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Question for gals who have been on Metformin and clomid together

farmerswife06farmerswife06 member
in Infertility

I know I haven?t posted in years... Sorry! But I'm back on the TTC wagon again. I lurk a lot and get so much information from reading all the post but I haven't seen one with this particular question.

I'm currently on my third round of clomid  At 150mgs. And I'm also on 1000 mgs of Metformin a day.

 My question is did your Metformin get bumped up along with your clomid? Or has your Metformin dose stayed the same? I didn't know if there were better odds of getting an ovulation if your metformin was higher... Just wondering! Thanks so much!

<08/03 diagnosed with PCOS started BCPs.
11/18/06 married
3/08 stoped BCP
10/08 gyno said to get a CBEFM and come back in 6 months
3/09 started acupuncture and herbs to help fertility started charting. No ovulation for over 6 months!
09/09 first appt with RE
10/09 HSG tubes clear everything looks good!
10/09 hubby has super sperm! He is perfect!
11/09 T.I. with Gonal-F, no Ovulation. cycle cancelled
MIL got diagnosed with stage 4 cancer and we put our TTC plans on hold until chemo appt weren't taking over our daily lives.
11/12 started on 1000mgs Metformin
2/13 1st round of Clomid 50mgs no Ovulation
3/13 2nd round of Clomid 100mgs no Ovulation
4/13 3rd round of Clomid 150 mgs no Ovulation
4/13 OB/GYN gave up and referred me to another RE
5/13 RE prescribed 2.5mg Femara with Follitism along w/ 1500mgs Met
5/13 Large Cyst ended up benching me for this cycle
6/13 Cyst ruptured on its own.
7/13 Benched for one cycle
8/13 Femara 2.5mg (5 days) 2x a day w/ 75 iuis of Gonal F. (8days) W/ 10000 mcg HCG only produced 2 good follies BFN
9/13 benched again (they called it a rest LOL!!)
10/13 femara 2.5mgs (5 days) 2x a day w/ 112.5 of Gonal F (8days)
w/ 1000 mcg of HCG produced 4 good follies
BFP!!! HOLY FREAKING CRAP!!! Didn't see that coming!! Not in a million years!! LOL!

11/26/13 no heartbeat at 7 wks waiting to miscarry

started to bleed on 12/1/13 bled off and on for 2wks ended up having to schdule a D&C

12/16/13 D&C

1/14 hubby and I talk ourselves into ourselves into one  last cycle, after this we are going to stop to give ourselves a break!

2/14 femara 2.5mgs (5 days) 2x a day w/ 150. iuis of Gonal F (11days)
w/ 1000 mcg of HCG produced 4 good follies (both of us got sick during prime baby making time so only a couple times of baby making happened.)

3/20/14 CD34 2 positive tests! Started progesterone as soon as I saw that positive! Stick Jelly bean stick!!

After 6 1/2 years of trying for a baby we are finally pregnant and this little one wants to stay put!

6/14 was told baby had 1 in 30 chance of having Down Syndrome from blood work... how should we proceed... Nothing! I worked my butt off for this lil one I'm not going to end its life before it begins!

7/14 20 wk ultrasound. 3 hours worth of scanning trying to measure all the soft markers! Not one soft marker for Down Syndrome. So I just quite worrying about it. Its a Healthy Little Boy!

11/14 measuring really large. 95th percentile! Head measuring very large!

11/24/14 went in for induction. Lil guy got stuck trying to push my bladder out so after 17 hours of labor had to have a c section... 

11/25/14 Lil Man Was born by C-section And I Wouldn't have changed anything! I tried really hard to get him here. I did everything I could do! >

 

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Re: Question for gals who have been on Metformin and clomid together

  • oO Angie OooO Angie Oo member

    I have done the two together and my metformin dose stayed the same. 

     

    GL to you!!! 

    Me: 29 DH: 32 Married: 10.25.07 Been dealing with amenorrheoa since I was young. (Literally go years w/o AF) Unexpected and very surprising BFP in Feb 2007. M/C April 2007. :( TTC since 2008 Metformin- Didn't help. :( Clomid 50mg/Provera cycle #1 7/2009 - BFN Clomid 50mg/Provera cycle #2- 8/2009- BFN Clomid 100mg/Provera cycle #3- 1/2010- BFN ...Took a break... 2012- Met with RE 09/12- Day 3 Labs- FSH 2.5, Estradiol 47, TSH 4.5 (Doc re-ordering Day 3 labs) DH sperm analysis- all good 11/12- Day 3 Labs- FSH 4.3, estradiol 38, TSH 2.51 Prescribed Synthroid 11/12- HSG all clear 1/13- IUI with Femara and trigger shot on 1/31- BFN 2/13-IUI #2- cancelled due to low response 3/13- planning IUI with injectables
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  • megs3084megs3084 member
    I'm not sure. My reproductive immunologist put me on metformin and by the 3rd week I should be up to 1500 mg. I'm on natural cycles till July so I didn't really think to chart.
    "Everything will be alright in the end. So if it's not alright, it is not yet the end."
    Me:29 DH:29  TTC since 1/11 Dx: unexplained IF/early DOR/immune issues 
    Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN
    8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F. 
    ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
    IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
    ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
    3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.  
    DX: High NK cells, cytokines, DHEAs& PAI1;  hypothyroid, +APA, restricted bloodflow
    7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
    (plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim)
    ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
    ET 5dt 7/24 2 fully expanded blasts.  SURPRISE 3 FROSTIES!!!
    Beta #1 8/2 335!!!! Beta #2 829!!!  1st u/s 8/14 showed TWINS!!!!!
    11/11: TEAM PURPLE!!!!!
    3/21/14-L&W born at 37w via csection
    Here Comes the Sun Blog
    PAIF/SAIF welcome!
    Report Reply
  • ufsandra85ufsandra85 member
    The 2 meds arent really related. What is your current metformin dosage? I am on 1500 and honestly i dont think it is doing anything for me but i have been taking it for 6 months... I have never heard for them being upped together. Metformin doesnt create follicles so I wouldnt think it would but doesnt hurt to check with your doctor to see if you are on the right dosage of metformin

    Married 11/27/09 and TTC right away
    Dx: Complete septate uterus with cervical duplication, endometrial polyps, PCOS, endometriosis, hypo thyroid, luteal phase defect
    4 uterus surgeries to correct my complete septum and to remove polyps and 2 years of seeing the RE, medicated cycles and IUIs
    Baby 1 and 2: BFP 3/3/11 with 2 babies EDD 11/1/11, M/C 4/6/11
    Baby #3: 8/11 pregnant EDD 4/27/11 and m/c:(
    Baby #4: 10/12/11 BFP! EDD 6/16/12m/c 10/26/11
    Baby #5: 3/13/12 BFP! EDD 11/25/12 ANOTHER m/c :(

    Baby #6: 2/14/13- BFP! EDD 10/24/13, CP 2/19/13
    Baby #7: 3/15/13- BFP! EDD 11/27/13, another CP
    Baby #8.  BFP 5/19/13 EDD 1/22/14. 8 was not our lucky number

    4th septum resection on 5/31/13.
    Baby #9: 6/29/13 BFP. C section scheduled for March 5th!

    My miracle baby was born March 5 at 9:33am. He was 8 lbs 12.5 oz and 21.25 inches long!

    image"">

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  • farmerswife06farmerswife06 member

    I know that the Metformin doesn't affect ovulation per se. But I have PCOS and my symptoms haven't really changed at ALL! I?ve been on 1000mgs of Metformin since November. And I thought I had seen other women post that they had been on 1500 mgs of Met. And some kept getting bumped up. But I didn?t know what the reason was for uping their dose.  So I was wondering if maybe uping my dose, would help me in the weight loss which in turn would help the PCOS? I still had to take Provera at the end of the last cycle to start a period. It?s so frustrating sometimes, trying to filter through all these what-ifs, that are out there. Thanks so Much! I realize I should put my history in the siggy I will try and work on that to help. But I?ve had PCOS since I was a teenager. I don?t have periods on my own. We have done one injectable cycle with TI a couple years ago but a sickness in the family kept us from starting another cycle until now. So I thought I would start out with Clomid and that is where we are now. Thanks so much!!

    <08/03 diagnosed with PCOS started BCPs.
    11/18/06 married
    3/08 stoped BCP
    10/08 gyno said to get a CBEFM and come back in 6 months
    3/09 started acupuncture and herbs to help fertility started charting. No ovulation for over 6 months!
    09/09 first appt with RE
    10/09 HSG tubes clear everything looks good!
    10/09 hubby has super sperm! He is perfect!
    11/09 T.I. with Gonal-F, no Ovulation. cycle cancelled
    MIL got diagnosed with stage 4 cancer and we put our TTC plans on hold until chemo appt weren't taking over our daily lives.
    11/12 started on 1000mgs Metformin
    2/13 1st round of Clomid 50mgs no Ovulation
    3/13 2nd round of Clomid 100mgs no Ovulation
    4/13 3rd round of Clomid 150 mgs no Ovulation
    4/13 OB/GYN gave up and referred me to another RE
    5/13 RE prescribed 2.5mg Femara with Follitism along w/ 1500mgs Met
    5/13 Large Cyst ended up benching me for this cycle
    6/13 Cyst ruptured on its own.
    7/13 Benched for one cycle
    8/13 Femara 2.5mg (5 days) 2x a day w/ 75 iuis of Gonal F. (8days) W/ 10000 mcg HCG only produced 2 good follies BFN
    9/13 benched again (they called it a rest LOL!!)
    10/13 femara 2.5mgs (5 days) 2x a day w/ 112.5 of Gonal F (8days)
    w/ 1000 mcg of HCG produced 4 good follies
    BFP!!! HOLY FREAKING CRAP!!! Didn't see that coming!! Not in a million years!! LOL!

    11/26/13 no heartbeat at 7 wks waiting to miscarry

    started to bleed on 12/1/13 bled off and on for 2wks ended up having to schdule a D&C

    12/16/13 D&C

    1/14 hubby and I talk ourselves into ourselves into one  last cycle, after this we are going to stop to give ourselves a break!

    2/14 femara 2.5mgs (5 days) 2x a day w/ 150. iuis of Gonal F (11days)
    w/ 1000 mcg of HCG produced 4 good follies (both of us got sick during prime baby making time so only a couple times of baby making happened.)

    3/20/14 CD34 2 positive tests! Started progesterone as soon as I saw that positive! Stick Jelly bean stick!!

    After 6 1/2 years of trying for a baby we are finally pregnant and this little one wants to stay put!

    6/14 was told baby had 1 in 30 chance of having Down Syndrome from blood work... how should we proceed... Nothing! I worked my butt off for this lil one I'm not going to end its life before it begins!

    7/14 20 wk ultrasound. 3 hours worth of scanning trying to measure all the soft markers! Not one soft marker for Down Syndrome. So I just quite worrying about it. Its a Healthy Little Boy!

    11/14 measuring really large. 95th percentile! Head measuring very large!

    11/24/14 went in for induction. Lil guy got stuck trying to push my bladder out so after 17 hours of labor had to have a c section... 

    11/25/14 Lil Man Was born by C-section And I Wouldn't have changed anything! I tried really hard to get him here. I did everything I could do! >

     

    Report Reply
  • yoder92yoder92
    I am on it both right now, this is my first round, just finished my last clomid pill yesterday. I only take 500mg of Metformin, seems like too low of a does since I haven't seen anyone taking less than 1000. I took the Metformin for nearly two months before the Clomid and it doesn't seem to help with anything. I have gotten hot flashes since starting Clomid, so I hope it works!
    Report Reply
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