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Neupogen?

Hi ladies. We are gearing up for our cycle this summer. My doctor is suggesting the kitchen sink approach, which I'm mostly up for, I guess. Her latest suggestion is Intrauterine Neupogen which she says can be helpful for recurrent implantation failure or repeated loss. Has anyone heard of it or tried it?

 She emailed me this link: https://www.ncbi.nlm.nih.gov/pubmed/23081869, but it seems that it was studied for thin lining, not necessarily implantation or loss. My lining has always been in the appropriate range, but I have had 4 transfers with 2 early losses and 2 BFN. Any insight you can offer is appreciated.

 

 

Age: 35 TTC since 2005, MFI & DOR 

IVF #1 Sep '11 - canceled poor response

 IVF #2 Nov '11  8R/8M/4F 3dt x2 - chemical

IVF #3 April '12  11R/6M/4F 3dt x2 - m/c

FET #1 Aug 2012  3dt x2 - BFN

**new RE**

 IVF #4 Jan '13 BFN 11R/6M/6F 5dt x2 - BFN

 IVF #5 July '13 16R/10M/10F 5dt x2 + 1 frostie

9dp5dt Beta 1 = 344!! 16dp5dt. Beta 2 = 4822 7wk u/s= 2 heartbeats!

Twin girls! 3/6/14

 

Re: Neupogen?

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    hmz819hmz819 member

    Dr. Braver.man has a lot of info on neupogen on his website.  For recurrent loss/implantaion failure it is not used as a wash but injected daily starting with stims through 12 weeks. 

     Also...you have a PM.

    TTC#1 since April 2011
    IVF#1 July 2012 5R, 3 made it to blast, sET c/p
    FET#1 Aug 2012 2 blasts transferred BFN
    IVF#2 Oct 2012
    16R/6M/6F/2-8 cell grade 1 transfer
    Beta 1-237.9, Beta 2-566, Beta 3-8657
    US 6w3d shows one baby w/ HB 115
    US 7w1d no more heartbeat/ D&C 11/30/12 normal karyotype
    IVF#3 Mar 2013
    6R/4M/4F 1 compacting and 2-8 cell transfer
    ectopic pg MTX given 3 month break from TTC

    IVF#4 Sept 2013--BFN
    IVF#5-7 Apr 2014, Jun 2014 and Aug 2014 banking embryos for CCS testing. Praying for normals! Image and video hosting by TinyPic imageimage

    http://i61.tinypic.com/34zll06
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    Braverman does the injects and uterine wash. I was not allowed to take Neupogen because the hematologist said it can recruit cancer cells. You need to look deeper into this because its a drug used to grow cells for bone marrow. I suggest consulting your PCP and a hematologist.
    6 m/c
    Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
    Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
    1 Clomid/Ovidrel BFN May 2011
    Natural cycle Aug 2011 BFP M/C 4 Weeks
    1 IUI Sept 2011 BFP M/c 7 weeks
    Provera Dec 2011 BFP M/C 3 Weeks
    DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
    IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
    IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
    Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
    Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
    Went to Beer Center- high tnf, low lad, implantation failure
    Nov/Dec 2012 LIT Treatment
    Dec 12 Humira
    Jan 2013 BFP
    Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
    Miracle Born August 2013 Premature

    Yours doesn't have to be a sad story



    image
    image


    Lilypie - (ugiy)


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    I used it as a uterine wash to promote lining growth. It didn't make a difference.
    Warning No formatter is installed for the format bbhtml
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    mm29mm29 member
    Hey Lady!  I've been thinking about you.   I have heard of this and I think a few girls on the vet fb page have experience with it.  Let me PM them and get back to you!
    ::: Married June 2003:::
    TTC #1 since: Aug. 2008
    Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
    DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
    Tx History: IUI 1&2= BFN
    IVF# 1 W/ICSI= BFN
    IVF# 2: cancelled d/t no response
    IVF# 3= 1 egg retrieved=immature/not viable
    IVF# 4= c/p
    ***CCRM ODWU***
    Found DHs BT and Me-decreased blood flow to uterus
    Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
    ***New RE***
    DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. 
    IVF# 6: (OE/DS) cancelled
    IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
    Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015


    http://icanhazbabyz.blogspot.com/
    imageimage image 
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    STL34STL34 member
    Under Dr. B's care, I used it in the injectable form for implantation failure.  I don't know much about the uterine washes.  Sending you a PM.

    imageimage


    ~SAIF/PAIF/Everyone Welcome~ 

    Me= 37 and DH = 41 

    Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)

    IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN

    IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.

    IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132.  Lil is here!

    TTC#2:  Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.

    IVF #4:  BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN

    IVF #5:  MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN

    IVF #6:  (New RE):  Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN

    FET#1:  BFN

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    zazu13zazu13 member
    Thank you for the replies everyone. I have some things to ponder and research.

    Age: 35 TTC since 2005, MFI & DOR 

    IVF #1 Sep '11 - canceled poor response

     IVF #2 Nov '11  8R/8M/4F 3dt x2 - chemical

    IVF #3 April '12  11R/6M/4F 3dt x2 - m/c

    FET #1 Aug 2012  3dt x2 - BFN

    **new RE**

     IVF #4 Jan '13 BFN 11R/6M/6F 5dt x2 - BFN

     IVF #5 July '13 16R/10M/10F 5dt x2 + 1 frostie

    9dp5dt Beta 1 = 344!! 16dp5dt. Beta 2 = 4822 7wk u/s= 2 heartbeats!

    Twin girls! 3/6/14

     

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    may2806may2806 member
    I used Neupogen injectable during my cycle until 12w pg under Dr B's care. My RE didn't want me to do it but after everything I'd been through I insisted because it was the last thing left to try. I can't say whether or not it's what worked this cycle, but I'm currently 24w6d. I don't think a hematologist or PCP would know much about Neupogen used for this purpose, although of course you could ask their opinion. The mainstream medical community doesn't believe in most of the immunological treatments, but they were the only thing left to try so I was willing to take any risks that came along with it. 
    Dx: High FSH, stage IV endo, homozygous C677T MTHFR and PAI-1
    Early loss 10/08
    Lap 1/09
    IVF #1 "natural IVF" - 1 egg retrieved, missed m/c
    Tried several mini-stim cycles with no response
    Switched clinics - dx'd as carrier for Fragile X
    IVF #2 MDL protocol Jan/Feb converted to IUI, BFN
    IVF #2 take 2: Antagonist, one embie, BFN
    IVF #3: Antagonist, no fertilization
    One last ditch effort at OE IVF (antagonist with Clomid) cancelled
    DE cycle #1 Jan/Feb 2011, BFP, ectopic
    DE cycle #2 June/July 2011 - BFP
    10/28/11 Baby girl lost at 17 weeks due to pre-term labor. We love and miss you.
    DE cycle #3 June/July 2012 - BFP, twins, both heartbeats stopped, D&C
    2 frosties but don't know what's next
    FET Dec 2012: BFP! Praying this one sticks for the long haul!
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    imageluvboston:
    Braverman does the injects and uterine wash. I was not allowed to take Neupogen because the hematologist said it can recruit cancer cells. You need to look deeper into this because its a drug used to grow cells for bone marrow. I suggest consulting your PCP and a hematologist.
    Luvboston is very smart with this one. Neupogen and any other similar drug has been used with success but also has to be used with caution. I took this drug during my cancer treatments to promote the growth of good cells because my other chemo drugs were killing all the cells. Keep in mind though, this DOES promote the growth of both normal AND abnormal or cancerous cells. That's not to say that it will but there is a risk of it. With that being said, I am still planning to be on HGH for a very short burst. We are using it for egg quality not for lining issues. I just want to make sure everyone knows that this is not something to jump into, research this option and recognize the risks like all the others we take on. :)
    TTC #1 Since May 2011 ~ Everyone Welcome
    Me (34): DOR d/t chemo/radiation, Immature Endometrial Lining, Hypothyroidism
    DH (35): MFI d/t testicular torsion and removal, Low T, Oligospermia, Anti-Sperm Antibodies, Currently on T supplements
    Sept '11-April '13 ~  Testing, failed multiple MFI treatments, saving & TONS of praying
    January 2014 ~ IVF/ICSI & PGS ~ no response to stims ~ converted to IUI ~ BFN
    February 2014 ~ On to donor embyros ~ 5 blasts!!! 
    March 2014 ~ FET #1 ~ Transferred 2 blasts ~ BFN
    July 2014 ~ Kliman's mock cycle with endometrial function test
    Sample too small for EFT, HE slide showed immature cells
    New protocol planned, saving for another biopsy for EFT
    January 2015 ~ Considering adoption options
    April 2015 ~ Privately arranged adoption of planned pregnancy
    DD#1 ~ Lillyana Violet Marie born 6/15/16, Finalized adoption 12/20/16
    July 13, 2018 ~ BFP....WTF?!?!
    7/16 Beta #1 ~ 466...7/18 Beta #2 ~ 1,077...7/23 Beta #3 ~ 5,291
    7/23 US #1 ~ 1 gestational sac seen and yolk sac
    7/30 US #2 and 1st OB appt ~ 1 perfectly round gestational sac, 1 perfect yolk sac and 1 teeny tiny heart beat seen!!!
    Lilypie Maternity tickers


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    zazu13zazu13 member

    Thanks for the advice. I scheduled a phone consult with Braverman to ask a few more ?s before I cycle locally...

     

    Age: 35 TTC since 2005, MFI & DOR 

    IVF #1 Sep '11 - canceled poor response

     IVF #2 Nov '11  8R/8M/4F 3dt x2 - chemical

    IVF #3 April '12  11R/6M/4F 3dt x2 - m/c

    FET #1 Aug 2012  3dt x2 - BFN

    **new RE**

     IVF #4 Jan '13 BFN 11R/6M/6F 5dt x2 - BFN

     IVF #5 July '13 16R/10M/10F 5dt x2 + 1 frostie

    9dp5dt Beta 1 = 344!! 16dp5dt. Beta 2 = 4822 7wk u/s= 2 heartbeats!

    Twin girls! 3/6/14

     

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    imagezazu13:

    Thanks for the advice. I scheduled a phone consult with Braverman to ask a few more ?s before I cycle locally...

     

    I think that is a great idea!

     

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