Infertility Veterans

Bad News Bear

It's official my body misbehaved again. I got the TNF back and it was 40 down from 43 so they want me to take another round of Humira and start 10mg of prednisone.

We cannot afford anymore Humira unless we steal it so I am hopping the company that makes it will take compassionate care and give me some.

We also have another quandry we were supposed to do an IUI on my next cycle because we thought everything would be ok and DH's bloodwork is expiring (it was 600). Well the other test was great (LAD) and that was part of my huge problem and we are not positive the Humira will make a huge difference but in the past the prednisone has made the TNF go down 5 points. So should we just go for the IUI and see if the trips to Mexico were the magic pill we needed or should we wait until the next round of Humira. Also if I get the Humira I could still take it before they actually do the IUI?

 

6 m/c
Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
1 Clomid/Ovidrel BFN May 2011
Natural cycle Aug 2011 BFP M/C 4 Weeks
1 IUI Sept 2011 BFP M/c 7 weeks
Provera Dec 2011 BFP M/C 3 Weeks
DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
Went to Beer Center- high tnf, low lad, implantation failure
Nov/Dec 2012 LIT Treatment
Dec 12 Humira
Jan 2013 BFP
Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
Miracle Born August 2013 Premature

Yours doesn't have to be a sad story



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Lilypie - (ugiy)


Re: Bad News Bear

  • I don't have any advice for you since I don't know enough about it, but just wanted you to know that I hope things start looking up soon. Big hugs

    ************ Signature/Ticker Warning ************
    Me (32) DH (36) - Finding our way to baby #1
    Me: POF/DOR - AMH <0.16, heterozygous c677t MTHFR, insulin resistant and gluten intolerant
    DH: Severe MFI

    12/2/11 - IUI #1- BFN 
    8/1/12 - IVF #1 - Zero response from max stims (600iu intramuscularly)

    My ovaries are just for decoration

    12/6/12 - Adopted five embryos that had been frozen for over ten years!
    2/11/13 - DEmbryo FET #1 Thawed four, sadly two didn't survive. Transferred two beautiful blasts. 
    2/16/13 - First BFP of my life @ 6dp5dt! EDD 10/30/13
    3/27/13 - After beta and u/s hell, no heartbeat ever detected. D&C at 9w1d.

    6/5/13 - Adopted four new embryos that had been frozen for seven years!
     
    9/12/13 - DEmbryo FET #2. Thawed and transferred two beautiful blasts
    9/17/13 - BFP @ 5dp6dt! EDD 05/31/14
    9/29/13 - m/c @ 5w1d. :(

    11/19/13 - DEmbryo FET #3. Thawed and transferred one blast from each batch. Wow!
    11/23/13 - BFP @ 4dp6dt! EDD 8/7/13
    Beta #1 @ 13dp6dt - 522  Beta #2 @ 16dp6dt - 1373 
    6w5d ultrasound showed one perfect baby with a beautiful heartbeat of 134bpm!

    Snowflake baby is a girl! 
    Our beautiful Snowflake girl arrived on July 22, 2014!   
    My embryo adoption blog: Wishing on a Snowflake
     
        image      image 
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  • I don't know enough about it either, but it sounds like the Humira hasn't proven to be effective. Is upping the dose on the prednisone an option? I wish you the best of luck!

    ***signature & ticker warning***


    Me: 30 ~ Stage IV Endo ~ AMH .38 ~ AFC 8
    AMH .97 as of 4/2012! ~ AMH 1.63 as of 4/2013!?!

    Him: 29 ~ perfect swimmers

    Laparotomy w/partial oophorectomy 8/2009 to remove cysts/endo.
    Stopped BCP 4/2010.
    Multiple clomid rounds from 11/2010 to 6/2011. ~ All BFN
    IUI w/clomid 7/2011. IUI w/clomid & injectables 11/2011 & 1/2012. ~ All BFN

    IVF:EPP 5/2012 ~ (4R, 3M, 2F w/ICSI). Both embryos txfrd. ~ BFN
    BCP to manage endo from 10/2012 to 12/2012.
    FET w/donor embryos #1: 10/2013 Cancelled
    FET w/donor embryos #1.2: 11/2013
    ~ ET of 2 beautiful blasts on 11/27.
    Beta 1: 503(12dp5dt) Beta 2: 1035(14dpt) Beta 3: 3001(16dpt)
    Beta 4: 8503(19dpt)
    Twins with an EDD of 8/15/14! Team Purple
    G&B born 6/30/14 at 33w3d via emergency c/s.


    If you're wondering about my avatar...it's a fried pickle chip shaped like a fetus!


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  • I don't know much about it but I wanted to jump in and say I am routing for it to all work out.
    This may cause me some grief no one beat me up please but what about buying humira on your trip to Mexico? My sister and father in law purchased Meds in another country at pennies of the cost here. My sister bought those stop smoking pills for 5 bucks when they cost 247 here and let's just say my FIL purchased a number of Meds in Turkey for pennies Lipitor, diabetes Meds.
    TTC 1/2010 DH Dx - Azoospermia 2/2011
    Hysteroscopy 3/2011 2 Polyps removed 4/2011
    DH on Clomid / Arimidex to address hormonal issues - Sperm found July 2011!
    IVF #1 September 2011 - ER 9/8/2011- 8R, 5M - icsi - 1 made it to transfer - BFFN :-(
    IVF #2 Lucky November 2011 - ER 11/25/2011 - 15 eggs!, 13 mature, 10 fertilized with isci - 7 made it to transfer! Transferred 1 - 8 cell and 2 - 7 cell. BFP!!!!
    1st U/S - Twins! 2nd U/S - 3 heartbeats!!! - HOLY COW!!!
    Prayers for our take home babies!
    2 babies born on 3/27/12 and lost. Last baby born on 3/29/12 and lost at 20 weeks.
    My angels grew wings shortly after birth.
    Ahava Raisel, Matisyahu Nissim & Zev Chaim - Mommy and Daddy will always love you.
    IVF #3 July 2012 - ER 7/17/2012 - 10 R. 5 F. 4 made it to ET
    Transferred 2 on 7/20/2012 no snow babies :-(
    Beta on 7/31/2012 = BFMFN
    A miracle gift expected to come to us through adoption around 9/2012
    Baby girl adopted - Birth Mother changed her mind and took the baby back
    IVF #4 October 2012 - New RE. Doing PGD Testing. 8 R, 7F, 2 made it to 5 day blast for PDG testing. Both Normal (Thank you G-d!!!) 1 boy and 1 girl
    transferred one beautiful 5day blast (girl)
    Please G-d the almighty one - let this be our take home baby!
    Beta #1 158, Beta #2 318, 1 Absolutely magnificent HB at 175! Thank you G-d!!!
    Baby Girl born August 5th. Thank you G-d for our precious miracle.
    AMA. PAIF & SAIF always welcome - I need all the prayers I can get!

    Lilypie Angel and Memorial tickers
  • imagePrettyAccountant:
    I don't know much about it but I wanted to jump in and say I am routing for it to all work out. This may cause me some grief no one beat me up please but what about buying humira on your trip to Mexico? My sister and father in law purchased Meds in another country at pennies of the cost here. My sister bought those stop smoking pills for 5 bucks when they cost 247 here and let's just say my FIL purchased a number of Meds in Turkey for pennies Lipitor, diabetes Meds.

     

    Humira is price fixed all over the world if I could I would 

    6 m/c
    Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
    Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
    1 Clomid/Ovidrel BFN May 2011
    Natural cycle Aug 2011 BFP M/C 4 Weeks
    1 IUI Sept 2011 BFP M/c 7 weeks
    Provera Dec 2011 BFP M/C 3 Weeks
    DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
    IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
    IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
    Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
    Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
    Went to Beer Center- high tnf, low lad, implantation failure
    Nov/Dec 2012 LIT Treatment
    Dec 12 Humira
    Jan 2013 BFP
    Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
    Miracle Born August 2013 Premature

    Yours doesn't have to be a sad story



    image
    image


    Lilypie - (ugiy)


  • ((hugs)) I wish I had some advice for you. I will keep you in my T&Ps
    imageimage

    Dx: DH - Azoo, Me - Mild PCOS
    DH - sperm found! Seems to produce only for a few days every 70 days!
    Over 1 million in cryo in 15 vials over 6 samples
    IVF #1 - 1 beautiful expanded blast transferred, 4 snowbabies - beta #1 11/30/11 = BFFN
    FET #1, transfered 2 embies 2/16/12 = BFFN; 1 snowbaby left in cryo
    IVF #2 + CGH = 4 genetically normal embies on ice. FET September 26th
    SAIF/PAIF always welcome

    a special GL and prayers to my IF sister Gregermis

    image
    check out my blog!


  • No advice, but hugs and lots of TandPs for you. Good luck with whatever you decide
    TTC #1 Since 4/2010, Cycle 30
    Positive for HLA-B27, I'm a mutant :p
    Testing - Me ok, gluten issue? DH - borderline count, low motility
    4/28/11 IUI#1 = BFP!(5/25), EDD 2/2/12 - m/c 5w3d
    7/3, 7/31, 9/25 - IUI#2-4=BFN
    IVF#1 - 1 blast = BFP!! (12/30), EDD 9/9/12, confirmed c/p 4w2d
    FET#1 3/2/12 - 2 blasts =BFP!! EDD 11/18/12, us#1 = twins! Confirmed m/c 5w6d
    4/20-surprise BFP and another c/p 4w2d
    FET#2 7/16/12 - 2 blasts = BFN
    FET#3 8/20/12 - 1 blast - BFP!! Beta #1-2=177, 354
    1st u/s 5w6d, one beautiful little HB :), 2nd u/s 146bpm
    baby girl born 5/10/13

    TTC#2 since 12/17/2014, Cycle 8
    Repeat Testing...FSH=12, AMH=3.8, AFC=28. 
    IUI#5 5/10/15- c/p?
    IVF#2 8/19/15 - cancelled due to cysts
    IVF#2 take two 10/2015 - 5 blasts frozen
    FET#4 12/11/2015 - BFN - 4 blasts remaining
    FET#5 2/18/16 - BFP!!!  Beta1-3, 126, 250, 745!!

    Image and video hosting by TinyPicLilypie Angel and Memorial tickers

    Tons of love and ((hugs)) to my IF sister NMscubagirl


  • Wish I had some helpful advice for you!  Sorry that the news wasn't better and sending many T&Ps your way!  GL!
    TTC since honeymoon in 9/2010
    Me: 39, Dx DOR (FSH = 10.5, AMH = 0.43, best AFC = 10), AMA
    MH: 37, Dx Obstructive Azoospermia, multiple successful sperm retrieval procedures

    1/2012: IVF/ICSI #1 Antagonist = cancelled d/t poor response to max stims
    2/2012: IVF/ICSI #2 MDLF (4R, 4M, 1F) = BFP, saw heartbeat, missed m/c 9w0d, D&E
    8/2012: IVF/ICSI #3 EPP/MDLF (7R, 2M, 1F) = BFN

    12/2012: (New RE) Operative hysteroscopy to remove scar tissue

    1/2013: IVF/ICSI #4 Low-dose stim/Antagonist (AFC=6); ER=1/26 (5R-couldn't access rt ovary, 5M, 4F), ET=1/29 (trans 3) = BFP!; 2/11 beta#1(13dp3dt)=2127, 2/13=3367; twin girls due 10/19/13

    PAIF/SAIF very welcome!

    <a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Pregnancy"><img src="http://global.thebump.com/tickers/tt16bf7d.aspx" alt=" BabyFruit Ticker" border="0"  /></a>
  • Offering hugs - and lots of well wishes. Sorry I don't have advice to give. :(

    Countless BFN(s)
    Moving to IVF

    IVF1 (ICSI): Long Lupron
    6R. 3F. 3DT. 8Cell 1Grade 2Embies. 1Frostie.
    Beta 1/22: 14 Beta 1/24: 24 Beta 1/26: 28
    Round One Result: Chemical Pregnancy

    Pressing Forward

    IVF2 (ICSI/AH/ACU): Microdose Lupron Flare
    13R. 11F. 5DT. 2TFR'ed. 1Frostie.
    Round Two Result 4/30: Harsh BFN

    FET. 2TFR'ed.
    Round Three Result 6/25: BFN
    Where do we go from here?

    Moving forward with CCRM in 2013
    ODWU revealed blocked tube(s). Lap 2/15.
    Bilateral Tubal Ligation. Stage IV Endo.
    Finally some (tough) answers.


    IVF3 (ICSI/CCS): Antagonist with EPP
    13R. We have 3 CCS Normal Embryos!


    Lupron Depot: May 2013 to August 2013
    Long awaited FET on 9/3. 2TFR'ed.
    BFP on FRER 5dp5dt: IN SHOCK!
    Beta1 9/10: 152.7! Beta2 9/12: 378! Beta3 9/14: 1224! 

    1st ultrasound 10/1: TWO beautiful heartbeats!  Overjoyed!

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