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MTHFR ladies?

brooklynesquebrooklynesque member
in Infertility Veterans

So I just got some lab results that I hadn't seen before -- they had been ordered by my new RE who I'm not using for my upcoming DE cycle, so I had my records sent to me from his office to show the old RE (who hasn't seen them yet because they just came in the mail today).  I tested positive for "a single copy for the C677T" MTHFR mutation.  My blood homocysteine is normal.

So, a quick, panicked search on Dr. Google seems to suggest that a single copy of the mutation shouldn't hurt anything, though some seem to disagree and say I shouldn't be taking regular folic acid, etc. etc.  

Anyone in the same boat?  Is this something I should worry about? 

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Re: MTHFR ladies?

  • Crystal120410Crystal120410 member
    My RE said it really wasn't anything to worry about and just has me take folgaurd with my prenatal vit.
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  • megs3084megs3084 member
    I'm a carrier dh is affected but its the other mutation. Were both on extra folic acid but that's it.
    "Everything will be alright in the end. So if it's not alright, it is not yet the end."
    Me:29 DH:29  TTC since 1/11 Dx: unexplained IF/early DOR/immune issues 
    Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN
    8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F. 
    ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
    IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
    ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
    3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.  
    DX: High NK cells, cytokines, DHEAs& PAI1;  hypothyroid, +APA, restricted bloodflow
    7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
    (plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim)
    ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
    ET 5dt 7/24 2 fully expanded blasts.  SURPRISE 3 FROSTIES!!!
    Beta #1 8/2 335!!!! Beta #2 829!!!  1st u/s 8/14 showed TWINS!!!!!
    11/11: TEAM PURPLE!!!!!
    3/21/14-L&W born at 37w via csection
    Here Comes the Sun Blog
    PAIF/SAIF welcome!
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  • kentcarriekentcarrie
    I just have the single mutation.  My doctor has me on 81mg aspirin, Folgard, and from ET through pregnancy I will be taking a daily Lovenox injection.  He said it is better to be safe than sorry. I am pleased that he is being proactive.
    Me - 38 (Endo, DOR) DH- 41 Married in 2003, TTC for 6+ years Dec 2012 - Lap, both tubes removed Jan 2013 - IVF #1 - MDLF, Cancelled March 2013 - IVF #2 - Antagonist - cancelled after ER May 2013 - IVF #3 - TPP Antagonist W/HGH
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  • brooklynesquebrooklynesque member
    Thanks for your responses, ladies.  It's interesting that doctors don't seem to be on the same page about what to do about the heterozygous (single) form of the mutation.  Something else to worry about!  Ugh.
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