Trouble TTC

Stupid LPD and crap P4 test

So I was chatting with lovely cycle buddy KatyJ today about P4s and how they're a mind fluck because you're damned if you're low (worried), damned if you're high (optimistic).  So I was hoping for a nice average kind of number today.  Something between 15 and 25.  Because on non medicated cycles back in 2010 when I first started seeing my RE my P4 was 8 but on treatment cycles it's been as low as 13 but as high as 25 so I thought...that's a good goal to shoot for.  

It came back today at 7dpIUI at 4.3.  WTF?  Never in my wildest dreams did I expect it to be that low!  Now the mind fluck of crashing hopes comes down on me.  This was on oral supps of 200mg of progesterone.  

So they said "what script would you like called in?  Endometrin or crinonin gel to add to your oral pills?  One is a goopey discharge, one is watery.  Pick based on which side effect you think is less annoying."  I said "I'll pick based on which is CHEAPEST!" (Since they know I am OOP.)  The nurse said, let me go check our samples....and boom free 10 days worth of endometrin.  Super.  Now I get to shove stuff up my cootch.  

So, since 200 oral gives me slight headaches and makes me a bit moody...can I just expect more of the same?  Or does anyone have any other side effects I should be on the look out from the new stuff?  And any hope you can throw at me telling me P4 is a useless test since high doesn't equal pregnant that low doesn't also mean failure would be good. 


TTC since July 2009. Dx MFI & LPD. 
IUI#1&2&3 (2011 & 2012) BFN
IUI#4 1/23/13 on 75iu x9 Follistim = BFP then chem preg m/c (Feb 2013)
IUI#5 BFN (April 2013)
IVF w/ICSI Oct. 2, 2012 - 13R, 11M, 7F, 1 frozen blast 4BB grade - - - FET Nov 15, 2013
BFP! Beta 1:104 @ 10dp6dt, Beta 2:178 @ 12dp6dt,  beta 3:366 @ 14dp6dt
Saw heartbeat twice before missed M/C at 8w3d on 12/27/13, missing my little angel boy
JUNE 2014 IVF#2;  5R, 2M, 1F Three day transfer 6/7.  Beta 6/18 - BFN
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Re: Stupid LPD and crap P4 test

  • Hey Kati!

    Sorry your P4 was so low. I hope doubling up the P4 gives you good results. The progesterone side effects I have on PIO are as follows (I've never done oral or vag P4, so I'm not sure how different the side effects are): exhaustion, sore boobs, and slight cramping

    My RE said he has seen women sustaining pregnancies with P4 levels as low as 3.5 before, so I've heard of it happening. Of course not trying to blow rainbows up your butt, but just passing along some hope to you!! 

    GL! Here's to hoping the next 7 days fly by for you! 

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  • I have no advice, but I just wanted to say good luck and I really hope doubling up works for you!
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  • Sorry you got a low result!  Honestly, my RE has not done any of this testing at 7 dpIUI so I don't have any advice on that....I'm going to demand it this go around, so I see what I have to look forward to!  What's one more mind fluck each month?! :/  

     I do however do the progesterone suppositories every month which I hate with all my being.  I have similar symptoms to what you both have mentioned, but now you will just get to deal with the constant discharge and overall uncomfortable sensation that goes along with it.  The sore boobs is a big one for me which is super annoying because it gives me false hope that I'm pregnant each time...I mean, really sore!  

    Awesome that you got a free sample though!   Good luck!

    TTC #1 since November 2011
    Me 32, DH 32
    Dx: Unexplained IF
    RE consult October 2012 
    Clomid and IUI Nov 2012-March 2013 BFNs
    IVF#1 on CD10! April 2013 - ER (27 retrieved, 19 fertilized) 4/21 - ET cancelled due to OHSS. 10 frosties 
    FET#1 w/ one blast May 2013-BFN
    FET #2 w/ one blast July 2013-BFP!!! Beta 9dp5dt: 129 Beta 13dp5dt: 867 Beta 20dp5dt: 13621 Beta 27dp5dt: 53341 U/S #1: 7/31 heartbeat 127 measuring right on time EDD March 20th, 2014
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  • That sucks.

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    TTC #1 since August 2011

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    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


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  • so sorry for low results!
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    Age: Me 26, DH 27, Married Oct. 10, 2009 ,TTC since March 2012
    Problem: Irregular menstruation, unexplained
    Nov&Dec-Provera because of no period after 35+ days
    First RE appt 1/10/2013
    Tests: TSH (normal), Prolactin (normal), SA (abnormal)
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  • I'm so sorry your numbers came back low :/

    As far as s/e I've had cramping, mild headaches and I was tired all the time.

    I wish you SO much luck, lady!
    Me: 37, DH: 35 :: TCC since 2/11 SA: Perfect! CD3  HSG = Blocked Right Tube
    April- Femara 2.5mg + Trigger + IUI = BFN   May- Femara 5mg = CX - No Response on Left = BFN
    June- Femara 7.5mg + Trigger + IUI = BFN  August- Lap & Hysteroscopy = Blocked & Partially Blocked Tubes
    September- Femara 5mg = CX - No Response on Left = BFN  October- 100mg Clomid + Trigger + TI = BFN
    IVF # 1: Stims 11/30 ER 12/12/12! (10R, 10M, 8F, 2T, 6 F) :: Beta #1- 176  c/p @ 4w4d
    FET #1 February 26th :: Lost 4 to Thaw, Transferred 2 = BFFN
    IVF # 2 Stims 5/10 ER 5/21 (15R, 13M, 13F, 2T, 7F- 6d3 & 1d5) :: Beta # 1- 15 c/p @ 4w
    FET #2 Cancelled, Right Tube Developed a Hydro  8/28 Hydro & Scar Tissue Removed  Cleared for FET
    FET #2.2 Scheduled for September 20th
    2 Thawed, 2 Transferred! Beta #1- 96, Beta #2 906! :: EDD June 10th
    2015- 2 failed FET. We are done
    SURPRISE! BFP 8/8/16   EDD 4/1/17

     
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  • Sorry it's low Kati. : Hope the doubling up helps! My fingers are extra crossed for you!!
    TTC #1 since Sept 2011
    Me: 33, DH: 35, DX: PCOS & MFI (low everything)
    IUI #1-3 - Low Post-Wash Counts - All BFNs
    IVF #1 w/ ICSI: Long Lupron Protocol - Freeze-All Cycle due to Severe OHSS
    ER 4/27, 33 Eggs Retrieved, 13 Frosties
    FET #1 6/5, Transferred One Perfect 4AA Blast, HPT BFP @ 6dp5dt
    Beta #1 - 209, Beta #2 - 508, Beta #3 - 1,059
    EDD 2/20/14
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  • I've not had a 7dpo blood test in about a year. I don't get a choice I just get vag sups every cycle. Jolly good fun! My symptoms aren't bad on progesterone. Estrogen and I are a different story all together.
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    TTC since 3/2011 Adenomyosis, LPD, hypothyroidism. 
    BFP on 7/20/12 after 4 cycles Clomid + IUI 
    2 large subchorionic hematomas & no heartbeat at 7w6d   
    D&E 8/18/12 Sonohysterography found septum and necrotic tissue.   
    Hysteroscopy to remove both 10/5
    IUI #5-7 50mg Clomid + trigger = BFN  
    IUI #8 Femara + Bravelle + HCG + Progesterone = BFP 3/27/13
    Beta 1 (13dpo) = 169  Beta 2 (17dpo) = 1073  No heartbeat at 9w3d. 
    D & C 5/10/13  Triploidy 69 (paternal inherited)
    IVF #1 with ICSI and PGS 11R 8M 5F 2 biopsied/frozen
    PGS results = 1 with trisomy 13 & 1 good embryo for FET 
    FET #1 EV, estrace, nitro patches.  Cancelled due to thin lining
    FET #1.2 oral estrace, f'ing nitro patches and no delestrogen.  Transfer 12/31. BFN
    PAIF/SAIF welcome
    Surprise BFP on 6/13/14  Our only unmedicated bfp ever.
    Beta #1 339  Beta #2 649 44 hour doubling time
  • *hugs* I'm sorry your P4 level sucked. I hope the endometrin does the trick. Good luck!
  • Sorry about the crappy P4!  Mine are always low.  Wish I had some advice on the suppositories, but I use prometrium as a suppository and have little or no side effects from it.  

    When I need to find some hope in a bad P4 result I always google "Progesterone of (insert yours) and pregnancy".  I usually get quite a few results of pregnancy still happening.  Maybe that's not the best thing to do, but I do it lol.  ((((hugs))))) 

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    After almost 2 years of TTC and fertility treatments we got a surprise BFP in May 2013
    1/14/14 Baby Boy!! 
    TTC for #2 October 2015

  • I'm sorry your numbers were low. FX the meds do the trick. Yay for samples!!!
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  • ugh, so sorry your level was low! I don't understand the point of the stupid test either since like you said "P4 is a useless test since high doesn't equal pregnant that low doesn't also mean failure". Especially since you're regularly monitored t/o your cycle you know you had follies, I'm sure you triggered which ensures you ovulate, & you did the IUI so they know something was there!! I've been told they want the p4 because it lets them know how well or how strong ovulation was? Not sure if this is right though...

    I'm also on 200mg of prometrium that I get to shove up my vag & I don't really notice much for s/e besides discharge. This cycle I finally only have to use them 1x/night whereas the last 2 cycles I've had to insert 2x/day which the morning one was always the worst!

    Fingers crossed this cycle works for you and all of this means nothing!!!!!!

    TTC since July 2010
    Me 26 (unexplained), DH 28 (SA GREAT!)
    Charting since April 2011
    Nurse Practitioner Fertility Specialist 9/11 Provera, Clomid for 3 months with no response.
    Metformin 1/12 to 3/12 with no regularity
    took break until 10/12
    CD1 11/9 + clomid 150, 4 follies (1 - 22mm) + hcg, progesterone level 9.3, put on progesterone supps, BFN 12/7
    CD1 12/9 + clomid 150, 2 follies 12mm & 13mm + no trigger, +OPK 12/23 + progesterone supps CD18, progesterone blood test=14.4, BFN 1/9
    CD 1 1/11, clomid 150 CD3-7 & dexamethasone CD 3-12, u/s 1/23 showed 3 follies 20+, triggered w/ hcg, started progesterone supps 1/25, 7dpo bw sched for 2/1
  • So sorry for the crappy numbers, but yay for samples! I also love the fact that I'm not the only one that says cootch! GL and FX for you!
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  • **ticker warning**

    Not to blow butterflies up your bum, but don't lose hope! I had a crappy lining this cycle, was put on Estrace and then had a P4 of 7 at my 7dpiui bloodwork so then I was put on Prometrium. So for almost 2 weeks now I've been shoving pills up my vag but... I think it was what I needed! Hence, the ticker.

    Hang in there lady!

    My Constantly Confusing Chart: My Ovulation Chart TTC#1 since 6/2011 DX IR 7/2011, started on Metformin IF testing with RE 6/2012 DX lowish TSH, Lowish AMH, and uterine polyp 7/2012 Uterine Polyp removal 8/2012 Started Synthroid and increased Vit D 7/2012 9/12 - IUI#1+Femara+Bravelle+Ovidrel=BFN 11-12/ Femara+ TI = BFN 12-12/Femara+ 75 Menopur = BFFN 1-13/ Femara+ 150 Menopur+ IUI# 2 = BFP! BabyFruit Ticker BabyFetus Ticker
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    I'm so sorry your P4 is so low... Ts and Ps coming your way. Hoping it's really higher and the oral dose just isn't showing up well in your b/w
    TTC #1 Since 4/2010, Cycle 30
    Positive for HLA-B27, I'm a mutant :p
    Testing - Me ok, gluten issue? DH - borderline count, low motility
    4/28/11 IUI#1 = BFP!(5/25), EDD 2/2/12 - m/c 5w3d
    7/3, 7/31, 9/25 - IUI#2-4=BFN
    IVF#1 - 1 blast = BFP!! (12/30), EDD 9/9/12, confirmed c/p 4w2d
    FET#1 3/2/12 - 2 blasts =BFP!! EDD 11/18/12, us#1 = twins! Confirmed m/c 5w6d
    4/20-surprise BFP and another c/p 4w2d
    FET#2 7/16/12 - 2 blasts = BFN
    FET#3 8/20/12 - 1 blast - BFP!! Beta #1-2=177, 354
    1st u/s 5w6d, one beautiful little HB :), 2nd u/s 146bpm
    baby girl born 5/10/13

    TTC#2 since 12/17/2014, Cycle 8
    Repeat Testing...FSH=12, AMH=3.8, AFC=28. 
    IUI#5 5/10/15- c/p?
    IVF#2 8/19/15 - cancelled due to cysts
    IVF#2 take two 10/2015 - 5 blasts frozen
    FET#4 12/11/2015 - BFN - 4 blasts remaining
    FET#5 2/18/16 - BFP!!!  Beta1-3, 126, 250, 745!!

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  • TICKER WARNING

    Hugs Kati! I have seen lots of women in your shoes go both ways. And you are right it does not mean you are out! But I am sure this is really frustrating :( As for the supps, I have taken crinone and honestly had no problems with it. I used it at night before bed so I was laying down for most of it and really didnt have much discharge. It did get a bit, um, clumpy and I had some spotting and different types of discharge when things, uh, backed up in there. Doesn't that sound like fun! I dont know anything about the other though, but YEY for free samples! Fingers and toes are crossed for you lady!

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  • I'm sorry your P4 was so low! I was just reading this on your blog this morning. Glad you got the free samples!! I know that the P4 number must have you worried though, and I absolutely hate that for you.
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