, IUI = BFN
    Prepping for IVF in with ER/ET slated for early February


  • I'm so sorry for your loss...
  • So sorry for your loss. I had a CP on my last cycle and totally understand why you feel there was some progress. Hope your next cycle is stickier.

    Official diagnosis: Unexplained IF. I am 32. I have low ovarian reserve (low AMH), and poor egg quality. I've also been diagnosed with mild glandular developmental arrest (lining problems, detected with EFT).

    We are using open ID donor sperm. IUIs #1-7=BFN. IVF September 2014 antagonist protocol, 8R,5M,3F, 5 day transfer of 1 morula = BFN. IVF#2 planned for January 2015 (antagonist protocol + HGH).

    Image and video hosting by TinyPic image

  • @tweetynicks - I'm so sorry for your loss!  But I want to second what other ladies have said.  I really admire your attitude towards the situation and seeing the positive in it (that you know you got to fertilization - which is a good sign really!).  Best of luck to you in starting your next round soon and having a better outcome next time.  Hugs.  
    **Formerly EastBayBride508**

    Me 34   Him 33

    Me - Left salpingo-oophorectomy at 19 due to large cyst/torsion  and 2 large uterine fibroids found at age 30
    Him - Borderline low sperm count (correcting through Fertility Blend supplement)

    Married 8/20/2011
    TTC #1 since Jan 2013
    First appointment with RE 10/2013.  
    April 2014 - Clomid 100mg CD3-7.  HCG shot CD10 IUI #1 done on 4/12/14 (CD12) ....BFN
    May 2014 - Break cycle to repeat saline sonogram and re-group.  Travel to Kauai 5/7-5/12 (Yay!!)
    June 2014 - Clomid 150mg CD4-8.  HCG shot CD14.  IUI#2 done on 6/9 and 6/10 (CD15-16) w/ Prometrium suppositories during TWW .... BFN
    July 2014 - Clomid 150mg CD3-7.  Ultrasound CD12 - 4 mature follies! HCG trigger shot CD12 AM.  IUI#3 on CD13 w/ Prometrium suppositories during TWW ....BFN
    July 2014 - Repeat ultrasound done to measure size of fibroid - 8x9cm (the size of a grapefruit!) Surgery referral made.
    August 2014 - MRI done which revealed 2 fibroids: a 13x15cm fibroid as well as an 8x7cm one.  Super freak out mode over surgery plan.  OB-GYN/surgeon said surgery would most likely have to be a laparotomy (open abdominal surgery)
    August 2014 - After a 2nd opinion, plan to take Lupron x 2 months to shrink fibroids then laparoscopic/robotic myomectomy.  Surgery date is set for Nov 21st!  
    November 2014 - Robotic myomectomy done (2 large fibroids removed, mild endo found).  Benched x 3 months

    PAIF/SAIF welcome
  • I'm so sorry for your loss.  I admire so much your positive thinking...when I experienced my loss it was such a struggle for me to get back to that mindset. ((hugs))
  • @KristenG2011: I probably won't take it as gracefully if it happens another time or two. For now, I'll enjoy not being upset.


    ***siggy warning***

    Me: 29; DH: 53
    TTC since February 2013 --- mild thin PCOS (or not, depending on which RE you ask), MFI

    TI#1: BFN (April 2014; Clomid 50mg x5 days, Estrace x5 days, Clomid 50 mg x4 days)
    IUI#1: c/p (May 2014; Letrozole 2.5 mg x5 days, Estrace x5 days, Bravelle 75 IU x10 days)
    IUI#2: abandoned... O'd early & DH hormone issues (June 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x2 days)
    IUI#2.1: BFN (July 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x4 days)

    Moving on to IVF. (Why we're moving on to IVF)

    IVF#1 (w/ICSI): BCP 9/9-9/23. Gonal-F, Ganirelix, Low-dose HCG (antagonist protocol). 41R/35M/32F... 2 transferred on 10/14, 14 frosties! On cabergoline to help avoid OHSS. BFN, possibly because of 90% drop in estrogen and progesterone a few days after ET.
    FET#1: Transferring 2 on January 8. BFP! beta#1 (1/17): 408, beta#2 (1/20): 1310, first u/s scheduled 2/5

     image 
     image    image
  • rubysirubysi member
    I am sorry for your loss.

    image
                ***TTCAL January siggy challenge ***
  • Aaaand, we're back to quick again.

    I went in to re-check HCG and progesterone and get a baseline for lining and estradiol. Baselines for everything look fine except progesterone is still elevated from the supplements (takes ~5 days for it to leave system completely). Nurse wasn't quite sure what the doc would want to do...

    Turns out I get to start my next treatment round tonight! Letrozole (aka Femara) for 5 days, then check-up u/s and possibly a few days of Bravelle (FSH) injects.

    And I got a big, new monitor at work today so I don't have to use my 15" laptop screen.

    And DH and I are going out for sushi and sake for date night tonight because I can.

    Today is a good day!

    I hope nothing blows up...


    ***siggy warning***

    Me: 29; DH: 53
    TTC since February 2013 --- mild thin PCOS (or not, depending on which RE you ask), MFI

    TI#1: BFN (April 2014; Clomid 50mg x5 days, Estrace x5 days, Clomid 50 mg x4 days)
    IUI#1: c/p (May 2014; Letrozole 2.5 mg x5 days, Estrace x5 days, Bravelle 75 IU x10 days)
    IUI#2: abandoned... O'd early & DH hormone issues (June 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x2 days)
    IUI#2.1: BFN (July 2014; Letrozole 2.5 mg x5 days, Bravelle 75 IU x4 days)

    Moving on to IVF. (Why we're moving on to IVF)

    IVF#1 (w/ICSI): BCP 9/9-9/23. Gonal-F, Ganirelix, Low-dose HCG (antagonist protocol). 41R/35M/32F... 2 transferred on 10/14, 14 frosties! On cabergoline to help avoid OHSS. BFN, possibly because of 90% drop in estrogen and progesterone a few days after ET.
    FET#1: Transferring 2 on January 8. BFP! beta#1 (1/17): 408, beta#2 (1/20): 1310, first u/s scheduled 2/5

     image 
     image    image
  • So sorry.  My CP was somewhere in the teens and SG counted it as a positive.  Waiting for the beta levels to drop was very frustrating but I was able to begin again fairly soon afterwards.

    Ready to take the road less traveled. 
  • BlueJell0BlueJell0 member
    edited June 2014
    I'm so sorry for your loss. :(

    I have also been there. My first loss was a CP. I didn't have a beta until I started bleeding, but it got high enough to turn a digital positive (so like 40-50? I'm not sure). My beta was 8 the day after I started bleeding, and <2 two days later. 

    My cycles went back to normal right away after my CP.

    Good luck to you!

    ETA: Thank you for that article. I am scientifically minded and I found it interesting.
    Image and video hosting by TinyPic
    Me:35, blocked left tube, RPL, AMA  DH: 34, low morph & borderline count
    TTC since 8/2012
    1st ever BFP 11/4/13 - CP 11/6 @ 4w4d
    12/2013: 50 mg Clomid + trigger + IUI TI + progesterone = BFN (all follies on left side)
    1/2014: 50 mg Clomid + trigger + IUI #1 + progesterone = BFP!
    Beta #1 14 dpIUI = 51 Beta #2 16 dpIUI = 144 Beta #3 19 dpIUI = 354
    U/S @ 6w1d = empty gestational sac. Heartbroken :( D&C 2/22/14
    ~Mental Health Break~
    6/2014: Clomid + ASA 81 mg + trigger + IUI #2 + progesterone = BFN
    7/2014: Clomid + ASA + trigger + IUI #3 + progesterone = CP
    ~Mental Health Break #2~
    1/2015: IVF #1 - please be our rainbow baby!
    image
  • I'm so sorry this happened...but like you said there is a silver lining at least you know you got that far...fx for a good cycle this time
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