TTC After a Loss

Does anybody know anything about estradiol?

I'm trying to become a little more informed about immunology before our appointment later this month.  So of course I go to Katharine.  This is what Katharine does to me:

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So, I started looking through the copies of my records I got from my RE because I couldn't remember if I had my ANAs tested.  As I'm going through the lab reports, I'm noticing that my mid-cycle estradiol has been high every single time it's been tested.  The lab report says the normal range is 118-355, and I've got a 477, 480, 834, 513, 530.  I was never told anything about my estradiol being out of the normal range.  (I also noticed a couple times where my progresterone was low and nobody said anything either.)

What does this mean?  Help me not lose my sh?t.  Cause I'm pretty furious right now.

ETA: I typed the high number for the normal range wrong, so they're not as high as they appeared.  Still high though.  Especially that 834...WTF?
PAIF/SAIF, PGAL/PAL welcome.
TTC since March 2010 ~ Dx Unexplained IF September 2011
2011: IUI + Clomid = CP#1
2012: 3 more IUIs + Clomid = 3 more CPs. One on-our-own pg, also CP
2013: BTB IUI + Lupron/Follistim/Prometrium/PIO = CP #6
IF testing, RPL testing, Autoimmune testing = all normal
So lost.
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Re: Does anybody know anything about estradiol?

  • I got nothing on the estrogen levels other than my sh!t would be flipping out too. And googling. lots and lots of googling. I'm surprised it was never discussed with you. You may be on to something though with your muscus theory. Estradiol And CM go hand in hand. But I would also ask are these medicated cycle levels? That may or may not be relevant... I don't know. Maybe that's why your RE doesn't think they are a big deal?

    Annnnnddddd, LMAO!! I may need to steal that picture for my siggy.
    Married My Love on 6/18/2006
    BFP#1 10/1/2011. Our perfect little girl, Her heart stopped @ 12w1d. D&E 11/23/11
    BFP#2 3/13/12 Weird CP/Possible EP @ 6w0d
    BFP#3 5/28/12 CP @ 5w0d
    BFP/WTF#4 10/26/12 CP
    BFP#5 12/10/12 EDD 8/23/2013
    <3 Baby Boy Born 8/22/13 <3
     photo ellie.gifPhotobucket
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    image
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  • I don't have any info for you, but can relate to the being furious part. I saw an RE for 4 months before she ever mentioned that my AMH was low which leads to low ovarian reserve. I was so, so angry. We switched RE's at that point. So, I'd be angry too if I were you. The doctor totally should have mentioned those results. Hope someone here can help with your questions. Hugs!
    TTC #1 since 6/08. Cycle #6 - BFP 12/22/08, EDD 9/3/09, DD 8/14/09 at 37w1d
    Baby Birthday Ticker Ticker
    TTC #2 since 6/11
    me=36 - low AMH, DH=38
    BFP #2 - 8/31/11, EDD 5/10/12, M/C 9/23/11
    BFP #3 - 3/4/12, EDD 11/14/12, CP 3/11/12
    BFP #4 - 5/9/12, EDD 1/19/13, CP 5/11/12
    BFP #5 - 8/22/12, EDD 5/5/13, CP 8/24/12
    IVF#1 - January 2013 - EPP/Antagonist - 7R, 3M, 2F, 3dt of 2 8-cell embies
    BFP #6 - 2/3/13, EDD 10/15/13, DS 9/18/13 at 36w1d
    Lilypie First Birthday tickers
  • imagekatharine25:
    I got nothing on the estrogen levels other than my sh!t would be flipping out too. And googling. lots and lots of googling. I'm surprised it was never discussed with you. You may be on to something though with your muscus theory. Estradiol And CM go hand in hand. But I would also ask are these medicated cycle levels? That may or may not be relevant... I don't know. Maybe that's why your RE doesn't think they are a big deal? Annnnnddddd, LMAO!! I may need to steal that picture for my siggy.

    Yes, they were medicated cycles - clomid. 

    You totally need to put that in your siggy.

    PAIF/SAIF, PGAL/PAL welcome.
    TTC since March 2010 ~ Dx Unexplained IF September 2011
    2011: IUI + Clomid = CP#1
    2012: 3 more IUIs + Clomid = 3 more CPs. One on-our-own pg, also CP
    2013: BTB IUI + Lupron/Follistim/Prometrium/PIO = CP #6
    IF testing, RPL testing, Autoimmune testing = all normal
    So lost.
    imageimage
    imageimage
  • I'm assuming that these estradiol levels coincided with medicated cycles? Your body produces more estradiol as your follicles become more mature. I believe that a 18mm follicle should have an estradiol level between 200 and 600. Your numbers seem decent, but the one in the 800s seems a bit high. My RE probably would have cancelled that cycle for us. My estradiol for this injectibles cycle was up near 500 and was deemed "perfect" by my RE. 

    Here's a good reference for hormone levels -https://www.fertilityplus.com/faq/hormonelevels.html

    TTC since 2007. Dx PCOS 6/2010
    4 unsuccessful rounds of Clomid
    Clomid 50mg - BFP #1 - February 7, 2010 Missed miscarriage March 25, 2010
    Clomid 100 mg - BFP #2 - October 28, 2010 Chemical pregnancy November 4, 2010
    IUI #1 - Gonal-F + Ovidrel = BFN
    IUI #2 - Femera + Gonal-F + Ovidrel + Endometrin = BFN
    IUI #3 - Gonal-F + Ovidrel + Endometrin = BFN
    IUI #4 - Gonal-F + Ovidrel + Endometrin = BFN
    IUI #5 - Menopur + Gonal-F + Ovidrel + Endometrin = BFN
    IVF #1 - Microdose Lupron Flare protocol = BFN
    FET = BFN - lost all remaining embryos
    IVF 2.0 - In progress. 20 retrieved. 16 mature. 10 fertilized with ICSI. 3, grade I embryos transferred, 7 made to freeze. Currently in the 2ww.
  • ***siggy***

    Hope you don't mind if I chime in... 

    You say the levels were taken mid-cycle so I take this to mean before O.  Your estrogen rises and peaks before ovulation and if these were medicated cycles, you probably had multiples follicles just not all mature.  Estrogen is what helps produce your fertile CM and build your plush ute lining.  There are a few different times to test your level...CD3 helps detect if there are any egg productions issues and while monitoring a cycle for ovulation (see previous comment about peaking before O).  I think sometimes they check it after O as I believe it also helps support your lining and pregnancy should conception and implantation occur.

    Now...your progesterone you said was also low.  If this was taken at the same pre-O time in your cycle, it means nothing.  Only at 6/7 dpo is this number valid.

    3 ectopic pregnancies (EDD's 1/30/12-tube removed, 6/2/12-methotrexate and 10/2/12-methotrexate)
    IVF and Natural FET resulted in BFN's and a hole in our wallets
    Natural BFP #4 on 9/7/12 gave us our miracle on 5/18/13
    Lilypie First Birthday tickers
  • Delino and Lauren - thanks for talking me off the ledge.  That makes sense.  Consider my sh?t found :)
    PAIF/SAIF, PGAL/PAL welcome.
    TTC since March 2010 ~ Dx Unexplained IF September 2011
    2011: IUI + Clomid = CP#1
    2012: 3 more IUIs + Clomid = 3 more CPs. One on-our-own pg, also CP
    2013: BTB IUI + Lupron/Follistim/Prometrium/PIO = CP #6
    IF testing, RPL testing, Autoimmune testing = all normal
    So lost.
    imageimage
    imageimage
  • PS - replied
    Married My Love on 6/18/2006
    BFP#1 10/1/2011. Our perfect little girl, Her heart stopped @ 12w1d. D&E 11/23/11
    BFP#2 3/13/12 Weird CP/Possible EP @ 6w0d
    BFP#3 5/28/12 CP @ 5w0d
    BFP/WTF#4 10/26/12 CP
    BFP#5 12/10/12 EDD 8/23/2013
    <3 Baby Boy Born 8/22/13 <3
     photo ellie.gifPhotobucket
    image
    image
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