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Help for a friend **Ticker Warning**

mnj05mnj05 member
in Infertility Veterans

Hello ladies, I recognize many of you but for those who may not remember me, I was active on 3T and IF for about a year total and now am on PAIF. I lurk here often to keep track of those I met on IF.

I have a question for you on behalf of a friend, I'm blanking and want to make sure I give her the best info I can. Backstory on her is she's been TTC on and off for four years. They can't afford much so they've been doing Femera, trigger, and TI. She's had success twice, but one ended in m/c and this recent one is blighted ovum. Her doctor is quack (my opinion) and is a fertillity specialist, not an RE (which was my first red flag). Their last SA was three years ago and this doctor doesn't feel the need to repeat. She has no clue what all could be going on with her other than the doctor says PCOS. I don't know what testing he did on her to diagnose her and he would not check her progesterone levels during either success cycle and only did two betas despite low numbers both times.

She's getting ready for an appointment tomorrow to check out the blighted ovum and make sure there's nothing else going on and she wants to know what all to ask. She's going to ask about testing for egg quality and another SA. I know most REs don't start getting concerned about m/c until three but should she ask about testing for that? Is there anything else you could think of she needs to ask about?

I think she's finally ready to move on to another doctor after they take a break but she wants to see about testing before moving on. TIA!

 imagePhotobucket

TTC #1 since 3/2011
DX: anovulatory and severe MFI
DH is a testicular cancer survivor
IVF#1 w/ICSI lupron, gonal f, ovidrel
ER 6/15/12 6R 6M 6F! ET 6/20/12
Beta #1: 154 Beta #2: 509 Beta #3: 7326
Baby Boy born 3/1/2013
Baby Birthday Ticker Ticker

TTC#2: 6/2014 all testing came back normal

IVF#2 (#1 for LO#2) 9/2014 - 17R 10M 10F 4 blasts frozen on day 6.

FET #1 10/15/14 - Beta #1: 216  Beta #2: 823


Baby Boy born 7/10/2015


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Re: Help for a friend **Ticker Warning**

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    luvbostonluvboston member
    She needs an FSH, 3dpo b/w, 21 day progesterone, her DH needs an SA and she should ask for the report from the last one. She should have a RPL panel with all clotting, she needs an HsG, also there are certain androgens to test for pCOs. She also needs a TSH, t3,t4 etc for thyroid. Blighted Ovums can also be caused by immune problems.
    6 m/c
    Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
    Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
    1 Clomid/Ovidrel BFN May 2011
    Natural cycle Aug 2011 BFP M/C 4 Weeks
    1 IUI Sept 2011 BFP M/c 7 weeks
    Provera Dec 2011 BFP M/C 3 Weeks
    DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
    IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
    IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
    Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
    Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
    Went to Beer Center- high tnf, low lad, implantation failure
    Nov/Dec 2012 LIT Treatment
    Dec 12 Humira
    Jan 2013 BFP
    Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
    Miracle Born August 2013 Premature

    Yours doesn't have to be a sad story


    image
    image


    Lilypie - (ugiy)


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    rockpaperloverockpaperlove member

    imageluvboston:
    She needs an FSH, 3dpo b/w, 21 day progesterone, her DH needs an SA and she should ask for the report from the last one. She should have a RPL panel with all clotting, she needs an HsG, also there are certain androgens to test for pCOs. She also needs a TSH, t3,t4 etc for thyroid. Blighted Ovums can also be caused by immune problems.

    I think you covered it off Luv!  Well said!  I would only add that she should consider the E-tegrity test, which indicates the presence of the beta 3 integrin necessary for implantation. 

    Countless BFN(s)
    Moving to IVF

    IVF1 (ICSI): Long Lupron
    6R. 3F. 3DT. 8Cell 1Grade 2Embies. 1Frostie.
    Beta 1/22: 14 Beta 1/24: 24 Beta 1/26: 28
    Round One Result: Chemical Pregnancy

    Pressing Forward

    IVF2 (ICSI/AH/ACU): Microdose Lupron Flare
    13R. 11F. 5DT. 2TFR'ed. 1Frostie.
    Round Two Result 4/30: Harsh BFN

    FET. 2TFR'ed.
    Round Three Result 6/25: BFN
    Where do we go from here?

    Moving forward with CCRM in 2013
    ODWU revealed blocked tube(s). Lap 2/15.
    Bilateral Tubal Ligation. Stage IV Endo.
    Finally some (tough) answers.


    IVF3 (ICSI/CCS): Antagonist with EPP
    13R. We have 3 CCS Normal Embryos!


    Lupron Depot: May 2013 to August 2013
    Long awaited FET on 9/3. 2TFR'ed.
    BFP on FRER 5dp5dt: IN SHOCK!
    Beta1 9/10: 152.7! Beta2 9/12: 378! Beta3 9/14: 1224! 

    1st ultrasound 10/1: TWO beautiful heartbeats!  Overjoyed!

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    mnj05mnj05 member
    Thanks so much! I was forgetting the TSH and I didn't know about the Etegrity test.

     imagePhotobucket

    TTC #1 since 3/2011
    DX: anovulatory and severe MFI
    DH is a testicular cancer survivor
    IVF#1 w/ICSI lupron, gonal f, ovidrel
    ER 6/15/12 6R 6M 6F! ET 6/20/12
    Beta #1: 154 Beta #2: 509 Beta #3: 7326
    Baby Boy born 3/1/2013
    Baby Birthday Ticker Ticker

    TTC#2: 6/2014 all testing came back normal

    IVF#2 (#1 for LO#2) 9/2014 - 17R 10M 10F 4 blasts frozen on day 6.

    FET #1 10/15/14 - Beta #1: 216  Beta #2: 823


    Baby Boy born 7/10/2015


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    J&D2007J&D2007 member
    imagerockpaperlove:

    imageluvboston:
    She needs an FSH, 3dpo b/w, 21 day progesterone, her DH needs an SA and she should ask for the report from the last one. She should have a RPL panel with all clotting, she needs an HsG, also there are certain androgens to test for pCOs. She also needs a TSH, t3,t4 etc for thyroid. Blighted Ovums can also be caused by immune problems.

    I think you covered it off Luv!  Well said!  I would only add that she should consider the E-tegrity test, which indicates the presence of the beta 3 integrin necessary for implantation. 

    ditto to all above posts.

    E-tegrity test? I never even heard of this. Is it a blood test I assume?  Any certain time of cycle it needs to be done? 

    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
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    BzeetyDBzeetyD member
    imageJ&D2007:
    imagerockpaperlove:

    imageluvboston:
    She needs an FSH, 3dpo b/w, 21 day progesterone, her DH needs an SA and she should ask for the report from the last one. She should have a RPL panel with all clotting, she needs an HsG, also there are certain androgens to test for pCOs. She also needs a TSH, t3,t4 etc for thyroid. Blighted Ovums can also be caused by immune problems.

    I think you covered it off Luv!  Well said!  I would only add that she should consider the E-tegrity test, which indicates the presence of the beta 3 integrin necessary for implantation. 

    ditto to all above posts.

    E-tegrity test? I never even heard of this. Is it a blood test I assume?  Any certain time of cycle it needs to be done? 

    It is an endometrial biopsy test - done in the luteal phase of a cycle. It is not a comfortable test, but it's an important one, especially if you've had early losses.

    BzeetyD = 38, Mr. BzeetyD = 44 together 12/02 married 9/08
    TTC #1 since 1/10
    DX: Unexplained/??? MFI issues

    Our lil' lost sparks:
    5w3d loss 7/30/10 - EDD March 2011
    8w loss 4/15/11 - EDD November 2011
    8w3d loss 8/2/12 - EDD March 2013
    4w c/p loss 10/29/12 - EDD July 2013

    Long story: trying on our own + testing testing testing with 6 rounds of Clomid, more testing, injectables + TI, laparoscopy - one tube blocked, 2 IUIs with Follistim...BFNs.
    RPL testing all normal, Karyotyping normal

    Moving on to IVF.

    IVF #1 April 2012 = BFN, IVF #2 June 2012 = BFP. U/S 7/23 = saw heartbeat but measuring behind. Follow up U/S on 7/30 - no heartbeat. D&C 8/2. Trisomy 12. IVF #3 Oct 2012 = Chemical Pregnancy

    Phone consult with CCRM on 12/12/12 - ODWU 1/4/13 - both tubes clear(!) - AFC 24, AMH 3.2, FSH 9.6, LH 5.4, E2 25. DH has high frag rate but improved!
    IVF #4 March 2013 CCRM. EP protocol w/ Menopur, Gonal-F & Dexamethasone. ER 3/29 & IMSI, PICSI. 43R 13M 10F 6blasts bio'd. CCS testing reveals 3 normals!!!
    FET 5/31/13 of 1 4AA blast - thawed and expanded. 4dp5dt BFP.
    Beta 9dp5dt = 181, 11dp5dt = 427. 1st u/s showed a healthy heartbeat! EDD 2/16/14

    After 4 years of hoping and heartbreak, our sweet little bean was born on 2/19/14
    We are so in love with her.

    "I'm not telling you it's going to be easy, I'm telling you it's going to be worth it."

    Everybody is welcome!!!
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