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Clomid effect on lining?

rox825rox825 member
in Trouble TTC
This is my 4th clomid cycle, all 4 on 50mg, and the first time that it's thinned my lining. If I stop clomid after this cycle and switch to something else in the future if this IUI doesn't work, will my lining eventually recover to where it should be? In other words, I guess I'm wondering whether the damage is reversible? I'll ask my RE when I see her next, hopefully tomorrow, but this morning I just saw an ultrasound tech briefly.

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TTC since Sept 2011, Unexplained IF
Oct 12 - Jan 14: 3 clomid/TI cycles, 2 hysteroscopies, 2 IUIs, 1 BFP (MMC @ 12w), 2 more IUIs
Feb 14: Gonal-f + IUI #5 = BFP! (EDD 11/4/14)
Baby boy arrived 11/13/14!

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Re: Clomid effect on lining?

  • Aurora1181Aurora1181 member
    Have you had breaks in between cycles? My RE won't do more than three medicated cycle without a "break" cycle in between to allow your body to reset. Clomid/Femara/Letrozole inhibit estrogen receptors, so yes, your lining might decrease. But it can be just fine the next cycle. It's not cumulative. I had lower linings on clomid/letrozole- mine were always around 7. Now that I'm on injectable drugs, with no clomid/letrozole, my lining is fine. They can also give you estrogen patches to help bump up your lining.
    ---------------Siggy Warning--------------------


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    Me: 32, DH: 34  / TTC since February 2011 / SA: all normal, HSG: all clear! / on Lovenox for anticardiolipid antibodies
    4 IUIs with Clomid, Letrozole, and Menopur. All BFN.
    9/12: lap / hysteroscopy: found and removed mild endometriosis, cervical polyp, and 2 para-tubular cysts
    5/13 IVF #1: Follistim, Menopur, Ganirelix, 10R/4M/4F, ET of 2, 5 cell and 4 cell, no frosties = BFN
    12/13 IVF #2 = November / December 2013. Microdose Lupron Protocol: 15R/6M/6F, Froze all 6 due to high E2 and P4
    FET 1: Jan 22, 2014 of one 4AB blast and one 3BB blast (3 blasts on ice!)
    BFP on HPT 4dp5dt, Beta #1 9dp5dt: 310, Beta #2 11dp5dt: 899
    First u/s on 2/17/14: TWINS!!!!! both w/HBs of 114 at 6w3d, HBs 150 and 152 at 7w5d
    5/27/2014: Team purple!!!!  EDD 10/10/2014 / 
    Delivered by c-section at 32w0d 8/15/2014 due to preeclampsia/HELLP syndrome
    Baby Boy 4lbs 1oz, 17 inches
    Baby Girl 3lbs 5oz, 16 inches

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  • katib77katib77 member
    Yes, it is reversible. I had poor lining that got worse with each of my three clomid cycles to wherr my RE said "never again"...and we moved on to injects. Now my lining is better than it ever was on clomid.

    TTC since July 2009. Dx MFI & LPD. 
    IUI#1&2&3 (2011 & 2012) BFN
    IUI#4 1/23/13 on 75iu x9 Follistim = BFP then chem preg m/c (Feb 2013)
    IUI#5 BFN (April 2013)
    IVF w/ICSI Oct. 2, 2012 - 13R, 11M, 7F, 1 frozen blast 4BB grade - - - FET Nov 15, 2013
    BFP! Beta 1:104 @ 10dp6dt, Beta 2:178 @ 12dp6dt,  beta 3:366 @ 14dp6dt
    Saw heartbeat twice before missed M/C at 8w3d on 12/27/13, missing my little angel boy
    JUNE 2014 IVF#2;  5R, 2M, 1F Three day transfer 6/7.  Beta 6/18 - BFN
    Child Free Now?
     S/PAIFW , S/PALW

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  • rox825rox825 member
    I have had a break in between, I did 2 in the fall and just started treatment again last cycle. I'll probably take a meds break after this one if it doesn't work to rest things, and maybe try injects next. Thanks ladies, I can sleep a little easier tonight!

    Baby Birthday Ticker Ticker

    TTC since Sept 2011, Unexplained IF
    Oct 12 - Jan 14: 3 clomid/TI cycles, 2 hysteroscopies, 2 IUIs, 1 BFP (MMC @ 12w), 2 more IUIs
    Feb 14: Gonal-f + IUI #5 = BFP! (EDD 11/4/14)
    Baby boy arrived 11/13/14!

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