Pgd testing

Mattysgirl04 · January 2013

Hi ladies,

I was on this board for several years when we were trying to get pregnant the first time and now back for round two of IVF. Because of my age (37) and egg quality my RE is recommending doing PGD testing. Just curious if any of you have had this done and if you felt it was worth it. I am on the fence but it increases or chances of getting pregnant by 75%.

Thanks for your thoughts.

Mattysgirl04 · January 2013

Oh my, baby pic here, I am so sorry. If anyone can guide me on how to remove I can do it. I know how hard it is to see that when going through stupid IF. Sorry in advance.

cupcake201 · January 2013

We are doing PGD, but due to a chromosomal issue, not because of age. I think it's a personal decision and you should do whatever your and DH are most comfortable with. PGD will tack on about an extra 4k to your IVF costs which is also something to think about. I know there are women on this board who are your age and doing IVF without PGD, and also women on PAIF who didn't use PGD. I know I am sort of babbling and not answering your question...but I hope that is somewhat helpful!

ETA I am mobile bumping and can't see if you have your history in your siggy, but if I were you I'd also speak with my RE about if there are concerns about your egg quality aside from just your age.

chucktgirl · January 2013

I am 41, poor egg quality. IVF we did PGD/PGS (I'm not clear on which). Five of nine fertilized embryos made it through. Unfortunately all five showed "severe genetic abnormalities" so we did not have a Transfer. (That sucked big time.) Before we started our 2nd cycle, my RE recommended that we do NOT do PGS (it requires a 5 day transfer) and instead transfer whatever embryos I may have on day 3. My husband and I decided against that. This is probably our last chance at at IVF (out of money) and we want the best chance for a healthy pregnancy. There are huge negatives, however. 1. It costs us $3250 no matter if we have one embryo or ten. 2. Not all embryos thrive outside of the uterus, so waiting 5 days might kill off some that might have otherwise survived inside my uterus. 3. Sometimes the removing of a cell for testing can damage the embryo, rendering it useless. 4. The test has a 5 - 10% failure rate, which means that it's possible you'll get an abnormal reading when really the embryo is fine. It's a huge double-edged sword. I think if we had more TIME we wouldn't do the testing. But we don't. I don't have enough months left to go through 3 months of pregnancy only to have it fail, then have a D&C, then recover, and by the end of all that, it's six months later. I am simply out of time. So, our decision is based on that. Good luck with your decision.

J&D2007 · January 2013

Hi and welcome. We've been through the PGS debate at my house for months and its very hard to make a decision for us. If I am not mistaken, PGD is used where they make a specific probe for a specific defect they are looking for. Say, you or DH has a chromosomal issue you could pass on, then they would make a probe for that and test each embryo for it. PGS I believe is a screening test for the embryos, basically making sure they have the correct number of chromosomes, no extra pairs, no deletions. We would have had PGS. My RE strongly recommended it but we chose not to thus far. And the only reason is that we have gotten only 4 eggs on retrieval. To me, it's pretty pointless to spend the extra money if only 1 egg is going to make it to blast anyway...it's not like we're 'weeding out' the bad ones.. Not sure how much research you've done, but my DH came across one of the larger studies that actually shows that pregnancy rate is no better with PGS than without.. Maybe it was on advanced fertility website? I don't remember. I'm not trying to talk you out if it, I would do it for sure if I had more embryos to deal with!

Rescuemom34 · January 2013

Im going through the process of PGD right now- but mine is for a diagnosed transloction that I carry. As others have mentioned it really is a personal decision, and honestly if I did not know for sure that I had a genetic issue I probably would not do it as I am constantly terrified that my embryos will not even make it to day 5 for testing. That being said, as mentioned in my siggy we did choose to skip the PGD with our last IVF and m/c'd at almost 12 weeks. That was horrific and for DH and myself we have decided that after going through that we will not put back any embryos that have not been tested. There are different ways to do the PGD, not all involve a probe (the one I am doing is called micro array). You may want to speak with a genetics counselor at whatever lab yoru RE uses for PGD and they may be able to give you more detailed info to help you decide. Sorry this was so long, but I hope it helps at least a little! Good luck!

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