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Genetic testing or no genetic testing...that is the question?

tampabayRNtampabayRN member
in TTC after 35
Tomorrow I go in for CD3 blood work and sonogram at my RE's office.  Part of the blood work testing is genetic counseling panel (which is voluntary).  I'm not really sure that I want to get the testing done and DH is 100% against it.  1) no genetic diseases run in either or our families 2) the test is 400$ out of pocket 3) DH's argument is that if we would have gotten pregnant on our own without any interventions we would have never had it done beforehand.  I would appreciate any advice on this topic or why you did choose to get tested.  TIA!
Photobucket Me:36 DH: 34 TTC since 02/2012, not preventing since 2010. Me: testing came back good. DH: dx: MIF low count/motility. RE recommends IVF with ICSI. Update: DH just diagnosed with severe Crohn's disease, so any IF treatment is on hold :(
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Re: Genetic testing or no genetic testing...that is the question?

  • Mrs.McIrishMrs.McIrish member
    I did not do it as there was nothing in either of our families and it was not covered by insurance. CF testing would have cost us $1000.

    TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
    DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
    5 IUI's: 2/11 to 6/11 and 1/12= BFN
    OE IVF#1-4 8/11-6/12= all BFN
    DE IVF#1 11/12 bad embryos= BFN
    DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
    CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
    DE IVF #3 1/14  ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d

    DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
    First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!

    K & K born 11/21/14 at 38wks 4 days

    imageimage

    SAIF/PAIF Welcome


    http://waitingforraintostop.wordpress.com

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  • Mayzie15Mayzie15 member
    I wasn't asked to do the testing by my previous RE but after a failed IVF cycle our new RE is requesting we do genetic testing and it's costing us about $1,400.00 - we are completely OOP too - I do the testing in a week or so.  We have no genetic diseases that run in our families either - but we are spending so much money on IVF that we are trying to rule everything out - good luck it's not an easy decision and the tests are expensive...

    Me 38 MH 41 - TTC since June 2010 - dx with Severe MFI. Straight to IVF with ICSI. IVF #1 - ER 06/13/12 - 9 Eggs Retrieved - 4 ICSI'd - only 2 fert. 06/15/12 - 2DT - 3 cell & 6 cell with fragmentation. Beta 06/29/12 - IVF #1 = BFN. 07/20/12 - WTF Appt -Told by our RE to quit IVF. Second Opinion from RE is good. IVF#2 - November 2012. Estradiol Pills Started 11/6. Stims start 11/16. ER 11/26 - 7 eggs retrieved - all mature. 4 fertilized with ICSI. ET 11/29 Transferred 3 embryos. Beta is 12/10. 1st Beta 81 2nd Beta 160 and 3rd beta 360!!! First U/S 12/21/12 - We saw one beautiful gest. sac. 2nd U/S is 01/04/2013 - H/B 183 02/05/13 - NT Scan - everything looks good and IT'S A BOY!  Aiden was born 08/20/2013.

    IVF #2 is in progress.  ER was 05/12/14 - 11 eggs retrieved, 8 fertilized with ICSI.  ET was 05/15/14 - we transferred 3 embryos as we did on the cycle my son was conceived.  We were able to freeze 3 embryos. Beta is scheduled for 05/26/14.  1st beta - 111.  2nd beta - 159 didn't double :( 3rd beta Friday 5/30) - not a lot of hope left. Beta # 3 is 247 - probably ectopic.  Beta # 4 is 813 - possibly vanishing multiple sydrome?  06/05/14 - 5w4days - first U/S - we see a gestational sac and yolk - still have hope!  06/17/14 - 7w1day - U/S and saw and heard the heartbeat - Finally!  06/27/14 - 8w4days - Baby and heartbeat look and sound great :)  EDD 02/01/14 and It's a boy!


     "Everything will be okay in the end. If it's not okay, it's not the end."


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  • BAKERMOMHDSBAKERMOMHDS member

    Prior to my first IVF my RE recommended Genetic testing.  At that point, I had 3 miscarriages.  The cost was about 1400 OOP, but the total cost of IVF#1 was about 16K.  Before spending 16K for IVF, I wanted to know if something genetically was preventing viable pregnancies.

    Both DH and I are normal.  3 miscarriages, 2 failed IVF's.. our next IVF (#3) we are moving forward with genetic testing of the embryos.

    Best of luck to you!

    Me = 39 DH = 50 TTC (since 01/2009 after a short break, I stopped counting *cycles* in 2010)
    DX 2010 : Unknown Infertility , AMA
    HSG 2005 = Normal / HSG 2010 = Normal
    SA 2005 = Normal / SA 2010 /2012 = Slightly low count : motility, morphology GREAT!
    Chromosomal analysis, MTHFR, ANA's, Lupus, Protein C, Protein S, APCR = Normal 2011

    M/C : 2005 (7wk), 2010 (6wk), 2011 (7wk)

    8 IUI's 2010-2011 all BFN

    IVF/ICSI antagonist 01/2012 #1 = BFN

    IVF/ICSI antagonist long 06/2012 #2 = BFN

    IVF/ICSI/CGH MDLF New Clinic/New RE 11/2012 #3 = One beautiful boy blasty frozen PGS normal

    IVF/ICSI/CGH MDLF 02/2013 #4 = One more beautiful boy blasty frozen PGS normal

    FET 6/20 : One 5AA PGS normal transferred Beta 1 6/28 = 53.9 / Beta 2 7/1 = 220 / Beta 3 7/3 = 550!

    1 U/S  6w3d - Heartbeat 119 /  2 U/S - 7w5d- Heartbeat 169 / 3 U/S (OB) 8w5d - Heartbeat still great!

    Baby G welcomed into the world 3/7/2014

    SAIF / PAIF always welcome ****

     

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  • chucktgirlchucktgirl member
    I think there needs to be some clarification. The way I read your post, you are asking about genetic testing of your blood, to see if you are genetically predisposed to one or more gene mutations that could cause problems with carrying to term. OR are you talking about the optional genetic testing that can be done on your eggs prior to IVF? If you are speaking about the first, then I guess I was lucky, because my IVF center covers the cost of that themselves (may be doing a study or something?) and I did sign a consent form. As a result, I found out I am positive for two gene abnormalities. One of them brought me insight as to why I may be having thyroid problems, and let me know that I have a clotting issue, which is good to know for all health reasons in the future (not just babymaking issues.) Because of the other, my hubby also had his blood tested to see if he is also a carrier. It will be helpful in determining what we are up against in trying to have a healthy baby. If, on the other hand, you are talking about the second situation, that is entirely up to you and your hubby, based on your financial ability and personal beliefs. If I am lucky enough to get that far, we will be doing that testing as well, even if I have to find a way to pay for it. Good luck! Smile

    imageimageimageimageimageimageimageimage
    My BLOG: www.ivfbabyquest.wordpress.com -Update - old blog.

    PAIF/SAIF Welcome!
    Me: 42, Hubby: 35, TTC since Jan 2010. Dx: DOR due to advanced maternal age. Also: Hypothyroidism (100mcg Levothyroxin). Positive for MTHFR (hetero-C677T), Factor V Leiden, and Fragile X (on DH side). Taking pre-natal vitamins    .
    First natural PG 9/27/11; mc: 1/20/12
    First RE visit: 8/8/12, Saline Sonogram: 8/28/12, IVF injection class: 10/11/12, add FaBB Tab for FVL, +Vitamin D.
    IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Prog- 0.3 The u/s showed 6 follicles in my right  & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 10/21/12: Add Ganirelix SQ every morning.
    ER 10/28/12: 13 Retreived. 7 Mature. 6 Fertilized. 5 Made it to PGS. ET 11/2/12: CANCELED. All 5 came back from PGS as having "severe abnormalities."
    IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 1/11/13: Add Ganirelix SQ every morning. hCG Trigger 1/16/13
    ER 1/18/13: 9 Retrieved. 5 Mature. 5 Fertilized. 2 Made it to PGS. ET 1/23/13: CANCELED. All embryos (he even sent the ones not growing) came back from PGS as having "multiple severe abnormalities."
    IVF #3:     NEW RE! 3/1/13 Baseline: FSH- 9.6, E2- 61, Prog- 0.94, 3 follicles in my right & 4 in my left. Rx: 150 Bravelle& 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ.
    ER 3/11/13: 6R, 2M, 2F. Day 3: one 8 cell, grade 0.  Five day ET 3/16/13: one early blast, grade Fair. 3/24/13 AF came a day before beta. BFN
    IVF #4:     (Added acupuncture to this cycle.) 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Prog- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right & 4 in my left. Rx: 225 Bravelle& 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM.hCG Trigger 4/3/13 SQ.
    ER 4/5/13: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). Five day ET 4/10/13: two blastocysts (the 3rd stopped growing.) Beta 4/18/13: 2.5 BFFN. RE recommends we stop trying and focus on living childless, due to the extremely poor quality of my eggs.
    ***Decided to stop trying and live CFNBC. I couldn't adjust. So, six months later...
    IVF #5: Changed RE. Going to one of the big name clinics now. OWDU: 10/29/13. Update: HORRIBLE experience. Disgusted and distraught at their complete unprofessionalism and how much money and precious time they cost us. Sickening. Have now changed RE again. New Patient appt. 1/30/14.
    BFP! Out of nowhere, I got KU the old fashioned way! POAS 1/26/14 - Positive! FDLM 12/30/13. Beta #1 16dpo= 373. Beta #2 18dpo= 801. EDD 10/6/14
    2/4/14 1st U/S revealed a 5wk2day sac but no fetal pole. Started 200mgs of progesterone suppositories daily
    2/11/14 2nd U/S revealed a perfect 6wk1day "diamond ring" embryo with a beating heart! 138bpm! Add 1mg folic acid and 40mg Lovenox
    2/25/14 3rd U/S: perfect 8w1d embryo, 178bpm. 3/6 start spotting. 3/11 10w1d U/S shows no heartbeat. Scheduling D&C. The Stork has forsaken me again.
    IVF #5.2: New in-state RE. Supplement priming for 1.5 cycles prior to start of cycle, including DHEA 50mg (stopped 5/15), CoQ10 200mg 2x/day, L-Arginine- 1000mg 2x/day (stopped 6/5 due to cold sore!), myo-inositol- 2g 2x/day, melatonin- 3mg, and Neevo (prenatal for MTHFR).
    5/16/14 Day 2 bw cycle prior: FSH- 12.22, E2- 38.37, Prog- 1.35, LH- 9.46. 6/2/14 Day 19 bw: Prog- 23
    6/12/14 Baseline: E2- 122.7, Prog- 0.4. 5 follicles in left, 4 follicles in right. Start stims: 375IU Follistim & 150IU Menopur. 6/19 Increase Follistim to 425IU, Menopur still 150IU. 6/18 add Ganirelix. 6/23 Ovidrel trigger SQ. 6/25 ER: 8R, 8M, 5F naturally. Start Medrol & Doxy. 6/26 Start Endometrin. 7/2 Start Lovenox.
    7/8/14 Beta= 137.4 BFP!!! (My first from IVF!) E2- 1109, Prog- >60. Stop CoQ10, myo-inositol, and melatonin. 7/9 2nd Beta= 281.4. TSH- 2.70. Increasing Synthroid to 100mcg daily. 7/24 6w3d u/s measured 6w3d, hb: 121bmp! 8/5 8w1d u/s measured 8w3d, hb: 164bpm! Graduated from RE to OB. Now I just need to find an OB!
    EDD 3/18/15!

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  • J&D2007J&D2007 member
    Are you doing Ivf? We decided to go ahead with genetic testing before our first Ivf starting soon. Actually DH had his blood work started today. We decided to because I hate to spend $15k on Ivf if there is a genetic problem that we are not aware of.  We both have no history of any problems, nor do our families. Just thought it was a smart investment before Ivf, we did not do it before Iui.
    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
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  • tampabayRNtampabayRN member
    No I am not doing IVF.  I am just starting all the testing with my RE.
    Photobucket Me:36 DH: 34 TTC since 02/2012, not preventing since 2010. Me: testing came back good. DH: dx: MIF low count/motility. RE recommends IVF with ICSI. Update: DH just diagnosed with severe Crohn's disease, so any IF treatment is on hold :(
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