Infertility

MFI ? for a friend

A friend of mine just called me last night after RE called from husbands SA, it showed 800,000 sperm.  Any good websites or info I can pass along to her to help explain this?  This is her 2nd marriage and she has a DS already from her 1st so this is all new to her.  Since my DH and I are not MFI I am at a loss of what to say to her. 
Me (37) DH (39); PCOS changed to Unexplained, changed to DOR in 2012 (finally a correct diagnosis!); 
Started TTC 2009 with RE after 6 months.  
Clomid + Trigger x2; 
IUI + Femara x1,
IUI + Follistim x2;
IVF #1 (MDL) February 2013- BFN.
IVF #2 (antagonist) May 2013, First BFP of my life. 
Identical twin miracle BOYS (!!) headed our way- due date is technically 2/4/14 but c section is scheduled for 1/7! 


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Re: MFI ? for a friend

  • My dh originally had a low count. He takes a mens fertility vitamin the urologist we saw suggested coq10 so he takes that too. I would suggest repeating the test maybe seeing a urologist.
    "Everything will be alright in the end. So if it's not alright, it is not yet the end."
    Me:29 DH:29  TTC since 1/11 Dx: unexplained IF/early DOR/immune issues 
    Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN
    8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F. 
    ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
    IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
    ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
    3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.  
    DX: High NK cells, cytokines, DHEAs& PAI1;  hypothyroid, +APA, restricted bloodflow
    7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
    (plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim)
    ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
    ET 5dt 7/24 2 fully expanded blasts.  SURPRISE 3 FROSTIES!!!
    Beta #1 8/2 335!!!! Beta #2 829!!!  1st u/s 8/14 showed TWINS!!!!!
    11/11: TEAM PURPLE!!!!!
    3/21/14-L&W born at 37w via csection

    Here Comes the Sun Blog
    PAIF/SAIF welcome!
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  • Unfortantely, I don't know of any really good sites. We started with a reg Uro, which was a waste of time for us. If there is a Uro in her area that specializes in MFI, I would start there, but every treatment takes at least 3 months for updated results. Many REs don't try to improve the sperm, they just work with what you've got. DH was on Clomid (which didn't work for us) because morph, motility, and count were all way below normal. We only had 1.5 mil after wash, so IUI wasn't an option. Boxers and vitamins improved everything to normal except his morph, but we still needed IVF. Your friend should also ask about sperm DNA fragmentation. They think we might have that because 11 of our embryos/blasts arrested after day 3. GL to her. It's so frustrating there aren't many effective treatments for men.

    ~ Everyone Welcome ~
    TTC: 05/2011 Me: 32, All Clear DH: 38 Dx: MFI Low Testosterone & 1% Morphology
    IVF #1 w/ICSI & IMSI, 12/03/12: ER: 27R, 20M, 15F
    4 blasts frozen (3BA 4BA 4BB 5BB) b/c of moderate OHSS
    FET #1: 02/08/13 Transferred 3BA & 4BA | HPT 5dp5dt BFP!

    10dp5dt Beta #1 - 810 | 12dp5dt Beta #2 - 1843 BabyFetus Ticker
  • Thanks everyone, will pass this along to her. 
    Me (37) DH (39); PCOS changed to Unexplained, changed to DOR in 2012 (finally a correct diagnosis!); 
    Started TTC 2009 with RE after 6 months.  
    Clomid + Trigger x2; 
    IUI + Femara x1,
    IUI + Follistim x2;
    IVF #1 (MDL) February 2013- BFN.
    IVF #2 (antagonist) May 2013, First BFP of my life. 
    Identical twin miracle BOYS (!!) headed our way- due date is technically 2/4/14 but c section is scheduled for 1/7! 


    BabyFetus Ticker image
  • OP is correct.  An MFI Uro is the way to go.  He will need to have labs drawn to check his hormone levels.  A regular uro was a complete waste of time.  It definitely sounds like they are IVF bound with that low number :(  Trying the supplements has worked for some people but not at all for us.  But I think its worth a try.  Can't hurt, might help.  
     36 DH 33 TTC for over 3 years
    First mini-IVF Sept 2011... Only 1 egg! ... BFN
    Switching RE
    IVF#2 May 2012 9 eggs and only 2 sperm, WTH!
    BFN
    IVF #3 March 2013~Tesa with back-up Donor Sperm,Tesa, unsuccessful used DS~ Chemical :(   

    Switching RE's within practice

    2 frosties waiting for us, November 2013!!!!!   Transferred 2 "average" blasts 11/20/2013
    BFP!!!!!!!  Boy/Girl Twins!!!!!! Due 08/08/2014

    My Blog




    *~God gives his hardest battles to his toughest solders. Unknown.
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  • I agree with everyone else...URL that specializes in MFI is the way to go! That being said, DH was told to take CoQ10 and they recommended a male supplement from Coast Science. It's a combo supplement. He was previously on clomid which improved his numbers somewhat, but current URL made him stop all but the supplements and this last SA was one of the better ones we have seen in a bit. Not great for things like IUI, but definitely good enough for IVF/ICSI. 

    I know things like hcg and Follistim are Lso used to increase sperm counts, but starting that low, it certainly looks like IVF might be a real possibility 

    Married 2007
    3 Clomid IUIs -- BFNs
    IVF #1 never made it to transfer
    On "egg health" cocktail DHEA/CoQ10/FRC/Pregnitude/Melatonin
    Starting IVF #2 for Feb 2013
    Follistim/Menopur/Ganirelix
    Cancelled mid-cycle due to high P4 levels early on.
    OCPs again for IVF 2.5 mid-March. IVF 2.5 transferred two "gorgeous" 5-day blasts and BFFN. Even REI is baffled
    On indefinite hold until a huge stroke of serendipity led me to IVF 3 May 2014
    Testing found positive cardiolipins/APS, now on lovenox and intralipid infusions
    Transfer of 2 5-day blasts and (FINALLY) BFFP!! 1st ultrasound shows two sacs and two HB, but one is sluggish, almost expecting vanishing twin Subsequent ultrasound confirmed vanishing twin, but my other Little critter looks fantastic!
    "You may have to fight a battle more than once to win it."
    -- Margaret Thatcher


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