TTC after 35

Lab tests in - help...

I did my 3 day testing & these are my results.  The Dr hasn't called me yet, but the lab gave me a copy of them :)

TSH 3.76  (.40 - 4.50 mIU/L)

T4, Free 1.1  (0.8 - 1.8 ng/dL)

LH 6.1   mIU/mL

FSH 7.4  mIU/mL

Prolactin 9.0  ng/mL

Estradiol 56  pg/ml

Anyone have a clue if this is good or bad news?  Tx in advance...

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Re: Lab tests in - help...

  • Here is a good link with values. https://fertilityplus.org/faq/hormonelevels.html

     

    All of your look good except for TSH. That is a little high for TTC. I don't have thyroid issues so I can't comment further but I know other ladies here can chime in.

    TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
    DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
    5 IUI's: 2/11 to 6/11 and 1/12= BFN
    OE IVF#1-4 8/11-6/12= all BFN
    DE IVF#1 11/12 bad embryos= BFN
    DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
    CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
    DE IVF #3 1/14  ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d

    DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
    First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!

    K & K born 11/21/14 at 38wks 4 days

    imageimage

    SAIF/PAIF Welcome


    http://waitingforraintostop.wordpress.com

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  • Thanks for the link, it is very helpful.  I see what you are saying - I am on the high end of the "normal" range for TSH. 

    I don't have any thyroid issues that I know of.  I definately don't have a weight problem - I am not super skinny nor am I heavy (I range 128-131 lbs & am 5' 6 1/2" tall).  I always thought I had a high metabolism & good genetics (both parents are thin) LOL

    If anyone else has similar blood results, please respond.  These results are going to my OBGYN, not an RE - so I don't know if he will read them the same way as an RE would...

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  • I also agree that the tsh is too high per my experience.  I've never had any thyroid issues or symptoms and mine ran about 4 over the last few years. That's technically normal, but my RE wants below 2, so I was started on thyroid med last year (25mcg) and got pregnant right away. Unfortunately I m/c that pregnancy, but it sure seemed to help conception! During my CP (last week) , my tsh went up to 3.5 so she is now doubling my thyroid med, so even that number she was unhappy with.
    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
  • Btw, let me point out that my ob first ran my tsh and said it was fine at 4.0 while the RE said it was way too high..
    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
  • Your TSH is high.  I have a history of thyroid issues and my previous endocrinologist thought my 3.0 level was fine.  I quit that endocrinologist (other issues) and my new one immediately honed in on my TSH as being a hurdle to conceiving.  He wants it under 2.  He started me on Synthroid (super easy drug to take - no side effects) and is going to see me to re-test my TSH this month.  My RE agrees with him.
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  • How important is it to test for the Free T4 vs just the TSH?
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  • Thanks for all the great responses.  I will look into that thyroid medicine & also ask my dr about it.  I am betting that being his is only an OBGYN, he will think my level is fine.  He had recommended I see an RE last year when I told him that after I got married we would be TTC, but I figured the RE was only for IVF & all that stuff - which is something my DH & I chose not to do.

    Question:  If or should I say, WHEN you conceive (must stay positive), will you have to stay on this thyroid medicine, or can you stop taking it?  Being we are in the "normal" range, I would think we could stop taking it.  You mentioned no side affects - that is awesome, I would hate for any side affects.

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  • Agree with pps.  Your thyroid level is definitely too high for TTC.  My endo likes it to be below 2 for TTC.  When you are pregnant, you see the endo pretty regularly to monitor your levels and they adjust the meds accordingly.  I think the OB/GYN can also do this, but I preferred to have the "expert" keeping an eye on things during my pregnancy.   I also take Armour Thyroid, not Synthroid.  My endo believes this is better option than Synthroid...I think it's supposed to be more natural or something like that.
     
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  • Definitely talk to your RE. I am overweight and it seems like (even before TTC) everytime I go into a doctor's office they test my thyroid.  TSH has been pretty consistently between 3 and 3.5 for the past few years and no one said anything.  I spoke to my RE, he tested it a couple of times- once it was 4.7 (!) and the next time it went right back down to 3.2.  He told me that the TSH is "highly variable" whatever that means, and didn't want to treat me at 3 (although he mentioned we'd monitor it closely if I got pregnant). I also had a ton of other thyroid tests by the RE (T3, T4, thyroid binding globulin, anti-thyroid antibodies, thyroglobulin, etc.)- all normal. 

    My GP ran the thyroid panel again and even further tests and they all came back normal (with the TSH at 3.2, again) and he thinks I don't need treatment.  He referred me to a medical endocrinologist after I badgered him about it. Given all the postings here, just today I made an appointment with the ME.

    It is my understanding (don't quote me), once you start thyroid meds, you are on them indefinitely.  I know that my mom took Armour Thyroid and had horrible side effects (ringing in ears, etc.).  Everyone is different. She is fine on synthroid.

    GL!

    image
    DOR and AMA
    2/12-5/12: 4 IUI cycles = all BFN;
    7/12: DE IVF # 1 (with ICSI)- 20R, 16M, 14F, 5DT of 2 blasts; 6 frosties = BFN;
    Lupus anticoagulant initially high, then found to be normal on hematology consult;
    Follow up testing in September all clear;
    Started synthroid for "high normal" TSH;
    FET # 1- late October 2012- BFP on FRER; beta # 1- 21(low), beta # 2- 48 (still low), beta # 3- 132, beta # 4- 1,293; beta # 5- 5,606; last beta- over 100,000. First u/s 11/21- heard heartbeat
    12/12- Officially an OB patient!
    Level 2 ultrasound at 20 weeks shows vasa previa and VCI
    Referral to MFM and mandatory c section for delivery
    Beautiful baby girl born at 34 weeks
    Finally home after 15 day NICU stay!
    Trying for sibling: FET # 2- May 2014; beta 5/31, BFN
    FET #3, early July 2014; beta 7/14, BFN
    DE IVF # 2- August 2014; 14R, 13M, 11F, 5dt of 2 blasts (3 AA), 5 frosties = BFN
    FET #4- December 2014, yet another BFN

    Dr. KK work up shows borderline uterine blood flow, elevated NK cells, and MTHFR mutation (homozygous for c677t)

    Added baby aspirin, prednisone, supplements, Metanx, and intralipids

    Switched to large clinic for final attempt; had endometrial receptivity testing in January; FET March 2015 = yet another BFN

    Likely OAD- NBC

  • When you conceive, you should stay on the thyroid medicine.  It is safe. I am on 100mcg of Synthroid and I took it throughout my pregnancies.  Being pregnant can actually cause a thryoid condition to worsen and it should be monitored closely. While pregnant, I was getting my thyroid checked every 2 months. 

    After I found out about being hypothryoid and being given Synthroid, I felt so much better!  I was always cold & was losing hair constantly.  I am still cold often but not like before and I lose much less hair now.  I too have experienced no side effects of being on Synthroid.

    Wishing you the best!

  • imageJ&D2007:
    I also agree that the tsh is too high per my experience.  I've never had any thyroid issues or symptoms and mine ran about 4 over the last few years. That's technically normal, but my RE wants below 2, so I was started on thyroid med last year (25mcg) and got pregnant right away. Unfortunately I m/c that pregnancy, but it sure seemed to help conception! During my CP (last week) , my tsh went up to 3.5 so she is now doubling my thyroid med, so even that number she was unhappy with.

    My response is going to be long! I found out two or so years ago I had hypothyroidism.   I didn't realize how important it was & my levels were mostly "ok" (below 5, above 3).  I was able to get pregnant, but unfortunately didn't stay pregnant.  My TSH levels were over 11 during week 5!!  Crazy high.   After all of this, I made a couple of appointments with different endocrinologists to get everything straightened out (and it's getting there) I agree with PP that TSH is too high,  esp. b/c you are on meds.  

    1. "Normal" range is 0.5 to 4.5 for TSH.  If you are on meds (regardless of TTC), your levels should always be below 2.5 (according to my endocrinologist).   

    2. IF you are taking generic levothyroxine,  ask to switch to Syntrhoid (name brand).  The generic form can vary up to 12%, batch to batch.  So if you are on 100 micrograms (like me!),  you could really be taking 88 micrograms one month and then 112 micrograms the next month.  

    3.   When TTC your levels should be under 2, as close to 1 as possible.   When you get pregnant, get blood drawn immediately.  My endocrinologist said to also up my synthroid by 25% immediately.  The fetal thyroid develops (around 7- 8 wks gestation/9-10 wks pregnant) towards the end of the first trimester. so for the first trimester you are you are providing all the T4 & T3 for the fetus & the demands increase for your T4 & T3.  First trimester- it should be below 2.  Second & third- below 3. 

    4.  How does TSH/T4/T3 work? TSH is thryroid stimulating hormone.   It's released by the pituitary,  travels to the thryroid & stimulates the release of T4 (the majority) & T3 (just a little bit) from the thyroid.   T3 is the form that your body really needs, and T4 gets converted to T3 in other organs.   It's important to measure both free T4 & free T3 to see if the TSH is really signaling the release of T4, and then to see if T4 is being converted to T3.  Levothyroxine & synthroid are both similar to T4 (and are synthetic).  A pp mentioned Armour, which is natural (from pig thyroids), and contains a combination of the inactive (T4) and the active (T3).    There is a feedback loop that goes back to the pituitary to tell the pituitary if T3 & T4 are actually being released.   If the levels are too low,  more TSH will be released.  If the levels are high,  less TSH will be released.   Levothyroixine should replace the T4 & decrease the amount of  TSH being released.

    5. Also ask them to test your antibody levels. 

    Be proactive and insist your levels get below 2 & close to 1.   Some doctors only test every 8wks til you level out,  but while pregnant you should be tested every 4. And while getting regulated, get blood drawn every 4-6 weeks.  

    I recommend doing some reading on this, as well. I've read both of these books, and they help give you the the background of what's going on.  I've also read a ton of actual research & medical articles (the thyroid is not my area of expertise, but I am a research scientist). 

    Book 1: by Mary Shoman. This one is way more anecdotal-   and some of the details regarding pregnancy are plain wrong (she jumps between gestational/embryological/conceptional dates- and they are not consistant). However, it's a quick read & easy to understand (if you ignore the inconsistencies)

    Book 2:    by Ken Blanchard & Marietta Abrams Brill.  This one is much better, in my opinion, and is a great place to start!

     Good luck!

    TTC since Feb 2012. Me: 39, DH: 37
    BFP #1 5/27/12- m/c 7/9/12 @ 10w2d (cytotec induced @11w).
    Fibroids, Hashimoto's Hypothyroidism
    BFP #2 11/18/12  EDD 7/27/13
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  • imagebabystoli:

    imageJ&D2007:
    I also agree that the tsh is too high per my experience.  I've never had any thyroid issues or symptoms and mine ran about 4 over the last few years. That's technically normal, but my RE wants below 2, so I was started on thyroid med last year (25mcg) and got pregnant right away. Unfortunately I m/c that pregnancy, but it sure seemed to help conception! During my CP (last week) , my tsh went up to 3.5 so she is now doubling my thyroid med, so even that number she was unhappy with.

    My response is going to be long! I found out two or so years ago I had hypothyroidism.   I didn't realize how important it was & my levels were mostly "ok" (below 5, above 3).  I was able to get pregnant, but unfortunately didn't stay pregnant.  My TSH levels were over 11 during week 5!!  Crazy high.   After all of this, I made a couple of appointments with different endocrinologists to get everything straightened out (and it's getting there) I agree with PP that TSH is too high,  esp. b/c you are on meds.  

    1. "Normal" range is 0.5 to 4.5 for TSH.  If you are on meds (regardless of TTC), your levels should always be below 2.5 (according to my endocrinologist).   

    2. IF you are taking generic levothyroxine,  ask to switch to Syntrhoid (name brand).  The generic form can vary up to 12%, batch to batch.  So if you are on 100 micrograms (like me!),  you could really be taking 88 micrograms one month and then 112 micrograms the next month.  

    3.   When TTC your levels should be under 2, as close to 1 as possible.   When you get pregnant, get blood drawn immediately.  My endocrinologist said to also up my synthroid by 25% immediately.  The fetal thyroid develops (around 7- 8 wks gestation/9-10 wks pregnant) towards the end of the first trimester. so for the first trimester you are you are providing all the T4 & T3 for the fetus & the demands increase for your T4 & T3.  First trimester- it should be below 2.  Second & third- below 3. 

    4.  How does TSH/T4/T3 work? TSH is thryroid stimulating hormone.   It's released by the pituitary,  travels to the thryroid & stimulates the release of T4 (the majority) & T3 (just a little bit) from the thyroid.   T3 is the form that your body really needs, and T4 gets converted to T3 in other organs.   It's important to measure both free T4 & free T3 to see if the TSH is really signaling the release of T4, and then to see if T4 is being converted to T3.  Levothyroxine & synthroid are both similar to T4 (and are synthetic).  A pp mentioned Armour, which is natural (from pig thyroids), and contains a combination of the inactive (T4) and the active (T3).    There is a feedback loop that goes back to the pituitary to tell the pituitary if T3 & T4 are actually being released.   If the levels are too low,  more TSH will be released.  If the levels are high,  less TSH will be released.   Levothyroixine should replace the T4 & decrease the amount of  TSH being released.

    5. Also ask them to test your antibody levels. 

    Be proactive and insist your levels get below 2 & close to 1.   Some doctors only test every 8wks til you level out,  but while pregnant you should be tested every 4. And while getting regulated, get blood drawn every 4-6 weeks.  

    I recommend doing some reading on this, as well. I've read both of these books, and they help give you the the background of what's going on.  I've also read a ton of actual research & medical articles (the thyroid is not my area of expertise, but I am a research scientist). 

    Book 1: by Mary Shoman. This one is way more anecdotal-   and some of the details regarding pregnancy are plain wrong (she jumps between gestational/embryological/conceptional dates- and they are not consistant). However, it's a quick read & easy to understand (if you ignore the inconsistencies)

    Book 2:    by Ken Blanchard & Marietta Abrams Brill.  This one is much better, in my opinion, and is a great place to start!

     Good luck!

    OP- thanks for asking this, as I have no idea what my numbers are or mean!
    Thanks to all posters for informing me. 

    Babystoli- thank you for posting this! I have copied and printed it so I can address these issues with my doctors. I think my last TSH came in around 9, so my RE raised my Levothyroxine from 88 to 100mcg. I will ask about the Synthroid. What a bummer if this could have been altered long ago! :(


    imageimageimageimageimageimageimageimage
    My BLOG: www.ivfbabyquest.wordpress.com -Update - old blog.

    PAIF/SAIF Welcome!
    Me: 42, Hubby: 35, TTC since Jan 2010. Dx: DOR due to advanced maternal age. Also: Hypothyroidism (100mcg Levothyroxin). Positive for MTHFR (hetero-C677T), Factor V Leiden, and Fragile X (on DH side). Taking pre-natal vitamins
    .
    First natural PG 9/27/11; mc: 1/20/12

    First RE visit: 8/8/12, Saline Sonogram: 8/28/12, IVF injection class: 10/11/12, add FaBB Tab for FVL, +Vitamin D.
    IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Prog- 0.3 The u/s showed 6 follicles in my right  & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 10/21/12: Add Ganirelix SQ every morning.
    ER 10/28/12: 13 Retreived. 7 Mature. 6 Fertilized. 5 Made it to PGS. ET 11/2/12: CANCELED. All 5 came back from PGS as having "severe abnormalities."
    IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 1/11/13: Add Ganirelix SQ every morning. hCG Trigger 1/16/13

    ER 1/18/13: 9 Retrieved. 5 Mature. 5 Fertilized. 2 Made it to PGS. ET 1/23/13: CANCELED. All embryos (he even sent the ones not growing) came back from PGS as having "multiple severe abnormalities."
    IVF #3:
    NEW RE! 3/1/13 Baseline: FSH- 9.6, E2- 61, Prog- 0.94, 3 follicles in my right & 4 in my left. Rx: 150 Bravelle& 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ.
    ER 3/11/13: 6R, 2M, 2F. Day 3: one 8 cell, grade 0.  Five day ET 3/16/13: one early blast, grade Fair. 3/24/13 AF came a day before beta. BFN

    IVF #4: 
    (Added acupuncture to this cycle.) 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Prog- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right & 4 in my left. Rx: 225 Bravelle& 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM.hCG Trigger 4/3/13 SQ.
    ER 4/5/13: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). Five day ET 4/10/13: two blastocysts (the 3rd stopped growing.) Beta 4/18/13: 2.5 BFFN. RE recommends we stop trying and focus on living childless, due to the extremely poor quality of my eggs.
    ***Decided to stop trying and live CFNBC. I couldn't adjust. So, six months later...

    IVF #5: Changed RE. Going to one of the big name clinics now. OWDU: 10/29/13. Update: HORRIBLE experience. Disgusted and distraught at their complete unprofessionalism and how much money and precious time they cost us. Sickening. Have now changed RE again. New Patient appt. 1/30/14.
    BFP! Out of nowhere, I got KU the old fashioned way! POAS 1/26/14 - Positive! FDLM 12/30/13. Beta #1 16dpo= 373. Beta #2 18dpo= 801. EDD 10/6/14
    2/4/14 1st U/S revealed a 5wk2day sac but no fetal pole. Started 200mgs of progesterone suppositories daily
    2/11/14 2nd U/S revealed a perfect 6wk1day "diamond ring" embryo with a beating heart! 138bpm! Add 1mg folic acid and 40mg Lovenox
    2/25/14 3rd U/S: perfect 8w1d embryo, 178bpm. 3/6 start spotting. 3/11 10w1d U/S shows no heartbeat. Scheduling D&C. The Stork has forsaken me again.
    IVF #5.2: New in-state RE. Supplement priming for 1.5 cycles prior to start of cycle, including DHEA 50mg (stopped 5/15), CoQ10 200mg 2x/day, L-Arginine- 1000mg 2x/day (stopped 6/5 due to cold sore!), myo-inositol- 2g 2x/day, melatonin- 3mg, and Neevo (prenatal for MTHFR).
    5/16/14 Day 2 bw cycle prior: FSH- 12.22, E2- 38.37, Prog- 1.35, LH- 9.46. 6/2/14 Day 19 bw: Prog- 23
    6/12/14 Baseline: E2- 122.7, Prog- 0.4. 5 follicles in left, 4 follicles in right. Start stims: 375IU Follistim & 150IU Menopur. 6/19 Increase Follistim to 425IU, Menopur still 150IU. 6/18 add Ganirelix. 6/23 Ovidrel trigger SQ. 6/25 ER: 8R, 8M, 5F naturally. Start Medrol & Doxy. 6/26 Start Endometrin. 7/2 Start Lovenox.
    7/8/14 Beta= 137.4 BFP!!! (My first from IVF!) E2- 1109, Prog- >60. Stop CoQ10, myo-inositol, and melatonin. 7/9 2nd Beta= 281.4. TSH- 2.70. Increasing Synthroid to 100mcg daily. 7/24 6w3d u/s measured 6w3d, hb: 121bmp! 8/5 8w1d u/s measured 8w3d, hb: 164bpm! Graduated from RE to OB. Now I just need to find an OB!
    EDD 3/18/15!

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