Infertility

Monitoring update and a ?

I had another monitoring appt today.  I don't have the results of my E2 yet but I will update later.  There are still no measurable follicles and I've had 8 nights of stims.  Today will be day 9.  The u/s tech didn't seem overly concerned at all, in fact she told us that it was "common" to have such a slow response.  I really hope my E2 level rises.  I mentioned that I was afraid of being cancelled and she said that I shouldn't be concerned with that at this point, sometimes their patient's stim up to 12-13 days before they see a response worth while.

She did see 1 follie on the right and I counted about 4-6 on the left but of course they were very small and she didn't measure them.

Question:  Does anyone know the max dosage of Bravelle and Menopur?  I thought it was 600 IU but today she said I am already on the max dose of them.  Does that mean 300 of each to total 600?
TTC #1 Since May 2011 ~ Everyone Welcome
Me (34): DOR d/t chemo/radiation, Immature Endometrial Lining, Hypothyroidism
DH (35): MFI d/t testicular torsion and removal, Low T, Oligospermia, Anti-Sperm Antibodies, Currently on T supplements
Sept '11-April '13 ~  Testing, failed multiple MFI treatments, saving & TONS of praying
January 2014 ~ IVF/ICSI & PGS ~ no response to stims ~ converted to IUI ~ BFN
February 2014 ~ On to donor embyros ~ 5 blasts!!! 
March 2014 ~ FET #1 ~ Transferred 2 blasts ~ BFN
July 2014 ~ Kliman's mock cycle with endometrial function test
Sample too small for EFT, HE slide showed immature cells
New protocol planned, saving for another biopsy for EFT
January 2015 ~ Considering adoption options
April 2015 ~ Privately arranged adoption of planned pregnancy
DD#1 ~ Lillyana Violet Marie born 6/15/16, Finalized adoption 12/20/16
July 13, 2018 ~ BFP....WTF?!?!
7/16 Beta #1 ~ 466...7/18 Beta #2 ~ 1,077...7/23 Beta #3 ~ 5,291
7/23 US #1 ~ 1 gestational sac seen and yolk sac
7/30 US #2 and 1st OB appt ~ 1 perfectly round gestational sac, 1 perfect yolk sac and 1 teeny tiny heart beat seen!!!
Lilypie Maternity tickers


Re: Monitoring update and a ?

  • Sorry you're not seeing much progress.

    Bravelle documentation:
    The maximum daily dose of Bravelle® should not exceed 450 IU and in most cases 
    dosing beyond 12 days is not recommended.

    Menopur documentation:
    The maximum daily dose of Menopur® given should not exceed 450 IU and 
    dosing beyond 20 days is not recommended.




    dx:  Unexplained IF
     TTC since May 2011, 1 year trying, and then 3 TI, 2 IUI = BFN
    IVF #1 (May 2013):  Antagonist Protocol: 
    24R, 18M, 15F w/ICSI; 5dt of 2 early blasts, no frosties = BFN
    IVF #2 (August 2013):  Lupron Stop Protocol: 
    28R, 23M, 15F w/ICSI; 5dt of 1 partially hatched blast, 7 frosties = BFP
    EDD 5/23/14, blighted ovum (6w6d), D&C (8w6d)
    FET #1 (April 2014):  transferred 2 5d blasts = BFP
    C.J. born 01/09/15


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  • I was on 600iu for my last 2 IVFs, but the clinic I was at prior to this one wouldn't dose me higher than 450iu.

    I hope your E2 is climbing and you start to progress soon!!!

    Me (32) DOR, elevated NK Cells/ 2 copies of MTHFR mutation/ MH (35) azoo/high DFI   (TTC#1 since 2009)

    IVFs#1-4: (4/10-2/12) all BFN

    Surprise Bfp (9/11) - c/p

    DS IUI#1-2 (9/12, 10/12) - BFN

    DS IVF: (11/12) - BFN

    DE/DS IVF#1: (10/13) - 2 day 3 embies transferred-BFFN

    FET of 2 day 6 blasts: (12/13) - c/p

    DE/DS IVF #2: (4/14) - 1 day 5 blast transferred...BFFN...again.

    FET 5/14: 1 day 5 hatching blast transferred...another BFFN

    Repeat SHG 6/14-normal / Endometrial Receptivity Array biopsy 7/14-Receptive Uterus

    New RE, additional testing reveals elevated NK Cells

    FET of 1 day 5 blast (RE recommends transferring 1 due to elevated NK cells) with lovenox, steroids & intralipids in October

     

     

     

  • 21.  My E2 is only 21!   :((  She's keeping me at the same dose and I go back Thursday.  She said that if they don't see anything by then, "she'll be concerned."
    TTC #1 Since May 2011 ~ Everyone Welcome
    Me (34): DOR d/t chemo/radiation, Immature Endometrial Lining, Hypothyroidism
    DH (35): MFI d/t testicular torsion and removal, Low T, Oligospermia, Anti-Sperm Antibodies, Currently on T supplements
    Sept '11-April '13 ~  Testing, failed multiple MFI treatments, saving & TONS of praying
    January 2014 ~ IVF/ICSI & PGS ~ no response to stims ~ converted to IUI ~ BFN
    February 2014 ~ On to donor embyros ~ 5 blasts!!! 
    March 2014 ~ FET #1 ~ Transferred 2 blasts ~ BFN
    July 2014 ~ Kliman's mock cycle with endometrial function test
    Sample too small for EFT, HE slide showed immature cells
    New protocol planned, saving for another biopsy for EFT
    January 2015 ~ Considering adoption options
    April 2015 ~ Privately arranged adoption of planned pregnancy
    DD#1 ~ Lillyana Violet Marie born 6/15/16, Finalized adoption 12/20/16
    July 13, 2018 ~ BFP....WTF?!?!
    7/16 Beta #1 ~ 466...7/18 Beta #2 ~ 1,077...7/23 Beta #3 ~ 5,291
    7/23 US #1 ~ 1 gestational sac seen and yolk sac
    7/30 US #2 and 1st OB appt ~ 1 perfectly round gestational sac, 1 perfect yolk sac and 1 teeny tiny heart beat seen!!!
    Lilypie Maternity tickers


  • I am sorry your levels aren't increasing that much. It is so hard for us DOR gals. If you look at my signature, I have been through many cycles. One thing I kept questioning was the use of ganirelix. Both of my RE's said that ganirelix is better for DOR and I thought it was stunting my growth and suppressing me. My RE's blew me off till I got to my 3rd RE. I begged her to try lupron. She was hesitant because she doesn't use microdose lupron at all so she allowed me to use regular lupron and boyyyyy what a difference it made. She could not believe it, but my e2 on that cycle was way better than any of my previous cycles with ganirelix. My body just does not like ganirelix. This might not be the same issue you are having but I just wanted to share my story. Not every DOR girl fits in a cookie cutter. I hope your cycle turns around. (((HUGS)))

    Me & DH (33), 3 Furbabies, TTC since October 2011
    Day 3 #’s (Dec 2012) FSH 9, AMH .77, LH 2.4, E2 31, AFC 9 

    DX: Me-DOR + No Tubes, DH-Fine

    Ectopic 2007; lost tube/2nd tube removed Dec 2011 (hydro)

    April 2012=IVF#1- EPP Antag+ICSI, 2R,0F (BFN), Now dx’d with DOR.

    June-July 2012=IVF#2- MDL+ICSI&AH, 8R,4M,3F (BFP 9dp3dt) Beta#1 at 11dp3dt=36, Beta#2 at 15dp3dt=156, Beta#3 at 19dp3dt=671, dx'd with SCH, no growth-m/c at 7wks/Lap Dec 2012 to remove small fibroid.

    Feb 2013=IVF#3-MDL, 2/1=baseline, started 10 units mdl, AFC-7, 2/3 start gonal f, self cxld cycle b/c of low e2.

    April 2013=IVF#3.5-(with new RE)AG/ANT Conv + ICSI. 4/10-4/23 bcp's, 4/20-4/27 lupron, 4/28-ganirelix until end of stimming, 5/2-600 gonal f, 5/4-add 1/2 vial menopur, 5/13-ER (9R,1M,1F), 5/17-ET, 1 beautiful 8 cell (please be my sticky baby!!!!) 5/28-BFFN.

    Oct 2013=IVF#4-LLP+ICSI &AH, 10/14 (6R, 2M, 2F), 10/17-ET, 1 seven cell & a six cell, BFP at 9dp3dt, 1st beta=56, 2nd beta=52, CP.

    Jan 2014=IVF #5-LLP, Cxld after 6 days of stims due to fast response and lead follicle. 

    March 2014=IVF 5.5-LLP, Lupron 3/10, BL 3/18, 11 days of stims, Trigger 3/29, ER 3/31. 7R, 2M, 2F. ET 4/3. Txfd one 5 cell & one 9 cell. BFP on hpt from 7dp3dt & on. Praise be to God. Beta #1 at 11dp3dt=106, #2 at 13dp3dt=239. First u/s 4/28, measuring on track & heartbeat seen. 5/5-2nd u/s, measuring on track with strong heartbeat. 5/12- 3rd u/s & released from RE. Grow baby grow, we love you! Baby G&T is a BOY! Born 12/2014 via c/s! 8lbs, 8oz & 21 inches.


     *******Ticker Warning**********

     
    Lilypie First Birthday tickers

     
    "God's Delay is not God's Denial"
  • I'm sorry you're not getting faster results *hugs* FX they pick up by Thursday
    **SIGGY TICKER WARNING**
    Me: 27 High FSH (POF?) DH: 33 Slightly Low Morphology / Married Aug '08 TTC since 7/2009
    6 rounds of clomid = no luck
    IVF w/ ICSI & AZH #1 - Jan/2011 = ET cancelled OHSS
    FET #1 & #2 - March/2011 & June/2011 = Chemical Preg.
    IVF w/ Half ICSI #2 New RE - May/2012 = BFN!
    May '12 - Sep '13 - Took A Break
    Dec '13 IVF w/ Half ICSI #3!!!!! Switched RE
    Protocol - Lupron trigger/Follistim/Ganirelix/Estrace/Vivelle/Crinone
    12/27 - BFP! TWINS! EDD 9/3/14 ...Team PURPLE!
    6/27/14 - Emergency C/S @ 30w2d - Baby A 2lb 14oz, Baby B 2lb 11 oz
    image
    ALL WELCOME :)
  • Ugh that sucks! Really pulling for you to see lots of growth Thursday.
    Me: 30 DH: 30 ~ TTC #1 Since August 2011 
    BFP #1 2/28/13, Ectopic, Tubal surgery 3/25 
    Began RE testing 8/8, Dx Unexplained, 
    IUI #1 11/1=BFN Moving on to IVF 
    IVF #1 12/2 ER 8R 7M 4 fertilized
    12/7 Transferred 2 "perfect" little blasts 12/17 BFN
    New DX= DOR, I fu*kng hate IF
    1/14 Hysteroscopy, new clean uterus!
    IVF #2: bcp, Lupron, follistim 300, menopur 225. 2/21 8R 4M 3F. 3dt of 2 perfect embryos. 1 little penguin 
     3/10 BFFN
    Regrouping. Seeing reproductive immunologist Dr. Kwak Kim 6/10 
    Kwak Kim protocol: Metformin 1000mg, vitamin D 4000iu, vitamin E 400iu, baby aspirin, Metanx, levothyroxine 75mcgs 
     Surprise BFP 9/21!!! Beta #1 247, Beta #2 630. Miscarried 10/13

  • Fx things turn around at your next appointment!
    Image and video hosting by TinyPic
    Anniversary

    TTC since 2008
    Dh:34, no issues.  Me:31, Endo, slightly hypothyroid, deformed ovary, paracentric inversion.
    4 Gonal-F, Cetrotide, HcG, Crinone +TI cycles= all BFN
    Lap in 2012 to remove large unresolving cyst discovered endo and double lobed ovary.
     6 Gonal-F, Cetrotide, HcG, Crinone IUI cycles= All BFN,
    1st IVF w/ICSI- June '13 Antagonist: Gonal-F, Menopur, Ganirelix, HcG, Estradiol, Crinone= 7 retrieved, 4 mature, 1 unfertilized, 2 abnormally fertilized, 1 normally fertilized.  2DT of only embryo and our miracle BFP.
    Our beloved baby boy was born sleeping Oct. 13, 2013 due to pROM/IC/Uterine infection.
    2nd IVF w/ICSI- Feb. '14 EPP/lupron/antagonist: Estrace, lupron, HGH, Gonal-F, Menopur, HcG, PIO, lovenox, doxy/dex.=21 retrieved, 16 mature, 15 fertilized!!  5dt of 1 blast/ 6 frozen. BFP!  Beta 1 9dp5dt:83.9  Beta 2: 11dp5dt: 145.2  Beta 3  14dp5dt: 497  Please be our sticky rainbow baby!

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    Lilypie Angel and Memorial tickers


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  • So sorry :( fingers crossed for a good appointment Thursday!!!
    image
    Me: 36, unexplained 
    Him: 36, slightly low count 
    TTC since May 2011 
    IUI #1 w/Clomid - 10/2012 BFN 
    Break for cysts 
    IUI #2 w/Clomid - 12/2012 BFN 
    Break for cysts 
    IUI #3 w/Clomid - 2/2013 BFN 
    Break for sanity and to work on health with diet, exercise, and acupuncture 
    IVF/ICSI #1 - BCP, 150 Follistim, 150 Menopur, and Ganirelix
    Retrieval 9/11/2013 - 31 eggs, 17 fertilized, 3 blasts frozen 
    Transfer cancelled - Moderate OHSS 
    FET #1 - 10/22/2013 Transferred 2 (1 did not survive thaw) BFP resulted in CP 
    IVF/ICSI #2 - EPP - Starting stims 1/5/2014 (100 Follistim, 150 Menopur)
    All welcome!


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