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Pregnant after a Loss
paisleybaby33
member
Post-Miscarriage Genetic Testing - Factor 13??
paisleybaby33
member
Hi ladies! I hope everyone is doing well and your little babes are growing beautifully in there! I am asking this over here seeing as I am not really active on TTCAL and thought that you ladies may have some insight to the situation below.
DH and I got our genetic testing and karyotyping results back late last week and I was wondering if anyone had any experience with an abnormality that they found in my testing. Apparently I have a heterozygous copy of Factor XIII(13) V34L. My RE told me that often times when this comes back abnormal, often the PAI-1 Genotype will come back abnormal as well and will result in Lovenox in the 1st tri. However, my PAI-1 came back normal, so he said he was a little stumped. He offered for me to go on the Lovenox for 1st tri anyways, but couldn't guarantee that it would affect the pregnancy in a positive way - he said it wouldn't hurt. I was just curious to see if anyone else had any experience at all with Factor 13??
My results also came back with a heterozygous copy of the MTHFR677 as well. He told me I would need additional folic acid and vitamin B for this - but was a pretty simple fix.
Any advice or insight would be so appreciated! (for those who remember my situation back this spring, with my kidney stones...well, I was in the ER all night and morning with another stuck stone. I am praying it passes on its own, or else I will be having my 5th surgery in 7 months. Any additional T&P's would be so appreciated!)
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Re: Post-Miscarriage Genetic Testing - Factor 13??
PAISLEYBABY!!! I'm sorry I haven't gotten back to you yet. Haven't been in the right mindset with the passing of my first EDD. How did you survive yours? I hope you're doing okay. It's great that you and DH are getting some answers. I hope with this knowledge, you & DH will be armed with all you need to bring on that rainbow baby!
Please forgive me for not replying to your email yet!
I have no advice or insight to offer on the subject, but still wanted to at least pass along some T&P for that kidney stone of yours, so you can avoid surgery - or if gosh forbid you'd need it - hope that you have a speedy recovery!
Also, I think it's wonderful that your getting some testing done, and hopefully all this will result in a great rainbow baby for you soon
______________________________________________________
BFP #1 06.20.11 I EDD 03.22.12 I MMC 09.01.11 (baby measured 6w4d) I D&C 09.07.11
BFP #2 02.21.12 I EDD 10.29.12 I DS born 11.06.12
Surprise BFP #3 07.27.13 I EDD 04.02.14 I Stick baby stick!
blog I pinterest
** I'm hopping all over boards these days, please @quote me for speedy replies
**
Hi ya there! Sending t&ps to you and hope it passes soon!
I too had abnormal blood work come back which wasn't definitive for much specific (also came back clear with hetero-MTHFR) and was put on extra folic acid (which coincidentally is good for DH's swimmers so he stays on it too), baby aspirin and lovenox from egg transfer until my NT scan at 13 weeks (still on extra folic acid and aspirin). I don't know if that combo did the trick but my LO is baking away at 28 weeks now. I agree that it can't hurt - well, the injections do hurt, but YKWIM. I didn't have a clear factor 13 diagnosis but it was discussed and that was the protocol given to me.
Since I was doing IVF isn't wasn't a big deal to add the lovenox, but if you are going unmediated every cycle, shooting yourself up once a day for 14 days during the 2ww every month may wear on you, but then again I would do just about anything for a baby.
GL and huge hugs to you!
#1 BFP 1/10/11; missed m/c discovered 7w5d
IF Dx: Endo, hetero MTHFR mutation, poor morphology
#1 IUI: 1/18/12 = BFN
#1 IVF/ICSI 4/2/12 = 2 x 7-cell and 1 x 5-cell transferred (3dt) = BFP!!
H was born at 41w2d on 12/29/12 - be still my heart!
#2 IVF/ICSI 1/19/14 = 2 x 8 cells transferred (3dt) = BFP!! EDD 10/09/14
M&W born at 37 weeks on 9/18/14 - I am the momma of 3 boys!!!
Do not worry at all. I know what you mean about your EDD......Saturday was really hard for me. I did think that maybe you were mad at me or something and weren't responding for that reason, but that is very indicative of my current state of mind! Again, do not worry, I will look forward to hearing from you soon!
Thank you for your kind words - they mean a lot!
Look at you so far along!!!! I am so happy for you, friend. Thank you for thinking of me. xoxo
Hey you! Thanks for the insight - it is helpful to me. I think the general consensus from my RE was to do the Lovenox. I am doing medicated cycles, not injects, but medicated nonetheless. Its exhausting either way, and my feeling is whats one more thing added onto my pile of sh!t? I know they will hurt like heck, but I am willing to do anything for my rainbow baby. Good luck to you and I am so excited for you!!!