Trouble TTC

Ovidrel vs. Pregnyl

I hope I'm not being redundant in asking this question...  If I am, please link me to the right thread and I can take this down.

Is there a significant difference between Ovidrel and Pregnyl?  I know Ovidrel is shot in the stomach, and Pregnyl goes in the upper thigh.  One is 250 MCG and the other is 10,000 IU HCG.  The price difference is certainly significant.  Damned Ovidrel cost me $134 :( Pregnyl cost me $80 in the past. 

Anyway, my doctor ordered my medicine for me and I got Follistim and Ovidrel.  I don't understand why she prescribed me with Ovidrel because she's used Pregnyl on me in the past.  Anyone know if it works better with Follistim or something?

Of course, I'll ask these questions at my next RE appointment but that won't be for a while.  Just curious to see if others have any ideas.

Re: Ovidrel vs. Pregnyl

  • Pintobean39Pintobean39 member
    edited April 2014
    Not sure, when they ordered my meds this last time they put down Pregnyl but made a note on the order whatever what cheaper so I got novarel. I just assumed they were all the same thing just diff brands.
    Fucking bump!!!!
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  • Lillovebug79Lillovebug79 member
    edited April 2014
    I have always used Pregnyl because it is the only one covered by my insurance. I have used Pregnyl and follistim several times. I'm not sure why they would switch you to a more expensive trigger. I was under the impression that they all worked the same. I only did a 5000u trigger so Pregnyl lasted me 2 cycles.

    edited because what my iPad autocorrected made no sense!



    ********Siggy/Ticker Warning***********



    Me (35) no known issues DH (37) MFI. TTC 21 months (24 cycles)
    Dx MFI with low to normal count, low motility, morphology 3%
    HSG normal, ultrasound and labs on me all normal. 

    1 cycle of Clomid 50mg and TI, unmonitored by OBGYN= BFN
    1 cycle of Clomid 50mg and IUI, unmonitored by OBGYN= BFN
    Started seeing an RE!!
    2 more cycles of clomid 50mg (great response), with IUI and Pregnyl trigger (4.8-8 mil good ones after wash) = all BFN
    1 cycle of clomid 50mg (3-7) followed by Follistim 75iu (7-11) + IUI = BFN
    December 2013 DH saw urologist and is taking Anastrozole, CoQ10, and L-Carnitine
    IUI #5 natural cycle (needed a med break) = BFN
    IUI #6 Follistim 75iu (CD3-10) + Pregnyl (CD11) + IUI (final count after wash 300K) = BFN
    IUI #7 Follistim 75iu (CD3-9) + Pregnyl (CD11) + IUI on 2/20 (post wash count 12.5 million)= BFN
    IUI cancelled (DH OOT) Clomid 50mg (CD3-7) 1 follicle +(not well timed) TI = BFN
    IUI #8 and last one!! Clomid 100mg (CD3-7) +OPK before US + IUI 4/17 (post wash 8.5 mil)= BFN

    Pre-IVF testing complete! SHG great and measurements taken! Labs for infectious diseases completed, FSH (5.4), TSH (1.6), Prolactin (11), AMH (2.6), Estradiol (40).

    Started BCP 5/29 and Lupron 6/11 prep for IVF #1! Started follistim 225u/day on 6/28. Monitoring on 7/2 >15 follicles measuring 11-14, E2 758. Monitoring on 7/5 all ready to go!! Great follicle sizes and lining is at 9. Tigger 7/5, ER 7/7 16R 9M 3F. Stimmed too fast in just 7 days. 7/10 3dt of 2 8-cell grade 2 & 4. 7/14 P4 >60.
    Holy crap BFP!!!
    Beta #1 (14dpo) 7/21 112 Beta #2 (16dpo) 7/23 286 a Beta #3 (18dpo) 7/25 761 Beta #4 (21dpo) 2631!!! Hold on tight little embies!!
      First Ultrasound 8/7- 1 perfect little bean with a beating heart 117bpm!! EDD 3/30.
    Second ultrasound 9/2 Little bean measuring a few days ahead with a heart rate of 161!



    PAIF/SAIF/All Welcome!

    image




    Pregnancy Ticker




    March 15 Siggy Challenge: You had one job

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  • Bah :( I suspected as much.  Next time - God forbid there will even BE a next time, anyway - I will be sure to ask for Pregnyl instead of Ovidrel.  I'd used Ovidrel before and it was ~$125 last time.  I want to have as few expenses as possible for this TTC business.
  • My RE said he was giving me pregnyl instead of ovidrel because it was a "weight" thing... I didn't ask anymore but assumed it was because I was overweight... But I was still instructed to put the pregnyl in my stomach.

    Me: 32  DH: 33  Married: March 2004

    July 2006: started TTC
    2008: HSG (normal), couple rounds of clomid through gyno
    2008 - 2010: dragging my feet out of fear and procrastination
    October 2010: first consultation with RE, dx PCOS and fibroids (DH slightly low count/motility)
    Oct. 2010 - Dec. 2012:  In DENIAL! avoided the issue because I was scared of surgery
    January 2013: returned to RE, fibroids grew significantly
    February 2013: second HSG, fibroids pushed on tubes which blocked them somewhat
    March 2013: MRI to determine what type of surgery may be necessary

    July 29, 2013: fibroids (5) removed via robotic laparascopy
    August 2013 - Nov 2013 : benched due to recent surgery

    IUI #1, Dec. 24, 2013, BFN 
    IUI #2, Jan. 25, 2014, BFN
    IUI #3, Feb. 25, 2014  BFN
    IUI #4 canceled due to lack of response to letrozole
    IUI #4.1 April 28, 2014, BFN

    May 16, 2014: wtf consult, start prepping for IVF in June and add injects for one last IUI in the meantime
    IUI #5 started letrozole and bravelle but canceled after HSG led to new diagnosis

    May 21, 2014: third HSG, tubes blocked, one at the beginning, one hydrosalpinx??
    June 11, 2014: consult, approved to move on to IVF because the hydro is not completely blocked therefore allowing fluid to move through slowly rather than backwards
    IVF #1 August 8, 2014 - 3dt of 2 embryos, BFN
    September 17, 2014 - 4th HSG, the right tube is very patent (open!!) dye went straight through this time. Weird!
    October 2, 2014 - started metformin treatment
    November 14, 2014 - blood work, brought A1C down from 5.8 to 5.5

    November 26, 2014 - RE finally back from vaca and reviewed my chart, no more IVFs for rest of calendar year
    December 1, 2014 - Right after Thanksgiving, I called a new clinic and got in right away! Plan for IVF
    December 17, 2014 - ER! 29 retrieved (!!), 16 mature, all 16 fertilized (ICSI)

    IVF #2 December 20, 2014 - 3dt of 3 embryos, BFN

    We are done with treatment unsuccessfully. :(


    PAIF/SAIF/All Welcome!

    image    image
  • I'm wondering if they can be used either IM or SQ. This time when I got my rx of novarel it came with 3 needles, mixing needle, IM, and SQ. They instructed me to inject in my stomach.

    So I googled the difference on Ovidrel and novarel and came across a post in July of last year on 3t with curlylocks and talon and they were saying the studies show there is no difference if it's IM, or SQ.
    Fucking bump!!!!
  • I did Follistim and Pregnyl this cycle. They didn't say anything about why. I got 5000iu trigger and a 5000iu booster, both in my butt.
    Jan15 December Siggy Challenge: Holiday Fails
    image
    image
    TTC Since 4/13 | Me: 28 DH: 29 | DX: PCOS + High T + Arcuate Uterus (11/13)
    Cycle #1+2 (4/13-6/13): Natural Cycles = BFN | Cycle #3+4 (6/13-11/13): Anovulatory (Provera)
    Cycle #5 (11/13-1/14): Femara + Clomid + Follistim = Cancelled | Cycle #6 (1/14-3/14): Benched
    Cycle #7 (3/14-4/14): Femara + Follistim + Estradiol + Pregnyl + Progesterone
    BFP: 4/22/14 | Due: 1/1/15 | TEAM BLUE!

  • I have only used pregnyl and it costs about $75. The first 2 months, I took the pregnyl SQ in my stomach. I got a huge, angry welt both times. My RE switched me to taking the pregnyl IM in my butt cheek. I have not had any bad reactions since the switch. 
    ********Siggy Warning********

    Me: 25 DH: 29
    Married 9/23/2012, TTC since 3/2013
    Dx: PCOS, Anovulation/Amenorrhea
    HSG: All clear, SA: Normal 
    Oct 2013: 1st consult with RE
    Nov 2013-Dec 2013: Letrozole + Trigger + TI = BFN
    Jan 2014-May 2014: IUI#1-4: Letrozole + Trigger + Progesterone= All BFN
    Sept 2014: IVF#1: 24R/13M/11F
    Transferred 2 embryos on 9/24, 2 frosties = BFP!!
    Beta#1: 8dp5dt: 188, Beta#2: 12dp5dt: 822
    Beta#3: 15dp5dt: 1965
    1st u/s 10/13: TWINS!!
    u/s 12/23: TEAM PURPLE!!
    All Welcome! 
    image

    Lilypie Pregnancy tickers
  • I have always given my pregnyl IM, my RE said the absorption is better. I'm not sure about it being better if you are overweight but I know the dose I take is 5,000 because my weight is less than 120lbs.



    ********Siggy/Ticker Warning***********



    Me (35) no known issues DH (37) MFI. TTC 21 months (24 cycles)
    Dx MFI with low to normal count, low motility, morphology 3%
    HSG normal, ultrasound and labs on me all normal. 

    1 cycle of Clomid 50mg and TI, unmonitored by OBGYN= BFN
    1 cycle of Clomid 50mg and IUI, unmonitored by OBGYN= BFN
    Started seeing an RE!!
    2 more cycles of clomid 50mg (great response), with IUI and Pregnyl trigger (4.8-8 mil good ones after wash) = all BFN
    1 cycle of clomid 50mg (3-7) followed by Follistim 75iu (7-11) + IUI = BFN
    December 2013 DH saw urologist and is taking Anastrozole, CoQ10, and L-Carnitine
    IUI #5 natural cycle (needed a med break) = BFN
    IUI #6 Follistim 75iu (CD3-10) + Pregnyl (CD11) + IUI (final count after wash 300K) = BFN
    IUI #7 Follistim 75iu (CD3-9) + Pregnyl (CD11) + IUI on 2/20 (post wash count 12.5 million)= BFN
    IUI cancelled (DH OOT) Clomid 50mg (CD3-7) 1 follicle +(not well timed) TI = BFN
    IUI #8 and last one!! Clomid 100mg (CD3-7) +OPK before US + IUI 4/17 (post wash 8.5 mil)= BFN

    Pre-IVF testing complete! SHG great and measurements taken! Labs for infectious diseases completed, FSH (5.4), TSH (1.6), Prolactin (11), AMH (2.6), Estradiol (40).

    Started BCP 5/29 and Lupron 6/11 prep for IVF #1! Started follistim 225u/day on 6/28. Monitoring on 7/2 >15 follicles measuring 11-14, E2 758. Monitoring on 7/5 all ready to go!! Great follicle sizes and lining is at 9. Tigger 7/5, ER 7/7 16R 9M 3F. Stimmed too fast in just 7 days. 7/10 3dt of 2 8-cell grade 2 & 4. 7/14 P4 >60.
    Holy crap BFP!!!
    Beta #1 (14dpo) 7/21 112 Beta #2 (16dpo) 7/23 286 a Beta #3 (18dpo) 7/25 761 Beta #4 (21dpo) 2631!!! Hold on tight little embies!!
      First Ultrasound 8/7- 1 perfect little bean with a beating heart 117bpm!! EDD 3/30.
    Second ultrasound 9/2 Little bean measuring a few days ahead with a heart rate of 161!



    PAIF/SAIF/All Welcome!

    image




    Pregnancy Ticker




    March 15 Siggy Challenge: You had one job

    image
  • I have only used Orvidrel and each time has cost about $80. The first time I got it at the pharmacy next to my REs office and this time I got it with my other meds from Conception Pharmacy and it was $79.50, each time they said it was going to cost more if I used my insurance versus being cash pay because they could use a manufacturers coupon.  I would look around at different pharmacies for prices and coupons. 

    Also I think I heard once you might be able to get a coupon from online for the Orvidrel.

    ~~~~~~~~~Siggy Warning~~~~~~~~

    Me~28 DH~27 

     6-12-2010  Miscarriage. 
    3-16-2012 D&C/Miscarriage.
     Blocked Left Tube. 
    Diminished Ovarian Reserve   
    MFI - Sperm Morphology 2%.  
    MTHFR 
     Abnormal Antiphospholipid Antibodies
    April 2013 ~  1st IUI attempt - 100 mg Clomid- Canceled
    May 2013  ~ 2nd IUI attempt -100 mg Clomid- Canceled
    June 2013 ~ 3rd IUI attempt - 100 mg Clomid+ Trigger+ Progesterone~BFN
     IVF/ICSI #1 May 2014 ~ Freeze All ~ Due to OHSS
     5/1/2014 ~ 22 retrieved, 12 fertilized, 3 frozen
    5/28/2014 ~ FET#1 ~ Transferred 2 Hatching Blasts
      6/1/2014~ **BFP**
    6/9/2014 Beta #1 ~ 1022
    6/12/2014 Beta #2 ~ 3099
    6/16/2014 Beta #3 ~ >5000
    6/19/2014 First U/S ~ TWINS!!!  
    1/7/2015 Twins born @ 34 weeks

    image image Image and video hosting by TinyPic



  • I have always given my pregnyl IM, my RE said the absorption is better. I'm not sure about it being better if you are overweight but I know the dose I take is 5,000 because my weight is less than 120lbs.

    I only had to take 1/4 of the dose this time. I asked why so little they said because I have so many follicles and it helps reduce the OHSS but it's still just as effective and I was told to just put it in my stomach.

    It's funny how all RE's have different protocols. Then again it could always depend on the patient too.

    Fucking bump!!!!
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