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Mood swings/rage on letrozole...??? Anyone else a little crazy??

oO Angie OooO Angie Oo member
in Infertility

Im not sure if its the letrozole but the past two days I've been a little bit of a grump. I'm always in a bubbly mood and the past two days I just want to cry for absolutely no reason. I went off on a lady sitting next to us at a restaurant today who was absolutely horrible to the waitress and everyone else who she interacted with. I literally lit into her saying she needs to learn respect and have a little class rather than acting like a mega ***. Yes, I called her a "mega ***". Later DH and I laughed so hard that I tell her to learn some class and in the same breath call her a mega ***. So unlike me so I wondered if its the meds. 

Oh, and as soon as they brought mega ***'s food to her I let her know that you should never be rude to those who make your food- AND I told her I hope there was a booger in it. LOL. 

Funny thing is that everyone sitting around us pretty much cheered me on and the manager thanked me and said breakfast was on the house.  

Me: 29 DH: 32 Married: 10.25.07 Been dealing with amenorrheoa since I was young. (Literally go years w/o AF) Unexpected and very surprising BFP in Feb 2007. M/C April 2007. :( TTC since 2008 Metformin- Didn't help. :( Clomid 50mg/Provera cycle #1 7/2009 - BFN Clomid 50mg/Provera cycle #2- 8/2009- BFN Clomid 100mg/Provera cycle #3- 1/2010- BFN ...Took a break... 2012- Met with RE 09/12- Day 3 Labs- FSH 2.5, Estradiol 47, TSH 4.5 (Doc re-ordering Day 3 labs) DH sperm analysis- all good 11/12- Day 3 Labs- FSH 4.3, estradiol 38, TSH 2.51 Prescribed Synthroid 11/12- HSG all clear 1/13- IUI with Femara and trigger shot on 1/31- BFN 2/13-IUI #2- cancelled due to low response 3/13- planning IUI with injectables
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Re: Mood swings/rage on letrozole...??? Anyone else a little crazy??

  • xladybassxxladybassx member
    Wow, that sounds intense! Personally I have not found the mood swings on letrozole to be as bad as when I was on clomid. I have felt grouchy and tired, but that's about it. Everyone is different though, and I don't think mood swings are uncommon with letrozole. At least you guys got free breakfast!
    TTC since June, 2011 with anovulatory PCOS, 1 blocked tube, and mild MFI
    3rd cycles clomid + Ovidrel = BFN
    4th cycles letrozole/Ovidrel + IUI = BFN
    IVF #1 = BFP! Twins due 2/5/2014
    Lilypie Pregnancy tickers
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  • oO Angie OooO Angie Oo member
    Thanks!  I did a few rounds of Clomid and don't recall feeling like this.  I did some research on letrozole and don't remember hearing about mood swings- but I'm sure it has to be the meds. Haha
    Me: 29 DH: 32 Married: 10.25.07 Been dealing with amenorrheoa since I was young. (Literally go years w/o AF) Unexpected and very surprising BFP in Feb 2007. M/C April 2007. :( TTC since 2008 Metformin- Didn't help. :( Clomid 50mg/Provera cycle #1 7/2009 - BFN Clomid 50mg/Provera cycle #2- 8/2009- BFN Clomid 100mg/Provera cycle #3- 1/2010- BFN ...Took a break... 2012- Met with RE 09/12- Day 3 Labs- FSH 2.5, Estradiol 47, TSH 4.5 (Doc re-ordering Day 3 labs) DH sperm analysis- all good 11/12- Day 3 Labs- FSH 4.3, estradiol 38, TSH 2.51 Prescribed Synthroid 11/12- HSG all clear 1/13- IUI with Femara and trigger shot on 1/31- BFN 2/13-IUI #2- cancelled due to low response 3/13- planning IUI with injectables
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  • BrideJackie11BrideJackie11 member

    Most of the research discusses mood swings on clomid and not with letrozole.  I didn't have any on clomid at all but I will say that I did feel similiar to you on letrozole.  I felt like I was on edge constantly and just generally an angry person on it.  I just had to remember to think before talking a little more and tried to avoid situations that in the past made me minorly frustrated. Good luck!

    <Image and video hosting by TinyPic
    Married June 2011 Dx: anovulatory due to prolactinoma (1.5cmx 1.5cm in 2006)
    April 2012: MRI- questionable cyst 8mg by 12mm in pituitary ; referred to RE by Ob-gyn after amenorrhea x 4+ months, provera ineffective, low estrogen level
    cycle 1: May 2012, clomid 50mg; cycle cancelled, thin lining, no response
    cycle 2: June 2012, femara 5mg; cycle cancelled, no response
    cycle 3: July 2012, femara 7.5mg; cycle cancelled (largest folli on Cd12 & cd 16: 11, lining 4)
    Repeat MRI July 25,2012- Cyst unchanged, likely old infarction.
    Aug. 8: met with RE, move to injectables if HSG and SA normal
    Aug. 23: HSG all clear; DH- perfect
    Switched to a new RE in early Sept. IVF here we come
    Genetic testing reveals: Fragile X- Intermediate risk/grey zone.
    IVF#1: ER 11/30: 14 retrieved, 10 mature, 7 fertilized. E2 prior to trigger 5200. Decision made to freeze 6 embryos and transfer later due to OHSS.
    IVF#1.2/FET #1: estrogen injects start 1/18, FET delayed to try to thicken lining. lining 5.4mm. FET- 2/18- transferred one 3AA expanded blast. BFP 5dp5dt. Beta #1- 2/27 9dp5dt- 102.27 beta #2 3/1: 147 :(, beta #3 3/4: 268 told to stop meds and let nature take its course. requested 4th beta (3/6); Beta hell for 2 months.

    FET # 2: endometrial scratch 5/6, added estrace vaginally and ASA to delestrogen and PIO. June 10- transferred one 4AA hatched embryo, BFP 4dp6dt, Beta 1 (9dp6dt) 187, Beta 2 (11dp6dt): 412; Beta 3 (15dp6dt ): 4452. U/S #1- one beautiful embryo with a heartbeat of 133 at 7 weeks.  8 weeks: heartbeat 156. EDD 2/26/2014: born 2-3-14 induced due to Pre-E and HELLP at 36w5d.

    12/1: met with RE to discuss trying for #2


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