Estrogen dropping during stims/ovulating before retrieval?

przemosbabe · June 2014

Jeez so another thing to worry about for me here! Ugh I hate this whole process, its like an emotional yo yo! Tonight is my last night of stims which is day 9, and I am suppose to take the trigger tomorrow. Today I had my last ultrasound and I had one yesterday also. Yesterday they saw 10 follices between 18-14mm and my estrogen was 2232 pg/mL. Today I went in and there was 12 follicles. One was 11mm and the others were 18-14mm. Besides for the two new follicles, they haven't grown much from yesterday. Is this normal? Today I also noticed that my estrogen was lower by 12 pg/mL so I asked the doctor what these means. He says it could mean that I am about to ovulate! But he also said my progesterone and LH are fine. Progesterone is 1.3 ng/mL and LH is 1.23 mIU/mL. I'm scared that I'm going to ovulate. I was finally starting to calm down about everything since I'm so close, and now he says my estrogen drop could me ovulation. I am on cetrotide and he of course the doctor knows this. I have read plenty of posts where women do ovulate through the cetrotide. Has anyone experienced an estrogen drop like this right before trigger? What happened?

pblge · June 2014

A drop of 12 sounds to me like a flat line/plateau, probably well within the margin of error for the test. I've had serious E2 declines ("crashes," really--like a drop of 50% or more), and this is different.Your LH also seems relatively low, and I do think ovulating on Cetrotide is relatively rare. Obviously it can happen, but FX you won't be in the small group!

RunCC37 · June 2014

I agree with PP that ovulating through the Cetrotide is so, very rare. And your hormone levels don't suggest that you'll be one of those cases. FX for you!!!

I'm paging @ronniesgirl1981‌ to this thread, because she had a pre-ER possible ovulation scare with IVF #1. The situation was quite different, but perhaps she can provide you some comfort.

Pintobean39 · June 2014

I'm on 9th day of stims and my LH is 2.3 and my Dr isn't worried about me ovulating yet, I haven't even started the ganarelix yet. Then again, my biggest follicle is only 13. Last medicated cycle my LH got up to 7.6 and that's when they thought I was going to ovulate. I don't know what the magic number is but in my non medical opinion I think your LH of 1.23 is good.

Also on my last medicated cycle when they started me on ganarelix my E2 dropped a little and they said it was fine sometimes that happens. Then again they also did drop my Gonal from 250 - 0 to slow me down. I wouldn't think a drop of 12 is a big concern.

I'm so glad I'm not the only one analyzing the numbers. I have copies from all my medicated cycles and I keep comparing every day.

Good luck on ER!!

ronniesgirl1981 · June 2014

So...are you not having another bw/us tomorrow before trigger? If so, I would request one. My bloodwork never indicated ovulation, yet after ER my RE initially said that I ovulated early, but that he had literally never had that happen before. Later, upon reviewing my total chart, he thought that I had several empty follicles (a controversial topic in and of itself) and that I had not ovulated. This cycle resulted in just 3 eggs retrieved and it was thought that I'd be a high responder. It's so hard not to worry when we have so much on the line. Aside from requesting additional monitoring tomorrow, I'm not sure what else you can do. Good luck and I've got everything crossed for you!

Sigh202 · June 2014

I asked about estrogen levels today and my nurse said that when it stops rising, you are no longer responding to meds.

gnl42 · June 2014

I was not on cetrotide, but I did ovulate through Ganirelix before retrieval during my first IVF cycle. My LH and progesterone were also fine (not suggesting ovulation), but my estrogen dropped the day before we were going to trigger. I ended up triggering just in case because we were hoping to save the cycle, but the following day my progesterone went up. Strangely enough, my LH was always suppressed. My RE was very confused about how it all went down, but she was pretty sure that I did ovulate.

That being said, I agree that a drop of 12 is more of a flat line/plateau. I don't remember my exact numbers, but it was definitely a more notable drop in my case. I sincerely hope everything turns out ok for you. I know how disappointing it is to get this far and then be cancelled. FX for no ovulation! Who would have thought we would be hoping for that?

przemosbabe · June 2014

I like that you ladies are honest and hopeful for me. I've given up hope for myself already. But I am so glad I have you gals. Thank you so much for your answers. Bless you all, really. You have all been my rock through this

przemosbabe · June 2014

@ronniesgirl1981‌ thanks to you I called and got another appointment early this morning. Last night ( my last night of stimming) they bumped me up one vile of bravelle. Today the ultrasound tech said the 12 follicles are still there, and there is more that she didnt measure. Must be really small. Anyways my estrogen rose to 4180. Does anyone know if its normal for it to double like that? I pray I make it to retrieval. My progesterone is a bit higher at 3.3. Thank you ladies for your help. You're all so amazing!

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