Infertility

ectopic?

So my nurse just called with beta #4 and it's 43.  Definitely a jump from 11 on Friday.  They are thinking ectopic is a possibility instead of a c/p.  Anyone else have experience with this?  What is the treatment?  TIA!
Me: 34 DH: 40
Removed ovarian cysts in Mar 2010 & removed left ovary in May 2010
TTC since Oct 2011
Sep 2012 IUI #1 Natural cycle BFN
Sep 2012 IUI #2 Natural cycle BFN
Oct 2012 IUI #3 Natural cycle BFN
Nov 2012 removed uterine polyp
Feb 2013 IVF #1 ER 2/8: 13R,6M,6F, 3dt of 1 6-cell & 1 7-cell embie, beta hell resulted in blighted ovum.
June 2013 IVF #2 cancelled due to lining too thick
July 2013 IVF #2.1 ER 7/9, 9R,4M,2F, 3dt of 2 8-cell embies, BFN
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Re: ectopic?

  • Unfortunately I got nothing but I hope it all works out ok for ya.
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  • Depends on the doctor, they can give you methotrexate (spelling) its what they give cancer patients to kill the cells. Or unfortunately they take the tube. I have had both so sorry to give you this type of advice. I pray an ectopic isn't the case.
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  • It could still be chemical. My first ivf my first beta was 12 second was 33 third was 130. Then four days later my beta fell to 10. I'm sorry your in this situation. I know how much it sucks

    TTC#1 since April 2011
    IVF#1 July 2012 5R, 3 made it to blast, sET c/p
    FET#1 Aug 2012 2 blasts transferred BFN
    IVF#2 Oct 2012
    16R/6M/6F/2-8 cell grade 1 transfer
    Beta 1-237.9, Beta 2-566, Beta 3-8657
    US 6w3d shows one baby w/ HB 115
    US 7w1d no more heartbeat/ D&C 11/30/12 normal karyotype
    IVF#3 Mar 2013
    6R/4M/4F 1 compacting and 2-8 cell transfer
    ectopic pg MTX given 3 month break from TTC

    IVF#4 Sept 2013--BFN
    IVF#5-7 Apr 2014, Jun 2014 and Aug 2014 banking embryos for CCS testing. Praying for normals! Image and video hosting by TinyPic imageimage

    http://i61.tinypic.com/34zll06
  • I hate that you are having to go through this. Praying for answers for you. 
    Me:40 DH: 43 m/c #1 4/8/08 @ 5w::natural
    m/c #2 missed m/c discovered 12/11/08 @ 8w3d :: d&c 12/15/08
    Feb 2009-began seeing an RE:: DX with unexplained IF
    Sept 2009 -2010 TTC using femara ...eventually work called me out of town.
    June 2011 DX with thyroid cancer-forced to put baby making on hold
    11/15/12 IUI #1 BFN and 12/15/12 IUI #2 BFN
    Feb 2013 IVF-BFN:: April 2013 FET-Cancelled:: July 2013 FET-1 frostie
    Image and video hosting by TinyPic  imageimage  
    image image
  • Thanks ladies!  I'm just extra disappointed since we might have to cancel my birthday getaway weekend to NYC.  My RE preferred I not travel this weekend.  :( 
    Me: 34 DH: 40
    Removed ovarian cysts in Mar 2010 & removed left ovary in May 2010
    TTC since Oct 2011
    Sep 2012 IUI #1 Natural cycle BFN
    Sep 2012 IUI #2 Natural cycle BFN
    Oct 2012 IUI #3 Natural cycle BFN
    Nov 2012 removed uterine polyp
    Feb 2013 IVF #1 ER 2/8: 13R,6M,6F, 3dt of 1 6-cell & 1 7-cell embie, beta hell resulted in blighted ovum.
    June 2013 IVF #2 cancelled due to lining too thick
    July 2013 IVF #2.1 ER 7/9, 9R,4M,2F, 3dt of 2 8-cell embies, BFN
    imageimageimage
  • Ugh I am sorry to hear that. Methotrexate is usually the first option if your beta isn't too high (>2000). It's an IM shot, like PIO, well, usually it's 2 shots at once. I went through increasing betas with no other visible signs of pregnancy on US. They thought it might have been ectopic but nothing was visualized in my tube (I only have 1).  The trophoblastic cells (which secrete the hcg) can be anywhere, not just in a tube.  My betas rose as high as 1800 but not on a curve that would sustain viability. The mtx is a much better option than surgery, if you qualify, but it just takes a lot of time for the beta to decrease to a point where you can cycle again.  Sometimes a second round of mtx is required a few weeks later.  As was said earlier, mtx is a chemo, it attacks fast growing cells.  It's a low dose though that is administered for ectopic.  It's a long road sadly, but what isn't in the world of infertility.  I hope your torture is short lived.  Good luck. 

    ps I'm a pharmacist 

    Me = 36 with PCOS and 1 tube removed for a cyst and adhesions
    DH = 35 with low morphology

    April '09 IVF (antagonist protocol) = 5R5M, none fertilized, cancelled at ET
    May/June '09 IVF/ICSI = 6R6M6F, 2ET on 6.18.09, 1 frostie, Beta on
    6.30.09 = 51 OMG!! Beta #2 = 167 Beta #3 = 2630!!!!! An uneventful pregnancy. 
    3.16.10 a healthy beautiful miracle boy born via unscheduled c-section

    Now on the quest for another, so our dear son is not alone.

    May/June '12 IVF/ICSI (antagonist protocol) =10R9M9F, 1ET = BFN, 2 frosties
    Aug '12 FET, 1ET= beta hell, 2 rounds of methotrexate, 4 months later Hcg < 2 
    Jan/Feb '13 IVF/ICSI (long lupron protocol) = 18R18M18F, 1ET = BFN, 10 frosties
    Apr '13 FET w 2ET (one from '09 and one newer) = (strep throat during 2ww) biochemical = BFN
    June '13 FET w 2ET = 1 baby boy lost at 10w, D/E with karyotyping, loss due to monosomy 21.
    Karyotyping of me and DH negative for a balance translocation.
    Dec '13 FET w 2ET, BFP!!!! 12/26 beta #1 10dp5dt = 781, beta 2 12dpt= 2234 could this be real?!
      Not giving up yet.
    5 frosties on ice.

    Truly realizing how much of a miracle my son is and praying this will be a sibling for him.
  • imageshell3879:
    Thanks ladies!  I'm just extra disappointed since we might have to cancel my birthday getaway weekend to NYC.  My RE preferred I not travel this weekend.  :( 

    So sorry to hear this. We had to cancel my birthday getaway due to monitoring appointments in the next couple of weeks, and it was one of my biggest disappointments of this process! Ha! Go figure. I'm so sorry you are dealing with this, Shell, and I hope it comes around and is a c/p instead of ectopic. Either way, it sounds like your doc is doing a great job monitoring you and keeping you safe. Sorry I have no advice. Hang in there.  

    | Married since 2008 | DH and I: Both 30 | Me: Endometriosis and Carrier of an X-Linked Dominant Genetic Disorder | DH: Low Morph | Planning IVF with PGD and PGS in 2013 | Freeze-All IVF #1: March 2013 ER 3/26. 29R, 12M, 11F. 4 5AA frozen blasts. Freeze-All IVF#2: May 2013 ER 5/15. 31R, 21M, 20F. 6 5AA frozen blasts. Our PGD probe was completed in late June (total of 20 weeks to develop). PGD and PGS Results came on 6/19: 3 healthy embryos (normal chromosomes and unaffected by my family's genetic disorder). FET #1: July 2013 Natural Cycle - Cancelled due to insufficient lining (only got to 7.5mm). FET #1.2: August 2013 - Medicated Cycle with Lupron & Estrogen Patches to build up lining. Single embryo transfer was 8/23. Beta #1: 240! Beta #2: 578! U/S on 9/19 at 6w4d: We saw the heart beating at 131bpm. Second U/S on 10/4 at 8w5d: We saw the heart beating at 178bpm. EDD 5/11/2014
    image
    PAIF/SAIF/Everyone Welcome! 


  • imagecarrera317:

    Ugh I am sorry to hear that. Methotrexate is usually the first option if your beta isn't too high (>2000). It's an IM shot, like PIO, well, usually it's 2 shots at once. I went through increasing betas with no other visible signs of pregnancy on US. They thought it might have been ectopic but nothing was visualized in my tube (I only have 1).  The trophoblastic cells (which secrete the hcg) can be anywhere, not just in a tube.  My betas rose as high as 1800 but not on a curve that would sustain viability. The mtx is a much better option than surgery, if you qualify, but it just takes a lot of time for the beta to decrease to a point where you can cycle again.  Sometimes a second round of mtx is required a few weeks later.  As was said earlier, mtx is a chemo, it attacks fast growing cells.  It's a low dose though that is administered for ectopic.  It's a long road sadly, but what isn't in the world of infertility.  I hope your torture is short lived.  Good luck. 

    ps I'm a pharmacist 

    Question: if you are given MTX, do you have to wait a certain amount of time to recycle because of the teratogenic effects?

    <Image and video hosting by TinyPic
    Married June 2011 Dx: anovulatory due to prolactinoma (1.5cmx 1.5cm in 2006)
    April 2012: MRI- questionable cyst 8mg by 12mm in pituitary ; referred to RE by Ob-gyn after amenorrhea x 4+ months, provera ineffective, low estrogen level
    cycle 1: May 2012, clomid 50mg; cycle cancelled, thin lining, no response
    cycle 2: June 2012, femara 5mg; cycle cancelled, no response
    cycle 3: July 2012, femara 7.5mg; cycle cancelled (largest folli on Cd12 & cd 16: 11, lining 4)
    Repeat MRI July 25,2012- Cyst unchanged, likely old infarction.
    Aug. 8: met with RE, move to injectables if HSG and SA normal
    Aug. 23: HSG all clear; DH- perfect
    Switched to a new RE in early Sept. IVF here we come
    Genetic testing reveals: Fragile X- Intermediate risk/grey zone.
    IVF#1: ER 11/30: 14 retrieved, 10 mature, 7 fertilized. E2 prior to trigger 5200. Decision made to freeze 6 embryos and transfer later due to OHSS.
    IVF#1.2/FET #1: estrogen injects start 1/18, FET delayed to try to thicken lining. lining 5.4mm. FET- 2/18- transferred one 3AA expanded blast. BFP 5dp5dt. Beta #1- 2/27 9dp5dt- 102.27 beta #2 3/1: 147 :(, beta #3 3/4: 268 told to stop meds and let nature take its course. requested 4th beta (3/6); Beta hell for 2 months.

    FET # 2: endometrial scratch 5/6, added estrace vaginally and ASA to delestrogen and PIO. June 10- transferred one 4AA hatched embryo, BFP 4dp6dt, Beta 1 (9dp6dt) 187, Beta 2 (11dp6dt): 412; Beta 3 (15dp6dt ): 4452. U/S #1- one beautiful embryo with a heartbeat of 133 at 7 weeks.  8 weeks: heartbeat 156. EDD 2/26/2014: born 2-3-14 induced due to Pre-E and HELLP at 36w5d.

    12/1: met with RE to discuss trying for #2


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