Trouble TTC

IUI w/Clomid vs. Injectibles

Found out IUI #2 was a BFN:(  We are pretty disappointed because our RE & us were very hopeful this time after seeing DH's numbers on the day of IUI.  I will be seeing my doctor later this week & I want to discuss options.  I have now been on Clomid for 8 months, had trigger injections that past 3 months.  I am responding to Clomid with normally 1 follie per cycle (sometimes 2) but I was told by the nurse that injections do increase your chances--of course I know it increases chances for multiples as well.  Anyway, I want to give IUI #3 my best shot as RE will want to move on to IVF after this.  I am turning 36 in 2 weeks so I feel more pressure (from myself) than previous months.  Can anyone give me advice for IUI w/injects vs Clomid?  Thanks!

Me (36) - LOR, DH (34) - MFI (low count & poor motility)

TTC since 01/2012

11/2012-04/2013 Unmonitored Clomid cycles through OB/GYN; Referred to RE

05/2013-Benched due to cyst

06/2013 - Clomid 50 mg + HCG Trigger + TI = BFN

07/2013 - Clomid 50 mg + HCG Trigger + IUI #1 = BFN

 08/2013 - Clomid 50 mg + HCG Trigger + IUI #2 = BFN

09/2013 - Benched for lap & hysteroscopy (Stage II Endo Removed)

10/2013 - Menopur + HCG Trigger + IUI #3 = BFN

11/2013 - Menopur + HCG Trigger + IUI #4 = BFN

 12/2013 - Clomid + HCG Trigger + IUI #5 = BFN

2/2014 - IVF #1 - Microdose Lupron Flare Protocol - 5R/4M/4F w/ICSI; 2 embies transferred on day 3 (none to freeze)

2/27/14 - First BFP Ever!!!  EDD 11/3/14

 

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Re: IUI w/Clomid vs. Injectibles

  • All the nurse ever says during my u/s is that my lining "looks good."  I have never asked for measurements but I have that on my list of questions to start asking now that I see other posters discussing it.  They measure & she records it on my chart but I have never been told before.  We are OOP so I know injectibles will be much more expensive but we expected that.

     

    Me (36) - LOR, DH (34) - MFI (low count & poor motility)

    TTC since 01/2012

    11/2012-04/2013 Unmonitored Clomid cycles through OB/GYN; Referred to RE

    05/2013-Benched due to cyst

    06/2013 - Clomid 50 mg + HCG Trigger + TI = BFN

    07/2013 - Clomid 50 mg + HCG Trigger + IUI #1 = BFN

     08/2013 - Clomid 50 mg + HCG Trigger + IUI #2 = BFN

    09/2013 - Benched for lap & hysteroscopy (Stage II Endo Removed)

    10/2013 - Menopur + HCG Trigger + IUI #3 = BFN

    11/2013 - Menopur + HCG Trigger + IUI #4 = BFN

     12/2013 - Clomid + HCG Trigger + IUI #5 = BFN

    2/2014 - IVF #1 - Microdose Lupron Flare Protocol - 5R/4M/4F w/ICSI; 2 embies transferred on day 3 (none to freeze)

    2/27/14 - First BFP Ever!!!  EDD 11/3/14

     

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  • There's slightly higher success rates with injects/IUI than clomid/IUI.
    Try freedomfertility.com for injects, I used Bravelle 75 iu vials and paid $49/each one, used 9 injects in 1 cycle and 1 Ovidrel ($79).
    Me: 32, DH: 34.
    Trying since Jan 2011. Unexplained IF.
    2 IUIs = BFN.
    1 IVF (Dec 2013) = BFN.
    FET, 2 frosties (June 13, 2014)

    14dp5dt-June 27 -BFP, beta 2061. 2nd beta >5000, 3rd beta >5000, 2 sacs 06/30.
    Twin Girls - 02/11/15 - at 37 weeks (no NICU, home with me at 3 days).
  • Loading the player...
  • I am now in this same boat.... what to do... how much to do it... 
    RE: wants to go straight to injectable IUI--- kinda freaking me out on cost.. and how well I responded to clomid... I even asked my RE about it...he said that is why we monitor... and we can scale back injectable dose.. but holy shit balls... If I got 4 on clomid... what would I get on injectables.... 

    who has gone from clomid to injectables.. and what response did you get?

    Me:38 DH:40 TTC for over 3 yrs~
    Every test known to man- comes out that we are both perfectly capable of conceiving- 

    Officially diagnosed with "unexplained infertility"

    7/17/13-1st try with 100mg Clomid+Novarel+Prog.
    7/25/13 Mid-cycle U/S- 4 Follicles! 17, 16,L 16,15 R
    7/25/13 Trigger shot
    8/6/13 Beta Blood Drawn... Big fat Neg. 
    New RE:- 101 tests done during break cycle.. All look great! green light to hit the deck running!
    9/18/13- Cd 1- FINALLY! 100 mg clomid CD3-7- 75iu Bravelle 7-10   
    9/30/13 Follie count.. 3 on right. 2 on left-- trigger today
    10/2/13- IUI #1
    10/15/13 Beta #1- BFN.. :(


     


  • My RE didn't recommend injects + IUI for us because he doesn't think it is cost effective given our unexplained diagnosis and the fact that we are 100% OOP (there is only a small increase in success rates and a very large increase in cost).  The one reason that I wish we would have done one injects + IUI cycle is that it may have changed the dose of stims prescribed for my IVF.  I didn't respond the greatest on the low dose of stims (only 6 eggs retrieved), but if I done an injects + IUI cycle he might have started me on a higher dose for IVF. 

    imageimageimageimageimage

     

    image

    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

  • That makes sense.. kinda like a trial run... did you respond to clomid, Twinkie?..
    Ivf is not an option for me... the cost is just not in my budget.... so 3 iui are my options...
    So I am thinking try one with clomid... then two with injectable....

    Me:38 DH:40 TTC for over 3 yrs~
    Every test known to man- comes out that we are both perfectly capable of conceiving- 

    Officially diagnosed with "unexplained infertility"

    7/17/13-1st try with 100mg Clomid+Novarel+Prog.
    7/25/13 Mid-cycle U/S- 4 Follicles! 17, 16,L 16,15 R
    7/25/13 Trigger shot
    8/6/13 Beta Blood Drawn... Big fat Neg. 
    New RE:- 101 tests done during break cycle.. All look great! green light to hit the deck running!
    9/18/13- Cd 1- FINALLY! 100 mg clomid CD3-7- 75iu Bravelle 7-10   
    9/30/13 Follie count.. 3 on right. 2 on left-- trigger today
    10/2/13- IUI #1
    10/15/13 Beta #1- BFN.. :(


     



  • My RE didn't recommend injects + IUI for us because he doesn't think it is cost effective given our unexplained diagnosis and the fact that we are 100% OOP (there is only a small increase in success rates and a very large increase in cost).  The one reason that I wish we would have done one injects + IUI cycle is that it may have changed the dose of stims prescribed for my IVF.  I didn't respond the greatest on the low dose of stims (only 6 eggs retrieved), but if I done an injects + IUI cycle he might have started me on a higher dose for IVF. 
    what dose did they start you on Twinkie? my dr wants to start me on 150iu... for 6-8 ish days during my cycle... that seems High to start me with... 


    Me:38 DH:40 TTC for over 3 yrs~
    Every test known to man- comes out that we are both perfectly capable of conceiving- 

    Officially diagnosed with "unexplained infertility"

    7/17/13-1st try with 100mg Clomid+Novarel+Prog.
    7/25/13 Mid-cycle U/S- 4 Follicles! 17, 16,L 16,15 R
    7/25/13 Trigger shot
    8/6/13 Beta Blood Drawn... Big fat Neg. 
    New RE:- 101 tests done during break cycle.. All look great! green light to hit the deck running!
    9/18/13- Cd 1- FINALLY! 100 mg clomid CD3-7- 75iu Bravelle 7-10   
    9/30/13 Follie count.. 3 on right. 2 on left-- trigger today
    10/2/13- IUI #1
    10/15/13 Beta #1- BFN.. :(


     


  • I had a "beautiful" response to all three of my clomid IUI's with 3, 2-3 and 5 mature follies... All BFN. Now I'm doing injects for the first time and am over responding. I wish my doctor started me on a lower dose given my history with the clomid, but it seems that the Cetrotide will salvage this cycle. Anyway, if I had it to do over again, I would have skipped over the third clomid cycle and gone straight to injects. I'm hoping this'll give me the edge I've needed all this time!

    @PPoppy2010, I started with two days at 150iu and my E2 spiked from 36 on CD 3 to 290 on CD5. Then my doctor lowered my dose to 100iu and 75iu the next two nights. Today on CD7, my E2 is over 500 and I have SEVEN measurable follies (ranging from 10-14mm). I took Cetrotide to slow things down and 50iu of Follistim tonight and go back for more monitoring tomorrow. FX my cycle doesn't get canceled because my follies are responding like crazy.
    **SIGGY WARNING**

    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
           Protein S Deficiency, Sjorgen's Syndrome 

    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN

    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently PREGNANT!!!!!!
    Synthroid + Prednisone + Metformin + Baby Aspirin + Supplements Galore = 15+ pills a day
    Lupron + Lovenox + Delestrogen + IVIG + B/W = 2-5 pokes a day
    19R, 17M, 17F - transferred two Grade A blasts 11/16, four frosties!!!
    Beta #1 11/24 (13dpo/8dp5dt) = 367 ~ Beta #2 11/26 (15dpo/10dp5dt) = 709
    Beta #3 11/29 (18dpo/13dp5dt) = 1,997 ~ Beta #4 12/1 (20dpo/15dp5dt) = 3,403

    imageimageimage

    My Blog: Running and Dreaming for Two ~ All are Welcome!
  • I hope so too RUN!... tell those ovaries of yours to calm the hell down!... aint nobody got time for 7!  lol
     I guess that was my dr;s reasoning... if i over respond... they can counter act that with different drugs... just seems like a lot to take in all at once... 

    I had 4 nice follies on my first round of clomid... so I think i will be in the same boat as you... I dont want a liter!!! :) 

    Me:38 DH:40 TTC for over 3 yrs~
    Every test known to man- comes out that we are both perfectly capable of conceiving- 

    Officially diagnosed with "unexplained infertility"

    7/17/13-1st try with 100mg Clomid+Novarel+Prog.
    7/25/13 Mid-cycle U/S- 4 Follicles! 17, 16,L 16,15 R
    7/25/13 Trigger shot
    8/6/13 Beta Blood Drawn... Big fat Neg. 
    New RE:- 101 tests done during break cycle.. All look great! green light to hit the deck running!
    9/18/13- Cd 1- FINALLY! 100 mg clomid CD3-7- 75iu Bravelle 7-10   
    9/30/13 Follie count.. 3 on right. 2 on left-- trigger today
    10/2/13- IUI #1
    10/15/13 Beta #1- BFN.. :(


     


  • @PPoppy2010, no bueno for me. IUi was canceled thanks to ELEVEN measurable follies, some smaller, five mature and E2 over 900. We are doing TI, and I'm having a hard time convincing myself that it could work with our very small odds.

    Good luck ladies :)
    **SIGGY WARNING**

    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
           Protein S Deficiency, Sjorgen's Syndrome 

    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN

    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently PREGNANT!!!!!!
    Synthroid + Prednisone + Metformin + Baby Aspirin + Supplements Galore = 15+ pills a day
    Lupron + Lovenox + Delestrogen + IVIG + B/W = 2-5 pokes a day
    19R, 17M, 17F - transferred two Grade A blasts 11/16, four frosties!!!
    Beta #1 11/24 (13dpo/8dp5dt) = 367 ~ Beta #2 11/26 (15dpo/10dp5dt) = 709
    Beta #3 11/29 (18dpo/13dp5dt) = 1,997 ~ Beta #4 12/1 (20dpo/15dp5dt) = 3,403

    imageimageimage

    My Blog: Running and Dreaming for Two ~ All are Welcome!

  • My RE didn't recommend injects + IUI for us because he doesn't think it is cost effective given our unexplained diagnosis and the fact that we are 100% OOP (there is only a small increase in success rates and a very large increase in cost).  The one reason that I wish we would have done one injects + IUI cycle is that it may have changed the dose of stims prescribed for my IVF.  I didn't respond the greatest on the low dose of stims (only 6 eggs retrieved), but if I done an injects + IUI cycle he might have started me on a higher dose for IVF. 
    what dose did they start you on Twinkie? my dr wants to start me on 150iu... for 6-8 ish days during my cycle... that seems High to start me with... 


    I started at 225IU for two days and then dropped down to 150IU and added a half vial of menopur. This was for IVF. I ended up stimming for 8 days, I had 9 or 10 follies, 6 eggs retrieved, and 5 were mature.

    imageimageimageimageimage

     

    image

    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

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