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Progesterone supplement

wanderlust508wanderlust508 member
in Trouble TTC
Hi ladies,

So I'm doing my 2nd round of IUI (double insemination this time). I went in for the first insemination today, returning tomorrow. I was told to start progesterone capsules (vaginally) twice daily beginning this Fri.

My first thought "Oh no, yuck!" Because I've read so many posts from you ladies talking about how awful they are. I'm dreading the side effects. But on the other hand I'm grateful that we are doing everything we can to make this happen. So ...are they really that bad? What can I expect (or rather what have you all felt while on them?).
**Formerly EastBayBride508**

Me 34   Him 33

Me - Left salpingo-oophorectomy at 19 due to large cyst/torsion  and 2 large uterine fibroids found at age 30
Him - Borderline low sperm count (correcting through Fertility Blend supplement)

Married 8/20/2011
TTC #1 since Jan 2013
First appointment with RE 10/2013.  
April 2014 - Clomid 100mg CD3-7.  HCG shot CD10 IUI #1 done on 4/12/14 (CD12) ....BFN
May 2014 - Break cycle to repeat saline sonogram and re-group.  Travel to Kauai 5/7-5/12 (Yay!!)
June 2014 - Clomid 150mg CD4-8.  HCG shot CD14.  IUI#2 done on 6/9 and 6/10 (CD15-16) w/ Prometrium suppositories during TWW .... BFN
July 2014 - Clomid 150mg CD3-7.  Ultrasound CD12 - 4 mature follies! HCG trigger shot CD12 AM.  IUI#3 on CD13 w/ Prometrium suppositories during TWW ....BFN
July 2014 - Repeat ultrasound done to measure size of fibroid - 8x9cm (the size of a grapefruit!) Surgery referral made.
August 2014 - MRI done which revealed 2 fibroids: a 13x15cm fibroid as well as an 8x7cm one.  Super freak out mode over surgery plan.  OB-GYN/surgeon said surgery would most likely have to be a laparotomy (open abdominal surgery)
August 2014 - After a 2nd opinion, plan to take Lupron x 2 months to shrink fibroids then laparoscopic/robotic myomectomy.  Surgery date is set for Nov 21st!  
November 2014 - Robotic myomectomy done (2 large fibroids removed, mild endo found).  Benched x 3 months

PAIF/SAIF welcome
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Re: Progesterone supplement

  • wanderlust508wanderlust508 member
    Thanks Amy! I'm taking capsules vaginally (instead of suppositories) so hopefully they won't be as messy. That's great that you haven't had too many awful side effects!
    **Formerly EastBayBride508**

    Me 34   Him 33

    Me - Left salpingo-oophorectomy at 19 due to large cyst/torsion  and 2 large uterine fibroids found at age 30
    Him - Borderline low sperm count (correcting through Fertility Blend supplement)

    Married 8/20/2011
    TTC #1 since Jan 2013
    First appointment with RE 10/2013.  
    April 2014 - Clomid 100mg CD3-7.  HCG shot CD10 IUI #1 done on 4/12/14 (CD12) ....BFN
    May 2014 - Break cycle to repeat saline sonogram and re-group.  Travel to Kauai 5/7-5/12 (Yay!!)
    June 2014 - Clomid 150mg CD4-8.  HCG shot CD14.  IUI#2 done on 6/9 and 6/10 (CD15-16) w/ Prometrium suppositories during TWW .... BFN
    July 2014 - Clomid 150mg CD3-7.  Ultrasound CD12 - 4 mature follies! HCG trigger shot CD12 AM.  IUI#3 on CD13 w/ Prometrium suppositories during TWW ....BFN
    July 2014 - Repeat ultrasound done to measure size of fibroid - 8x9cm (the size of a grapefruit!) Surgery referral made.
    August 2014 - MRI done which revealed 2 fibroids: a 13x15cm fibroid as well as an 8x7cm one.  Super freak out mode over surgery plan.  OB-GYN/surgeon said surgery would most likely have to be a laparotomy (open abdominal surgery)
    August 2014 - After a 2nd opinion, plan to take Lupron x 2 months to shrink fibroids then laparoscopic/robotic myomectomy.  Surgery date is set for Nov 21st!  
    November 2014 - Robotic myomectomy done (2 large fibroids removed, mild endo found).  Benched x 3 months

    PAIF/SAIF welcome
    Report Reply
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  • Pintobean39Pintobean39 member
    I took Endometrin suppositories twice a day. I had horrible leakage, it was like a light white period, panty liners weren't friend. My other symptoms were sore boobs, moody, and frequent urination. Then again a lot of this was prob also the HCG trigger too. Basically I felt pregnant the whole 2ww.

    Good luck!
    Fucking bump!!!!
    Report Reply
  • jkrempjkremp member
    "Oh no, yuck!" is right. I do Prometrium twice a day (vaginal suppository) and I "leak" pretty much all day. Pantiliners are a must. I tend to be moody, bloated, and have sore boobs. Not fun. I start again tomorrow.

    Good luck!!
    6/2014: IUI #3 - Menopur + trigger = BFP!!
    Betas: 9dpiui=15.3, 14dpiui=385, 16dpiui=1162
    7/10/2014: 1st ultrasound - 1 beautiful little heartbeat (121bpm)

    DD born 12/2012:
    Image and video hosting by TinyPic
    Report Reply
  • runawaylaurelrunawaylaurel member
    I have done endometrin and prometrium... They both sort of suck. You need a pantyliner, but at least since you're taking it vaginally and not orally, the systemic side effects are minimal. I had some stomach issues but other than that, nothing. It's just another thing we do in this whole crazy process.
    *****************siggy/ticker warning*****************************


    -Me: anovulatory/ hypothalamic amenorrhea / H: all good
    -IUI  Medicated TI Cycle #1 (Dec): Menopur  + Ovidrel + TI  = BFN
    -Benched for work issues Jan/Feb
    -IUI 1.2: Menopur + Ovidrel = BFN
    -IVF #1- Menopur + Follistim = 12R / 7M / 4F -- first beta-260, second 520. EDD 2/22/15

    Welcome Dane 02/09!


    Report Reply
  • jaytee16jaytee16 member
    Another vote for panty liners are a must! I also have the sore boobs and bloat. And honestly, I have some really moody moments. Not consistently but some ragey moments here and there where I feel a little crazy 8-}
                                                  *********************SIGGY WARNING*************************
                                        May 14 Siggy                                             
    TTC #1 since June 2012.  DX: Unexplained Infertility.  Me: Hypothyroid
    3 Failed Femara + TI cycles and 4 Failed Injects + B2B IUI cycles
    Cycle 23: IVF#1 CoQ10 + Lupron + Puregon = BFP!!
    Beta #1: 199   Beta #2: 800+   It's TWINS!  EDD: Feb 19, 2015
    Team Purple!!!!
    L & E arrived early on January 5, 2015!!
    ~~~All are welcome!~~~

    BabyFruit Ticker
    Report Reply
  • Sigh202Sigh202 member
    They're a pain but not too bad. Panty liners are a must. I also set an alarm on my phone for every 12 hours because it gets hard to remember to take it.
    Ready to take the road less traveled. 
    Report Reply
  • wishiwaspreggowishiwaspreggo member

    I, personally, hate progesterone suppositories.  They create all the symptoms of early pregnancy without the benefit of being pregnant, at least for me.  My symptoms are usually: fatigue, hunger (oh, lord, the hunger!), mood swings, and very sore breasts (like I moan when I take my bra off because it feels like they're expanding after being compressed all day).

    And of course, the leakage is disgusting.  And it's kind of stinky too, like an oily smell.  And it tanks my sex drive.  No fun.

    Funny story, though.  I went to the pharmacy to get my prescription and I wanted an applicator (my vag is long and I can't really get my fingers to reach that deep - sorry if that's TMI!).  Of course, I asked quietly hoping for discretion since the pharmacy was full of people.  The lady asked in a loud voice "What do you need an applicator for?"  To which I responded "Um..."  And then she was like "Oh, you need one for your VAGINAL SUPPOSITORIES!"  A bunch of people turned and looked my way.

    THANKS CVS tech lady.

    Report Reply
  • Lindsey7348Lindsey7348 member
    wishiwaspreggo said:

    I, personally, hate progesterone suppositories.  They create all the symptoms of early pregnancy without the benefit of being pregnant, at least for me.  My symptoms are usually: fatigue, hunger (oh, lord, the hunger!), mood swings, and very sore breasts (like I moan when I take my bra off because it feels like they're expanding after being compressed all day).

    And of course, the leakage is disgusting.  And it's kind of stinky too, like an oily smell.  And it tanks my sex drive.  No fun.

    Funny story, though.  I went to the pharmacy to get my prescription and I wanted an applicator (my vag is long and I can't really get my fingers to reach that deep - sorry if that's TMI!).  Of course, I asked quietly hoping for discretion since the pharmacy was full of people.  The lady asked in a loud voice "What do you need an applicator for?"  To which I responded "Um..."  And then she was like "Oh, you need one for your VAGINAL SUPPOSITORIES!"  A bunch of people turned and looked my way.

    THANKS CVS tech lady.

    THIS. ALL OF THIS!

    Me: 31 DH: 31
    TTC#1 since Sept. 2011
    March 2012-June 2012 - IUI's- BFN

    Sept 2012= IVF #1- 14 eggs, 9 fert, no frosties. 2 blasts 5dt=BFN
    Oct/Nov 2012= IVF #2- 20 eggs, 14 fert, no frosties. 2 blasts transferred despite mild OHSS=BFN
    Nov 2012= hubby got transferred, moving to new state, time for a break until summer!
    Feb 2013= Natural BFP!! Valentine's day surprise! 
    Mar 2013= m/c @ 7.5 weeks :(

    *New RE*
    July 2013= ER for a freeze all cycle. 21 eggs, 9 fert, freeze all day 1.
    Lab is closed in August! (Of course!) 
    Sept 2013= FET #1 - transferred 3 not so great quality day 3 embies=BFN
    Oct 2013= FET #2- transferred 4! 3 good, 1 poor= BFP! On hubby's birthday :)
    Started bleeding at 5w5d. ER trip confirms one gest sac, one yolk sac, no fetal pole. 6w u/s showed nothing. Levels drop from 4,500 to 250. 
    Nov.2013=meet with RE to discuss where to go from here.
           *Tests showed PCOS-ish. High testosterone. Start Metformin 1500 mg.
    February 2014- CLomid, IUI, Trigger. 4 juicy and ripe follies (24,25, 28 and 34!) 111 million post wash sperm count. BFFN!!!! WTH?
    March 2014- Over my RE. Year of fun for us and looking into RMANJ.
    Report Reply
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