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Beer Immunology Consult

luvbostonluvboston member
in Infertility Veterans

I spoke with Dr.Trobough he has the personality of a wet rag, he started out going over my history some of it annoyed me because he clearly didn't read my file that closely. Then he went over my testing (PM me if you want to know everything)

Here are the findings:

Leukocyte Antibody Detection 

T Cells IGG+  8.7   Range 50-100

B Cells IGG+   22 Range 50-100

The B cells are blocking antibodies they coat the pregnancy

The B cells need to be greater then 50 for the pg to work

For this problem he suggested LIT (Lymphocyte Immunization Therapy) I would have it 2x 3 weeks apart and then retest. It's $600 a treatment, it's only available in Mexico right over the border from AZ or England (Canada is doing a study right now)because Bush thought it was too close to stem cells and had it outlawed.

T Regulatory CELL

Treg (CD4/CD25/Foxp3+)  1.2   Range >.7

Mine is normal 

Treg measures immune cell suppression

 

 NK Assay Follow Up was normal and my NK Cells are on the low end so clearly Dr. Sher saying my NK's were high was incorrect.

Cytokine Rations

TNF-a:IL-10 (CD3+ CD4+)  43.9 Range 13.2-30.3

IFN-g:IL-10 (CD3+CD4+) 22 range 5.6-21 

Clearly my TNF is high and to bring this down I need Humira 2 shots then retest 3 weeks later. He also suggested doing IVIG possibly for the TNF if it won't drop. I do not want to do IVIG because I get migraines and it increases them and also I am not comfortable with getting 1000 peoples blood, and paying 4k out of pocket is not feasible if we had to do it and pay full price for Humira.

 Now Troubough wanted to do the LIT then Humira Then IVIG and I asked why I couldn't have the Humira and LIT concurrently and it literally stumped him I had to ask 3 times. Finally he said that is just how they do it but that if I wanted to do both at once it would be fine. 

Dh is unhappy about going to Mexico, I am not going to do the IVIG unless someone can give me a success story. We are def going to do LIT and Humira I think of course a part of me thinks we should just try with the Humira once of course that would mean heartbreak #7. Opinions please 

6 m/c
Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
1 Clomid/Ovidrel BFN May 2011
Natural cycle Aug 2011 BFP M/C 4 Weeks
1 IUI Sept 2011 BFP M/c 7 weeks
Provera Dec 2011 BFP M/C 3 Weeks
DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
Went to Beer Center- high tnf, low lad, implantation failure
Nov/Dec 2012 LIT Treatment
Dec 12 Humira
Jan 2013 BFP
Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
Miracle Born August 2013 Premature

Yours doesn't have to be a sad story


image
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Lilypie - (ugiy)


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Re: Beer Immunology Consult

  • GregermisGregermis member
    Boy that's a lot of info. I'd be concerned about doing a treatment in Mexico, but that's got to be cheaper than going to England.

    Whatever you decide, I hope it works out for you!!
    TTC #1 Since 4/2010, Cycle 30
    Positive for HLA-B27, I'm a mutant :p
    Testing - Me ok, gluten issue? DH - borderline count, low motility
    4/28/11 IUI#1 = BFP!(5/25), EDD 2/2/12 - m/c 5w3d
    7/3, 7/31, 9/25 - IUI#2-4=BFN
    IVF#1 - 1 blast = BFP!! (12/30), EDD 9/9/12, confirmed c/p 4w2d
    FET#1 3/2/12 - 2 blasts =BFP!! EDD 11/18/12, us#1 = twins! Confirmed m/c 5w6d
    4/20-surprise BFP and another c/p 4w2d
    FET#2 7/16/12 - 2 blasts = BFN
    FET#3 8/20/12 - 1 blast - BFP!! Beta #1-2=177, 354
    1st u/s 5w6d, one beautiful little HB :), 2nd u/s 146bpm
    baby girl born 5/10/13

    TTC#2 since 12/17/2014, Cycle 8
    Repeat Testing...FSH=12, AMH=3.8, AFC=28. 
    IUI#5 5/10/15- c/p?
    IVF#2 8/19/15 - cancelled due to cysts
    IVF#2 take two 10/2015 - 5 blasts frozen
    FET#4 12/11/2015 - BFN - 4 blasts remaining
    FET#5 2/18/16 - BFP!!!  Beta1-3, 126, 250, 745!!

    Image and video hosting by TinyPicLilypie Angel and Memorial tickers

    Tons of love and ((hugs)) to my IF sister NMscubagirl


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  • mdluv21mdluv21

    3 ladies from my resolve have one the LIT in Mexico through Beer.  It sounded scetchy to me but they ll had good experiences and two are pregnant now.  I know one did IVIG with hers...

     My main problem with immune is NK cells so I have only done intralipids with Beer.  

     

    I hope these treatments work for you!! 

    TTC since 07/2009
    Me: PCOS, Blood/Immune Issues DH: Low all 3
    Jun.- Sep. 2010 IUI#1-#3 = BFN
    Oct. 2010 = IVF #1 = B/G Twins (passed away Feb. 2011)
    May 2011 = Myomectomy and trans-abdominal cerclage (TAC)
    Sep. 2011 = Surprise BFP = C/P
    Feb. 2012 = sFET #1 = BFN
    Feb.2012 = Hail Mary IUI #4 = BFN
    April/May 2012 = FET #2 w/our last two embies = BFP (Please let this be it!)
    Beta #1 8dp5/6dt = 234 Beta #2 10dp5/6dt = 695 Beta #3 12dp5/6dt = 1796 Beta #4 17dp5/6dt = 17,888 U/S #1 May 17, 2012 = Twins
    Baby B's heart stop beating at 9 weeks 5 days
    Our little miracle baby is a boy. :)

    Baby Boy Owen and Baby Girl Avery were born too early on Feb. 13, 2011 due to a pedunculated fibroid, incompetent cervix and suspected placental abruption.
    Lilypie Angel and Memorial tickers

    "What the heart has once owned and had, it shall never lose." - Henry Ward Beecher
    SAIF/PAIF Welcome
    Lots of love and luck to my PAIF/3T/IF Veteran ladies, especially my dear friend Zookie. Congrats to Papps, Teach84 and Starbuck on their little ones.
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  • thewormstheworms member

    I did IVIG with my RPL dr after immune testing while pregnant.  My nk cells are normal until I'm pregnant and then they skyrocket. 

    I had to do 2 rounds.  I was also on prednisone and neupogen.

    I now have a beautiful baby girl, after 4 m/c's.  We have no idea why my son passed away still waiting for autopsy,

    image
    Worrying does not empty tomorrow of its troubles, It empties today of its strength. ~Corrie ten Boom
    Courage doesn't always roar. Sometimes courage is the little voice at the end of the day that says I'll try again tomorrow. ~Mary Anne Radmacher (thank you beadinglady)

    It's been a long journey. TTC since 9/06. multiple IUI's and IVF's and 4 m/c's. IVF#3 = BFP, twins, induced at 34w6d due to baby b passing away (no explanation). Delivered on 35w1d, Baby A - baby girl, and Baby B - baby boy, our little angel.
    MTHFR A1298C & C677T, Immune Issues and Factor II
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