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Question about follicle growth on IVF....

Amyou06Amyou06 member
in Infertility
So I'm obsessing a little here. Yesterday was my first monitoring appointment and I have 8 total follicles, 3, that were 9-10 and 5 that were 4-6. We increased my dose of folistim from 150 to 225 menapur stays the same at 75...My question is this...If we speed up the growth of the small ones, in theory the big ones should also get a boost...so what if those 3 get to the max size way before the rest? Will RE give time for the rest to catch up? I just read someone who said they had a similar situation and the bigger ones got maxed out early so she was forced to trigger....I want them all to have a chance to get nice and mature...just looking for some insight.

*Siggy Warning*

TTC since 11/11. 10 months natural= 10 BFN 8/12 First appt with RE 4 semen anaylsis later 1.9 million count, 21% motility and very poor morphology Me- bloodwork, 2 ultrasounds, HSG exam =I'm fine / 3 months of testosterone treatments = 3 more BFN DH bloodwork after 3 months treatment= no change/  

RE says we can continue with hormone treatment for MIF, RE says we can try IUI but doesn't expect the results to be good based on severe MIF/ 

 IVFw/ICSI Cycle #1 1/11/13 Antagonist Protocol IVF Cycle #1 Canceled due to poor response and lead follicle problems. 1/18/13 started Provera to get body back to baseline / take a break to re-evaluate and recoop finances

IVFw/ICSI Cycle #2 4/13/14 Supressed with Estrace for 7 days. / Started injections 4/22/14. Baseline -0 follicles  Started 75iu menapur/150iu follistim, morning and evening injections   ER- 8 Retrieved, 7M, 7F, 5/8 transferred2 Good 8 and 9 cell Embryos. Beta #1 at 11dp3dt  67! I'm pregnant! Beta #2 174! Ultrasound scheduled 6/6/14

Ultrasound on 6/6 confirmed a singleton pregnancy and a heartbeat, although my iradic breathing would allow us to get the rate.  Second ultrasound measured great and got to hear he heartbeat!! 176 bpm Graduating to my OBGYN with our next appointment with them being 7/23/14

 

 
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Re: Question about follicle growth on IVF....

  • chucktgirlchucktgirl member
    I am going through similar right now. I am on Stim day 9, and mine range from 10 - 20 (as of Mon). My RE considered triggering me early, but I only had 4 ready. Instead, he's having me stim two more days in hopes of letting the others grow. If the big ones get too big, then I think they just let them go. They will be lost follicles. It's a gamble. I'm hoping for the best. I will find out in about six hours if it worked for me. Fingers crossed!

    imageimageimageimageimageimageimageimage
    My BLOG: www.ivfbabyquest.wordpress.com -Update - old blog.

    PAIF/SAIF Welcome!
    Me: 42, Hubby: 35, TTC since Jan 2010. Dx: DOR due to advanced maternal age. Also: Hypothyroidism (100mcg Levothyroxin). Positive for MTHFR (hetero-C677T), Factor V Leiden, and Fragile X (on DH side). Taking pre-natal vitamins    .
    First natural PG 9/27/11; mc: 1/20/12
    First RE visit: 8/8/12, Saline Sonogram: 8/28/12, IVF injection class: 10/11/12, add FaBB Tab for FVL, +Vitamin D.
    IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Prog- 0.3 The u/s showed 6 follicles in my right  & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 10/21/12: Add Ganirelix SQ every morning.
    ER 10/28/12: 13 Retreived. 7 Mature. 6 Fertilized. 5 Made it to PGS. ET 11/2/12: CANCELED. All 5 came back from PGS as having "severe abnormalities."
    IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 1/11/13: Add Ganirelix SQ every morning. hCG Trigger 1/16/13
    ER 1/18/13: 9 Retrieved. 5 Mature. 5 Fertilized. 2 Made it to PGS. ET 1/23/13: CANCELED. All embryos (he even sent the ones not growing) came back from PGS as having "multiple severe abnormalities."
    IVF #3:     NEW RE! 3/1/13 Baseline: FSH- 9.6, E2- 61, Prog- 0.94, 3 follicles in my right & 4 in my left. Rx: 150 Bravelle& 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ.
    ER 3/11/13: 6R, 2M, 2F. Day 3: one 8 cell, grade 0.  Five day ET 3/16/13: one early blast, grade Fair. 3/24/13 AF came a day before beta. BFN
    IVF #4:     (Added acupuncture to this cycle.) 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Prog- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right & 4 in my left. Rx: 225 Bravelle& 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM.hCG Trigger 4/3/13 SQ.
    ER 4/5/13: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). Five day ET 4/10/13: two blastocysts (the 3rd stopped growing.) Beta 4/18/13: 2.5 BFFN. RE recommends we stop trying and focus on living childless, due to the extremely poor quality of my eggs.
    ***Decided to stop trying and live CFNBC. I couldn't adjust. So, six months later...
    IVF #5: Changed RE. Going to one of the big name clinics now. OWDU: 10/29/13. Update: HORRIBLE experience. Disgusted and distraught at their complete unprofessionalism and how much money and precious time they cost us. Sickening. Have now changed RE again. New Patient appt. 1/30/14.
    BFP! Out of nowhere, I got KU the old fashioned way! POAS 1/26/14 - Positive! FDLM 12/30/13. Beta #1 16dpo= 373. Beta #2 18dpo= 801. EDD 10/6/14
    2/4/14 1st U/S revealed a 5wk2day sac but no fetal pole. Started 200mgs of progesterone suppositories daily
    2/11/14 2nd U/S revealed a perfect 6wk1day "diamond ring" embryo with a beating heart! 138bpm! Add 1mg folic acid and 40mg Lovenox
    2/25/14 3rd U/S: perfect 8w1d embryo, 178bpm. 3/6 start spotting. 3/11 10w1d U/S shows no heartbeat. Scheduling D&C. The Stork has forsaken me again.
    IVF #5.2: New in-state RE. Supplement priming for 1.5 cycles prior to start of cycle, including DHEA 50mg (stopped 5/15), CoQ10 200mg 2x/day, L-Arginine- 1000mg 2x/day (stopped 6/5 due to cold sore!), myo-inositol- 2g 2x/day, melatonin- 3mg, and Neevo (prenatal for MTHFR).
    5/16/14 Day 2 bw cycle prior: FSH- 12.22, E2- 38.37, Prog- 1.35, LH- 9.46. 6/2/14 Day 19 bw: Prog- 23
    6/12/14 Baseline: E2- 122.7, Prog- 0.4. 5 follicles in left, 4 follicles in right. Start stims: 375IU Follistim & 150IU Menopur. 6/19 Increase Follistim to 425IU, Menopur still 150IU. 6/18 add Ganirelix. 6/23 Ovidrel trigger SQ. 6/25 ER: 8R, 8M, 5F naturally. Start Medrol & Doxy. 6/26 Start Endometrin. 7/2 Start Lovenox.
    7/8/14 Beta= 137.4 BFP!!! (My first from IVF!) E2- 1109, Prog- >60. Stop CoQ10, myo-inositol, and melatonin. 7/9 2nd Beta= 281.4. TSH- 2.70. Increasing Synthroid to 100mcg daily. 7/24 6w3d u/s measured 6w3d, hb: 121bmp! 8/5 8w1d u/s measured 8w3d, hb: 164bpm! Graduated from RE to OB. Now I just need to find an OB!
    EDD 3/18/15!

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  • jadweddjadwedd member
    I think that this is one of those situations where you just have to trust the dr and that they he/she knows what they are doing.  They will do whatever is best for you.  I always figure that they want this to work just as much as I do because they have to publish their success rates.  Good luck!
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  • kflynn81kflynn81 member

    You'll probably know more about the growth of the follicles as a whole at your next appointment. That first appt. is like a jumping off point to see how you're responding to meds...since they bumped you up you just needed a little extra boost. My first cycle started at the same doses you were on but wound up being 300iu of Follistim and 150iu Menopur to get me where I needed to go.

    Good luck, when is your next appt.??

    Me: 33, Endocrine issues & FVL       DH: 32, Nothing 
    NTNP 2009-2012         TTC since 2012:
    • Clomid, 2 IUI cycles, and 5 IVF cycles = BFN
    • FET #1   August 2013 = BFP!     EDD 5/11/14
    • Jack dx at 19w1d with Dandy Walker on 12/16/13
    • Severe Pre-e /HELLP set in Jack born sleeping at 20w1d on 12/23/13
    • FET #2 --July 2014  BFP!  ---  EDD  4/5/15

    Jack has handpicked his sibling up there :)

    My blog about IF and loss ... Kate's IF Blog

            Lilypie Angel and Memorial tickers 

                                                      

                                                                              Lilypie Pregnancy tickers


                  Anniversary





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  • new+tothisnew+tothis member
    My RE can go either way - sometimes they let a couple get too big to let smaller ones catch up and sometimes they trigger before the smaller ones catch up. I'm not sure how they decide but it's all about what they think will give the best results. I had one follie that was way too big - like 28. It was always the leader and by letting it get too big I think they were hoping for 4 smaller ones to catch up. I'm not positive but I'm pretty sure that's how it happened too.
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  • Amyou06Amyou06 member
    Hey Ladies, thanks for the feedback. I had my 2nd monitoring appointment today. I have my third on Friday. I started my ganirelex this morning at the RE's office, and we're looking for  ER on Sunday or Monday. As far as follicles, things are looking better. I had about 12 total. still 3 leading the charge at 14-15 and I have a few 10, 11, and 12's they are hoping will catch up by the time I go in. Which is completely plausible since we have another 4-5 days before the ER. So my coordnator said by looking at everything now, she is thinking come retrival, we could get around 8 eggs. Which would make me feel loads better than the 3 I was originally thinking based on my first appointment. So I'm hoping by Friday even some of the ones at 5-6 might catch up in 4-5 days. I think they could! Staying postive!  :)

    *Siggy Warning*

    TTC since 11/11. 10 months natural= 10 BFN 8/12 First appt with RE 4 semen anaylsis later 1.9 million count, 21% motility and very poor morphology Me- bloodwork, 2 ultrasounds, HSG exam =I'm fine / 3 months of testosterone treatments = 3 more BFN DH bloodwork after 3 months treatment= no change/  

    RE says we can continue with hormone treatment for MIF, RE says we can try IUI but doesn't expect the results to be good based on severe MIF/ 

     IVFw/ICSI Cycle #1 1/11/13 Antagonist Protocol IVF Cycle #1 Canceled due to poor response and lead follicle problems. 1/18/13 started Provera to get body back to baseline / take a break to re-evaluate and recoop finances

    IVFw/ICSI Cycle #2 4/13/14 Supressed with Estrace for 7 days. / Started injections 4/22/14. Baseline -0 follicles  Started 75iu menapur/150iu follistim, morning and evening injections   ER- 8 Retrieved, 7M, 7F, 5/8 transferred2 Good 8 and 9 cell Embryos. Beta #1 at 11dp3dt  67! I'm pregnant! Beta #2 174! Ultrasound scheduled 6/6/14

    Ultrasound on 6/6 confirmed a singleton pregnancy and a heartbeat, although my iradic breathing would allow us to get the rate.  Second ultrasound measured great and got to hear he heartbeat!! 176 bpm Graduating to my OBGYN with our next appointment with them being 7/23/14

     

     
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  • new+tothisnew+tothis member
    That's great news! I had a monitoring appt the day I started my Ganirelix and they estimated I would have 15 mature eggs.... and they were spot on! Hopefully the same is true for you and you'll get 8 awesome eggs!
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  • Amyou06Amyou06 member
    Thanks and best of luck to you too!!

    *Siggy Warning*

    TTC since 11/11. 10 months natural= 10 BFN 8/12 First appt with RE 4 semen anaylsis later 1.9 million count, 21% motility and very poor morphology Me- bloodwork, 2 ultrasounds, HSG exam =I'm fine / 3 months of testosterone treatments = 3 more BFN DH bloodwork after 3 months treatment= no change/  

    RE says we can continue with hormone treatment for MIF, RE says we can try IUI but doesn't expect the results to be good based on severe MIF/ 

     IVFw/ICSI Cycle #1 1/11/13 Antagonist Protocol IVF Cycle #1 Canceled due to poor response and lead follicle problems. 1/18/13 started Provera to get body back to baseline / take a break to re-evaluate and recoop finances

    IVFw/ICSI Cycle #2 4/13/14 Supressed with Estrace for 7 days. / Started injections 4/22/14. Baseline -0 follicles  Started 75iu menapur/150iu follistim, morning and evening injections   ER- 8 Retrieved, 7M, 7F, 5/8 transferred2 Good 8 and 9 cell Embryos. Beta #1 at 11dp3dt  67! I'm pregnant! Beta #2 174! Ultrasound scheduled 6/6/14

    Ultrasound on 6/6 confirmed a singleton pregnancy and a heartbeat, although my iradic breathing would allow us to get the rate.  Second ultrasound measured great and got to hear he heartbeat!! 176 bpm Graduating to my OBGYN with our next appointment with them being 7/23/14

     

     
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