Infertility

Consecutive IVF back to back or take a break in between?

Not sure if there is any preference, but if the first IVF is not successful does your RE recommend to do another round immediately the following cycle? Or take a break the following cycle/cycles and try again later?
Me: 38, DH: 41
TTC#2 since Feb 2013
10/13: 1st IUI, BFN
02/14: 2nd IUI, BFN
03/14: HSG done, found out right tube is slightly blocked
04/14: 3rd IUI, BFN
05/14: 4th IUI, BFN
07/14: IVF no. 1, BFN
11/14: IVF no. 2, BFP



Pregnancy Ticker

Re: Consecutive IVF back to back or take a break in between?

  • I can't tell you by experience since we won't be doing our first IVF cycle until August, but my RE has recommended that if the first cycle is unsuccessful to have at least a one month break in between. 
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  • We had a month off between IVF and FET. I think it is pretty standard to take at least a month off to allow your body a bit of a rest & a chance to get back to normal after IVF before starting a new round of treatment. But each doctor has their own protocols, so yours may recommend more or less time off.

    *************Siggy Warning. Loss mentioned.************




    Me: 36, DH:37

    Married 4/2010, TTC since 7/2011

    Dx: Officially Unexplained (I have Polycystic Ovaries diagnosed via ultrasound, but few classic PCOS symptoms, he has mild MF issues. So... not issue free, but nothing so severe as to explain IF)

    I also deal with post-surgical Hypothyroidism following Thyroid Cancer in 2009, but under control with Levothyroxine

    4 months Clomid (thinned lining) and 10 months Letrozole (every indication that I responded perfectly)

    6 failed IUIs in 2013, 3 with trigger

    IVF #1 in March 2014

    ER 3/21/14, 31R/21F, 12 frosties!

    ET 3/26/14, 1 perfect blast transferred: BFN

    FET#1 5/28/14, 2 "beautiful" early blasts transferred. BFP!!

    Beta #1 (6/11/14) 798; Beta #2 (6/18/14) 7,966.

    1st u/s (6/25/14) showed 2 sacs, 1 empty & 1 with a beautiful little bean doing what it needs to do!

    EDD 2/14/15, missed miscarriage, DX: Trisomy 21. D&C 8/1/14

    FET#2 Transferred 3 embies, 2 looking pretty good, one not so much. BFN.

    IVF#2 January 2015, tentative ER 1/23

  • My clinic does batched cycles and the way the cycle calendar falls, it would be impossible to do back to back cycles. We did our first cycle in August and after that cycle was canceled, went back on BCPs for our second cycle in October. After my confirmed c/p in early November, I had one natural cycle and then started BCPs for my third cycle in January (We couldn't make it into the December cycle because it was early in the month due to the holidays).

    imageimageimageimageimage

     

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    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

  • I believe most REs want one "rest" cycle in between failed IVF cycles. TBH, you probably will too. IVF is physically and emotionally draining. Best of luck to you!
    Me: 34 / DH: 33
    19-year history of endometriosis. Multiple surgeries and cyst removals. Forced directly into IVF due to blocked tubes and severe adhesions.
    IVF w/ICSI and CCS #1 - Dec 2013 - Only 1 normal. Ended in CP
    IVF w/ICSI and CCS #2, at CCRM - March 2014!
    14R, 12 ICSI'd, 11F, 6 for CCS, 5 healthy blasts frozen!
    Two 5BB blasts transferred 9/10; First beta 9/19: 109; second beta 9/22: 550!
    EDD: 5/29/15

    imageimage


    BabyFetus Ticker
  • For a fresh IVF to another IVF, typically your RE will suggest taking a break in between cycles. Going from IVF to FET or FET to FET is not as harsh on the body so it is possible to cycle back to back. But every RE and each cycle is different. A big part of the decision ill depend on how your body responds to meds.

    *~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~
    Waited a long time, tried a lot of stuff, science made me a mom.
     Loss and IF veteran. Current mom of DS 5.5, DD 2, and sometimes DH 40. Due June 2021 with TWINS
  • My clinic does batched cycles and the way the cycle calendar falls, it would be impossible to do back to back cycles. We did our first cycle in August and after that cycle was canceled, went back on BCPs for our second cycle in October. After my confirmed c/p in early November, I had one natural cycle and then started BCPs for my third cycle in January (We couldn't make it into the December cycle because it was early in the month due to the holidays).
    Same with my clinic - batched cycles would be impossible to do back to back, and I find that the monthly cycles often over laps (for example, baseline for July would be the same week as June transfer).  But every clinic is different.  I know that my clinic will not do fresh cycles back to back, but it is possible to do frozen cycles back to back. 
  • Mine (same as @jaztaz1) requires you to take one month off (get AF) but then you can start prepping. I did IVF #1 in Jan and IVF #2 in March. I'm finishing up stimming for IVF #3, but could have done it in May, if we hadn't done the hysteroscopy and endometrial biopsy.

    However, I really wish I had taken more time off between #1 and #2- I was so anxious to try again, but I don't think I was mentally or physically ready for #2 and wish I had waited at least another month. I feel a lot better with the slightly longer break for #3. I did ask my RE about it and he said that there are no studies to show a benefit to taking a longer break than a month (but that they do show that a month off has better results).

    ***************************Loss Mentioned***************************


    Me 37 y/o, DH 45 y/o; DH vasectomy reversal (his 2nd marriage) 11/8/12; TTC since 12/8/12. IVF due to MFI. DOR diagnosis April 2015.

     

    IVF #1 BCPs/Antagonist w/ICSI Jan 2014 = BFN

    IVF #2 MDL w/PICSI March 2014 = BFN

    IVF #3 EPP/Antagonist w/PICSI May/June 2014 = BFP!; MMC 6w4d

    IVF #4 No suppression/Antagonist Nov 2014/Converted to IUI #1 = BFN
    IVF #4.1 Feb 2015 = cancelled
    IVF #4.2 April 2015 - Lupron Stop Protocol with ICSI = PGD testing of embryo indicated it was abnormal
    IVF #5 June 2015 EPP with Antagonist 

     

    image
    Everyone welcome!

  • gnl42gnl42 member
    As already mentioned...  I think most of the time you have to take at least one cycle off after a fresh IVF to allow your body (specifically your giant ovaries) to return to normal before starting stims again. If you are going from IVF to FET, it is usually safe to start right away - but as everyone says, different REs and clinics may have their own views and protocols.
    **warning**
    Me (31), DH (33), one furbaby (7) - unexplained IF 
    hysteroscopy and polypectomy 2/14
    IVF #1 3/2014 - cancelled (early ovulation)
    IVF #1.2  ER 5/16/14: 23R 18F -  freeze all (12) due to concern for late onset OHSS 
    FET #1 in June - delayed due to thin lining, 7/18 SET (7.5 mm lining) resulted in chemical pregnancy
    FET #2 in Sept - 9/4 transferred 2 CCS tested embryos (6.5mm lining)
    9/13 beta #1 - 400, 9/15 beta #2 - 950, U/S 9/22 one gestational/yolk sac - next up 9/29
    3 frozen CCS tested embryos remaining
  • Both of my first two REs allowed me to do back to back fresh cycles. It was easier for me because I was in the "groove" and because, as an AMA gal, I have no time to spare. If you have a preference, just ask your RE.

    imageimageimageimageimageimageimageimage
    My BLOG: www.ivfbabyquest.wordpress.com -Update - old blog.

    PAIF/SAIF Welcome!
    Me: 42, Hubby: 35, TTC since Jan 2010. Dx: DOR due to advanced maternal age. Also: Hypothyroidism (100mcg Levothyroxin). Positive for MTHFR (hetero-C677T), Factor V Leiden, and Fragile X (on DH side). Taking pre-natal vitamins
    .
    First natural PG 9/27/11; mc: 1/20/12

    First RE visit: 8/8/12, Saline Sonogram: 8/28/12, IVF injection class: 10/11/12, add FaBB Tab for FVL, +Vitamin D.
    IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Prog- 0.3 The u/s showed 6 follicles in my right  & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 10/21/12: Add Ganirelix SQ every morning.
    ER 10/28/12: 13 Retreived. 7 Mature. 6 Fertilized. 5 Made it to PGS. ET 11/2/12: CANCELED. All 5 came back from PGS as having "severe abnormalities."
    IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 1/11/13: Add Ganirelix SQ every morning. hCG Trigger 1/16/13

    ER 1/18/13: 9 Retrieved. 5 Mature. 5 Fertilized. 2 Made it to PGS. ET 1/23/13: CANCELED. All embryos (he even sent the ones not growing) came back from PGS as having "multiple severe abnormalities."
    IVF #3:
    NEW RE! 3/1/13 Baseline: FSH- 9.6, E2- 61, Prog- 0.94, 3 follicles in my right & 4 in my left. Rx: 150 Bravelle& 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ.
    ER 3/11/13: 6R, 2M, 2F. Day 3: one 8 cell, grade 0.  Five day ET 3/16/13: one early blast, grade Fair. 3/24/13 AF came a day before beta. BFN

    IVF #4: 
    (Added acupuncture to this cycle.) 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Prog- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right & 4 in my left. Rx: 225 Bravelle& 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM.hCG Trigger 4/3/13 SQ.
    ER 4/5/13: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). Five day ET 4/10/13: two blastocysts (the 3rd stopped growing.) Beta 4/18/13: 2.5 BFFN. RE recommends we stop trying and focus on living childless, due to the extremely poor quality of my eggs.
    ***Decided to stop trying and live CFNBC. I couldn't adjust. So, six months later...

    IVF #5: Changed RE. Going to one of the big name clinics now. OWDU: 10/29/13. Update: HORRIBLE experience. Disgusted and distraught at their complete unprofessionalism and how much money and precious time they cost us. Sickening. Have now changed RE again. New Patient appt. 1/30/14.
    BFP! Out of nowhere, I got KU the old fashioned way! POAS 1/26/14 - Positive! FDLM 12/30/13. Beta #1 16dpo= 373. Beta #2 18dpo= 801. EDD 10/6/14
    2/4/14 1st U/S revealed a 5wk2day sac but no fetal pole. Started 200mgs of progesterone suppositories daily
    2/11/14 2nd U/S revealed a perfect 6wk1day "diamond ring" embryo with a beating heart! 138bpm! Add 1mg folic acid and 40mg Lovenox
    2/25/14 3rd U/S: perfect 8w1d embryo, 178bpm. 3/6 start spotting. 3/11 10w1d U/S shows no heartbeat. Scheduling D&C. The Stork has forsaken me again.
    IVF #5.2: New in-state RE. Supplement priming for 1.5 cycles prior to start of cycle, including DHEA 50mg (stopped 5/15), CoQ10 200mg 2x/day, L-Arginine- 1000mg 2x/day (stopped 6/5 due to cold sore!), myo-inositol- 2g 2x/day, melatonin- 3mg, and Neevo (prenatal for MTHFR).
    5/16/14 Day 2 bw cycle prior: FSH- 12.22, E2- 38.37, Prog- 1.35, LH- 9.46. 6/2/14 Day 19 bw: Prog- 23
    6/12/14 Baseline: E2- 122.7, Prog- 0.4. 5 follicles in left, 4 follicles in right. Start stims: 375IU Follistim & 150IU Menopur. 6/19 Increase Follistim to 425IU, Menopur still 150IU. 6/18 add Ganirelix. 6/23 Ovidrel trigger SQ. 6/25 ER: 8R, 8M, 5F naturally. Start Medrol & Doxy. 6/26 Start Endometrin. 7/2 Start Lovenox.
    7/8/14 Beta= 137.4 BFP!!! (My first from IVF!) E2- 1109, Prog- >60. Stop CoQ10, myo-inositol, and melatonin. 7/9 2nd Beta= 281.4. TSH- 2.70. Increasing Synthroid to 100mcg daily. 7/24 6w3d u/s measured 6w3d, hb: 121bmp! 8/5 8w1d u/s measured 8w3d, hb: 164bpm! Graduated from RE to OB. Now I just need to find an OB!
    EDD 3/18/15!

  • jaztaz1 said:

    For a fresh IVF to another IVF, typically your RE will suggest taking a break in between cycles. Going from IVF to FET or FET to FET is not as harsh on the body so it is possible to cycle back to back. But every RE and each cycle is different. A big part of the decision ill depend on how your body responds to meds.


    This is what my RE said also.  I did my FET the same month as IVF/freeze all due do OHSS

    ~~~~~~~~~Siggy Warning~~~~~~~~

    Me~28 DH~27 

     6-12-2010  Miscarriage. 
    3-16-2012 D&C/Miscarriage.
     Blocked Left Tube. 
    Diminished Ovarian Reserve   
    MFI - Sperm Morphology 2%.  
    MTHFR 
     Abnormal Antiphospholipid Antibodies
    April 2013 ~  1st IUI attempt - 100 mg Clomid- Canceled
    May 2013  ~ 2nd IUI attempt -100 mg Clomid- Canceled
    June 2013 ~ 3rd IUI attempt - 100 mg Clomid+ Trigger+ Progesterone~BFN
     IVF/ICSI #1 May 2014 ~ Freeze All ~ Due to OHSS
     5/1/2014 ~ 22 retrieved, 12 fertilized, 3 frozen
    5/28/2014 ~ FET#1 ~ Transferred 2 Hatching Blasts
      6/1/2014~ **BFP**
    6/9/2014 Beta #1 ~ 1022
    6/12/2014 Beta #2 ~ 3099
    6/16/2014 Beta #3 ~ >5000
    6/19/2014 First U/S ~ TWINS!!!  
    1/7/2015 Twins born @ 34 weeks

    image image Image and video hosting by TinyPic



  • My RE told me there is usually a month break due to cysts. I think I will take a month off if this cycle doesn't work. I have been seeing lots of women do better with frozen egg transfers too because their body is more calm and not full of abnormal hormone levels. Sounds right to me.
    Lilypie Pregnancy tickers
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