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Karyotyping ?variants?

SophistikittySophistikitty member
in Infertility Veterans

DH and I had karyotyping done after our first failed IVF.  Everything came back ?normal? and I put it out of my mind.  


Today I was reviewing the patient forms that I need to fill out to see Dr. K (RI) and I noticed that it asked for my karyotype.  I dug up my results and when I looked at the sheet for some reason one section stood out to me ? ?variants?.  Apparently I am ?1qh-? and ?15pss?.  After a lot of Googling I gleaned that this apparently means I have ?double satellites on the short arm of chromosome 15?. I then found a study done in 2011 in India that followed 440 couples with a history of repeated loss and 42.68% that had similar ?heterochromatic variations? with chromosome 15 had 1st trimester losses.  There were other variations that were worse but I wonder why nothing was said to me???  I know this doesn?t explain my most recent loss but when you mix borderline MFI, DOR, AMA all together and add this no wonder I didn?t have a hope in hell with my OE!  It just brings home the fact that tests mean nothing if the doctor can?t synthesize the information.  I still haven?t figured out the ?1qh-?.  There seems to be more on ?1qh+?.


Does anyone have similar ?variants??


***SIGNATURE WARNING***


TTC #1

Me 42, DH 47

Dx = AMA/DOR, MFI

IVF/ICSI #1 = BFN

IVF/ICSI #2 = BFP; early loss

IVF/ICSI #3 (DE) = BFP; early loss

FET = BFN

IVF/ICSI #4 (DE w/ CCS) = BFP

Beta #1 @ 10dp6dt = 265; Beta #2 @ 14dp6dt = 1251. 

1st U/S @ 6w2d showed one perfect little heartbeat! 

2nd U/S @ 7w2d. HB 132 & everything measuring on track.

Our beautiful little girl arrived January 2015!


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Re: Karyotyping ?variants?

  • J&D2007J&D2007 member
    I am not familiar at all with variants in karyotyping, but I know I had a mutation on the MTHFR gene that the RE says doesn't mean anything. I think I may look into it now that you found more info on yours. I'm sorry I have no info, but good luck in your
    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
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  • DoublePortionDoublePortion member
    I don't have any answers but hope you find the info you need!

    ***signature & ticker warning***

    Me: 30 ~ Stage IV Endo ~ AMH .38 ~ AFC 8
    AMH .97 as of 4/2012! ~ AMH 1.63 as of 4/2013!?!
    Him: 29 ~ perfect swimmers
    Laparotomy w/partial oophorectomy 8/2009 to remove cysts/endo.
    Stopped BCP 4/2010.
    Multiple clomid rounds from 11/2010 to 6/2011. ~ All BFN
    IUI w/clomid 7/2011. IUI w/clomid & injectables 11/2011 & 1/2012. ~ All BFN
    IVF:EPP 5/2012 ~ (4R, 3M, 2F w/ICSI). Both embryos txfrd. ~ BFN
    BCP to manage endo from 10/2012 to 12/2012.
    FET w/donor embryos #1: 10/2013 Cancelled
    FET w/donor embryos #1.2: 11/2013     ~ ET of 2 beautiful blasts on 11/27.
    Beta 1: 503(12dp5dt) Beta 2: 1035(14dpt) Beta 3: 3001(16dpt)     Beta 4: 8503(19dpt)
    Twins with an EDD of 8/15/14! Team Purple
    G&B born 6/30/14 at 33w3d via emergency c/s.

    If you're wondering about my avatar...it's a fried pickle chip shaped like a fetus!

    image

    image
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  • violetmarie61516violetmarie61516 member
    imageSophistikitty:

    DH and I had

    TTC #1 Since May 2011 ~ Everyone Welcome
    Me (34): DOR d/t chemo/radiation, Immature Endometrial Lining, Hypothyroidism
    DH (35): MFI d/t testicular torsion and removal, Low T, Oligospermia, Anti-Sperm Antibodies, Currently on T supplements
    Sept '11-April '13 ~  Testing, failed multiple MFI treatments, saving & TONS of praying
    January 2014 ~ IVF/ICSI & PGS ~ no response to stims ~ converted to IUI ~ BFN
    February 2014 ~ On to donor embyros ~ 5 blasts!!! 
    March 2014 ~ FET #1 ~ Transferred 2 blasts ~ BFN
    July 2014 ~ Kliman's mock cycle with endometrial function test
    Sample too small for EFT, HE slide showed immature cells
    New protocol planned, saving for another biopsy for EFT
    January 2015 ~ Considering adoption options
    April 2015 ~ Privately arranged adoption of planned pregnancy
    DD#1 ~ Lillyana Violet Marie born 6/15/16, Finalized adoption 12/20/16
    July 13, 2018 ~ BFP....WTF?!?!
    7/16 Beta #1 ~ 466...7/18 Beta #2 ~ 1,077...7/23 Beta #3 ~ 5,291
    7/23 US #1 ~ 1 gestational sac seen and yolk sac
    7/30 US #2 and 1st OB appt ~ 1 perfectly round gestational sac, 1 perfect yolk sac and 1 teeny tiny heart beat seen!!!
    Lilypie Maternity tickers


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