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IUI #4 BFN

demi1demi1 member
in Trouble TTC

Hello,

My 4th iui is a bfn... I went to RE today and he is suggesting IVF however he is concerned with my low estradiol levels. This past iui cycle I slimmed with menopur for 16 days: 7 days with 75iu, 2 days 112.5, 7 days 150. My estradiol started at 20 came up to 58.8 after 11 days of meds and ended at 481 with 2 follicles. I am worried that if we move to IVF will the egg quality be poor due to my strongmen level?  My AMH level was 2.85 however at one time I did have an elevated FSH. I bring up multiple small follicles so RE thought I may have pcos but he tested my testosterone and it was 20 which is low and I have no other pcos symptoms. I am just so frustrated and don't know what to do. We will be oop for the IVF procedure ($10,000) but I do have coverage for meds and iuis. Should we try another iui to see what my estrogen levels show?  I will be sitting out this month due to 2 large cysts so I guess I have some time to think about it :( any advice would be great!

TTTC since 2010 Me 32-issues r/t thin uterine lining; blocked tubes DH-35-no issue as of now March 2012 lap hysteroscopy-l tube 100% blocked; r tube 30% open May 2012 First visit to RE-started provera June 2012 HSG test l tube still blocked; started clomid July 2012 u/s f/u on clomid July 2012 changed to femara 5mg Aug 2012 started femara 5mg Sept 2012 Femara 5 mg Oct 2012 Femara 5 mg Nov 2012 repeat lap with RE tubes are clear!!! Dec 2012 Femara w/ovidrel trigger shot and iui #1 bfn Jan. 1, 2013 Femara w/ovidrel trigger shot and iui #2 bfn Jan. 16,2013 clomid 100 mg no trigger shot iui # 3 bfn Feb 2013 injectable cycle w/follistim 75iu cycle cancelled due to poor response Feb 2013 started 750 mg metaformin and Provera
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Re: IUI #4 BFN

  • Jellyfish42Jellyfish42 member
    No advice, just wanted to say I am sorry this cycle wasn't the one. :(
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  • Cara1024Cara1024 member
    I'm so sorry for the BFN. I'm also sorry about the 2 large cysts. I don't really have advice about your decision, but good luck moving forward whichever way you decide.
             *********************************************************************************
                      

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    Married October 2009. Me 29 H 28.
    After 1 year of infertility, our little miracle was conceived via our 3rd IUI on May 5, 2013.
    Holland Sophia was born Jan 24, 2014.
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  • Looking4bfp2Looking4bfp2 member
    Youre history sounds a bit like mine regarding PCOS. My blood work shows up alright and i show no physical PCOS symptoms. I was diagnosed early because of amenorrhea. But I do producd multiple follicles and have difficulty ovulating etc. after every medic
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  • katib77katib77 member
    I would do one more, but ask to start on a higher level of meds to kick start and see your response. You e2 level was slow going because of your low and slow stimming. Whule you don't want to overstimulate and get OHSS starting at 112.5 and monitoring if

    TTC since July 2009. Dx MFI & LPD. 
    IUI#1&2&3 (2011 & 2012) BFN
    IUI#4 1/23/13 on 75iu x9 Follistim = BFP then chem preg m/c (Feb 2013)
    IUI#5 BFN (April 2013)
    IVF w/ICSI Oct. 2, 2012 - 13R, 11M, 7F, 1 frozen blast 4BB grade - - - FET Nov 15, 2013
    BFP! Beta 1:104 @ 10dp6dt, Beta 2:178 @ 12dp6dt,  beta 3:366 @ 14dp6dt
    Saw heartbeat twice before missed M/C at 8w3d on 12/27/13, missing my little angel boy
    JUNE 2014 IVF#2;  5R, 2M, 1F Three day transfer 6/7.  Beta 6/18 - BFN
    Child Free Now?
     S/PAIFW , S/PALW

    My Blog

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  • scbediscbedi
    No advice but I wanted to say that I am so sorry for BFN ((HUGS!!))
    Anniversary Image and video hosting by TinyPic
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    Age: Me 26, DH 27, Married Oct. 10, 2009 ,TTC since March 2012
    Problem: Irregular menstruation, unexplained
    Nov&Dec-Provera because of no period after 35+ days
    First RE appt 1/10/2013
    Tests: TSH (normal), Prolactin (normal), SA (abnormal)
    Hysteroscopy (normal) and PCOS labs (negative/normal) 1/15/2013
    2/1/13- HPT BFP but Beta Hcg was negative
    Plan: Femara + Trigger + IUI in April if no real BFP before then Bloggy Blog!
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  • EIK2013EIK2013 member
    No advice here but sorry about the BFN, hang in there!
    Me: 27, DH: 29*** TTC since November 2011 *** Dx with PCOS in September 2012 
    ***September 2012: IUI #1 = BFN*** 
     ***October 2012: IUI #2 = cancelled due to not responding to meds ***
     ***February 2013: IUI #3 - BFN ***
     *** April 2013: Gonal-f, HCG Trigger and TI = BFN*** 
     ***May/June 2013: TAKING A BREAK.***
    ***July 2013: Gonal-f, Trigger and TI = BFN***
    ***August 2013: Gonal-f, Trigger and TI = Cancelled due to over-stimulating***
    ***September/October 2013: Fermara, Gonal-f, Trigger and TI = BFP!!!!!!!!!!!!!!! Beta #1: 65, Beta #2: 210!!!!!!***




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  • ttuprincessttuprincess member
    I don't have any advice either but wanted to say I am sorry this cycle wasn't the one for you.  sending (((hugs))) your way. 

    **************SIGGY WARNING**************

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    Me 32 :: DH 41

     TTC since November, 2011

    DH's SA : Excellent

    Lap and Hysteroscopy June 2012

    DX: PCOS, Stage III Endo, slight Adenomyosis, blocked tube, and probable LPD

    Treatments:  6 Months Lupron Depot injections; 1500 mg metformin; 3 cycles of Clomid + TI = BFN

    3 endometrial biopsies all were "out of phase" 

    September - December, 2013:  Break to lose weight and get healthy

    40 lb weight loss but still not ovulating "in phase"  

    February - March 2014: bcps + follistim + trigger + TI = BFP

     Beta #1 (12dpo): 30; Beta #2 (18dpo): 500; Beta #3 (25dpo): 7,000!!! 

    1st u/s 4/16: One beautiful hb at 144 bmp 

    2nd u/s 4/29: hb at 166 bmp.  Graduated from RE!!

    TEAM PINK! 

    Baby girl arrived on Thanksgiving day weighing 7lbs 6oz and measuring 20 inches

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  • GermanGirl2007GermanGirl2007 member
    I don't have any advice, but I did want to say that I am so sorry that IUI #4 didn't work and that you are at the point of having to make this decision. Sad

    ** After  2 1/2 years of Unexplained IF, 2 failed medicated cycles, and 4 failed IUI's - our baby girl came to us through the miracle of     Mini IVF! **

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  • babydreams13babydreams13 member
    So sorry.  I know its a hard decision to make so I would say sit down with your DH and discuss what is best for you guys.  
    ***SIGGY WARNING***

    DX: Unexplained
    6 Failed IUIs (Clomid and Gonal F).  
    IVF #1 began August 2013- BC, 4 days of Estrace, stimmed with Gonal F and Menopur, Ganirelix, 9R 5M 5F, Medrol and Doxycycline, 5 day transfer of 2 early blastocysts- good quality, Progesterone, Estrace, and baby aspirin, BETA on 9/20 BFN,   IVF #2 began September 2013, stimming with Gonal F (higher dose) and Menopur, Ganirelix, 18R 14M 9F with ICSI, 5 day transfer of 2 BBs one was starting to hatch, 2 frosties: 1  BB and 1 AC, BETA on 10/21, BFN BETA was a 5- chemical 
    Getting some more testing and trying to figure out what the issue is before FET in December, started acupuncture on 11/10, RLP and some other BW nothing major to report except slightly high Prolactin. Prolactin was slightly high when I started with my RE and I already had an MRI which was Neg.  Endo biopsy=negative.  WTF is wrong with us???
    12/18/13 FET of 1 BB and 1 AC.  Hoping for a miracle.  Beta 12/26 Low BETA-8 2nd BETA 5- chemical
    After 3 failed transfers IDK where to go from here.  Still no real answers as to why this isn't working.  Getting a second opinion in February and looking into immune testing.  
    2/14- NEW RE- Immune testing showed a partial dq alpha match with DH- On prednisone and did intralipids prior to transfer.  3/14 Lupron, gonal f, menopur, HGH.  ER 15 mature all 15 fertilized!  5dt of an early blast grade 1 and an expanded blast grade 2.  BETA on 4/21.  1 grade 2 embryo frozen
    BETA #1 59 BETA #2 148 BETA #3 283 BETA #4 2,783! US at 6w2d shows 1 bean measuring right on track! HR 121.  US at 8w3d measuring on track HR 177. Released form my RE.  EDD 12/28


    All Welcome
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