CD3 testing vs. CD21 testing — The Bump
Trouble TTC

CD3 testing vs. CD21 testing

So I already love my new OBGYN. I spoke with him for about 5 min explained my frustration with my old OBGYN and he's suggesting CD21 testing instead of CD3 testing because of my age. He absolutely agrees that testing needs to be redone after the poss preg test. He even bumped my appointment up to August 13 instead of sept 3. I'm so so excited. Anyone else have CD21 testing done?

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  • Started dating the love of my life: October 31, 2004
  • He asked me to be his wife: January 31, 2010
  • Happiest day of my life: September 10, 2011
  • Off birth control pills: November 2011
  • First and Only BFP ending in chemical pregnancy: June 2013
  • Diagnosed with poor luteal phase:14 days and ovulating but low progesterone: July 2013
  • First month on Progesterone 200mg: August 2013

Re: CD3 testing vs. CD21 testing

  • CD3 and CD21 blood tests are for two completely different things.
    CD21 tests are usually done to see if you are ovulating.  However, testing on CD21 is worthless unless you actually ovulated on CD14.  This test should actually be done 7DPO, not CD21.




    dx:  Unexplained IF
     TTC since May 2011, 1 year trying, and then 3 TI, 2 IUI = BFN
    IVF #1 (May 2013):  Antagonist Protocol: 
    24R, 18M, 15F w/ICSI; 5dt of 2 early blasts, no frosties = BFN
    IVF #2 (August 2013):  Lupron Stop Protocol: 
    28R, 23M, 15F w/ICSI; 5dt of 1 partially hatched blast, 7 frosties = BFP
    EDD 5/23/14, blighted ovum (6w6d), D&C (8w6d)
    FET #1 (April 2014):  transferred 2 5d blasts = BFP
    C.J. born 01/09/15


  • CD 3 testing tests for hormone levels such as E2, TSH, FSH, LH, AMH, and Prolactin.

    There is no such thing as CD 21 testing.  What some doctors order as CD 21 testing should be done 7 DPO and since not everyone ovulates on CD 14 it should not always be done on CD 21.  7 DPO testing checks progesterone (P4) levels.

    I would ask for a referral to a RE.  Many OB/GYNs just aren't qualified to test for or treat IF.

    imageimageimageimageimage

     

    image

    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

    [Deleted User]
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  • Thank you so much to you both. I will keep the 7dpo in mind. Unfortunately, I need a referral for the RE so for now just getting the initial testing done.

    image

    • Started dating the love of my life: October 31, 2004
    • He asked me to be his wife: January 31, 2010
    • Happiest day of my life: September 10, 2011
    • Off birth control pills: November 2011
    • First and Only BFP ending in chemical pregnancy: June 2013
    • Diagnosed with poor luteal phase:14 days and ovulating but low progesterone: July 2013
    • First month on Progesterone 200mg: August 2013
  • 1Baby4Me said:
    Thank you so much to you both. I will keep the 7dpo in mind. Unfortunately, I need a referral for the RE so for now just getting the initial testing done.


    Can you just ask for a referral?  I didn't need a written referral to see a RE (my insurance doesn't require referrals and also doesn't cover IF), but I did ask my OB/GYN's office for a referral since I needed somewhere to start my search for a RE. 

    I did do my testing with my OB/GYN and one round of Clomid + IUI.  When I was ready to move on to a RE, I just called the office and said I felt more comfortable moving on to a RE and asked for some names. 

    imageimageimageimageimage

     

    image

    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

    [Deleted User]
  • Unfortunately, I have to go through my obgyn for now. Not only do I have to have a referral but they have to be justified too. Annoying I know. :-/ I know clomid is to help you ovulate but what is an IUI? And why would you need one? I'm still very new to IF.

    image

    • Started dating the love of my life: October 31, 2004
    • He asked me to be his wife: January 31, 2010
    • Happiest day of my life: September 10, 2011
    • Off birth control pills: November 2011
    • First and Only BFP ending in chemical pregnancy: June 2013
    • Diagnosed with poor luteal phase:14 days and ovulating but low progesterone: July 2013
    • First month on Progesterone 200mg: August 2013
  • 1Baby4Me said:

    Unfortunately, I have to go through my obgyn for now. Not only do I have to have a referral but they have to be justified too. Annoying I know. :-/ I know clomid is to help you ovulate but what is an IUI? And why would you need one? I'm still very new to IF.

    I would definitely recommend reading the link at the top of the page if you're very new to this. I'm mobile and can't see it, but it's in the page header area and says something like "New to TTTC". I found it very helpful to review standard testing and treatments prior to my conversations with the OB and RE.
    Pregnancy Ticker

    TTC #1 since June 2012
    Me (28) - DOR (AFC <10, undetectable AMH, >10 FSH), homozygous E429A MTHFR
    DH (29) - MFI low count and morphology

    September 2013 IUI#1 - Clomid + Trigger + IUI = BFN
    October 2013 IUI#2 - Letrozole + Menopur + Trigger + IUI = BFN

    Nov 2013 IVF/ICSI #1 - Protocol: BCP prep, high doses Menopur and Bravelle (12 days), ganirelex
    Results: 5 retrieved / mature, 4 fertilized, 1 arrested and 3 complex abnormal after day 3 PGS = Cancelled after ER
    Jan/Feb 2014 IVF/ICSI #2 - Protocol: Estrogen priming, high doses Menopur and Bravelle (11 days), microdose lupron
    Results: Cancelled after 11 days of stims due to low response and E2 levels
    Feb 2014 IVF/ICSI #3 - Protocol: No prep, low dose Menopur (6 days), ganirelex, Bravelle booster with trigger
    Results: 1 retrieved / 0 mature = Cancelled after ER

    Officially moving on to embryo adoption! We used and love Embryo Adoption Services of Cedar Park
    October 2014 FET #1 - BCP/Lupron/Estrace/Prometrium, transferred 2 of 4 from match #1, BFN
    December 2014 FET #2 - BCP/Lupron/Estrace/Prometrium, transferred 2 of 4 from match #1, BFN
    March 2015 FET #3 - BCP/Lupron/Estrace/Prometrium, transferred 2 of 6 from match #2, BFN
    May 2015 FET #4 - BCP/Lupron/Estrace/Prometrium, lost 2 to thaw, transferred 2 of 6 from match #2, BFN
    October 2015 FET #5 - Natural cycle, lost 1 from match #3 and 1 from clinic backup to thaw, transferred 1 backup, BFN
    February 2016 FET #6 - Natural cycle, transferred 1 from match #4, B FREAKING P!
    Beta 1 = 162, Beta 2 = 316, doubling just over 48 hours

     

  • I'm also using the mobile app but I'll take a look on the computer. Thank you!

    image

    • Started dating the love of my life: October 31, 2004
    • He asked me to be his wife: January 31, 2010
    • Happiest day of my life: September 10, 2011
    • Off birth control pills: November 2011
    • First and Only BFP ending in chemical pregnancy: June 2013
    • Diagnosed with poor luteal phase:14 days and ovulating but low progesterone: July 2013
    • First month on Progesterone 200mg: August 2013
  • 1Baby4Me said:
    Unfortunately, I have to go through my obgyn for now. Not only do I have to have a referral but they have to be justified too. Annoying I know. :-/ I know clomid is to help you ovulate but what is an IUI? And why would you need one? I'm still very new to IF.

    IUI stands for Intra Uterine Insemination. It is a treatment option where the take your DH/SO's semen sample, wash it so that only the best sperm are left, and then inject the washed sample into your uterus. It's a treatment option that can be helpful for MFI and sometimes unexplained IF.

    imageimageimageimageimage

     

    image

    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

  • I am glad you like your new OB/GYN, but I would talk with him and see if what he meant by CD21 testing was really meant to be 7dpo testing. I would also verify with him if you shouldn't have both. I totally get where you need some tests to prove that you need to see an RE, but I believe most REs will want the results of both CD3 and 7dpo tests. GL!
    TTC Since January 2012 Me:37 DH:34      DX July 2013: Unexplained Infertility      New DX Dec 2013: DOR
    BFP#1 6/4/12 EDD 2/13/13 M/C 6/6/12  BFP#2 2/21/13 EDD 11/3/13 M/C 2/26/13 BFP#3 C/P
    4 rounds of clomid, 2 with IUI = BFN
    November/December Retesting/Natural Cycle = Surprise BFP @ 11dpo! Beta#1 [email protected] Beta #2 [email protected] u/s#1 6w2d hb113 u/s#2 8w2d, measuring 8w4d hb168! 10w2d hb171 12w3d Verifi results are in and good! EDD 8/23 Our Baby Girl Rainbow Baby born 8/20/2014!!!
    Um...what? BFP 11/2/15!?! EDD 7/4/16
  • Thank you everyone. One question ... What is MFI?

    image

    • Started dating the love of my life: October 31, 2004
    • He asked me to be his wife: January 31, 2010
    • Happiest day of my life: September 10, 2011
    • Off birth control pills: November 2011
    • First and Only BFP ending in chemical pregnancy: June 2013
    • Diagnosed with poor luteal phase:14 days and ovulating but low progesterone: July 2013
    • First month on Progesterone 200mg: August 2013
  • Thank you.

    image

    • Started dating the love of my life: October 31, 2004
    • He asked me to be his wife: January 31, 2010
    • Happiest day of my life: September 10, 2011
    • Off birth control pills: November 2011
    • First and Only BFP ending in chemical pregnancy: June 2013
    • Diagnosed with poor luteal phase:14 days and ovulating but low progesterone: July 2013
    • First month on Progesterone 200mg: August 2013
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