Secondary IF

Femara/Letrozole and trigger shot ?s

Hi everyone, I'm fairly new here, but hope it's okay to ask a question.  I just started Letrozole (generic for Femara) this cycle.  I go in Wednesday for the U/S and will hopefully have some plump little follies abrewin'.  I'm curious what type of success you guys may have had with Letrozole/Femara, in terms of the number and size of follicles.  I don't have a tube on the right side, so I am hoping I am able to ovulate on both sides each month to increase my chances.  I'm not sure what to expect.

Also, did you do trigger shots, and if so, did you do them yourself at home?  I am a little intimidated about that whole process....

Any info/thoughts/advice you can provide will be much appreciated!

Me: 42. DH: 46.

1st Pregnancy: MC, 11/19/00.

2nd Pregnancy: DS born 04/10/06.

3rd Pregnancy: CP, 03/11.

4th Pregnancy: MMC, D&C 11/30/11, Genetic testing revealed Trisomy 4.

5th Pregnancy: Ectopic, 2 doses of Methotrexate unsuccessful, surgery 4/10/12, right tube removed.

Tried Letrozole January 2013-July 2013 (including 2 IUIs), all BFN.  After 2 1/2 years of trying for child #2, decided to "give up" after July cycle, based on AMA.

August 16, 2013:  BFP our first month of "not trying!"  Still in shock.  Beta #1 (14dpo): 183.  Beta #2 (17dpo):  611.  Ultrasound 8/30/13: baby measured 6 weeks, 1 day, heart rate of 118 bpm! 
Ultrasound 9/13/13:  8 weeks, heart rate of 176!
Baby is due 4/26/14

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Re: Femara/Letrozole and trigger shot ?s

  • Most I ever had was 2 follies. Don't remember sizes. Sorry
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  • IUI number one i had two: a 22 and a 16, I believe. IUI number 2 I didnt have ultrasound. IUI number three I had a 30. I did HCG trigger at the ultrasound sound appt. They did the shot.




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  • I've taken Letrozole two times so far.

    The first time my left side had a tiny irrelevant follicle in it. I can't remember whether it was at a 11 or a 14. My right side had 3 follicles in it. 1 was irrelevant but the other 2 were at a 19 and a 22. I didn't trigger that cycle.

    This current cycle my left ovary contributed absolutely nothing to the group and my right ovary did all of the work. I had one 22ish follicle and two others in my right ovary were only around 12ish. I triggered that night with a shot of Ovidrel. At home. Thank goodness my Mom was in town and she is an RN. I had her do it for me. This month I'll have to do it to myself though. It's not a huge needle so I know I can handle it, I think it's just mentally making yourself do it.

    I had my monitoring appt and trigger on a Monday, IUI on Wednesday morning first thing.

     

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    Me:24 DH:27
    TTC #2 since August 2011

    DX: Low AMH 1.79 Mildly elevated FSH 9.9

    1 month of Letrozole, 3 IUI's with Letrozole, All BFN. 1 canceled IVF cycle, BFN.


    May 2013 IVF w/ICSI #1.5: Start BCP 5/8 2 pills a day. Suppression Ultrasound 5/29. Begin Dexamethasone & Lupron Microdose 5/31. Started Gonal F and Menopur 6/2.


    ER 6/12 13R,9M,8F.


    5DT CANCELLED due to moderate OHSS


    5DT UNcancelled due to embryos not being capable of cryopreservation


    Transfered 2 "poor quality" embryo's on 6/17

    No frozen embryos.


    Beta #1 6/25 6. Chemical Pregnancy confirmed. Beta #2 6/28 -1
    Done trying

  • Thanks for the responses, ladies.  I really appreciate the info.

    Me: 42. DH: 46.

    1st Pregnancy: MC, 11/19/00.

    2nd Pregnancy: DS born 04/10/06.

    3rd Pregnancy: CP, 03/11.

    4th Pregnancy: MMC, D&C 11/30/11, Genetic testing revealed Trisomy 4.

    5th Pregnancy: Ectopic, 2 doses of Methotrexate unsuccessful, surgery 4/10/12, right tube removed.

    Tried Letrozole January 2013-July 2013 (including 2 IUIs), all BFN.  After 2 1/2 years of trying for child #2, decided to "give up" after July cycle, based on AMA.

    August 16, 2013:  BFP our first month of "not trying!"  Still in shock.  Beta #1 (14dpo): 183.  Beta #2 (17dpo):  611.  Ultrasound 8/30/13: baby measured 6 weeks, 1 day, heart rate of 118 bpm! 
    Ultrasound 9/13/13:  8 weeks, heart rate of 176!
    Baby is due 4/26/14

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  • Hi.  I have been on femara many times.  I got pregnant with DD on my first cycle of femara. 

    My follicle sizes have been anywhere from 16-22.  My RE's office considers anything over 16 mature. 

    I used to bring my trigger shot to my scanning appointment and let the nurse trigger for me.  Now that I have been on injectibles I always do it at home now since DH and I are pros now.

    One tip, I always have sex the night before my scan to check for mature follicles.  Sperm lives for up to 72 hours, better chances IMO.

    Good Luck!

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    Pregnant with Letrazole (Femara) on the first cycle with DD after TTC 2+ years
    TTC#2 with Letrazole (Femara) since January 2012
    BFP 06.29.12 EDD 03.11.13 natural m/c 07.13.12
    BFP 09.22.12 EDD 05.31.13 natural m/c 10.07.12
    CP 11.09.12
    BFP 01.01.13 EDD 09.15.13 d&c 01.24.13

    BFP 03.26.13 EDD 12.04.13
     

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  • imageLauren79:

    Hi.  I have been on femara many times.  I got pregnant with DD on my first cycle of femara. 

    My follicle sizes have been anywhere from 16-22.  My RE's office considers anything over 16 mature. 

    I used to bring my trigger shot to my scanning appointment and let the nurse trigger for me.  Now that I have been on injectibles I always do it at home now since DH and I are pros now.

    One tip, I always have sex the night before my scan to check for mature follicles.  Sperm lives for up to 72 hours, better chances IMO.

    Good Luck!

    Thanks, Lauren. Ugh, my husband is already in bed asleep (he gets up at 4:45am!), so tonight is out.  But good thought for next time.  We are on the every 48 hours schedule, and last night was BD night (sorry, TMI?).  Anyways.... I saw that were TTC for 2+ years and got pregnant on your first Letrozole cycle.  That is our situation exactly; I hope that we luck out with our first cycle like you did.  And your daughter is adorable (as are all of the kiddos pictured on this thread)!

    Me: 42. DH: 46.

    1st Pregnancy: MC, 11/19/00.

    2nd Pregnancy: DS born 04/10/06.

    3rd Pregnancy: CP, 03/11.

    4th Pregnancy: MMC, D&C 11/30/11, Genetic testing revealed Trisomy 4.

    5th Pregnancy: Ectopic, 2 doses of Methotrexate unsuccessful, surgery 4/10/12, right tube removed.

    Tried Letrozole January 2013-July 2013 (including 2 IUIs), all BFN.  After 2 1/2 years of trying for child #2, decided to "give up" after July cycle, based on AMA.

    August 16, 2013:  BFP our first month of "not trying!"  Still in shock.  Beta #1 (14dpo): 183.  Beta #2 (17dpo):  611.  Ultrasound 8/30/13: baby measured 6 weeks, 1 day, heart rate of 118 bpm! 
    Ultrasound 9/13/13:  8 weeks, heart rate of 176!
    Baby is due 4/26/14

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  • Hi everyone,

    I'm new here and hubby and I have been TTC for 27 months now. We started seeing a fertility specialist in August. We went through all the testing and were diagnosed with unexplained infertility, so he gave us a prescription for 6 months worth of Letrozole and sent us on our way. Just said to let him know how it goes. Is this normal? I've been seeing a lot of posts regarding Letrozole and most women are monitored while on it, having ultrasounds each cycle to measure the follicles. He never mentioned any of this to us. Is this something we should be requesting to have done? So far we've gone through 2 unsuccesful cycles with the letrozole and I will be starting the third cycle on it tomorrow.

    Thanks in advance!

  • vbchick0788vbchick0788 member
    edited February 2014

    I am on my first round of Femara after no success with Clomid. Went in yesterday for ultrasound and had two good ones. Both around 19mm. Much bigger than I ever had with Clomid! I am also using the trigger shot. I haven't had any issues with either as far as side effects. Hopefully Femara does the job! Will let you know in a few weeks! :)

  • vbchick0788vbchick0788 member
    edited February 2014
  • I've done 3 Clomid cycles. This current one was my best one yet. It resulted in 3 follices, all over 20mm. 2 were from the right, 1 from the left.

    The nurse triggered me in the office the first time. The 2nd and 3rd times I triggered myself because it had to be done at 10pm. The anticipation was much worse than the actual shot. 
    BFP: 5/10/14 after 14 cycles of trying!
    EDD: 1/21/15
    5/12 1st beta: 28
    5/14 2nd beta: 87.5
    5/23: 3rd beta: 4000.6 + saw gestational sac and yolk sac
    5/30: 4th beta: 17,852 + saw fetal pole and heard heartbeat! 127 BPM!
  • This thread is old and the OP is a grad that is almost in her third trimester- just FYI
    image

    Me: 27 DH: 33
    Married 6 years
    Conceived DS after 4 years of MFI

    TTC # 2 (not trying,not preventing ever)
    May 2013 - August 2013 Timed Intercourse = BFN
    September 2013 Timed Intercourse, Weekly Acupuncture, Herbs=BFN
    October 2013 Timed Intercourse, Weekly Acupuncture, Herbs, and "warming foods" = BFP
    Beta #1 19, Beta #2 18 Progesterone 4.6 Miscarried 11/9/13
    November 2013 - Benched, waiting for first post-loss AF.
    No longer benched per New RE/OB!
    Jan. 15 2014 - BFP. HCG 3900 - Ectopic :( 
    Jan. 16 2014 Left tube removed and D&C
    March 2, 2014 First AF


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