Infertility

Long vs. short protocol -- Did you do both?

I'm already a little nervous about changing the protocol over my previous fresh cycle. We did the long protocol last time with Lupron, Bravelle and Menopur and we did retrieve 14 eggs. 12 were mature, all fertilized and developed, then we got 3 blasts out of the batch. Obviously it led to two BFNs, so I guess I shouldn't be so attached to a protocol that didn't work. Now I'm on the Bravelle/Menopur/Ganirelix short protocol.

Someone who's done both, were your results better/worse with one over the other?

Re: Long vs. short protocol -- Did you do both?

  • I just got a BFN with long Lupron with Bravelle and menopur. Only 5R. Moving forward with micro dose Lupron with same stims, but just more of them. I'm actually very excited about the change. I feel the RE was too conservative the first time and I feel we will finally get our chance this time!
    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
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  • Good luck!
  • No advice, but wanted to wish you good luck!!

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    Stopped BCP 4/2010.
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  • Thanks. I'm just looking for something to freak out about, as per usual.
  • Long Lupron protocol didn't work well for me details are in my siggy. I did antagonistic approach this time and I felt better about this cycle but don't want to jinx myself lol. I have to realize I won't be the one that will produce lots of eggs or make it to a 5dt. I'm hoping this change in protocol will make this your lucky cycle. Good Luck!!!

    Me 38 MH 41 - TTC since June 2010 - dx with Severe MFI. Straight to IVF with ICSI. IVF #1 - ER 06/13/12 - 9 Eggs Retrieved - 4 ICSI'd - only 2 fert. 06/15/12 - 2DT - 3 cell & 6 cell with fragmentation. Beta 06/29/12 - IVF #1 = BFN. 07/20/12 - WTF Appt -Told by our RE to quit IVF. Second Opinion from RE is good. IVF#2 - November 2012. Estradiol Pills Started 11/6. Stims start 11/16. ER 11/26 - 7 eggs retrieved - all mature. 4 fertilized with ICSI. ET 11/29 Transferred 3 embryos. Beta is 12/10. 1st Beta 81 2nd Beta 160 and 3rd beta 360!!! First U/S 12/21/12 - We saw one beautiful gest. sac. 2nd U/S is 01/04/2013 - H/B 183 02/05/13 - NT Scan - everything looks good and IT'S A BOY!  Aiden was born 08/20/2013.

    IVF #2 is in progress.  ER was 05/12/14 - 11 eggs retrieved, 8 fertilized with ICSI.  ET was 05/15/14 - we transferred 3 embryos as we did on the cycle my son was conceived.  We were able to freeze 3 embryos. Beta is scheduled for 05/26/14.  1st beta - 111.  2nd beta - 159 didn't double :( 3rd beta Friday 5/30) - not a lot of hope left. Beta # 3 is 247 - probably ectopic.  Beta # 4 is 813 - possibly vanishing multiple sydrome?  06/05/14 - 5w4days - first U/S - we see a gestational sac and yolk - still have hope!  06/17/14 - 7w1day - U/S and saw and heard the heartbeat - Finally!  06/27/14 - 8w4days - Baby and heartbeat look and sound great :)  EDD 02/01/14 and It's a boy!


     "Everything will be okay in the end. If it's not okay, it's not the end."


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  • imageMayzie15:
    Long Lupron protocol didn't work well for me details are in my siggy. I did antagonistic approach this time and I felt better about this cycle but don't want to jinx myself lol. I have to realize I won't be the one that will produce lots of eggs or make it to a 5dt. I'm hoping this change in protocol will make this your lucky cycle. Good Luck!!!

    Improvements are good and it's all about quality, not quantity, right? I'm crossing my fingers for your beta. GL!

  • I've had three IVFs all failed. The first two were long lupron, this last one was antagonist. I was really, really nervous about moving on bc I responded fairly well to the lupron protocol 12 and 10 eggs, 7 nights of stimming each. I don't have DOR or anything we are basically unexplained.

    Even though the antagon protocol was also a BFN, it was so much better for me. We got 26 eggs, got to a 5dt for the first time, and even had a few expanded blasts to freeze.

    Don't be nervous. Everyone really does respond differently. :
    yeah, there she was ... like disco lemonade ...
  • imageScoop77:

    imageMayzie15:
    Long Lupron protocol didn't work well for me details are in my siggy. I did antagonistic approach this time and I felt better about this cycle but don't want to jinx myself lol. I have to realize I won't be the one that will produce lots of eggs or make it to a 5dt. I'm hoping this change in protocol will make this your lucky cycle. Good Luck!!!

    Improvements are good and it's all about quality, not quantity, right? I'm crossing my fingers for your beta. GL!



    Thank you!

    Me 38 MH 41 - TTC since June 2010 - dx with Severe MFI. Straight to IVF with ICSI. IVF #1 - ER 06/13/12 - 9 Eggs Retrieved - 4 ICSI'd - only 2 fert. 06/15/12 - 2DT - 3 cell & 6 cell with fragmentation. Beta 06/29/12 - IVF #1 = BFN. 07/20/12 - WTF Appt -Told by our RE to quit IVF. Second Opinion from RE is good. IVF#2 - November 2012. Estradiol Pills Started 11/6. Stims start 11/16. ER 11/26 - 7 eggs retrieved - all mature. 4 fertilized with ICSI. ET 11/29 Transferred 3 embryos. Beta is 12/10. 1st Beta 81 2nd Beta 160 and 3rd beta 360!!! First U/S 12/21/12 - We saw one beautiful gest. sac. 2nd U/S is 01/04/2013 - H/B 183 02/05/13 - NT Scan - everything looks good and IT'S A BOY!  Aiden was born 08/20/2013.

    IVF #2 is in progress.  ER was 05/12/14 - 11 eggs retrieved, 8 fertilized with ICSI.  ET was 05/15/14 - we transferred 3 embryos as we did on the cycle my son was conceived.  We were able to freeze 3 embryos. Beta is scheduled for 05/26/14.  1st beta - 111.  2nd beta - 159 didn't double :( 3rd beta Friday 5/30) - not a lot of hope left. Beta # 3 is 247 - probably ectopic.  Beta # 4 is 813 - possibly vanishing multiple sydrome?  06/05/14 - 5w4days - first U/S - we see a gestational sac and yolk - still have hope!  06/17/14 - 7w1day - U/S and saw and heard the heartbeat - Finally!  06/27/14 - 8w4days - Baby and heartbeat look and sound great :)  EDD 02/01/14 and It's a boy!


     "Everything will be okay in the end. If it's not okay, it's not the end."


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  • Hard to say what the differences for you will be. I can share my experience thus far...

    I did antagonist protocol in June, and Dr. (a new one due to relocating to a new state) suspects that I ovulated through the antagonist protocol. So, we're switching it up and going long lupron this time. 

    With antagonist, I got 13 eggs which was a surprise and a bit disappointing given than 30+ were counted a few days earlier. Dr. & embryologist thought, at first glance, they did not look like great quality either. 8 fertilized, 6 made it to freeze, we've transferred 4 total (2 FET cycles of 2 transferred each time) and BFN's both time. 

     

    My Food Blog - Dinner Delish
    TTC since Oct '09
    Missed miscarriage 3/24/10 @ 16 wks, Partial Molar Pregnancy
    Began our IF journey in May '11
    Asherman's Diagnosis (cervical & uterine scarring) - Surgery 8/17/11
    IUIs #1-#5 & 1 canceled IUI, IVF #1, 2 FETs - all BFN
    IVF# 2 December '12, BFP 1/13! EDD 9/21 
    Complete Previa and Short Cervix. C-section scheduled for 9/3
    Delivered 8/5 @ 33 weeks, 4lbs, 6oz. 
    4-week NICU stay, home 9/3
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