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PGS PGD Question

KayteeGeeKayteeGee member
in Success after IF
Hi ladies - Anyone here do PGS? I just did our last FET yesterday - 2 6-plus day blasts that were deemed "normal" via PGS I know it still may not work (and that's ok) but it occurred to me that I don't even really know what "normal" means .... Does it mean I don't have to do MaterniTI or CVS or worry about the NT screening? I know I'm getting ahead of myself but I'm just curious. Essentially I barely got a look at the results - we didn't want to know genders and so all of the sudden when we realized it was there and we didn't want to know it all went really fast... Anyway.. Just curious if anyone had anyone had gone through this?
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Re: PGS PGD Question

  • PurpleIris30PurpleIris30 member
    You should ask how many and which chromosomes were screened. There are different techniques (FISH versus assay) and different numbers of chromosomes screened and the terms PGS/PGD/CGH/CCS are often used imprecisely. Today most companies are doing assay for all chromosomes (a type of PGS called CGH) but you should find out.

    Maternit21 only screens for 3 trisomies - 13, 18, and 21. PGS is not 100 percent guaranteed, but I would probably be confident enough to skip maternit21 and the like. The NT scan is primarily used to detect the most common chromosomal abnormalities, but can also be used to detect non-chromosomal deformities (these would also likely be apparent at your anatomy scan, but sometimes people want to know as early as possible for planning or termination purposes). Sometimes people just like the extra ultrasound to see the baby, too.

    Cvs and amnio aren't routinely done unless you have other tests or ultrasounds showing abnormalities, and these can also be used to diagnose a whole host of other, non-chromosomal genetic diseases.
    Married 8/2008. IVF with PGD March 2013.
    3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
    3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
    4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
    PPROM at 31w, delivery at 32 weeks of two beautiful girls
    image
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  • PurpleIris30PurpleIris30 member
    EmAzeem said:

    I did PGD/PGS. Normal means that all the chromosomes came back with the correct amount. No deletions,repeats,extras.

    Just to be clear, PGS just counts the number of chromosomes (making sure you don't have 1 copy or 3 copies, for instance); it does not look closer in the genetic code to see if there are smaller gene deletions or repeats. That can be done, but it's a separate process and something you need to set up ahead of time.

    Married 8/2008. IVF with PGD March 2013.
    3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
    3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
    4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
    PPROM at 31w, delivery at 32 weeks of two beautiful girls
    image
    Report Reply
  • KayteeGeeKayteeGee member
    Thanks ladies, we only did PGS and it was the full screen. I just kept googling and it felt like everything was coming up PGD...got confused. This is helpful, thanks again
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