Potentially really dumb question — The Bump
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Potentially really dumb question

I was just wondering.... Considering I'm DOR, but I ovulate on my own (according to tests etc) we pursued ivf for MFI reasons, I'm just wondering if I ovulate on my own what the chances are it's actually a mature egg? Considering it takes a truck load of drugs to get me to get multiple eggs. Does my question make sense? No real reason for my question other than curiosity.

 


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*******siggy/ticker warning***** 

 Me(31). DH (31)

DH SA normal count and motility, 1% morphology
Me .72 AMH, Fragile X premutation carrier
IVF #1 (6/12/13) BFN

IVF #2 (8/16/13) BFN

FET 10/4/13 Chemical

IVF #3 MC 5 weeks 5 days

IVF #4 DE 11/7 BFP, edd 7/28/15

All Welcome

BabyFruit Ticker

Re: Potentially really dumb question

  • I'm DOR too and still ovulate. I think the egg is mature but cruddy....

    TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
    DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
    5 IUI's: 2/11 to 6/11 and 1/12= BFN
    OE IVF#1-4 8/11-6/12= all BFN
    DE IVF#1 11/12 bad embryos= BFN
    DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
    CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
    DE IVF #3 1/14  ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d

    DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
    First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!

    K & K born 11/21/14 at 38wks 4 days

    imageimage

    SAIF/PAIF Welcome


    http://waitingforraintostop.wordpress.com

  • I agree with mcirish
    6 m/c
    Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
    Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
    1 Clomid/Ovidrel BFN May 2011
    Natural cycle Aug 2011 BFP M/C 4 Weeks
    1 IUI Sept 2011 BFP M/c 7 weeks
    Provera Dec 2011 BFP M/C 3 Weeks
    DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
    IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
    IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
    Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
    Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
    Went to Beer Center- high tnf, low lad, implantation failure
    Nov/Dec 2012 LIT Treatment
    Dec 12 Humira
    Jan 2013 BFP
    Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
    Miracle Born August 2013 Premature

    Yours doesn't have to be a sad story



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    Lilypie - (ugiy)


  • Just curious, I always thought before ivf that I ovulated normally, now that I know more about myself I was thinking maybe I ovulate but it's not normal

     


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    *******siggy/ticker warning***** 

     Me(31). DH (31)

    DH SA normal count and motility, 1% morphology
    Me .72 AMH, Fragile X premutation carrier
    IVF #1 (6/12/13) BFN

    IVF #2 (8/16/13) BFN

    FET 10/4/13 Chemical

    IVF #3 MC 5 weeks 5 days

    IVF #4 DE 11/7 BFP, edd 7/28/15

    All Welcome

    BabyFruit Ticker

  • I have DOR and a good FSH. I went through a natural IVF cycle in which I went about my normal ovulation but still went through ER and my egg made it to a 5 day blast. So it's definitely possible.
    ***WARNING***

    TTC Since 12/2008;  DH: 32, Azoospermia     me: 33, DX during IVF #4: Low AMH (Normal FSH) / SER due 
    to IVF Meds (causing failure to fertilize) Recent DX: Hashimoto's, Lupus Anticoagulant, White Blood Cell Disorder 
    High ANA, ATA, & APA, PAI-1 Heterozygous= blood clotting disorder; connective tissue disorder 
    IVF w/ ICSI #1 2/2011     IVF w/ ICSI #2 5/2011    IVF w/ ICSI #3 12/2012   *New RE* IVF w/ ICSI #4  5/2013
    IVF w/ ICSI #5 8/2013 (Natural Cycle- No drugs)- One follicle->one blast. CCS normal. FET 9/10- 6BB blast. m/c @ 5w
    IUI #1 12/23- BFN  IUI #2 Cancelled (ovulated during AF)  Prep:CoQ10 (300 mg); DHEA (25 mg); Melatonin (3 mg), Folgard 2.2, Metformin 500 2x, Levothyroxine 50mcg, Aspirin 81mg w/ calcium, B12,  Vit. D 4000 & Prenate Elite Daily; Cabergoline 1/2 pill 2x week-  Cycling: Estrace Priming; Prednisone 10mg, Lovenox 40mg 2x,  Femera & Menopur   
    IUI #2.1 6/30 & 7/1. 1st Beta: 90 (7/15); 2nd Beta: 226 (7/17); 3rd Beta: 766   EDD: 3/23/2015

       **ALL WELCOME**                                    My Blog 
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  • I ovulate on my own, but my own eggs are crap because of endo. A different reason, but same idea, I think. I had to take a TON of supplements to help. Basically, I have a lot of really shitty eggs. So, that's not helpful either.

    When I ovulate on my own, it's either an early ovulation or late ovulation, or I just get a cyst instead. So on my own, my eggs are either not mature or too mature.

    I think your question makes sense and it's worth looking into for sure!

    BabyFruit Ticker

     ttc #2 since 2004 Me (35): Stage 3 Endo, DH (34): High DNA Frag

    IVF/ICSI #2: April 2014: BFP!!!!!!

    ET of 2 great quality embryos. + BFP on 9dp5dt. Beta #1 (10dp5dt): 257, Beta #2 (14dp5dt): 1561,

    Beta #3 (21dp5d5): 8,172. Wow. It seems this is actually working. Shocked beyond belief.

    1st u/s @6w5d: Baby A hb 124, Baby B hb 127 (Both measuring perfectly!)

    Lost baby A. Praying that baby B stays healthy. Baby B hb 175 at 11 weeks

    It's a GIRL!!!

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    My Blog

  • mm29mm29
    Long-Lasting Membership 2500 Comments 500 Love Its Photogenic
    member
    I'm DOR too, and we have unexplained MFI and DH has a BT.  Our next cycle is going to be DS IUI.  My RE has the opinion the better indicator for pregnancy for those with DOR is age, and not reserve. We did IVF with my OE's and I did get a couple of mature eggs.  I think it's possible you can ovulate a mature egg
    ::: Married June 2003:::
    TTC #1 since: Aug. 2008
    Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
    DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
    Tx History: IUI 1&2= BFN
    IVF# 1 W/ICSI= BFN
    IVF# 2: cancelled d/t no response
    IVF# 3= 1 egg retrieved=immature/not viable
    IVF# 4= c/p
    ***CCRM ODWU***
    Found DHs BT and Me-decreased blood flow to uterus
    Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
    ***New RE***
    DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. 
    IVF# 6: (OE/DS) cancelled
    IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
    Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015

    http://icanhazbabyz.blogspot.com/
    imageimage image 
  • Perhaps sometimes we have an lh surge but don't actually ovulate. Or we ovulate crappy eggs?
    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
  • I have totally crappy, immature eggs when I do IVF, and yet when I wasn't doing treatments I ovulated like clockwork. My FF charts were lovely. A doc suggested that (basically like poohniki mentioned) we try some no stim mini IVFs to see what my unmedicated eggs were like. I ultimately decided to go to DE instead, because we found a donor we liked and, even more importantly, if I had been ovulating decent eggs all this time why would I have never gotten KU once in 4 years of trying?! (We don't have mfi or tubal/uterine issues.)
  • I'm not considered DOR officially because we always had plenty of eggs, but the main issue I had was with maturity of my eggs in all our retrievals (example, our last IVF was 10 mature out of 43 collected) - for us it was the last question mark and the only work around our doc suggested was to stim/coast longer - and I wondered the same thing as you did about how it works "naturally". Especially because I ovulated early, often. I suspect it's possible like a PP said to have over mature or under mature eggs, naturally.

    I wonder if we could have gotten more eggs to be mature in our first cycles (retrieved about 20 each time) if we could have gotten a sticky baby sooner... but I don't know, and it's moot now.

    We've also got/had other things going on - so it's not the only issue.
    BzeetyD = 38, Mr. BzeetyD = 44 together 12/02 married 9/08
    TTC #1 since 1/10
    DX: Unexplained/??? MFI issues

    Our lil' lost sparks:
    5w3d loss 7/30/10 - EDD March 2011
    8w loss 4/15/11 - EDD November 2011
    8w3d loss 8/2/12 - EDD March 2013
    4w c/p loss 10/29/12 - EDD July 2013

    Long story: trying on our own + testing testing testing with 6 rounds of Clomid, more testing, injectables + TI, laparoscopy - one tube blocked, 2 IUIs with Follistim...BFNs.
    RPL testing all normal, Karyotyping normal

    Moving on to IVF.

    IVF #1 April 2012 = BFN, IVF #2 June 2012 = BFP. U/S 7/23 = saw heartbeat but measuring behind. Follow up U/S on 7/30 - no heartbeat. D&C 8/2. Trisomy 12. IVF #3 Oct 2012 = Chemical Pregnancy

    Phone consult with CCRM on 12/12/12 - ODWU 1/4/13 - both tubes clear(!) - AFC 24, AMH 3.2, FSH 9.6, LH 5.4, E2 25. DH has high frag rate but improved!
    IVF #4 March 2013 CCRM. EP protocol w/ Menopur, Gonal-F & Dexamethasone. ER 3/29 & IMSI, PICSI. 43R 13M 10F 6blasts bio'd. CCS testing reveals 3 normals!!!
    FET 5/31/13 of 1 4AA blast - thawed and expanded. 4dp5dt BFP.
    Beta 9dp5dt = 181, 11dp5dt = 427. 1st u/s showed a healthy heartbeat! EDD 2/16/14

    After 4 years of hoping and heartbreak, our sweet little bean was born on 2/19/14
    We are so in love with her.

    "I'm not telling you it's going to be easy, I'm telling you it's going to be worth it."

    Everybody is welcome!!!
  • brooklynesque.

    I ovulate every month like clockwork.  My RE thinks my eggs are immature ( based on my e2 levels etc...) We tried several different protocols and used Menopur to see if that would help the maturing but it didn't.  We have no male issues.  After 2 years and many failed attempts we moved on to DEIVF.
    ***siggy/ticker warning***

    Me:36 DH:38 TTC#1 since 4/2012
    Me DX: Hashimotos,Hypothyroid, DOR, MTHFR,  DH: normal

     IUI #1-#4 BFNs and a few cancelled cycles in the mix.
    - poor responder
    ***Suprise BFP on 6/13/13. Natural MC @6wks 3days
    IVF#1 and 2- Cancelled due to no response on max stimms
    FET 5/20- BFP
    1st Beta- 641
    2nd beta- 2166
    Sono- TWINS!!!!
    Two Boys! Born January 2015 @36 weeks.  Healthy and no NICU!  So blessed!



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  • I totally didn't even think this would be the case.  But it definitely makes sense.  I think I assumed since I'm only 30 that I still was ovulating good eggs?
    ****************SIGGY WARNING****************

    image
    TTC since 2011
    DH: 29, Severe MFI; grade III varicocele; surgery postponed till KU
    Me: 30, POF/DOR, factor II hetero, MTHFR homo
    5 IVF's, LLP, EEP, MDLF all BFN
    IVF 6 using DEB USA frozen eggs
    developed bilateral PE's from BCP, cancelled/delayed 6 mths, taking lovenox
    Feb'15 SURPRISE 1st BFP ever! EDD: 10/10/15, FX
    Still have frozen donor eggs on ice
    All are welcome!
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