Infertility

tell me about ICSI please

I just got a message from our ivf coordinator with DH's analysis results and it's not awesome. Everything is lower than it should be asked she said we'd definitely need to be doing ICSI. I haven't researched this at all because the analysis he'd had at our old re's office was fine except the morphology was low. I'm at work so no time to research really and I'm posting and dashing. Anything anyone can give is much appreciated. Any clues to why it change so much? Thanks ladies!
Me: 26  DH: 29
TTC since December '11 -- stopped BC
No cycle for 3 months
Diagnosed PCOS/anovulatory in March '12 and started Clomid 100 mg
2 cycles of Clomid 100 mg - nothing
1 cycle of Clomid 150 mg - nothing but thinned lining
1 cycle of Femara - nothing
Started Gonal-F + Ovidrel + TI 6/28/12 -- BFN
Started Follistim + Ovidrel + TI x 2 cycles-- BFN
Follistim + Ovidrel + TI -- 3 weeks of this and cancelled
~Break from the doctor, still no bc-- We bought a house and moved :)

New RE & Starting up again!! :D
Prepping for 1st IVF cycle!

New SA:  DH has lower numbers across the board. ICSI added to IVF protocol
OHSS after ER in December:  Hospital for 5 days :/ Obviously freeze-all for our beautiful 13 embryos!

2 FETs (February and March) = 2 chemical pregnancies :(
3rd FET= Twins!! Due January 2015
5 embryos left for the future 


Re: tell me about ICSI please

  • My clinic does ICSI on everyone, it's just part of the standard IVF package.  It can really improve fertilization rates.  It think the average fert rate with traditional IVF is only 50%, where with ICSI it's more like 80% (and maybe higher, I can't remember the exact stat).

    imageimageimageimageimage

     

    image

    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

  • ICSI basically helps leave nothing to change- the embryolgist fertilizes the egg with the sperm.  Men's semen can change very quickly, and for no know reason.  It happens.  We're doing ICSI.  Good luck.

    IVF #1 Oct 2013- cancelled 
    IVF #2 Mar 2014- success.... baby girl born 11/28/14
    FET #1 Mar 2016- baby boy due 12/16/16


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  • my clinic does ICSI on everyone as well. I think its fine and wouldn't worry about it. Better success rates :)
    Me: 35  low AMH, normal FSH
    DH: 31 Fair DNA fragmentation test :( Normal SA
    TTC: since March 2012

    09-21-13 start IVF #1
    10-04-13 ER 6 eggs, 6 mature, all 6 fertilized. 3 frozen
    10-08-13 fresh transfer canceled due to high progesterone
    waiting for FET
    10-18 started BCP
    10-29 baseline appt scheduled
    11-20 scheduled date of FET #1
    12-2 BFN :(

    3-1-14 moving on to the next step. Switched RE. going to plan 3 IUI cycles while saving for IVF#2

    April 2014- IUI#1  BFN
    May 2014- IUI#2 BFN
    June 2014 IUI#3 BFN

    Taking a break for a while, focusing on our wedding.

    Sept 24th missed period! Surprise natural BFP
    10-15-14 first ultrasound
    06-05-15 EDD

    imageimage

  • My clinic did not do ICSI for me on my first IVF because dh's sperm was fine and the doctor said he thought it was best to let everything happen naturally and not to mess with the eggs as much as possible. I WISH they had done ICSI because out of 15 eggs retrieved, only FIVE fertilized and I never even made it to transfer because 4/5 embryos arrested by day  3 and the one that made it to blast was abnormal. This time, I hope the ICSI helps improve our fert rate so that we potentially get more viable embryo options!

    When you have time later, look icsi up on youtube...it is pretty interesting to see if being done!

    Good luck!


    **Siggy/Ticker Warning**   

             image
                  TTC #1 since May 2012

                  May 2013: First R.E. appointment

                  DH: SA is good

                   May 2013: CD3 Blood work-normal
               June 2013: Hsg-Right tube blocked

                   July 26, 2013: Starting Follistim for IVF #1

                  August 2013: IVF #1 Cancelled- Abnormal embryos

             October/November 2013: IVF #2 w/ICSI

                        November 8, 2013: Transferred two early blasts (no frosties) 

    November 18, 2013: First EVER BFP! 

    Beta#1: 91  Beta#2: 288

    1st U/S- 5w2d Saw yolk sac!

    3rd U/S- 7w4d HB of 157bpm!

    TEAM BLUE!

           http://movingtolight.blogspot.com/

          imageimage

                                        BabyFruit Ticker

                                        BabyFetus Ticker

  • @weeklyplanner Thanks! That gives me some hope! I am so stressed that the same thing will happen...even my doctor is not convinced!

    @Neesey I know it's not really a funny situation but I died laughing at your description of your eggs being slutty and having threesomes! I didn't even know eggs could let more than one sperm in at a time! No more fun for you eggies! LOL


    **Siggy/Ticker Warning**   

             image
                  TTC #1 since May 2012

                  May 2013: First R.E. appointment

                  DH: SA is good

                   May 2013: CD3 Blood work-normal
               June 2013: Hsg-Right tube blocked

                   July 26, 2013: Starting Follistim for IVF #1

                  August 2013: IVF #1 Cancelled- Abnormal embryos

             October/November 2013: IVF #2 w/ICSI

                        November 8, 2013: Transferred two early blasts (no frosties) 

    November 18, 2013: First EVER BFP! 

    Beta#1: 91  Beta#2: 288

    1st U/S- 5w2d Saw yolk sac!

    3rd U/S- 7w4d HB of 157bpm!

    TEAM BLUE!

           http://movingtolight.blogspot.com/

          imageimage

                                        BabyFruit Ticker

                                        BabyFetus Ticker

  • @neesey I literally just laughed so hard reading that. I had a visual of party eggs and sperm!
    Me: 35  low AMH, normal FSH
    DH: 31 Fair DNA fragmentation test :( Normal SA
    TTC: since March 2012

    09-21-13 start IVF #1
    10-04-13 ER 6 eggs, 6 mature, all 6 fertilized. 3 frozen
    10-08-13 fresh transfer canceled due to high progesterone
    waiting for FET
    10-18 started BCP
    10-29 baseline appt scheduled
    11-20 scheduled date of FET #1
    12-2 BFN :(

    3-1-14 moving on to the next step. Switched RE. going to plan 3 IUI cycles while saving for IVF#2

    April 2014- IUI#1  BFN
    May 2014- IUI#2 BFN
    June 2014 IUI#3 BFN

    Taking a break for a while, focusing on our wedding.

    Sept 24th missed period! Surprise natural BFP
    10-15-14 first ultrasound
    06-05-15 EDD

    imageimage

  • I'm with @krdesi I know it's not a funny situation, but your description @Neesy made me lol.

    My fert rates weren't stellar even with ICSI.  IVF #1 was 60% and IVF #2 was 71%.  I can't imagine what they would have been if  we hadn't done ICSI.

    imageimageimageimageimage

     

    image

    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

  • Without ICSI, I don't think we would have any chance.  It's standard at my clinic, and I am so thankful for that.  SA's can literally change from day to day, but ICSI will give you the best chance at fertilization regardless.  They only need as many "good' sperm as they have eggs!  GL <3
    Image and video hosting by TinyPic
    Anniversary

    TTC since 2008
    Dh:34, no issues.  Me:31, Endo, slightly hypothyroid, deformed ovary, paracentric inversion.
    4 Gonal-F, Cetrotide, HcG, Crinone +TI cycles= all BFN
    Lap in 2012 to remove large unresolving cyst discovered endo and double lobed ovary.
     6 Gonal-F, Cetrotide, HcG, Crinone IUI cycles= All BFN,
    1st IVF w/ICSI- June '13 Antagonist: Gonal-F, Menopur, Ganirelix, HcG, Estradiol, Crinone= 7 retrieved, 4 mature, 1 unfertilized, 2 abnormally fertilized, 1 normally fertilized.  2DT of only embryo and our miracle BFP.
    Our beloved baby boy was born sleeping Oct. 13, 2013 due to pROM/IC/Uterine infection.
    2nd IVF w/ICSI- Feb. '14 EPP/lupron/antagonist: Estrace, lupron, HGH, Gonal-F, Menopur, HcG, PIO, lovenox, doxy/dex.=21 retrieved, 16 mature, 15 fertilized!!  5dt of 1 blast/ 6 frozen. BFP!  Beta 1 9dp5dt:83.9  Beta 2: 11dp5dt: 145.2  Beta 3  14dp5dt: 497  Please be our sticky rainbow baby!

    Image and video hosting by TinyPic

    Lilypie Angel and Memorial tickers


    imageimage
  • Thank you thank you everyone :) I feel a lot better about it.  Our coordinator was pretty nonchalant about it, but it still made me nervous.  You guys rock!
    Me: 26  DH: 29
    TTC since December '11 -- stopped BC
    No cycle for 3 months
    Diagnosed PCOS/anovulatory in March '12 and started Clomid 100 mg
    2 cycles of Clomid 100 mg - nothing
    1 cycle of Clomid 150 mg - nothing but thinned lining
    1 cycle of Femara - nothing
    Started Gonal-F + Ovidrel + TI 6/28/12 -- BFN
    Started Follistim + Ovidrel + TI x 2 cycles-- BFN
    Follistim + Ovidrel + TI -- 3 weeks of this and cancelled
    ~Break from the doctor, still no bc-- We bought a house and moved :)

    New RE & Starting up again!! :D
    Prepping for 1st IVF cycle!

    New SA:  DH has lower numbers across the board. ICSI added to IVF protocol
    OHSS after ER in December:  Hospital for 5 days :/ Obviously freeze-all for our beautiful 13 embryos!

    2 FETs (February and March) = 2 chemical pregnancies :(
    3rd FET= Twins!! Due January 2015
    5 embryos left for the future 


  • I'm at a point now where I can laugh about it. Damn slutty eggs. Either slutty or lazy.
    image 
     image image image
    TTC since 3/2011 Adenomyosis, LPD, hypothyroidism. 
    BFP on 7/20/12 after 4 cycles Clomid + IUI 
    2 large subchorionic hematomas & no heartbeat at 7w6d   
    D&E 8/18/12 Sonohysterography found septum and necrotic tissue.   
    Hysteroscopy to remove both 10/5
    IUI #5-7 50mg Clomid + trigger = BFN  
    IUI #8 Femara + Bravelle + HCG + Progesterone = BFP 3/27/13
    Beta 1 (13dpo) = 169  Beta 2 (17dpo) = 1073  No heartbeat at 9w3d. 
    D & C 5/10/13  Triploidy 69 (paternal inherited)
    IVF #1 with ICSI and PGS 11R 8M 5F 2 biopsied/frozen
    PGS results = 1 with trisomy 13 & 1 good embryo for FET 
    FET #1 EV, estrace, nitro patches.  Cancelled due to thin lining
    FET #1.2 oral estrace, f'ing nitro patches and no delestrogen.  Transfer 12/31. BFN
    PAIF/SAIF welcome
    Surprise BFP on 6/13/14  Our only unmedicated bfp ever.
    Beta #1 339  Beta #2 649 44 hour doubling time
  • @Neesey, thanks for the laugh!

    @kcm187 - my clinic does ICSI and traditional, but for us recommended ICSI due to DH's SA results. There was a TV segment recently (I think it was on the Today show) where they showed an Egg Retrieval, and then the embryologist was fertilizing the eggs with ICSI. I watched it on YouTube, and it is fascinating. My nurse told me that the embryologist will clean DH's sample, pick the best tadpoles, cut off their tails, and use a needle to inject the tadpole into the mature egg. Hope this helps!
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