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Successful IVF protocol?

MrsMcC.10409MrsMcC.10409 member
in Pregnant after IF
I hope you don't mind the intrusion, but I was hoping some here might be able to lend some advice to a friend of mine. She has had 2 IVFs and 2 FETs. The IVFs resulted in early miscarriages, the FETs were unsuccessful. She has an apt with her RE next week, and is wanting to discuss where to go from here. I thought maybe if some of you shared the protocols that led to success for you, she might be able to discuss these alternatives with her doctor. So, if you don't mind, I'd love to know what your IVF regimen was that led to your pregnancies. Thank you so much, and all the best to you!

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Re: Successful IVF protocol?

  • afsalinasafsalinas member
    It really depends on her diagnosis, whether or not there is a male factor, her age, and what was previously unsuccessful for her. For what it's worth, I'm early DOR, was under 30 at time of transfer, in good health, and no male factor. Antagonist protocol worked beautifully for me. I also did acupuncture. Maybe she can add that?
    ***Siggy Warning***

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    Anniversary

    Started TTC June 2011Cycles #1-10 = BFNCycle #11: 100 mg Clomid + TI =BFNReferred to RE March 2012HSG all clear, FSH = 13, Prolactin = 28, S/A = greatApril 2012 MRI to check for brain tumor due to elevated Prolactin = clearJune 2012 Hysteroscopy to remove uterine polyps and partial septateJuly 2012 IUI #1 7/7/12 = BFNAugust 2012 IUI #2.1 Cancelled due to early/missed ovulation = BFNSeptember 2012 Forced break due to one huge cyst October 2012 IUI #2.2 = BFNNovember 2012 Begin BCPs for IVF #1December 2012 IVF #1 = Delayed due to cyst. Start stims 12/22January 2013 ER: 1/2, 14R, 10M, 9FET: 1/7 Transferred 1 "Perfect" blast! 4 frosties!Beta #1: 99 BFP! #2: 227 #3: 584 #4: 3,020Baby Boy born September 25, 2013

    TTC #2
    November 2014 - Begin BCPs
    December 2014 - Start Lupron 12/25
    January 2015 - FET #1

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    *Everyone Welcome*


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  • jezebel57jezebel57 member
    I second pp that it depends on diagnosis. I am DOR did a microdose lupron flare that failed and had success with antagonist. I also did acupuncture for several months leading up to the Ivf and am continuing through my pregnancy.
    Me (37) DH (39); PCOS changed to Unexplained, changed to DOR in 2012 (finally a correct diagnosis!); 
    Started TTC 2009 with RE after 6 months.  
    Clomid + Trigger x2; 
    IUI + Femara x1,
    IUI + Follistim x2;
    IVF #1 (MDL) February 2013- BFN.
    IVF #2 (antagonist) May 2013, First BFP of my life. 
    Identical twin miracle BOYS (!!) headed our way- due date is technically 2/4/14 but c section is scheduled for 1/7! 


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  • BlueEyedDreamerBlueEyedDreamer member
    Agreed - a successful protocol is going to depend on her diagnosis. She may also want to think about getting a second opinion from another RE at a different clinic if possible.

    FWIW, our diagnoses was "unexplained IF" and long lupron worked for us.
    *** Trigger Warnings ***

    TTC #1 since March 2011
    Dx = Unexplained IF
    1 medicated TI cycle & 4 clomid IUIs = all BFNs
    June 2013 IVF #1 = 6 frosties + BFP!
    DS1 born 2/14

    TTC #2 since December 2014
    May 2015 unassisted BFP ended in m/c at 7wks
    April 2016 FET #1 = BFN
    June 2016 FET #2 = c/p
    August 2016 FET #3 = BFP!
    DS2 born 4/17
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  • megs3084megs3084 member
    We did long lupron w our successful cycle. Im also working with a reproductive immunologist and I feel that contributed to our success.
    "Everything will be alright in the end. So if it's not alright, it is not yet the end."
    Me:29 DH:29  TTC since 1/11 Dx: unexplained IF/early DOR/immune issues 
    Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN
    8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F. 
    ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
    IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
    ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
    3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.  
    DX: High NK cells, cytokines, DHEAs& PAI1;  hypothyroid, +APA, restricted bloodflow
    7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
    (plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim)
    ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
    ET 5dt 7/24 2 fully expanded blasts.  SURPRISE 3 FROSTIES!!!
    Beta #1 8/2 335!!!! Beta #2 829!!!  1st u/s 8/14 showed TWINS!!!!!
    11/11: TEAM PURPLE!!!!!
    3/21/14-L&W born at 37w via csection
    Here Comes the Sun Blog
    PAIF/SAIF welcome!
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  • MrsMcC.10409MrsMcC.10409 member
    Thank you for your responses. My friend is actually undergoing IVF because she is single and desires a child. Based on her blood work and examinations, she has no known fertility issues.  She was unsuccessful with 4 IUI's, and her RE thought she would be a good IVF candidate. She is considering seeking another practice. Again, I appreciate your time!

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  • PurpleIris30PurpleIris30 member
    edited September 2013
    MrsMcC.10409 said:
    Thank you for your responses. My friend is actually undergoing IVF because she is single and desires a child. Based on her blood work and examinations, she has no known fertility issues.  She was unsuccessful with 4 IUI's, and her RE thought she would be a good IVF candidate. She is considering seeking another practice. Again, I appreciate your time!
    A second opinion with another RE is probably a good idea.  If I were your friend, I'd probably seek further testing for recurrent pregnancy loss (if she hasn't done that already).  Also, if she responded well to her first two IVF cycles, a change in protocol might not be helpful (she obviously had frozen embryos, which is great).  If she is getting a good number of embryos to a 5-day blast stage, CGH or PGS to screen for chromosomal abnormalities might also be helpful, as chromosomal issues are a common cause of early miscarriage. 

    However, to answer your original question, a long lupron protocol is pretty standard for your friend's situation.
    Married 8/2008. IVF with PGD March 2013.
    3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
    3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
    4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
    PPROM at 31w, delivery at 32 weeks of two beautiful girls
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  • hootie123hootie123 member
    I had to go to three different doctors before one figured out what would work for us.  So I definitely encourage your friend get another opinion on her case. 
     TTC #1 since 6/09
    Dx: PCOS and MFI
    3 IUIs, 4 IVFs = BFFN
      3rd RE: IVF #5/FET = BFP
    14dp5dt=1170 16dp5dt=2573
    1st u/s=    TWINS!
    It's a Boy and a Girl!

    Born at 34w3d! 
     

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  • jezebel57jezebel57 member
    I definitely agree on an RPL panel.  After my first failed IVF I had one done and found out I had 2 clotting disorders.  I think meds for those contributed to my success!
    Me (37) DH (39); PCOS changed to Unexplained, changed to DOR in 2012 (finally a correct diagnosis!); 
    Started TTC 2009 with RE after 6 months.  
    Clomid + Trigger x2; 
    IUI + Femara x1,
    IUI + Follistim x2;
    IVF #1 (MDL) February 2013- BFN.
    IVF #2 (antagonist) May 2013, First BFP of my life. 
    Identical twin miracle BOYS (!!) headed our way- due date is technically 2/4/14 but c section is scheduled for 1/7! 


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  • zazu13zazu13 member

    I went through several cycles and two losses before we found success. The things that we did differently this time were:

    estrogen priming (no BCP) in addition to Antagonist protocol

    Human Growth Horomone with stims

    Endometrial biopsy (scratch) the cycle before

    intralipid infusions

    lovenox after BFP

    I will never know which of these helped, but I was ready to pull out all the stops. I hope your friend finds success soon!

     

    Age: 35 TTC since 2005, MFI & DOR 

    IVF #1 Sep '11 - canceled poor response

     IVF #2 Nov '11  8R/8M/4F 3dt x2 - chemical

    IVF #3 April '12  11R/6M/4F 3dt x2 - m/c

    FET #1 Aug 2012  3dt x2 - BFN

    **new RE**

     IVF #4 Jan '13 BFN 11R/6M/6F 5dt x2 - BFN

     IVF #5 July '13 16R/10M/10F 5dt x2 + 1 frostie

    9dp5dt Beta 1 = 344!! 16dp5dt. Beta 2 = 4822 7wk u/s= 2 heartbeats!

    Twin girls! 3/6/14

     

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