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Infertility
BrideJackie11
member
Refrigerate meds?
BrideJackie11
member
in Infertility
Meds arrived today!! So the only medication that said to keep refrigerated was the Gonal-F pen. The rest either didn't say or said keep at room temp:
Progesterone injects, menopur, novarel, lupron
Should I be refrigerating any of the others?
On the bright side, I got 2 sharps containers. Or maybe that is a bad sign...
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Married June 2011 Dx: anovulatory due to prolactinoma (1.5cmx 1.5cm in 2006)
April 2012: MRI- questionable cyst 8mg by 12mm in pituitary ; referred to RE by Ob-gyn after amenorrhea x 4+ months, provera ineffective, low estrogen level
cycle 1: May 2012, clomid 50mg; cycle cancelled, thin lining, no response
cycle 2: June 2012, femara 5mg; cycle cancelled, no response
cycle 3: July 2012, femara 7.5mg; cycle cancelled (largest folli on Cd12 & cd 16: 11, lining 4)
Repeat MRI July 25,2012- Cyst unchanged, likely old infarction.
Aug. 8: met with RE, move to injectables if HSG and SA normal
Aug. 23: HSG all clear; DH- perfect
Switched to a new RE in early Sept. IVF here we come
Genetic testing reveals: Fragile X- Intermediate risk/grey zone.
IVF#1: ER 11/30: 14 retrieved, 10 mature, 7 fertilized. E2 prior to trigger 5200. Decision made to freeze 6 embryos and transfer later due to OHSS.
IVF#1.2/FET #1: estrogen injects start 1/18, FET delayed to try to thicken lining. lining 5.4mm. FET- 2/18- transferred one 3AA expanded blast. BFP 5dp5dt. Beta #1- 2/27 9dp5dt- 102.27 beta #2 3/1: 147 
, beta #3 3/4: 268 told to stop meds and let nature take its course. requested 4th beta (3/6); Beta hell for 2 months.
FET # 2: endometrial scratch 5/6, added estrace vaginally and ASA to delestrogen and PIO. June 10- transferred one 4AA hatched embryo, BFP 4dp6dt, Beta 1 (9dp6dt) 187, Beta 2 (11dp6dt): 412; Beta 3 (15dp6dt ): 4452. U/S #1- one beautiful embryo with a heartbeat of 133 at 7 weeks. 8 weeks: heartbeat 156. EDD 2/26/2014: born 2-3-14 induced due to Pre-E and HELLP at 36w5d.
12/1: met with RE to discuss trying for #2
This discussion has been closed.
Re: Refrigerate meds?
My meds come tomorrow! Super excited and nervous lol. The pharmacy did say something about medication needing refrigeration but I don't know which one. Hopefully somebody will give us insight. Good luck on your cycle!
[spoiler] My Blog: Grow Baby Grow
BFP #1: 12/2009 m/c 1/2010 BFP #2: 6/2010 m/c 8/2010
BFP #3: 10/2011 ectopic 11/2011 (right tube removed, learned left tube was probably nonfunctional due to scar tissue from infection after m/c)
3 failed IUIs, IVF #1: 18R, 12M, 10F, 3 poor quality 5d embryos transferred= BFP #4!!!!!
Betas: 9dp5dt: 64 ~14dp5dt: 91 (expecting miscarriage, doubling time of 236 hours) ~16dp5dt: 200~18dp5dt: 500
First Ultrasound at 6w2d revealed two sacs, only one with a heartbeat
LK arrived after 42 weeks on August 14, 2013! Beautiful, healthy, and happy!
TTC#2: IVF booked for April 2015
Surprise BFP#5 February 19, 2015 EDD: November 2, 2015
Betas: 10dpo: 10, 14dpo: 77, 17dpo: 270
First Ultrasound at 5w1d showed a miracle UTE baby! And right ovary ovulation to left fallopian tube.
JD arrived at 38 weeks on October 20, 2015.
TTC #3: Since October 2017. BFP #6 July 2, 2018 EDD: March 16, 2019 [/spoiler]
10/11: after 2 years, saw a RE, FSH 5.4
11/11: BFP! (surprise after thyroid & normal hsg),
12/11: missed m/c after 7 week u/s, 1/12: D&C
6/12 IUI#1-IUI #3: clomid = BFP!, C/P
IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
Baby Will born 8/18. He's perfect.
My Progesterone goes in the fridge... Menopur didn't. I haven't used the others but I would follow the instructions you got. I've heard of some of the same meds saying they need to be refrigerated, some say once opened refrigerate, and some say keep at room temp.
GL!
Infertility blog
Trying for a baby since 4/10
DX: Infertile 6/11 Me: LPD, all other blood work clear.
DH: low sperm motility,low count.
Met with RE start clomid + TI + IUI 5/12= IUI cancelled due to positive Cystic Fibrosis carrier test. DH tested Neg. for Cystic Fibrosis,
6/12 Clomid + TI +IUI=BFN 8/10 IVF consult.
IVF #1 Started BCP 9/2 Lupron 10/11 stims 10/27 ER 11/6!! 5 eggs retreived only 1 mature. FERT report shows none made it.Cancelled cycle.
IVF #2 BCP 11/18 Lupron 12/14
Stims start 12/29 ER 1/8 ET 1/11 put in 1 grade B and 1 grade C. Beta: 1/20 = BFN
IVF# 3 7/13 BFP ended in chemical pregnancy
9/15 diagnosed with PCOS and insulin resistance gearing up for IVF# 4 Dec/ Jan
Everyone Welcome!
Sept '11-April '13 ~ Testing, failed multiple MFI treatments, saving & TONS of praying
January 2014 ~ IVF/ICSI & PGS ~ no response to stims ~ converted to IUI ~ BFN
February 2014 ~ On to donor embyros ~ 5 blasts!!!
March 2014 ~ FET #1 ~ Transferred 2 blasts ~ BFN
July 2014 ~ Kliman's mock cycle with endometrial function test
Sample too small for EFT, HE slide showed immature cells
New protocol planned, saving for another biopsy for EFT
January 2015 ~ Considering adoption options
April 2015 ~ Privately arranged adoption of planned pregnancy
DD#1 ~ Lillyana Violet Marie born 6/15/16, Finalized adoption 12/20/16
July 13, 2018 ~ BFP....WTF?!?!
7/16 Beta #1 ~ 466...7/18 Beta #2 ~ 1,077...7/23 Beta #3 ~ 5,291
7/23 US #1 ~ 1 gestational sac seen and yolk sac
7/30 US #2 and 1st OB appt ~ 1 perfectly round gestational sac, 1 perfect yolk sac and 1 teeny tiny heart beat seen!!!
Most likely yes, once they are mixed they should be refrigerated. It has to do with the preservatives in them.
Sept '11-April '13 ~ Testing, failed multiple MFI treatments, saving & TONS of praying
January 2014 ~ IVF/ICSI & PGS ~ no response to stims ~ converted to IUI ~ BFN
February 2014 ~ On to donor embyros ~ 5 blasts!!!
March 2014 ~ FET #1 ~ Transferred 2 blasts ~ BFN
July 2014 ~ Kliman's mock cycle with endometrial function test
Sample too small for EFT, HE slide showed immature cells
New protocol planned, saving for another biopsy for EFT
January 2015 ~ Considering adoption options
April 2015 ~ Privately arranged adoption of planned pregnancy
DD#1 ~ Lillyana Violet Marie born 6/15/16, Finalized adoption 12/20/16
July 13, 2018 ~ BFP....WTF?!?!
7/16 Beta #1 ~ 466...7/18 Beta #2 ~ 1,077...7/23 Beta #3 ~ 5,291
7/23 US #1 ~ 1 gestational sac seen and yolk sac
7/30 US #2 and 1st OB appt ~ 1 perfectly round gestational sac, 1 perfect yolk sac and 1 teeny tiny heart beat seen!!!
Dx: balanced translocation and LPD
TTC since Oct 2011
BPF 02/19/12, EDD 10/31/12, natural m/c 02/28/12 (4w6d)
IVF (BCPs starting 10/30/12, ER 11/18/12, 5dt of 1 beautiful, healthy embryo 11/23/12)
BFP 12/02/12, u/s @ 6w,5d showed 2 HBs! Identical twins!!
Bed rest from 21w-35w due to short cervix, hospital bed rest from 23w-32w due to PTL
Our rainbows were born 07/19/13 (36w, 5d)
<
, beta #3 3/4: 268 told to stop meds and let nature take its course. requested 4th beta (3/6); Beta hell for 2 months.
Married June 2011 Dx: anovulatory due to prolactinoma (1.5cmx 1.5cm in 2006)
April 2012: MRI- questionable cyst 8mg by 12mm in pituitary ; referred to RE by Ob-gyn after amenorrhea x 4+ months, provera ineffective, low estrogen level
cycle 1: May 2012, clomid 50mg; cycle cancelled, thin lining, no response
cycle 2: June 2012, femara 5mg; cycle cancelled, no response
cycle 3: July 2012, femara 7.5mg; cycle cancelled (largest folli on Cd12 & cd 16: 11, lining 4)
Repeat MRI July 25,2012- Cyst unchanged, likely old infarction.
Aug. 8: met with RE, move to injectables if HSG and SA normal
Aug. 23: HSG all clear; DH- perfect
Switched to a new RE in early Sept. IVF here we come
Genetic testing reveals: Fragile X- Intermediate risk/grey zone.
IVF#1: ER 11/30: 14 retrieved, 10 mature, 7 fertilized. E2 prior to trigger 5200. Decision made to freeze 6 embryos and transfer later due to OHSS.
IVF#1.2/FET #1: estrogen injects start 1/18, FET delayed to try to thicken lining. lining 5.4mm. FET- 2/18- transferred one 3AA expanded blast. BFP 5dp5dt. Beta #1- 2/27 9dp5dt- 102.27 beta #2 3/1: 147
FET # 2: endometrial scratch 5/6, added estrace vaginally and ASA to delestrogen and PIO. June 10- transferred one 4AA hatched embryo, BFP 4dp6dt, Beta 1 (9dp6dt) 187, Beta 2 (11dp6dt): 412; Beta 3 (15dp6dt ): 4452. U/S #1- one beautiful embryo with a heartbeat of 133 at 7 weeks. 8 weeks: heartbeat 156. EDD 2/26/2014: born 2-3-14 induced due to Pre-E and HELLP at 36w5d.
12/1: met with RE to discuss trying for #2
Me:27, DH:28 - DX: MFI, varicocele repair Nov 2011
Post-Op SA: Count- 15 million, Motility- 75%, Morphology- 3%
IVF with ICSI - Stimming 10/4/12 - 10/13/12, Lupron Trigger
ER 10/18/12, 12 eggs retrieved, 8 mature, 5 fertilized
5 day transfer 10/23/12, 3 frosties
Beta #1 11/5/12: 453, Beta #2 11/7/12: 1,013, DD born 7/19/13
What type of progesterone are you using? You should not refrigerate PIO, and crinone doesn't need refrigeration, either.
FWIW, there was so much conflicting information on the gonal-f pen when I cycled with it. I finally went to the pharmacist and she confirmed that it could be kept at room temperature (which is what my RE said). I always responded fine to the gonal-f (but no BFP).
The only drug I refrigerated was the HCG, after mixed. And, it only keeps for 30 days after that.
DOR and AMA
2/12-5/12: 4 IUI cycles = all BFN;
7/12: DE IVF # 1 (with ICSI)- 20R, 16M, 14F, 5DT of 2 blasts; 6 frosties = BFN;
Lupus anticoagulant initially high, then found to be normal on hematology consult;
Follow up testing in September all clear;
Started synthroid for "high normal" TSH;
FET # 1- late October 2012- BFP on FRER; beta # 1- 21(low), beta # 2- 48 (still low), beta # 3- 132, beta # 4- 1,293; beta # 5- 5,606; last beta- over 100,000. First u/s 11/21- heard heartbeat
12/12- Officially an OB patient!
Level 2 ultrasound at 20 weeks shows vasa previa and VCI
Referral to MFM and mandatory c section for delivery
Beautiful baby girl born at 34 weeks
Finally home after 15 day NICU stay!
Trying for sibling: FET # 2- May 2014; beta 5/31, BFN
FET #3, early July 2014; beta 7/14, BFN
DE IVF # 2- August 2014; 14R, 13M, 11F, 5dt of 2 blasts (3 AA), 5 frosties = BFN
FET #4- December 2014, yet another BFN
Dr. KK work up shows borderline uterine blood flow, elevated NK cells, and MTHFR mutation (homozygous for c677t)
Added baby aspirin, prednisone, supplements, Metanx, and intralipids
Switched to large clinic for final attempt; had endometrial receptivity testing in January; FET March 2015 = yet another BFN
Likely OAD- NBC