Prothrombin mutation gene

Medic99 · October 2013

Does anyone here have the prothrombin mutation gene? I was just diagnosed with it. I am going to have to give myself 2 shots a day of heparin for the rest of my pregnancy as well as baby aspirin a day. I am hoping for advice or insight as to what I will be dealing with. Thank you!

Lzyrhu · October 2013

I am in a similar boat. Did just baby aspirin for my last pregnancy and am on Heparin for this one. I did not feel any different with blood thinners either time. Last time I was still allowed an epidural even though I took the blood thinners through delivery. It can lead to a bit more bleeding during delivery though but your medical team should be well aware of that.

Medic99 · October 2013

Are you doing the injections or the pills? I so appreciate you responding!!! Thank you!!

Medic99 · October 2013

Also, they are telling me that I will need a repeat c-section since they cannot induce me. They do not want me on the heparin the day of delivery. Have you heard of this? I know you said you were on it through delivery so I am just curious.

daltosostarby · October 2013

I'm on 2x daily heparin shots and baby aspirin. I may be induced a week early, so I'm off the heparin for the delivery. I think it's pretty standard to be induced a week early when on blood thinners. There is a risk of spinal embolism if you stay on them and get an epidural. I am definitely not getting a c-section though, unless there are other medical reasons for it.

Medic99 · October 2013

I was told a c-section is needed because the blood thinners are a risk and so that they can control the bleeding. I need to talk to my OB about it. I will be an automatic c-section because they cannot induce me because of a prior c-section.

Chris&AmyDunn · October 2013

I have Factor V Leiden, and take one shot of Lovenox every day and one baby aspirin as well. I have been told that I should be induced one week prior to due date to control when the last dose of Lovenox is given. I have the same questions and fears as all of you. I have asked what happens if I go early and am unable to delivery vaginally, and have been told that I would be put under General Anesthesia because of the risk of a spinal hematoma. I've tried to do research to see how all of this is handled and it appears that most drs switch to Heparin @ 36 weeks and induce, or deliver via c-section at or around 38 weeks. And most of the pregnancy when I have asked questions, I just get told the delivery is so far away, we'll worry about it later. Well, I'm 29 weeks now, and in all honestly just need a few more answers. I do wonder however, have any of you on a blood thinner had an INR done to check your blood? I haven't but will be asking about it at my next appointment.

Medic99 · October 2013

I am going to ask my Dr at my next appointment about the delivery. I have heard so many different things concerning delivery and meds. I am glad you brought up the risk of spinal hematoma because I need to ask about that as well. I am not sure what all of the labs were that my MFM drew so I am not sure if they did an INR. Keep us posted! I so appreciate you guys talking about this because this is new territory for me. Thank you!!

Lzyrhu · October 2013

I was only on baby aspirin when I delivered my first at 40 weeks having been advised by my specialist to continue taking it through delivery. My hospital was fine with me having an epidural; I think they just had to run a bit of bloodwork first. I had the epi as planned & did not have any issues. I did, however have a post partum haemorrhage but that was more likely due to the 21h labor with a 10.5lb baby. (Thank goodness for the epidural!)

BeesKnees181 · October 2013

Thanks for posting! I am Factor V (hetero) and take daily shots of enoxoparin. I was diagnosed after having a pulmonary embolism a few years ago. Sometimes, I really hate the shots. Mostly because they hurt. But, I know it is a necessary treatment. Is it true that most women on Lovenox end up having labor induced? I have read this several times and was wondering if anyone can weigh in on it...

BeesKnees181 · October 2013

I only had INR done when I was on Coumadin/warfarin. I have been told that Lovenox/heparin/enoxoparin do not require INR because they are not as touchy and thrown off easily by Vitamin K and other environmental factors. I was training for a half-marathon when I was on Coumadin and the doc couldn't figure out why my INR was so low (in a risky range) when he kept upping the mg of Coumadin. Then I told him more about my lifestyle and it all made sense. My body was metabolizing the Coumadin t a fast rate because of my physical activity. Also, I believe the half-life of Lovenox is much shorter than Coumadin. So it does not last in our bodies as long as Coumadin.

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